scholarly journals Biocompatible Polymers Combined with Cyclodextrins: Fascinating Materials for Drug Delivery Applications

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3404 ◽  
Author(s):  
Bartłomiej Kost ◽  
Marek Brzeziński ◽  
Marta Socka ◽  
Małgorzata Baśko ◽  
Tadeusz Biela
Keyword(s):  
Drug Delivery ◽  
Polyethylene Oxide ◽  
Biomedical Applications ◽  
Controlled Drug Delivery ◽  
Natural Polymers ◽  
Supramolecular Systems ◽  
Aliphatic Polyesters ◽  
Different Types ◽  
Functional Biomaterials ◽  
Synthetic And Natural Polymers

Cyclodextrins (CD) are a group of cyclic oligosaccharides with a cavity/specific structure that enables to form inclusion complexes (IC) with a variety of molecules through non-covalent host-guest interactions. By an elegant combination of CD with biocompatible, synthetic and natural polymers, different types of universal drug delivery systems with dynamic/reversible properties have been generated. This review presents the design of nano- and micro-carriers, hydrogels, and fibres based on the polymer/CD supramolecular systems highlighting their possible biomedical applications. Application of the most prominent hydrophobic aliphatic polyesters that exhibit biodegradability, represented by polylactide and polycaprolactone, is described first. Subsequently, particular attention is focused on materials obtained from hydrophilic polyethylene oxide. Moreover, examples are also presented for grafting of CD on polysaccharides. In summary, we show the application of host-guest interactions in multi-component functional biomaterials for controlled drug delivery.

scholarly journals Injectable Cryogels in Biomedicine

Gels ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. 38
Author(s):  
Duygu Çimen ◽  
Merve Asena Özbek ◽  
Nilay Bereli ◽  
Bo Mattiasson ◽  
Adil Denizli
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Biomedical Applications ◽  
Natural Polymers ◽  
Research Areas ◽  
Macroporous Materials ◽  
Monomer Solution ◽  
Recent Developments ◽  
Physical Resistance ◽  
Synthetic And Natural Polymers

Cryogels are interconnected macroporous materials that are synthesized from a monomer solution at sub-zero temperatures. Cryogels, which are used in various applications in many research areas, are frequently used in biomedicine applications due to their excellent properties, such as biocompatibility, physical resistance and sensitivity. Cryogels can also be prepared in powder, column, bead, sphere, membrane, monolithic, and injectable forms. In this review, various examples of recent developments in biomedical applications of injectable cryogels, which are currently scarce in the literature, made from synthetic and natural polymers are discussed. In the present review, several biomedical applications of injectable cryogels, such as tissue engineering, drug delivery, therapeutic, therapy, cell transplantation, and immunotherapy, are emphasized. Moreover, it aims to provide a different perspective on the studies to be conducted on injectable cryogels, which are newly emerging trend.

Biomedical Applications of Natural Polymers for Drug Delivery

2014 ◽  
Vol 18 (2) ◽  
pp. 152-164 ◽  
Author(s):  
Mariana Chifiriuc ◽  
Alexandru Grumezescu ◽  
Valentina Grumezescu ◽  
Eugenia Bezirtzoglou ◽  
Veronica Lazar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Natural Polymers

scholarly journals Topographical and Biomechanical Guidance of Electrospun Fibers for Biomedical Applications

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2896
Author(s):  
Sara Ferraris ◽  
Silvia Spriano ◽  
Alessandro Calogero Scalia ◽  
Andrea Cochis ◽  
Lia Rimondini ◽  
...  
Keyword(s):  
Surface Modification ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Electrospun Fibers ◽  
Natural Polymers ◽  
Polymeric Fibers ◽  
Biological Phenomena ◽  
Proper Design ◽  
Synthetic And Natural Polymers ◽  
Selection Of

Electrospinning is gaining increasing interest in the biomedical field as an eco-friendly and economic technique for production of random and oriented polymeric fibers. The aim of this review was to give an overview of electrospinning potentialities in the production of fibers for biomedical applications with a focus on the possibility to combine biomechanical and topographical stimuli. In fact, selection of the polymer and the eventual surface modification of the fibers allow selection of the proper chemical/biological signal to be administered to the cells. Moreover, a proper design of fiber orientation, dimension, and topography can give the opportunity to drive cell growth also from a spatial standpoint. At this purpose, the review contains a first introduction on potentialities of electrospinning for the obtainment of random and oriented fibers both with synthetic and natural polymers. The biological phenomena which can be guided and promoted by fibers composition and topography are in depth investigated and discussed in the second section of the paper. Finally, the recent strategies developed in the scientific community for the realization of electrospun fibers and for their surface modification for biomedical application are presented and discussed in the last section.

scholarly journals Modeling of the Behavior of Natural Polysaccharides Hydrogels for Bio-pharma Applications

2017 ◽  
Vol 12 (6) ◽  
pp. 1934578X1701200
Author(s):  
Diego Caccavo ◽  
Sara Cascone ◽  
Gaetano Lamberti ◽  
Annalisa Dalmoro ◽  
Anna Angela Barba
Keyword(s):  
Biomedical Applications ◽  
Release Kinetics ◽  
A Priori ◽  
Trial And Error ◽  
Solidification Behavior ◽  
Natural Polymers ◽  
Case Histories ◽  
Micro Particles ◽  
Natural Polysaccharide ◽  
Synthetic And Natural Polymers

Hydrogels, even if not exclusively obtained from natural sources, are widely used for pharmaceuticals and for biomedical applications. The reasons for their uses are their biocompatibility and the possibility to obtain systems and devices with different properties, due to variable characteristics of the materials. In order to effectively design and produce these systems and devices, two main ways are available: i) trial-and-error process, at least guided by experience, during which the composition of the system and the production steps are changed in order to get the desired behavior; ii) production process guided by the a-priori simulation of the systems’ behavior, thanks to proper tuned mathematical models of the reality. Of course the second approach, when applicable, allows tremendous savings in term of human and instrumental resources. In this mini-review, several modeling approaches useful to describe the behavior of natural polysaccharide-based hydrogels in bio-pharma applications are reported. In particular, reported case histories are: i) the size calculation of micro-particles obtained by ultrasound assisted atomization; ii) the release kinetics from core-shell micro-particles, iii) the solidification behavior of blends of synthetic and natural polymers for gel paving of blood vessels, iv) the drug release from hydrogel-based tablets. This material can be seen as a guide toward the use of mathematical modeling in bio-pharma applications.

Nanoformulations of core–shell type hydroxyapatite-coated gum acacia with enhanced bioactivity and controlled drug delivery for biomedical applications

2020 ◽  
Vol 44 (17) ◽  
pp. 7175-7185 ◽  
Author(s):  
Varun Prasath Padmanabhan ◽  
Subha Balakrishnan ◽  
Ravichandran Kulandaivelu ◽  
Sankara Narayanan T. S. N. ◽  
Muthukrishnan Lakshmipathy ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Antibacterial Activity ◽  
Biomedical Applications ◽  
Controlled Drug Delivery ◽  
Core Shell ◽  
Gum Acacia ◽  
Shell Type

In this work, nanospherical hydroxyapatite (HAP) was prepared that has combined properties of controlled drug delivery, biocompatibility, and antibacterial activity to have applications in the biomedical sector.

In Situ Generation of Polyaniline inside Zeolite Pores for Retention of Ions and for Controlled Drug Delivery

2013 ◽  
Vol 583 ◽  
pp. 91-94 ◽  
Author(s):  
Aurelia Cristina Nechifor ◽  
Alexandrina Ivan ◽  
Stefan Ioan Voicu ◽  
Valeriu Danciulescu ◽  
Roxana Trusca
Keyword(s):  
Drug Delivery ◽  
Composite Materials ◽  
Biomedical Applications ◽  
Controlled Drug Delivery ◽  
Sodium Vanadate ◽  
Biological Interest

In order to improve the capabilities of zeolites for biomedical applications, new composite materials based on polyaniline in-situ generated inside zeolite pores were developed. As precursors for polyaniline several monomers (like aniline and p-phnylenediamine) were used and different oxidant systems (like ammonium peroxodisulphate/HCl, sodium vanadate/ethylic alcohol) were studied and were used for the separation of different biological interest ions and release of antibiotics.

scholarly journals Trends in the Development of Tailored Elastin-Like Recombinamer–Based Porous Biomaterials for Soft and Hard Tissue Applications

2021 ◽  
Vol 7 ◽  
Author(s):  
Lubinda Mbundi ◽  
Miguel González-Pérez ◽  
Fernando González-Pérez ◽  
Diana Juanes-Gusano ◽  
José Carlos Rodríguez-Cabello
Keyword(s):  
Extracellular Matrix ◽  
Biomedical Applications ◽  
Physicochemical Characteristics ◽  
Matrix Composition ◽  
Natural Polymers ◽  
Hard Tissue ◽  
Modular Assembly ◽  
Cell Compartmentalization ◽  
Porous Biomaterials ◽  
Synthetic And Natural Polymers

Porous biomaterials are of significant interest in a variety of biomedical applications as they enable the diffusion of nutrients and gases as well as the removal of metabolic waste from implants. Pores also provide 3D spaces for cell compartmentalization and the development of complex structures such as vasculature and the extracellular matrix. Given the variation in the extracellular matrix composition across and within different tissues, it is necessary to tailor the physicochemical characteristics of biomaterials and or surfaces thereof for optimal bespoke applications. In this regard, different synthetic and natural polymers have seen increased usage in the development of biomaterials and surface coatings; among them, elastin-like polypeptides and their recombinant derivatives have received increased advocacy. The modular assembly of these molecules, which can be controlled at a molecular level, presents a flexible platform for the endowment of bespoke biomaterial properties. In this review, various elastin-like recombinamer–based porous biomaterials for both soft and hard tissue applications are discussed and their current and future applications evaluated.

scholarly journals PLGA – THE SMART POLYMER FOR DRUG DELIVERY

2021 ◽  
Vol 9 (5) ◽  
pp. 334-345
Author(s):  
N. Surya ◽  
S. Bhattacharyya
Keyword(s):  
Drug Delivery ◽  
Biodegradable Polymers ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Glycolic Acid ◽  
Delivery Systems ◽  
Nano Particles ◽  
Natural Polymers ◽  
Smart Polymer ◽  
Novel Drug

Polymers have become an integral part of novel drug delivery system. One such successful biodegradable polymer is poly lactic-co-glycolic acid (PLGA) which consists of polyesters of lactic acid and glycolic acid. It is one of the FDA-approved biodegradable polymers which is extensively used for therapeutic purposes in recent times.The aim. To illuminate researchers on the chemistry, novel properties and applications of PLGA in pharmaceutical fields.Materials and methods. Various internet sources like Science Direct, Scopus, Web of Science, PubMed and google scholar were used as the data source. The key words search was carried out for the following words and combinations: PLGA, Novel drug delivery, PLGA Nano particles, biomedical applications of PLGA.Results. Pharmaceutical and biomedical industries are flooded with the use of synthetic and natural polymers. The mechanical and viscoelastic properties of the polymers make them suitable for the temporal and spatial delivery of therapeutic agents for an extended period. Employment of copolymerization techniques lead to the modification of water solubility of the polymers and make them suitable for various applications of drug delivery systems. Biodegradable polymers due to their biocompatibility and biodegradable property have attracted their use in novel drug delivery systems. PLGA is one of them. PLGA is versatile as it can be fabricated into any size, shape, and can be used to encapsulate small molecules, tissue engineering, and bone repair, etc.Conclusion. The sensitivity and biodegradability of PLGA makes it a smart polymer for targeted and sustained delivery of drugs and in various biomedical applications.

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