scholarly journals In Vitro Corrosion and Cell Response of Hydroxyapatite Coated Mg Matrix in Situ Composites for Biodegradable Material Applications

Materials ◽  
2019 ◽  
Vol 12 (21) ◽  
pp. 3474 ◽  
Author(s):  
Cao ◽  
Le ◽  
Pham ◽  
Nguyen ◽  
Hiromoto ◽  
...  
Keyword(s):  
Cell Culture ◽  
Corrosion Resistance ◽  
Solution Treatment ◽  
Potential Candidate ◽  
Test Results ◽  
Biodegradable Implant ◽  
Culture Test ◽  
Sintering Time ◽  
Cell Culture Test

In this study, hydroxyapatite (HAp) coated Mg matrix composites were fabricated for biodegradable implant applications. Spark plasma sintering was employed to fabricate the Mg-10 wt% ZnO composite substrates. HAp was coated on the surface of the sintered composites and pure Mg by a chemical solution treatment. SEM and optical micrographs of coated samples showed that HAp grew homogeneously and formed a layer on the entire surface of both pure sintered Mg and Mg composites. The immersion and polarization test results demonstrated that the HAp coating significantly improved the corrosion resistance of the sintered composites. While the HAp coating layer is not effective in the improvement of the pure Mg substrate, cell culture test results revealed that the HAp coating improved cell adhesion and proliferation on the composites effectively through 72 h, while no cell could survive on the uncoated composites after 72 h. In addition, the corrosion tests and cell culture test results indicated that the composite with longer sintering time has better corrosion resistance and cell viability than those of the composite with shorter sintering time. The findings suggested that the HAp-coated Mg-10 wt% ZnO-2.5 h + 10 min composite is a high-potential candidate for biodegradable implant applications.

scholarly journals In vitro and in vivo assessment of biomedical Mg–Ca alloys for bone implant applications

2018 ◽  
Vol 16 (3) ◽  
pp. 126-136 ◽  
Author(s):  
Preeti Makkar ◽  
Swapan Kumar Sarkar ◽  
Andrew R. Padalhin ◽  
Byoung-Gi Moon ◽  
Young Seon Lee ◽  
...  
Keyword(s):  
Corrosion Resistance ◽  
Bone Formation ◽  
Femoral Condyle ◽  
Immersion Test ◽  
Hydrogen Gas ◽  
In Vivo Studies ◽  
Biodegradable Implant ◽  
In Vitro Degradation

Background: Magnesium (Mg)-based alloys are considered to be promising materials for implant application due to their excellent biocompatibility, biodegradability, and mechanical properties close to bone. However, low corrosion resistance and fast degradation are limiting their application. Mg–Ca alloys have huge potential owing to a similar density to bone, good corrosion resistance, and as Mg is essential for Ca incorporation into bone. The objective of the present work is to determine the in vitro degradation and in vivo performance of binary Mg– xCa alloy ( x = 0.5 or 5.0 wt%) to assess its usability for degradable implant applications. Methods: Microstructural evolutions for Mg– xCa alloys were characterized by optical, SEM, EDX, and XRD. In vitro degradation tests were conducted via immersion test in phosphate buffer saline solution. In vivo performance in terms of interface, biocompatibility, and biodegradability of Mg– xCa alloys was examined by implanting samples into rabbit femoral condyle for 2 and 4 weeks. Results: Microstructural results showed the enhancement in intermetallic Mg2Ca phase with increase in Ca content. Immersion tests revealed that the dissolution rate varies linearly, with Ca content exhibiting more hydrogen gas evolution, increased pH, and higher degradation for Mg–5.0Ca alloy. In vivo studies showed good biocompatibility with enhanced bone formation for Mg–0.5Ca after 4 weeks of implantation compared with Mg–5.0Ca alloy. Higher initial corrosion rate with prolonged inflammation and rapid degradation was noticed in Mg–5.0Ca compared with Mg–0.5Ca alloy. Conclusions: The results suggest that Mg–0.5Ca alloy could be used as a temporary biodegradable implant material for clinical applications owing to its controlled in vivo degradation, reduced inflammation, and high bone-formation capability.

A Comparative Study of the Corrosion Resistance of Stainless Steels Obtained by Powder Metallurgy Techniques for Application in Dental Prosthesis

2010 ◽  
Vol 660-661 ◽  
pp. 617-622 ◽  
Author(s):  
Rogério Albuquerque Marques ◽  
Adonis M. Saliba-Silva ◽  
Sizue Ota Rogero ◽  
Maria de Fátima Montemor ◽  
Isolda Costa
Keyword(s):  
Corrosion Resistance ◽  
Powder Metallurgy ◽  
Stainless Steels ◽  
Electrochemical Techniques ◽  
Phosphate Buffer Solution ◽  
Dental Prosthesis ◽  
Powder Injection ◽  
Potential Candidate ◽  
Buffer Solution

- Ferromagnetic stainless steels (SS) produced by powder metallurgy (PM) techniques have been investigated as potential candidates for dental prosthesis applications in replacement of magnetic attachments made of noble and expensive alloys. Two SS were investigated: SS 17-4 PH produced by powder injection (PIM) and SS PM2000 obtained by mechanical alloying. In vitro cytotoxicity analysis of the two SS showed no cytotoxic effects. The magnetic retention force of both tested SS was also evaluated and they were comparable to noble commercially available material that is in use at the moment. The corrosion resistance of both SS was evaluated by electrochemical techniques in sodium phosphate buffer solution (PBS) at 37°C. The AISI 316L SS was also tested under the same conditions for comparison reasons. SS samples tested showed passive behaviour in the electrolyte, but they also presented susceptibility to pitting. The best pitting resistance was associated to the PM2000 whereas the 17-4PH PIM showed the highest pitting susceptibility among the tested steels. The results pointed out that the PM2000 SS might be considered a potential candidate for substitution of high cost magnetic alloys used in dental prosthesis.

Preparation, Corrosion and Cytocompatability In Vitro of Fluoride-Coated Mg-Zn-Zr Alloy

2016 ◽  
Vol 852 ◽  
pp. 1293-1299
Author(s):  
Hao Ran Zheng ◽  
Jing Zhang ◽  
Chen You ◽  
Min Fang Chen
Keyword(s):  
Aqueous Solution ◽  
Corrosion Resistance ◽  
Body Fluid ◽  
Immersion Time ◽  
Processing Time ◽  
Corrosion Potential ◽  
Solution Treatment ◽  
Good Biocompatibility ◽  
Zr Alloy

The present investigation was carried out to optimize the hydrogen fluoride (HF) aqueous solution treatment for an Mg-2.5Zn-0.5Zr alloy, in order to improve the corrosion resistance of the material for orthopaedic applications. An MgF2 coating was formed on the surface of Mg-2.5Zn-0.5Zr alloy treated with HF solution. The effect of the HF concentration and processing time on the morphology and electrochemical performance of the MgF2 coating was systematically studied. The results showed that the MgF2 coating became thick gradually with the increase of the concentration of HF solution. However, the pinhole on the surface treated with 40% HF increased significantly. The coating thickness immersed in the same concentration of HF solution increased with immersion time, and cracks formed in the surface after four hours of immersion, resulting in a decrease in the corrosion potential. When the alloy was immersed in the HF solution with a concentration 20% at 37°C for 2h, a uniform and dense fluoride coating was formed, with a thickness of MgF2 layer of about 0.5μm. The corrosion potential of the coated Mg alloy in simulated body fluid (SBF) was 0.28V higher than the uncoated one. In addition, the fluoride-coated showed a good biocompatibility.

Workshop on Cell-Culture Test Methods

2009 ◽  
pp. 127-127-27
Author(s):  
SA Brown ◽  
TD Nickel ◽  
TW Walker
Keyword(s):  
Cell Culture ◽  
Test Methods ◽  
Culture Test ◽  
Cell Culture Test

Detection of teratogens in theDrosophila embryonic cell culture test: Assay of 100 chemicals

Teratology ◽  
1983 ◽  
Vol 28 (1) ◽  
pp. 109-122 ◽  
Author(s):  
Nicole Bournias-Vardiabasis ◽  
Raymond L. Teplitz ◽  
Gerald F. Chernoff ◽  
Robert L. Seecof
Keyword(s):  
Cell Culture ◽  
Embryonic Cell ◽  
Culture Test ◽  
Cell Culture Test

Cell culture test of TCP/CPLA composite

1999 ◽  
Vol 48 (2) ◽  
pp. 108-110 ◽  
Author(s):  
Masanori Kikuchi ◽  
Junzo Tanaka ◽  
Yoshihisa Koyama ◽  
Kazuo Takakuda
Keyword(s):  
Cell Culture ◽  
Culture Test ◽  
Cell Culture Test

The activity of environmental samples in a cell culture test for asbestos toxicity

1980 ◽  
Vol 22 (2) ◽  
pp. 315-321 ◽  
Author(s):  
Betti Reiss ◽  
James R. Millette ◽  
Gary M. Williams
Keyword(s):  
Cell Culture ◽  
Environmental Samples ◽  
Culture Test ◽  
A Cell ◽  
Cell Culture Test
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