scholarly journals Challenges in the Use of Compact Disc-Based Centrifugal Microfluidics for Healthcare Diagnostics at the Extreme Point of Care

Micromachines ◽  
2016 ◽  
Vol 7 (4) ◽  
pp. 52 ◽  
Author(s):  
Jordon Gilmore ◽  
Monsur Islam ◽  
Rodrigo Martinez-Duarte
Keyword(s):  
Extreme Point ◽  
Point Of Care ◽  
Compact Disc ◽  
Centrifugal Microfluidics

scholarly journals Challenges and Opportunities of Centrifugal Microfluidics for Extreme Point-of-Care Testing

Micromachines ◽  
2016 ◽  
Vol 7 (2) ◽  
pp. 32 ◽  
Author(s):  
Issac Michael ◽  
Tae-Hyeong Kim ◽  
Vijaya Sunkara ◽  
Yoon-Kyoung Cho
Keyword(s):  
Extreme Point ◽  
Point Of Care ◽  
Centrifugal Microfluidics ◽  
Point Of Care Testing ◽  
Challenges And Opportunities

scholarly journals CD-Based Microfluidics for Primary Care in Extreme Point-of-Care Settings

Micromachines ◽  
2016 ◽  
Vol 7 (2) ◽  
pp. 22 ◽  
Author(s):  
Suzanne Smith ◽  
Dario Mager ◽  
Alexandra Perebikovsky ◽  
Ehsan Shamloo ◽  
David Kinahan ◽  
...  
Keyword(s):  
Primary Care ◽  
Extreme Point ◽  
Point Of Care

Rapid sample preparation for detection of antibiotic resistance on a microfluidic disc platform

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Alexandra Perebikovsky ◽  
Yujia Liu ◽  
Alexander Hwu ◽  
Horacio Kido ◽  
Ehsan Shamloo ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Sample Preparation ◽  
Point Of Care ◽  
Susceptibility Test ◽  
Centrifugal Microfluidics ◽  
Sample Treatment ◽  
Care Situation ◽  
The Way

We demonstrated a novel instrument and a centrifugal microfluidics disc design that is capable of remarkably accomplishing the sample treatment steps, which pave the way to realize the antibody susceptibility test in point-of-care situation.

scholarly journals A technology platform for digital nucleic acid diagnostics at the point of care

2017 ◽  
Vol 41 (5) ◽  
Author(s):  
Nadine Borst ◽  
Friedrich Schuler ◽  
Simon Wadle ◽  
Martin Schulz ◽  
Mara Specht ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Single Cell Analysis ◽  
Point Of Care ◽  
Centrifugal Microfluidics ◽  
Resistant Bacteria ◽  
Cell Analysis ◽  
Unit Operation ◽  
Antibiotic Resistant ◽  
Novel Approach ◽  
Nucleic Acid Analysis

AbstractThe combination of digital amplification and centrifugal microfluidics can enable quantitative and fast diagnostics at the point of care (PoC). The new unit operation of centrifugal step emulsification allows high throughput droplet generation. Different methods for digital nucleic acid analysis, including PCR, recombinase polymerase amplification (RPA) and loop mediated isothermal amplification (LAMP), have already been demonstrated. Our novel approach of integrated sample-to-answer analysis is introduced, and examples for the detection of HIV and single cell analysis of antibiotic resistant bacteria are presented. Next to these LabDisk based systems, a microfluidic cartridge termed DropChip allows for digital amplification using only commercially available laboratory devices.

scholarly journals Integrated Microfluidic Compact Disc Device with Potential Use in Both Centralized and Point-of-Care Laboratory Settings

2005 ◽  
Vol 51 (10) ◽  
pp. 1985-1987 ◽  
Author(s):  
Mats Inganäs ◽  
Helene Dérand ◽  
Ann Eckersten ◽  
Gunnar Ekstrand ◽  
Ann-Kristin Honerud ◽  
...  
Keyword(s):  
Point Of Care ◽  
Compact Disc ◽  
Potential Use

scholarly journals Smartphone-Enabled Paper-Based Hemoglobin Sensor for Extreme Point-of-Care Diagnostics

ACS Sensors ◽  
2021 ◽  
Author(s):  
Sujay K. Biswas ◽  
Subhamoy Chatterjee ◽  
Soumya Bandyopadhyay ◽  
Shantimoy Kar ◽  
Nirmal K. Som ◽  
...  
Keyword(s):  
Extreme Point ◽  
Point Of Care ◽  
Point Of Care Diagnostics

“Aspirin - resistance”? A few critical considerations on definition, terminology, diagnosis, clinical value, natural course of atherosclerotic disease, and therapeutic consequences

VASA ◽  
2011 ◽  
Vol 40 (6) ◽  
pp. 429-438 ◽  
Author(s):  
Berent ◽  
Sinzinger
Keyword(s):  
Platelet Function ◽  
Point Of Care ◽  
Aspirin Resistance ◽  
Point Of View ◽  
Evidence Based ◽  
Platelet Function Tests ◽  
Clinical Value ◽  
Vascular Events ◽  
Therapeutic Consequences ◽  
Function Tests

Based upon various platelet function tests and the fact that patients experience vascular events despite taking acetylsalicylic acid (ASA or aspirin), it has been suggested that patients may become resistant to the action of this pharmacological compound. However, the term “aspirin resistance” was created almost two decades ago but is still not defined. Platelet function tests are not standardized, providing conflicting information and cut-off values are arbitrarily set. Intertest comparison reveals low agreement. Even point of care tests have been introduced before appropriate validation. Inflammation may activate platelets, co-medication(s) may interfere significantly with aspirin action on platelets. Platelet function and Cox-inhibition are only some of the effects of aspirin on haemostatic regulation. One single test is not reliable to identify an altered response. Therefore, it may be more appropriate to speak about “treatment failure” to aspirin therapy than using the term “aspirin resistance”. There is no evidence based justification from either the laboratory or the clinical point of view for platelet function testing in patients taking aspirin as well as from an economic standpoint. Until evidence based data from controlled studies will be available the term “aspirin resistance” should not be further used. A more robust monitoring of factors resulting in cardiovascular events such as inflammation is recommended.

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