scholarly journals Hyaluronic Acid as a Component of Natural Polymer Blends for Biomedical Applications: A Review

Molecules ◽  
2020 ◽  
Vol 25 (18) ◽  
pp. 4035
Author(s):  
Alina Sionkowska ◽  
Magdalena Gadomska ◽  
Katarzyna Musiał ◽  
Jacek Piątek
Keyword(s):  
Hyaluronic Acid ◽  
Biomedical Applications ◽  
Review Paper ◽  
Natural Polymer ◽  
New Materials ◽  
Natural Polymers ◽  
Materials Development ◽  
Cosmetic Industry ◽  
Significant Interest ◽  
Available Information

In this review, we provide a report on recent studies in the field of research on the blends of hyaluronic acid with other natural polymers, namely collagen and chitosan. Hyaluronic acid has attracted significant interest in biomedical and cosmetic applications due to its interesting properties. In recent years, blends of hyaluronic acid with other polymers have been studied for new materials development. New materials may show improved properties that are important in the biomedical applications and in cosmetic preparations. In this review paper, the structure, preparation, and properties of hyaluronic acid blends with collagen and chitosan have been discussed and examples of new materials based on such blends have been presented. A comparison of the currently available information in the field has been shown. Future aspects in the field of hyaluronic acid blends and their applications in the biomedical and cosmetic industry have also been mentioned.

scholarly journals A Review of Bioactive Glass/Natural Polymer Composites: State of the Art

Materials ◽  
2020 ◽  
Vol 13 (23) ◽  
pp. 5560
Author(s):  
Rachele Sergi ◽  
Devis Bellucci ◽  
Valeria Cannillo
Keyword(s):  
Mechanical Properties ◽  
Hyaluronic Acid ◽  
Bioactive Glass ◽  
Silk Fibroin ◽  
State Of The Art ◽  
Wide Spectrum ◽  
Natural Polymer ◽  
Natural Polymers ◽  
Final System ◽  
Injectable Fillers

Collagen, gelatin, silk fibroin, hyaluronic acid, chitosan, alginate, and cellulose are biocompatible and non-cytotoxic, being attractive natural polymers for medical devices for both soft and hard tissues. However, such natural polymers have low bioactivity and poor mechanical properties, which limit their applications. To tackle these drawbacks, collagen, gelatin, silk fibroin, hyaluronic acid, chitosan, alginate, and cellulose can be combined with bioactive glass (BG) nanoparticles and microparticles to produce composites. The incorporation of BGs improves the mechanical properties of the final system as well as its bioactivity and regenerative potential. Indeed, several studies have demonstrated that polymer/BG composites may improve angiogenesis, neo-vascularization, cells adhesion, and proliferation. This review presents the state of the art and future perspectives of collagen, gelatin, silk fibroin, hyaluronic acid, chitosan, alginate, and cellulose matrices combined with BG particles to develop composites such as scaffolds, injectable fillers, membranes, hydrogels, and coatings. Emphasis is devoted to the biological potentialities of these hybrid systems, which look rather promising toward a wide spectrum of applications.

scholarly journals The Use of Megamolecular Polysaccharide Sacran in Food and Biomedical Applications

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3362
Author(s):  
Lisa Efriani Puluhulawa ◽  
I Made Joni ◽  
Ahmed Fouad Abdelwahab Mohammed ◽  
Hidetoshi Arima ◽  
Nasrul Wathoni
Keyword(s):  
Genetic Engineering ◽  
Biomedical Applications ◽  
Water Retention ◽  
Active Material ◽  
Pharmaceutical Preparations ◽  
Pharmaceutical Formulations ◽  
Natural Polymer ◽  
Natural Polymers ◽  
Food Applications ◽  
Dietary Food

Natural polymer is a frequently used polymer in various food applications and pharmaceutical formulations due to its benefits and its biocompatibility compared to synthetic polymers. One of the natural polymer groups (i.e., polysaccharide) does not only function as an additive in pharmaceutical preparations, but also as an active ingredient with pharmacological effects. In addition, several natural polymers offer potential distinct applications in gene delivery and genetic engineering. However, some of these polymers have drawbacks, such as their lack of water retention and elasticity. Sacran, one of the high-molecular-weight natural polysaccharides (megamolecular polysaccharides) derived from Aphanothece sacrum (A. sacrum), has good water retention and elasticity. Historically, sacran has been used as a dietary food. Moreover, sacran can be applied in biomedical fields as an active material, excipient, and genetic engineering material. This article discusses the characteristics, extraction, isolation procedures, and the use of sacran in food and biomedical applications.

The Application of Hydrogels Based on Natural Polymers for Tissue Engineering

2020 ◽  
Vol 27 (16) ◽  
pp. 2658-2680 ◽  
Author(s):  
Yasamin Davatgaran Taghipour ◽  
Vahideh Raeisdasteh Hokmabad ◽  
Azizeh Rahmani Del Bakhshayesh ◽  
Nahideh Asadi ◽  
Roya Salehi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Soft Tissue ◽  
Tissue Regeneration ◽  
Natural Environment ◽  
Review Article ◽  
Natural Polymer ◽  
Natural Polymers ◽  
Injectable Hydrogels ◽  
Cellular Behavior

: Hydrogels are known as polymer-based networks with the ability to absorb water and other body fluids. Because of this, the hydrogels are used to preserve drugs, proteins, nutrients or cells. Hydrogels possess great biocompatibility, and properties like soft tissue, and networks full of water, which allows oxygen, nutrients, and metabolites to pass. Therefore, hydrogels are extensively employed as scaffolds in tissue engineering. Specifically, hydrogels made of natural polymers are efficient structures for tissue regeneration, because they mimic natural environment which improves the expression of cellular behavior. : Producing natural polymer-based hydrogels from collagen, hyaluronic acid (HA), fibrin, alginate, and chitosan is a significant tactic for tissue engineering because it is useful to recognize the interaction between scaffold with a tissue or cell, their cellular reactions, and potential for tissue regeneration. The present review article is focused on injectable hydrogels scaffolds made of biocompatible natural polymers with particular features, the methods that can be employed to engineer injectable hydrogels and their latest applications in tissue regeneration.

scholarly journals Recent Trends in Three-Dimensional Bioinks Based on Alginate for Biomedical Applications

Materials ◽  
2020 ◽  
Vol 13 (18) ◽  
pp. 3980 ◽  
Author(s):  
Farnoosh Pahlevanzadeh ◽  
Hamidreza Mokhtari ◽  
Hamid Reza Bakhsheshi-Rad ◽  
Rahmatollah Emadi ◽  
Mahshid Kharaziha ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Review Paper ◽  
Cell Attachment ◽  
Three Dimensional ◽  
Natural Polymers ◽  
Cell Printing ◽  
Tissue Printing ◽  
Artificial Tissue ◽  
Recent Trends ◽  
Synthetic And Natural Polymers

Three-dimensional (3D) bioprinting is an appealing and revolutionary manufacturing approach for the accurate placement of biologics, such as living cells and extracellular matrix (ECM) components, in the form of a 3D hierarchical structure to fabricate synthetic multicellular tissues. Many synthetic and natural polymers are applied as cell printing bioinks. One of them, alginate (Alg), is an inexpensive biomaterial that is among the most examined hydrogel materials intended for vascular, cartilage, and bone tissue printing. It has also been studied pertaining to the liver, kidney, and skin, due to its excellent cell response and flexible gelation preparation through divalent ions including calcium. Nevertheless, Alg hydrogels possess certain negative aspects, including weak mechanical characteristics, poor printability, poor structural stability, and poor cell attachment, which may restrict its usage along with the 3D printing approach to prepare artificial tissue. In this review paper, we prepare the accessible materials to be able to encourage and boost new Alg-based bioink formulations with superior characteristics for upcoming purposes in drug delivery systems. Moreover, the major outcomes are discussed, and the outstanding concerns regarding this area and the scope for upcoming examination are outlined.

Biomedical Applications of Natural Polymers for Drug Delivery

2014 ◽  
Vol 18 (2) ◽  
pp. 152-164 ◽  
Author(s):  
Mariana Chifiriuc ◽  
Alexandru Grumezescu ◽  
Valentina Grumezescu ◽  
Eugenia Bezirtzoglou ◽  
Veronica Lazar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Natural Polymers

scholarly journals Topographical and Biomechanical Guidance of Electrospun Fibers for Biomedical Applications

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2896
Author(s):  
Sara Ferraris ◽  
Silvia Spriano ◽  
Alessandro Calogero Scalia ◽  
Andrea Cochis ◽  
Lia Rimondini ◽  
...  
Keyword(s):  
Surface Modification ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Electrospun Fibers ◽  
Natural Polymers ◽  
Polymeric Fibers ◽  
Biological Phenomena ◽  
Proper Design ◽  
Synthetic And Natural Polymers ◽  
Selection Of

Electrospinning is gaining increasing interest in the biomedical field as an eco-friendly and economic technique for production of random and oriented polymeric fibers. The aim of this review was to give an overview of electrospinning potentialities in the production of fibers for biomedical applications with a focus on the possibility to combine biomechanical and topographical stimuli. In fact, selection of the polymer and the eventual surface modification of the fibers allow selection of the proper chemical/biological signal to be administered to the cells. Moreover, a proper design of fiber orientation, dimension, and topography can give the opportunity to drive cell growth also from a spatial standpoint. At this purpose, the review contains a first introduction on potentialities of electrospinning for the obtainment of random and oriented fibers both with synthetic and natural polymers. The biological phenomena which can be guided and promoted by fibers composition and topography are in depth investigated and discussed in the second section of the paper. Finally, the recent strategies developed in the scientific community for the realization of electrospun fibers and for their surface modification for biomedical application are presented and discussed in the last section.

Computational Exploration of Functional Nanoscale Carbonaceous Materials

2021 ◽  
Vol 17 ◽  
Author(s):  
Grigoriy Sereda ◽  
Md Tusar Uddin ◽  
Jacob Wente
Keyword(s):  
Biomedical Applications ◽  
Chemical Processes ◽  
Computational Power ◽  
Carbonaceous Materials ◽  
New Materials ◽  
New Era ◽  
Physico Chemical ◽  
Computational Exploration ◽  
Properties Of Materials ◽  
Computational Research

Background: The unique ability of carbon to form a wide variety of allotrope modifications has ushered a new era in the material science. Tuning the properties of these materials by functionalization is a must-have tool for their design customized for a specific practical use. The exponentially growing computational power available to researchers allows for the prediction and thorough understanding of the underlying physico-chemical processes responsible for the practical properties of pristine and modified carbons using the methods of quantum chemistry. Method: This review focuses on the computational assessment of the influence of functionalization on the properties of carbons and enabling desired practical properties of the new materials. The first section of each part of this review focuses on graphene - nearly planar units built from sp2-carbons. The second section discusses patterns of sp2-carbons rolled-up into curved 3D-structures in a variety of ways (fullerenes). The overview of other types of carbonaceous materials including those with a high abundance of sp3-carbons, including nanodiamonds, can be found in the third section of each manuscript’s part. Conclusion: The computational methods are especially critical for predicting electronic properties of materials such as the band gap, conductivity, optical and photoelectronic properties, solubility, adsorptivity, potential for catalysis, sensing, imaging and biomedical applications. We expect that introduction of defects to carbonaceous materials as a type of their functionalization will be a point of growth in this area of computational research.

scholarly journals Ultrasonic, Molecular and Mechanical Testing Diagnostics in Natural Fibre Reinforced, Polymer-Stabilized Earth Blocks

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
C. Galán-Marín ◽  
C. Rivera-Gómez ◽  
F. Bradley
Keyword(s):  
Soil Stabilization ◽  
Ultrasonic Pulse Velocity ◽  
Mechanical Tests ◽  
Pulse Velocity ◽  
Mechanical Resistance ◽  
Chemical Compositions ◽  
Natural Polymer ◽  
Natural Polymers ◽  
X Ray ◽  
Earth Blocks

The aim of this research study was to evaluate the influence of utilising natural polymers as a form of soil stabilization, in order to assess their potential for use in building applications. Mixtures were stabilized with a natural polymer (alginate) and reinforced with wool fibres in order to improve the overall compressive and flexural strength of a series of composite materials. Ultrasonic pulse velocity (UPV) and mechanical strength testing techniques were then used to measure the porous properties of the manufactured natural polymer-soil composites, which were formed into earth blocks. Mechanical tests were carried out for three different clays which showed that the polymer increased the mechanical resistance of the samples to varying degrees, depending on the plasticity index of each soil. Variation in soil grain size distributions and Atterberg limits were assessed and chemical compositions were studied and compared. X-ray diffraction (XRD), X-ray fluorescence spectroscopy (XRF), and energy dispersive X-ray fluorescence (EDXRF) techniques were all used in conjunction with qualitative identification of the aggregates. Ultrasonic wave propagation was found to be a useful technique for assisting in the determination of soil shrinkage characteristics and fibre-soil adherence capacity and UPV results correlated well with the measured mechanical properties.

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