scholarly journals Ishophloroglucin A, a Novel Phlorotannin for Standardizing the Anti-α-Glucosidase Activity of Ishige okamurae

Marine Drugs ◽  
2018 ◽  
Vol 16 (11) ◽  
pp. 436 ◽  
Author(s):  
BoMi Ryu ◽  
Yunfei Jiang ◽  
Hyun-Soo Kim ◽  
Jee-Min Hyun ◽  
Sang-Bin Lim ◽  
...  
Keyword(s):  
Analytical Method ◽  
Inhibitory Activity ◽  
Glucosidase Activity ◽  
Ishige Okamurae ◽  
Effective Use

Nutraceutical use of algae requires understanding of the diversity and significance of their active compositions for intended activities. Ishige okamurae (I. okamurae) extract is well-known to possess α-glucosidase inhibitory activity; however, studies are needed to investigate its active composition in order to standardize its α-glucosidase inhibitory activity. In this study, we observed the intensity of the dominant compounds of each I. okamurae extract harvested between 2016 and 2017, and the different potency of each I. okamurae extract against α-glucosidase. By comparing the anti-α-glucosidase ability of the dominant compounds, a novel Ishophloroglucin A with highest α-glucosidase inhibitory activity was identified and suggested for standardization of anti-α-glucosidase activity in I. okamurae extract. Additionally, a validated analytical method for measurement of Ishophloroglucin A for future standardization of I. okamurae extract was established in this study. We suggest using Ishophloroglucin A to standardize anti-α-glucosidase potency of I. okamurae and propose the significance of standardization based on their composition for effective use of algae as marine-derived nutraceuticals.

scholarly journals Suppressing the oxidation of LDL and DNA strand breakage of bioactives in dehulled and hull fraction of lentils

2020 ◽  
Vol 12 ◽  
Author(s):  
JuDong Yeo ◽  
Fereidoon Shahidi
Keyword(s):  
Seed Coat ◽  
Inhibitory Activity ◽  
Plant Cells ◽  
Glucosidase Activity ◽  
Parenchyma Cells ◽  
Strand Breakage ◽  
Inhibitory Activities ◽  
Dna Strand ◽  
Bound Phenolics ◽  
Dna Strand Breakage

Hull/seed coat contains various plant cells that are responsible for sustaining the life of seeds in which phenolics perform significant roles in supporting their functions. In the present study, inhibitory activities against the oxidation of LDL and DNA of soluble- and insoluble-bound phenolics in the dehulled and hull fractions of lentils were determined. In addition, their α-glucosidase inhibitory activity was also assessed. The hulls possessed much higher levels of phenolics in both the soluble- and insoluble-bound forms than dehulled grain fractions, and this led to their potent activities in suppressing the oxidation of LDL and DNA and inhibiting α-glucosidase activity. The high bioactivities of hulls might be due to the existence of various types of cells such as palisade and parenchyma cells containing numerous phenolics for sustaining their functions. This study may help in a better understanding of the localization of soluble- and insoluble-bound phenolics in the structure of lentil.

scholarly journals Effective Utilization of Citrus unshiu Plant Waste Extracts with Lipase Inhibitory Activities

2021 ◽  
Vol 10 (2) ◽  
pp. 1
Author(s):  
Kimihisa Itoh ◽  
Tetsuya Matsukawa ◽  
Takahiro Deguchi ◽  
Momona Yamagami ◽  
Norimichi Tomohiro ◽  
...  
Keyword(s):  
Natural Resources ◽  
Pancreatic Lipase ◽  
Inhibitory Activity ◽  
Citrus Unshiu ◽  
Unripe Fruit ◽  
Methanolic Extracts ◽  
Fruit Cultivation ◽  
Inhibitory Activities ◽  
Citrus Leaves ◽  
Effective Use

During the course of Citrus unshiu fruit cultivation, large amounts of plant material including pruned leaves, thinned-out flowers and unripe fruit are obtained; these materials are generally considered unusable and discarded as plant wastes. We have previously attempted to establish an effective use of such plant wastes as beneficial natural resources and found that a methanolic extract of pruned Citrus leaves (CUL-ext) exhibited inhibitory activity against porcine pancreatic lipase. In this study, we sought to identify further the effective uses of C. unshiu plant wastes by determining the lipase inhibitory activity of methanolic extracts of thinning out flowers (CUF-ext) and unripe fruit (CUUF-ext). We accordingly found that the inhibitory activity of CUF-ext was superior to that of CUUF-ext and comparable to that previously observed using CUL-ext. Fractionation of CUF-ext and CUUF-ext, followed by chromatographic analyses, revealed that the pancreatic lipase inhibitory activities of these extracts could be attributed, at least in part, to the flavonoids hesperidin, nobiletin, narirutin and rutin. On the basis of present findings, we propose that, in addition to pruned Citrus leaves, the thinned-out flowers and unripe fruit of C. unshiu are natural resources which are suitable for preparing constituents with lipase inhibitory activity.

Inhibitory activity on HIV-1 reverse transcriptase and integrase of a carmalol derivative from a brown Alga,Ishige okamurae

2006 ◽  
Vol 20 (8) ◽  
pp. 711-713 ◽  
Author(s):  
M.-J. Ahn ◽  
K.-D. Yoon ◽  
C. Y. Kim ◽  
J. H. Kim ◽  
C.-G. Shin ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Inhibitory Activity ◽  
Brown Alga ◽  
Ishige Okamurae ◽  
Hiv 1

scholarly journals Inhibition of α-glucosidase activity, metals content, and phytochemical profiling of Andrographis paniculata from different geographical origins based on FTIR and UHPLC-Q-Orbitrap HRMS metabolomics

2021 ◽  
Vol 22 (3) ◽  
Author(s):  
Mohamad Rafi ◽  
DEWI ANGGRAINI SEPTANINGSIH ◽  
ALFI HUDATUL KAROMAH ◽  
LUKMAN LUKMAN ◽  
BAMBANG PRAJOGO ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Geographical Origin ◽  
Raw Materials ◽  
Herbal Medicines ◽  
Water Extract ◽  
Ethanol Extract ◽  
Ftir Spectra ◽  
Andrographis Paniculata ◽  
Active Components ◽  
Glucosidase Activity

Abstract. Rafi M, Septaningsih DA, Karomah AH, Lukman, Prajogo B, Amran MB, Rohman A. 2021. Inhibition of α-glucosidase activity, metals content, and phytochemical profiling of Andrographis paniculata from different geographical origins based on FTIR and UHPLC-Q-Orbitrap HRMS metabolomics. Biodiversitas 22: 1535-1542. Ensuring consistency of quality, safety, and efficacy of herbal medicines from raw materials to finished products is important because of the variability in medicinal plants' active components. One of the plants that have been used as an antidiabetic herbal medicine is A. paniculata. This study aims to determine α-glucosidase inhibitory activity, the content of several metals, FTIR spectrum profile, and putative identification of A. paniculata metabolites using UHPLC-Q-Orbitrap HRMS from different geographical origin. We found that ethanol extract of A. paniculata gave higher inhibition of α-glucosidase activity compared to water extract. Eight metals were determined using FAAS and FAES, and calcium showed the highest content in all A. paniculata samples. FTIR spectra of A. paniculata showed a similar profile and only differed in the absorbance. We detected the presence of OH, C=O, C=C aromatic, and C-O functional groups in A. paniculata extract. About 32 metabolites were putatively identified in A. paniculata, mainly from phenolic and diterpene lactones class compounds based on UHPLC-Q-Orbitrap HRMS. Using a combination of FTIR spectra and peak area from 32 identified peaks, we can clustered A. paniculata based on its geographical origin. Based on the result obtained, the geographical origin of A. paniculata affected the metals and metabolites composition and level, resulting in different levels of α-glucosidase inhibitory activity.

Inhibitory activity of flavonoids against human sucrase-isomaltase (α-glucosidase) activity in a Caco-2/TC7 cellular model

2022 ◽  
Author(s):  
Carina Proença ◽  
Ana T. Rufino ◽  
José Miguel P. Ferreira de Oliveira ◽  
Marisa Freitas ◽  
Pedro A. Fernandes ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Cellular Model ◽  
Oh Groups ◽  
Glucosidase Activity

Flavonoids may be effective inhibitors of SI in Caco-2/TC7 cells when using natural substrates maltose and sucrose. The chemical features that favor the SI inhibition by flavonoids are the presence of –OH groups at C-3, C-3′, C-4′, C-7 and C-8.

scholarly journals Chemical synthesis, inhibitory activity and molecular mechanism of 1-deoxynojirimycin–chrysin as a potent α-glucosidase inhibitor

RSC Advances ◽  
2021 ◽  
Vol 11 (61) ◽  
pp. 38703-38711
Author(s):  
Ran Zhang ◽  
Yueyue Zhang ◽  
Gaiqun Huang ◽  
Xiangdong Xin ◽  
Liumei Tang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Chemical Synthesis ◽  
Molecular Mechanism ◽  
Inhibitory Activity ◽  
Effective Strategy ◽  
Glucosidase Inhibitor ◽  
Glucosidase Activity

Hyperglycemia can be efficaciously regulated by inhibiting α-glucosidase activity and this is regarded as an effective strategy to treat type 2 diabetes.

scholarly journals A novel analytical method based on HPLC-PDA coupled post-column derivatization to evaluate the ability to inhibit tyrosine nitration in lotus leaf extracts

RSC Advances ◽  
2018 ◽  
Vol 8 (68) ◽  
pp. 38715-38720
Author(s):  
Yin Qian ◽  
Xi Chen ◽  
Jin Qi ◽  
Xuming Liu
Keyword(s):  
Analytical Method ◽  
Inhibitory Activity ◽  
Tyrosine Nitration ◽  
Leaf Extracts ◽  
Lotus Leaf

A novel analytical method based on HPLC-PDA coupled post-column derivatization to evaluate the inhibitory activity of tyrosine nitration in lotus leaf extracts.

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