scholarly journals Pushing the Limits of Spatial Assay Resolution for Paper-Based Microfluidics Using Low-Cost and High-Throughput Pen Plotter Approach

Micromachines ◽  
2020 ◽  
Vol 11 (6) ◽  
pp. 611
Author(s):  
Reza Amin ◽  
Fariba Ghaderinezhad ◽  
Caleb Bridge ◽  
Mikail Temirel ◽  
Scott Jones ◽  
...  
Keyword(s):  
High Resolution ◽  
Low Cost ◽  
Microfluidic Devices ◽  
Regenerated Cellulose ◽  
Substrate Thickness ◽  
Paper Substrate ◽  
Cellulose Paper ◽  
Fabrication Cost ◽  
Paper Based Microfluidics ◽  
Colorimetric Assays

To transform from reactive to proactive healthcare, there is an increasing need for low-cost and portable assays to continuously perform health measurements. The paper-based analytical devices could be a potential fit for this need. To miniaturize the multiplex paper-based microfluidic analytical devices and minimize reagent use, a fabrication method with high resolution along with low fabrication cost should be developed. Here, we present an approach that uses a desktop pen plotter and a high-resolution technical pen for plotting high-resolution patterns to fabricate miniaturized paper-based microfluidic devices with hundreds of detection zones to conduct different assays. In order to create a functional multiplex paper-based analytical device, the hydrophobic solution is patterned on the cellulose paper and the reagents are deposited in the patterned detection zones using the technical pens. We demonstrated the effect of paper substrate thickness on the resolution of patterns by investigating the resolution of patterns on a chromatography paper with altered effective thickness. As the characteristics of the cellulose paper substrate such as thickness, resolution, and homogeneity of pore structure affect the obtained patterning resolution, we used regenerated cellulose paper to fabricate detection zones with a diameter as small as 0.8 mm. Moreover, in order to fabricate a miniaturized multiplex paper-based device, we optimized packing of the detection zones. We also showed the capability of the presented method for fabrication of 3D paper-based microfluidic devices with hundreds of detection zones for conducting colorimetric assays.

Imprint Materials for Nanoscale Devices

MRS Bulletin ◽  
2005 ◽  
Vol 30 (12) ◽  
pp. 947-951 ◽  
Author(s):  
Michael D. Stewart ◽  
C. Grant Willson
Keyword(s):  
High Resolution ◽  
Integrated Circuit ◽  
Nanoimprint Lithography ◽  
Low Cost ◽  
Microfluidic Devices ◽  
Development Work ◽  
New Materials ◽  
Related Development ◽  
Patterning Technique ◽  
Processing Techniques

AbstractNanoimprint lithography is a potentially low-cost, high-resolution patterning technique, but most of the surrounding development work has been directed toward tool designs and processing techniques. There remains a tremendous opportunity and need to develop new materials for specific nanoimprint applications. This article provides an overview of relevant materials-related development work for nanoimprint lithographic applications. Material requirements for nanoimprint patterning for the sub-45-nm integrated-circuit regime are discussed, along with proposed nanoimprint applications such as imprintable dielectrics, conducting polymers, biocompatible materials, and materials for microfluidic devices. Polymers available for thermal nanoimprint processing and photocurable precursors for ultraviolet-assisted nanoimprint lithography are discussed.

scholarly journals Microfabrication with Very Low-Average Power of Green Light to Produce PDMS Microchips

Polymers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 607
Author(s):  
Lucero M. Hernandez-Cedillo ◽  
Francisco G. Vázquez-Cuevas ◽  
Rafael Quintero-Torres ◽  
Jose L. Aragón ◽  
Miguel Angel Ocampo Mortera ◽  
...  
Keyword(s):  
Low Cost ◽  
Average Power ◽  
Green Light ◽  
Microfluidic Devices ◽  
Processing Parameters ◽  
Coating Film ◽  
Two Dimensional ◽  
Dimethyl Siloxane ◽  
Visible Laser ◽  
High Absorption

In this article, we show an alternative low-cost fabrication method to obtain poly(dimethyl siloxane) (PDMS) microfluidic devices. The proposed method allows the inscription of micron resolution channels on polystyrene (PS) surfaces, used as a mold for the wanted microchip’s production, by applying a high absorption coating film on the PS surface to ablate it with a focused low-power visible laser. The method allows for obtaining micro-resolution channels at powers between 2 and 10 mW and can realize any two-dimensional polymeric devices. The effect of the main processing parameters on the channel’s geometry is presented.

scholarly journals Fabrication and Compressive Behavior of a Micro-Lattice Composite by High Resolution DLP Stereolithography

Polymers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 785
Author(s):  
Chow Shing Shin ◽  
Yu Chia Chang
Keyword(s):  
High Resolution ◽  
Lattice Structure ◽  
Low Cost ◽  
Hierarchical Structures ◽  
Dip Coating ◽  
Unit Cell ◽  
Digital Light Processing ◽  
Unit Cell Size ◽  
Wide Range ◽  
And Performance

Lattice structures are superior to stochastic foams in mechanical properties and are finding increasing applications. Their properties can be tailored in a wide range through adjusting the design and dimensions of the unit cell, changing the constituent materials as well as forming into hierarchical structures. In order to achieve more levels of hierarchy, the dimensions of the fundamental lattice have to be small enough. Although lattice size of several microns can be fabricated using the two-photon polymerization technique, sophisticated and costly equipment is required. To balance cost and performance, a low-cost high resolution micro-stereolithographic system has been developed in this work based on a commercial digital light processing (DLP) projector. Unit cell lengths as small as 100 μm have been successfully fabricated. Decreasing the unit cell size from 150 to 100 μm increased the compressive stiffness by 26%. Different pretreatments to facilitate the electroless plating of nickel on the lattice structure have been attempted. A pretreatment of dip coating in a graphene suspension is the most successful and increased the strength and stiffness by 5.3 and 3.6 times, respectively. Even a very light and incomplete nickel plating in the interior has increase the structural stiffness and strength by more than twofold.

AMANDA—low-cost production of microfluidic devices

1998 ◽  
Vol 70 (1-2) ◽  
pp. 153-158 ◽  
Author(s):  
W.K. Schomburg ◽  
R. Ahrens ◽  
W. Bacher ◽  
C. Goll ◽  
S. Meinzer ◽  
...  
Keyword(s):  
Low Cost ◽  
Microfluidic Devices

Microwave-induced, thermally assisted solvent bonding for low-cost PMMA microfluidic devices

2009 ◽  
Vol 20 (1) ◽  
pp. 015026 ◽  
Author(s):  
Mona Rahbar ◽  
Sumanpreet Chhina ◽  
Dan Sameoto ◽  
M Parameswaran
Keyword(s):  
Low Cost ◽  
Microfluidic Devices ◽  
Solvent Bonding

A HIGH-RESOLUTION 2D IMAGING LASER RADAR FOR OCCLUDED HARD TARGET VIEWING AND IDENTIFICATION

2008 ◽  
Vol 18 (02) ◽  
pp. 393-400 ◽  
Author(s):  
ROBERT J. GRASSO ◽  
JOHN C. WIKMAN ◽  
DAVID P. DROUIN ◽  
GEORGE F. DIPPEL ◽  
PAUL I. EGBERT
Keyword(s):  
High Resolution ◽  
Target Identification ◽  
Low Cost ◽  
System Size ◽  
Operating Conditions ◽  
Array Technology ◽  
Diode Pumped ◽  
Target Ranging ◽  
2D Imaging ◽  
Gated Imaging

BAE SYSTEMS has developed a Low Cost Targeting System (LCTS) consisting of a FLIR for target detection, laser-illuminated, gated imaging for target identification, laser rangefinder and designator, GPS positioning, and auto-tracking capability within a small compact system size. The system is based upon BAE Systems proven micro-bolometer passive LWIR camera coupled with Intevac's new EBAPS camera. A dual wavelength diode pumped laser provides eyesafe ranging and target illumination, as well as designation; a custom detector module senses the return pulse for target ranging and to set the range gates for the gated camera. Trials show that the current detectors offer complete extinction of signals outside of the gated range, thus, providing high resolution within the gated region. The images have shown high spatial resolution arising from the use of solid state focal plane array technology. Imagery has been collected in both the laboratory and the field to verify system performance during a variety of operating conditions.

scholarly journals Fabrication of Porous Silicon Based Humidity Sensing Elements on Paper

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Tero Jalkanen ◽  
Anni Määttänen ◽  
Ermei Mäkilä ◽  
Jaani Tuura ◽  
Martti Kaasalainen ◽  
...  
Keyword(s):  
Porous Silicon ◽  
Smart Cities ◽  
Low Cost ◽  
Electrical Characterization ◽  
Fabrication Process ◽  
Sensing Element ◽  
Paper Substrate ◽  
Roll To Roll ◽  
Silver Electrodes ◽  
Silicon Based

A roll-to-roll compatible fabrication process of porous silicon (pSi) based sensing elements for a real-time humidity monitoring is described. The sensing elements, consisting of printed interdigitated silver electrodes and a spray-coated pSi layer, were fabricated on a coated paper substrate by a two-step process. Capacitive and resistive responses of the sensing elements were examined under different concentrations of humidity. More than a three orders of magnitude reproducible decrease in resistance was measured when the relative humidity (RH) was increased from 0% to 90%. A relatively fast recovery without the need of any refreshing methods was observed with a change in RH. Humidity background signal and hysteresis arising from the paper substrate were dependent on the thickness of sensing pSi layer. Hysteresis in most optimal sensing element setup (a thick pSi layer) was still noticeable but not detrimental for the sensing. In addition to electrical characterization of sensing elements, thermal degradation and moisture adsorption properties of the paper substrate were examined in connection to the fabrication process of the silver electrodes and the moisture sensitivity of the paper. The results pave the way towards the development of low-cost humidity sensors which could be utilized, for example, in smart packaging applications or in smart cities to monitor the environment.

High-Resolution Monitoring of Atmospheric Pollutants Using a System of Low-Cost Sensors

2014 ◽  
Vol 52 (7) ◽  
pp. 3823-3832 ◽  
Author(s):  
Sutharshan Rajasegarar ◽  
Timothy C. Havens ◽  
Shanika Karunasekera ◽  
Christopher Leckie ◽  
James C. Bezdek ◽  
...  
Keyword(s):  
High Resolution ◽  
Low Cost ◽  
Atmospheric Pollutants

scholarly journals High-Resolution Atmospheric Sensing of Multiple Atmospheric Variables Using the DataHawk Small Airborne Measurement System

2013 ◽  
Vol 30 (10) ◽  
pp. 2352-2366 ◽  
Author(s):  
Dale A. Lawrence ◽  
Ben B. Balsley
Keyword(s):  
High Resolution ◽  
Measurement System ◽  
Current System ◽  
Low Cost ◽  
Structure Constant ◽  
Turbulence Structure ◽  
Quality Of Data ◽  
Airborne Measurement ◽  
Atmospheric Measurement ◽  
Atmospheric Variables

Abstract The DataHawk small airborne measurement system provides in situ atmospheric measurement capabilities for documenting scales as small as 1 m and can access reasonably large volumes in and above the atmospheric boundary layer at low cost. The design of the DataHawk system is described, beginning with the atmospheric measurement requirements, and articulating five key challenges that any practical measurement system must overcome. The resulting characteristics of the airborne and ground support components of the DataHawk system are outlined, along with its deployment, operating, and recovery modes. Typical results are presented to illustrate the types and quality of data provided by the current system, as well as the need for more of these finescale measurements. Particular focus is given to the DataHawk's ability to make very-high-resolution measurements of a variety of atmospheric variables simultaneously, with emphasis given to the measurement of two important finescale turbulence parameters, (the temperature turbulence structure constant) and ɛ (the turbulent energy dissipation rate). Future sensing possibilities and limitations using this approach are also discussed.

Sign in / Sign up

Export Citation Format

Share Document