scholarly journals Chemical synthesis, inhibitory activity and molecular mechanism of 1-deoxynojirimycin–chrysin as a potent α-glucosidase inhibitor

RSC Advances ◽  
2021 ◽  
Vol 11 (61) ◽  
pp. 38703-38711
Author(s):  
Ran Zhang ◽  
Yueyue Zhang ◽  
Gaiqun Huang ◽  
Xiangdong Xin ◽  
Liumei Tang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Chemical Synthesis ◽  
Molecular Mechanism ◽  
Inhibitory Activity ◽  
Effective Strategy ◽  
Glucosidase Inhibitor ◽  
Glucosidase Activity

Hyperglycemia can be efficaciously regulated by inhibiting α-glucosidase activity and this is regarded as an effective strategy to treat type 2 diabetes.

IN VITRO SCREENING OF ACTINIOPTERIS DICHOTOMA FOR ENZYME INHIBITORY ACTIVITY RELATED TO TYPE 2 DIABETES

INDIAN DRUGS ◽  
2016 ◽  
Vol 53 (06) ◽  
pp. 70-73
Author(s):  
M Telagari ◽  
◽  
K. K. Hullatti
Keyword(s):  
Type 2 Diabetes ◽  
Inhibitory Activity ◽  
Skin Diseases ◽  
In Vitro Screening ◽  
Glucosidase Activity ◽  
Ic50 Values ◽  
Calculated Fraction

Actiniopteris dichotoma Mett. (Pteridaceae) is documented in Ayurveda for treatment of Prameha (Diabetes), Atisara and skin diseases. However, the antidiabetic properties of this plant have not been fully validated using scientific tools. The present study screens the A. dichotoma extract and fractions for enzyme inhibitory (α–amylase and α–glucosidase) activity related to type 2 diabetes. The extract was prepared using cold maceration followed by Soxhlation and finally fractionated the combined extracts. Different concentrations (0.1–0.5 mg/mL) of extract and four fractions were subjected to enzyme inhibitory assays. The absorbance was measured at 540 and 405 nm and IC50 values were calculated. Fraction 2 has shown highest α–amylase and α–glucosidase inhibitory activity, (IC50 values are 0.131 and 0.114 mg/mL) which was comparable with acarbose (0.125 and 0.093 mg/mL). Hence, further studies may throw light on the antidiabetic potential of A. dichotoma especially in the management of T2D.

scholarly journals Phenolic composition and inhibitory activity of Mangifera indica and Mucuna urens seeds extracts against key enzymes linked to the pathology and complications of type 2 diabetes

2014 ◽  
Vol 4 (11) ◽  
pp. 903-910 ◽  
Author(s):  
Emmanuel Anyachukwu Irondi ◽  
Ganiyu Oboh ◽  
Afolabi Akintunde Akindahunsi ◽  
Aline Augusti Boligon ◽  
Margareth Linde Athayde
Keyword(s):  
Type 2 Diabetes ◽  
Inhibitory Activity ◽  
Mangifera Indica ◽  
Phenolic Composition ◽  
Key Enzymes

scholarly journals Insights Into the Molecular Mechanism for Type 2 Diabetes Susceptibility at the KCNQ1 Locus From Temporal Changes in Imprinting Status in Human Islets

Diabetes ◽  
2012 ◽  
Vol 62 (3) ◽  
pp. 987-992 ◽  
Author(s):  
M. E. Travers ◽  
D. J. G. Mackay ◽  
M. Dekker Nitert ◽  
A. P. Morris ◽  
C. M. Lindgren ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Molecular Mechanism ◽  
Human Islets ◽  
Temporal Changes ◽  
Diabetes Susceptibility

scholarly journals DPP-4 inhibitor and alpha-glucosidase inhibitor equally improve endothelial function in patients with type 2 diabetes (EDGE study)

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P1432-P1432
Author(s):  
H. Kihara ◽  
K. Nakamura ◽  
H. Oe ◽  
K. Shimada ◽  
S. Fukuda ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Endothelial Function ◽  
Glucosidase Inhibitor ◽  
Alpha Glucosidase

scholarly journals Chemical Composition andα-Glucosidase Inhibitory Activity of VietnameseCitrusPeels Essential Oils

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Nguyen Hai Dang ◽  
Pham Huong Nhung ◽  
Bui Thi Mai Anh ◽  
Dinh Thi Thu Thuy ◽  
Chau Van Minh ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Inhibitory Activity ◽  
Inhibitory Effect ◽  
Potential Use

Background. Inhibition ofα-glucosidase is an important factor to control postprandial hyperglycemia in type 2 diabetes mellitus.Citrusessential oils (CEO) are among the most widely used essential oils, and some of them exhibited promising antidiabetic effect. However, theα-glucosidase inhibition of CEO has not been investigated so far. The present work aims to evaluate theα-glucosidase inhibition of essential oils from six VietnameseCitruspeels.Methods. The chemical composition of essential oils obtained by hydrodistillation from sixCitruspeels was analyzed by GC-MS. All essential oils were tested for their inhibitory activity onα-glucosidase usingp-nitrophenyl-α-D-glucopyranoside as substrate.Results. In Buddha’s hand and lime peels, the major components were limonene (59.0–61.31%) andγ-terpinene (13.98–23.84%) while limonene (90.95–95.74%) was most abundant in pomelo, orange, tangerine, and calamondin peels. Among the essential oils, the Buddha’s hand oil showed the most significantα-glucosidase inhibitory effect with the IC50value of 412.2 μg/mL. The combination of the Buddha’s hand essential oil and the antidiabetic drug acarbose increased the inhibitory effect.Conclusions. The results suggested the potential use of Buddha’s hand essential oil as an alternative in treatment of type 2 diabetes mellitus.

scholarly journals Evaluating α-glucosidase inhibitory activity of hairy roots cultured from some plants in malvaceae family induced by Agrobacterium rhizogenes ATCC 15834

2020 ◽  
Vol 2 (6) ◽  
pp. 165-174
Author(s):  
Vu Thi Bach Phuong ◽  
Pham Thi Anh Hong ◽  
Quach Ngo Diem Phuong
Keyword(s):  
Type 2 Diabetes ◽  
Agrobacterium Rhizogenes ◽  
Hairy Root ◽  
Hairy Roots ◽  
Inhibitory Activity ◽  
Root Culture ◽  
Root Induction ◽  
Hibiscus Sabdariffa ◽  
Sida Acuta

One of the most effective methods for type 2 diabetes treatments is inhibition of enzyme α-glucosidase in the intestines to slow down the release of glucose from carbohydrates in the diet, reduce plasma glucose levels and prevent hyperglycemia after meals. Therefore, seeking α-glucosidase inhibitors used in the treatment of diabetes from plant is the attention of many scientists. Based on the potential of the hairy root culture technology in increasing valuable chemical compounds accumulating, this study aimed to induce hairy roots from six plants of the Malvaceae family including Urena lobata, Abutilon indicum, Hibiscus Sabdariffa, Hibiscus rosa-sinensis, Sida acuta, Sida rhombifolia, and screening which materials has the highest in α-glucosidase inhibitory activity. We have successfully induced hairy roots from six plant species by using the Agrobacterium rhizogenes ATCC 15834 strain. The highest rates of hairy root induction were observed in Hibiscus Sabdariffa and Urena lobata. The stable introduction of rolB and rolC genes to plant genomes was confirmed by PCR. Under liquid-shake culture conditions on MS medium, hairy roots of Hibiscus sabdariffa, Urena lobata and Sida acuta showed better development than other species, and therefore, they are selected for the study of α-glucosidase inhibitory activity. This study proved that Urena lobata was stronger in inhibiting α-glucosidase activity than other studied plants, with the IC50 value of 7.65 μg/ml. The results of this study demonstrated Urena lobata hairy root might be considered as a potential supply of medicinal plants for the treatment of type 2 diabetes.  

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