scholarly journals Recent Trends in Three-Dimensional Bioinks Based on Alginate for Biomedical Applications

Materials ◽  
2020 ◽  
Vol 13 (18) ◽  
pp. 3980 ◽  
Author(s):  
Farnoosh Pahlevanzadeh ◽  
Hamidreza Mokhtari ◽  
Hamid Reza Bakhsheshi-Rad ◽  
Rahmatollah Emadi ◽  
Mahshid Kharaziha ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Review Paper ◽  
Cell Attachment ◽  
Three Dimensional ◽  
Natural Polymers ◽  
Cell Printing ◽  
Tissue Printing ◽  
Artificial Tissue ◽  
Recent Trends ◽  
Synthetic And Natural Polymers

Three-dimensional (3D) bioprinting is an appealing and revolutionary manufacturing approach for the accurate placement of biologics, such as living cells and extracellular matrix (ECM) components, in the form of a 3D hierarchical structure to fabricate synthetic multicellular tissues. Many synthetic and natural polymers are applied as cell printing bioinks. One of them, alginate (Alg), is an inexpensive biomaterial that is among the most examined hydrogel materials intended for vascular, cartilage, and bone tissue printing. It has also been studied pertaining to the liver, kidney, and skin, due to its excellent cell response and flexible gelation preparation through divalent ions including calcium. Nevertheless, Alg hydrogels possess certain negative aspects, including weak mechanical characteristics, poor printability, poor structural stability, and poor cell attachment, which may restrict its usage along with the 3D printing approach to prepare artificial tissue. In this review paper, we prepare the accessible materials to be able to encourage and boost new Alg-based bioink formulations with superior characteristics for upcoming purposes in drug delivery systems. Moreover, the major outcomes are discussed, and the outstanding concerns regarding this area and the scope for upcoming examination are outlined.

scholarly journals RECENT ADVANCES IN HYDROGELS FOR BIOMEDICAL APPLICATIONS

2018 ◽  
Vol 11 (11) ◽  
pp. 62
Author(s):  
Surojeet Das ◽  
Vivek Kumar ◽  
Rini Tiwari ◽  
Leena Singh ◽  
Sachidanand Singh
Keyword(s):  
Biomedical Applications ◽  
Three Dimensional ◽  
Primary Objective ◽  
Cellular Interactions ◽  
Natural Polymers ◽  
Synthetic Materials ◽  
Physical And Chemical ◽  
Modern Era ◽  
Synthetic And Natural Polymers

Hydrogels are three-dimensional polymeric network, capable of entrapping substantial amounts of fluids. Hydrogels are formed due to physical or chemical cross-linking in different synthetic and natural polymers. Recently, hydrogels have been receiving much attention for biomedical applications due to their innate structure and compositional similarities to the extracellular matrix. Hydrogels fabricated from naturally derived materials provide an advantage for biomedical applications due to their innate cellular interactions and cellular-mediated biodegradation. Synthetic materials have the advantage of greater tunability when it comes to the properties of hydrogels. There has been considerable progress in recent years in addressing the clinical and pharmacological limitations of hydrogels for biomedical applications. The primary objective of this article is to review the classification of hydrogels based on their physical and chemical characteristics. It also reviews the technologies adopted for hydrogel fabrication and the different applications of hydrogels in the modern era.

scholarly journals Topographical and Biomechanical Guidance of Electrospun Fibers for Biomedical Applications

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2896
Author(s):  
Sara Ferraris ◽  
Silvia Spriano ◽  
Alessandro Calogero Scalia ◽  
Andrea Cochis ◽  
Lia Rimondini ◽  
...  
Keyword(s):  
Surface Modification ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Electrospun Fibers ◽  
Natural Polymers ◽  
Polymeric Fibers ◽  
Biological Phenomena ◽  
Proper Design ◽  
Synthetic And Natural Polymers ◽  
Selection Of

Electrospinning is gaining increasing interest in the biomedical field as an eco-friendly and economic technique for production of random and oriented polymeric fibers. The aim of this review was to give an overview of electrospinning potentialities in the production of fibers for biomedical applications with a focus on the possibility to combine biomechanical and topographical stimuli. In fact, selection of the polymer and the eventual surface modification of the fibers allow selection of the proper chemical/biological signal to be administered to the cells. Moreover, a proper design of fiber orientation, dimension, and topography can give the opportunity to drive cell growth also from a spatial standpoint. At this purpose, the review contains a first introduction on potentialities of electrospinning for the obtainment of random and oriented fibers both with synthetic and natural polymers. The biological phenomena which can be guided and promoted by fibers composition and topography are in depth investigated and discussed in the second section of the paper. Finally, the recent strategies developed in the scientific community for the realization of electrospun fibers and for their surface modification for biomedical application are presented and discussed in the last section.

scholarly journals Application of piezoelectric cells printing on three-dimensional porous bioceramic scaffold for bone regeneration

2019 ◽  
Vol 5 (2) ◽  
pp. 22 ◽  
Author(s):  
Ming-You Shie ◽  
Hsin-Yuan Fang ◽  
Yen-Hong Lin ◽  
Alvin Kai-Xing Lee ◽  
Joyce Yu ◽  
...  
Keyword(s):  
Cell Attachment ◽  
Three Dimensional ◽  
Fluorescein Isothiocyanate ◽  
Cellular Adhesion ◽  
Additive Manufacture ◽  
Cell Printing ◽  
Ceramic Scaffold ◽  
Porous Bioceramic ◽  
Bone Structures ◽  
Extrusion Technology

In recent years, the additive manufacture was popularly used in tissue engineering, as the various technologies for this field of research can be used. The most common method is extrusion, which is commonly used in many bioprinting applications, such as skin. In this study, we combined the two printing techniques; first, we use the extrusion technology to form the ceramic scaffold. Then, the stem cells were printed directly on the surface of the ceramic scaffold through a piezoelectric nozzle. We also evaluated the effects of polydopamine (PDA)-coated ceramic scaffolds for cell attachment after printing on the surface of the scaffold. In addition, we used fluorescein isothiocyanate to simulate the cell adhered on the scaffold surface after ejected by a piezoelectric nozzle. Finally, the attachment, growth, and differentiation behaviors of stem cell after printing on calcium silicate/polycaprolactone (CS/PCL) and PDACS/PCL surfaces were also evaluated. The PDACS/PCL scaffold is more hydrophilic than the original CS/PCL scaffold that provided for better cellular adhesion and proliferation. Moreover, the cell printing technology using the piezoelectric nozzle, the different cells can be accurately printed on the surface of the scaffold that provided and analyzed more information of the interaction between different cells on the material. We believe that this method may serve as a useful and effective approach for the regeneration of defective complex hard tissues in deep bone structures.

scholarly journals Modeling of the Behavior of Natural Polysaccharides Hydrogels for Bio-pharma Applications

2017 ◽  
Vol 12 (6) ◽  
pp. 1934578X1701200
Author(s):  
Diego Caccavo ◽  
Sara Cascone ◽  
Gaetano Lamberti ◽  
Annalisa Dalmoro ◽  
Anna Angela Barba
Keyword(s):  
Biomedical Applications ◽  
Release Kinetics ◽  
A Priori ◽  
Trial And Error ◽  
Solidification Behavior ◽  
Natural Polymers ◽  
Case Histories ◽  
Micro Particles ◽  
Natural Polysaccharide ◽  
Synthetic And Natural Polymers

Hydrogels, even if not exclusively obtained from natural sources, are widely used for pharmaceuticals and for biomedical applications. The reasons for their uses are their biocompatibility and the possibility to obtain systems and devices with different properties, due to variable characteristics of the materials. In order to effectively design and produce these systems and devices, two main ways are available: i) trial-and-error process, at least guided by experience, during which the composition of the system and the production steps are changed in order to get the desired behavior; ii) production process guided by the a-priori simulation of the systems’ behavior, thanks to proper tuned mathematical models of the reality. Of course the second approach, when applicable, allows tremendous savings in term of human and instrumental resources. In this mini-review, several modeling approaches useful to describe the behavior of natural polysaccharide-based hydrogels in bio-pharma applications are reported. In particular, reported case histories are: i) the size calculation of micro-particles obtained by ultrasound assisted atomization; ii) the release kinetics from core-shell micro-particles, iii) the solidification behavior of blends of synthetic and natural polymers for gel paving of blood vessels, iv) the drug release from hydrogel-based tablets. This material can be seen as a guide toward the use of mathematical modeling in bio-pharma applications.

scholarly journals Trends in the Development of Tailored Elastin-Like Recombinamer–Based Porous Biomaterials for Soft and Hard Tissue Applications

2021 ◽  
Vol 7 ◽  
Author(s):  
Lubinda Mbundi ◽  
Miguel González-Pérez ◽  
Fernando González-Pérez ◽  
Diana Juanes-Gusano ◽  
José Carlos Rodríguez-Cabello
Keyword(s):  
Extracellular Matrix ◽  
Biomedical Applications ◽  
Physicochemical Characteristics ◽  
Matrix Composition ◽  
Natural Polymers ◽  
Hard Tissue ◽  
Modular Assembly ◽  
Cell Compartmentalization ◽  
Porous Biomaterials ◽  
Synthetic And Natural Polymers

Porous biomaterials are of significant interest in a variety of biomedical applications as they enable the diffusion of nutrients and gases as well as the removal of metabolic waste from implants. Pores also provide 3D spaces for cell compartmentalization and the development of complex structures such as vasculature and the extracellular matrix. Given the variation in the extracellular matrix composition across and within different tissues, it is necessary to tailor the physicochemical characteristics of biomaterials and or surfaces thereof for optimal bespoke applications. In this regard, different synthetic and natural polymers have seen increased usage in the development of biomaterials and surface coatings; among them, elastin-like polypeptides and their recombinant derivatives have received increased advocacy. The modular assembly of these molecules, which can be controlled at a molecular level, presents a flexible platform for the endowment of bespoke biomaterial properties. In this review, various elastin-like recombinamer–based porous biomaterials for both soft and hard tissue applications are discussed and their current and future applications evaluated.

scholarly journals Biocompatible Polymers Combined with Cyclodextrins: Fascinating Materials for Drug Delivery Applications

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3404 ◽  
Author(s):  
Bartłomiej Kost ◽  
Marek Brzeziński ◽  
Marta Socka ◽  
Małgorzata Baśko ◽  
Tadeusz Biela
Keyword(s):  
Drug Delivery ◽  
Polyethylene Oxide ◽  
Biomedical Applications ◽  
Controlled Drug Delivery ◽  
Natural Polymers ◽  
Supramolecular Systems ◽  
Aliphatic Polyesters ◽  
Different Types ◽  
Functional Biomaterials ◽  
Synthetic And Natural Polymers

Cyclodextrins (CD) are a group of cyclic oligosaccharides with a cavity/specific structure that enables to form inclusion complexes (IC) with a variety of molecules through non-covalent host-guest interactions. By an elegant combination of CD with biocompatible, synthetic and natural polymers, different types of universal drug delivery systems with dynamic/reversible properties have been generated. This review presents the design of nano- and micro-carriers, hydrogels, and fibres based on the polymer/CD supramolecular systems highlighting their possible biomedical applications. Application of the most prominent hydrophobic aliphatic polyesters that exhibit biodegradability, represented by polylactide and polycaprolactone, is described first. Subsequently, particular attention is focused on materials obtained from hydrophilic polyethylene oxide. Moreover, examples are also presented for grafting of CD on polysaccharides. In summary, we show the application of host-guest interactions in multi-component functional biomaterials for controlled drug delivery.

scholarly journals Interpenetrating polymeric hydrogels as favorable materials for hygienic applications

2020 ◽  
Vol 10 (2) ◽  
pp. 5011-5020
Keyword(s):  
Biomedical Applications ◽  
Three Dimensional ◽  
Synthetic Polymers ◽  
Poly Vinyl Alcohol ◽  
Ambient Conditions ◽  
Natural Polymers ◽  
Dimensional Network ◽  
Swelling Capacity ◽  
Polymeric Chains ◽  
Poly Ethylene

Polymers can crosslink to produce intermingled materials with three-dimensional network structure known as interpenetrating polymeric network (IPN). They comprise elastic crosslinked polymeric chains. The chains of the hydrogels are either physically or chemically entangled together. Interpenetrating hydrogels can be tailored to provide enhanced materials. They can be classified according to methods of their synthesis as simultaneous or sequential IPNs and the structure to be homo or semi IPNs. The preparation factors play a role in controlling the properties of the produced IPNs. Moreover, the ambient conditions such as pH, temperature as well as the ionic strength may affect the performance of these hydrogels. The swelling capacity is an important feature that allows the prepared hydrogel to perform the required application. Some disadvantages may arise such as the low mechanical properties that are suggested to be overcome. IPNs can be used in various applications that serve the human requirements like drug delivery, tissue engineering, medical and packaging applications. Hydrogels present biocompatibility and nontoxicity when used in biomedical applications. Interpenetrating hydrogels can be prepared from natural or synthetic polymers. Polysaccharides as natural polymers can be used to produce efficient interpenetrating hydrogels. Polyacrylates, poly(ethylene glycol) and poly(vinyl alcohol) are designated as promising synthetic polymers capable of forming interpenetrating hydrogels.

Nanocellulose-based Hydrogels for Biomedical Applications

2019 ◽  
Vol 15 (4) ◽  
pp. 371-381 ◽  
Author(s):  
Amalnath John ◽  
Wen Zhong
Keyword(s):  
Biomedical Applications ◽  
High Performance ◽  
Polymer Networks ◽  
Three Dimensional ◽  
Drug Carriers ◽  
Wound Dressings ◽  
Self Healing ◽  
Natural Polymers ◽  
Wide Range ◽  
Materials Used

Hydrogels are three-dimensional polymer networks capable of absorbing and holding a large amount of water. They have a wide range of biomedical applications including drug carriers, biosensors, tissue scaffolds and wound dressings owning to their innate resemblance to the living tissue. Recently biodegradable and renewable natural polymers, especially nanocellulose, have gained immense attention in the development of hydrogels for biomedical applications. This review provides a brief analysis of the various nanocellulosic materials used in the fabrication of hydrogels for various biomedical applications. Recent developments in high performance hydrogels based on nanocellulose, including self-healing, highly tough and/or stretchable and 3D printable hydrogels will also be covered in this review.

scholarly journals Hyaluronic Acid as a Component of Natural Polymer Blends for Biomedical Applications: A Review

Molecules ◽  
2020 ◽  
Vol 25 (18) ◽  
pp. 4035
Author(s):  
Alina Sionkowska ◽  
Magdalena Gadomska ◽  
Katarzyna Musiał ◽  
Jacek Piątek
Keyword(s):  
Hyaluronic Acid ◽  
Biomedical Applications ◽  
Review Paper ◽  
Natural Polymer ◽  
New Materials ◽  
Natural Polymers ◽  
Materials Development ◽  
Cosmetic Industry ◽  
Significant Interest ◽  
Available Information

In this review, we provide a report on recent studies in the field of research on the blends of hyaluronic acid with other natural polymers, namely collagen and chitosan. Hyaluronic acid has attracted significant interest in biomedical and cosmetic applications due to its interesting properties. In recent years, blends of hyaluronic acid with other polymers have been studied for new materials development. New materials may show improved properties that are important in the biomedical applications and in cosmetic preparations. In this review paper, the structure, preparation, and properties of hyaluronic acid blends with collagen and chitosan have been discussed and examples of new materials based on such blends have been presented. A comparison of the currently available information in the field has been shown. Future aspects in the field of hyaluronic acid blends and their applications in the biomedical and cosmetic industry have also been mentioned.

scholarly journals Preparation and Characterization of Electrospun Collagen Based Composites for Biomedical Applications

Materials ◽  
2020 ◽  
Vol 13 (18) ◽  
pp. 3961 ◽  
Author(s):  
Mioara Drobota ◽  
Luiza Madalina Gradinaru ◽  
Stelian Vlad ◽  
Alexandra Bargan ◽  
Maria Butnaru ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Close Correlation ◽  
Attenuated Total Reflectance ◽  
Vapor Sorption ◽  
Natural Polymers ◽  
Dynamic Vapor Sorption ◽  
Promising Candidate ◽  
Nanofiber Mats ◽  
Synthetic And Natural Polymers

Electrospinning is a widely used technology for obtaining nanofibers from synthetic and natural polymers. In this study, electrospun mats from collagen (C), polyethylene terephthalate (PET) and a blend of the two (C-PET) were prepared and stabilized through a cross-linking process. The aim of this research was to prepare and characterize the nanofiber structure by Fourier-transform infrared with attenuated total reflectance spectroscopy (FTIR-ATR) in close correlation with dynamic vapor sorption (DVS). The studies indicated that C-PET nanofibrous mats shows improved mechanical properties compared to collagen samples. A correlation between morphological, structural and cytotoxic proprieties of the studied samples were emphasized and the results suggest that the prepared nanofiber mats could be a promising candidate for tissue-engineering applications, especially dermal applications.

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