scholarly journals Low Physical Activity in Patients with Complicated Type 2 Diabetes Mellitus Is Associated with Low Muscle Mass and Low Protein Intake

2020 ◽  
Vol 9 (10) ◽  
pp. 3104
Author(s):  
Ilse J. M. Hagedoorn ◽  
Niala den Braber ◽  
Milou M. Oosterwijk ◽  
Christina M. Gant ◽  
Gerjan Navis ◽  
...  
Keyword(s):  
Physical Activity ◽  
Type 2 Diabetes ◽  
Muscle Mass ◽  
Dietary Protein ◽  
Protein Intake ◽  
Outcome Variable ◽  
Dietary Protein Intake ◽  
Cross Sectional ◽  
Creatinine Excretion

Objective: In order to promote physical activity (PA) in patients with complicated type 2 diabetes, a better understanding of daily movement is required. We (1) objectively assessed PA in patients with type 2 diabetes, and (2) studied the association between muscle mass, dietary protein intake, and PA. Methods: We performed cross-sectional analyses in all patients included in the Diabetes and Lifestyle Cohort Twente (DIALECT) between November 2016 and November 2018. Patients were divided into four groups: <5000, 5000–6999, 7000–9999, ≥ 10,000 steps/day. We studied the association between muscle mass (24 h urinary creatinine excretion rate, CER) and protein intake (by Maroni formula), and the main outcome variable PA (steps/day, Fitbit Flex device) using multivariate linear regression analyses. Results: In the 217 included patients, the median steps/day were 6118 (4115–8638). Of these patients, 48 patients (22%) took 7000–9999 steps/day, 37 patients (17%) took ≥ 10,000 steps/day, and 78 patients (36%) took <5000 steps/day. Patients with <5000 steps/day had, in comparison to patients who took ≥10,000 steps/day, a higher body mass index (BMI) (33 ± 6 vs. 30 ± 5 kg/m2, p = 0.009), lower CER (11.7 ± 4.8 vs. 14.8 ± 3.8 mmol/24 h, p = 0.001), and lower protein intake (0.84 ± 0.29 vs. 1.08 ± 0.22 g/kg/day, p < 0.001). Both creatinine excretion (β = 0.26, p < 0.001) and dietary protein intake (β = 0.31, p < 0.001) were strongly associated with PA, which remained unchanged after adjustment for potential confounders. Conclusions: Prevalent insufficient protein intake and low muscle mass co-exist in obese patients with low physical activity. Dedicated intervention studies are needed to study the role of sufficient protein intake and physical activity in increasing or maintaining muscle mass in patients with type 2 diabetes.

scholarly journals Clinical and Dietary Determinants of Muscle Mass in Patients with Type 2 Diabetes: Data from the Diabetes and Lifestyle Cohort Twente

2021 ◽  
Vol 10 (22) ◽  
pp. 5227
Author(s):  
Annis C. Jalving ◽  
Milou M. Oosterwijk ◽  
Ilse J. M. Hagedoorn ◽  
Gerjan Navis ◽  
Stephan J. L. Bakker ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Muscle Mass ◽  
Dietary Protein ◽  
Protein Intake ◽  
Modifiable Risk Factors ◽  
Dietary Protein Intake ◽  
Cross Sectional ◽  
The Mean

Low muscle mass in patients with type 2 diabetes is associated with a progressively higher risk of morbidity and mortality. The aim of this study was to identify modifiable targets for intervention of muscle mass in type 2 diabetes. Cross-sectional analyses were performed in 375 patients of the Diabetes and Lifestyle Cohort Twente-1 study. Muscle mass was estimated by 24 h urinary creatinine excretion rate (CER, mmol/24 h). Patients were divided in sex-stratified tertiles of CER. To study determinants of CER, multivariable linear regression analyses were performed. Protein intake was determined by Maroni formula and by a semi-quantitative Food Frequency Questionnaire. The mean CER was 16.1 ± 4.8 mmol/24 h and 10.9 ± 2.9 mmol/24 h in men and women, respectively. Lower CER was significantly associated with older age (p < 0.001) as a non-modifiable risk factor, whereas higher BMI (p = 0.015) and lower dietary protein intake (both methods p < 0.001) were identified as modifiable risk factors for lower CER. Overall body mass index (BMI) was high, even in the lowest CER tertile the mean BMI was 30.9 kg/m2, mainly driven by someone’s body weight (p = 0.004) instead of someone’s height (p = 0.58). In the total population, 28% did not achieve adequate protein intake of >0.8 g/kg/day, with the highest percentage in the lowest CER tertile (52%, p < 0.001). Among patients with type 2 diabetes treated in secondary care, higher BMI and low dietary protein intake are modifiable risk factors for lower muscle mass. Considering the risk associated with low muscle mass, intervention may be useful. To that purpose, dietary protein intake and BMI are potential targets for intervention.

scholarly journals Impact of Meeting Different Guidelines for Protein Intake on Muscle Mass and Physical Function in Physically Active Older Women

Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1156 ◽  
Author(s):  
Andreas Nilsson ◽  
Diego Montiel Rojas ◽  
Fawzi Kadi
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Physical Function ◽  
Older Women ◽  
Muscle Mass ◽  
Dietary Protein ◽  
Protein Intake ◽  
Dietary Protein Intake ◽  
Physical Limitations

The role of dietary protein intake on muscle mass and physical function in older adults is important for the prevention of age-related physical limitations. The aim of the present study was to elucidate links between dietary protein intake and muscle mass and physical function in older women meeting current guidelines of objectively assessed physical activity. In 106 women (65 to 70 years old), protein intake was assessed using a 6-day food record and participants were classified into high and low protein intake groups using two Recommended Dietary Allowance (RDA) thresholds (0.8 g·kg−1 bodyweight (BW) and 1.1 g·kg−1 BW). Body composition, aerobic fitness, and quadriceps strength were determined using standardized procedures, and self-reported physical function was assessed using the SF-12 Health Survey. Physical activity was assessed by accelerometry and self-report. Women below the 0.8 g·kg−1 BW threshold had a lower muscle mass (p < 0.05) with no differences in physical function variables. When based on the higher RDA threshold (1.1 g·kg−1 BW), in addition to significant differences in muscle mass, women below the higher threshold had a significantly (p < 0.05) higher likelihood of having physical limitations. In conclusion, the present study supports the RDA threshold of 0.8 g·kg−1 BW of proteins to prevent the loss of muscle mass and emphasizes the importance of the higher RDA threshold of at least 1.1 g·kg−1 BW to infer additional benefits on constructs of physical function. Our study also supports the role of protein intake for healthy ageing, even in older adults meeting guidelines for physical activity.

scholarly journals Dietary Protein Intake and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study

Diabetes Care ◽  
2014 ◽  
Vol 37 (7) ◽  
pp. 1854-1862 ◽  
Author(s):  
Monique van Nielen ◽  
Edith J.M. Feskens ◽  
Marco Mensink ◽  
Ivonne Sluijs ◽  
Esther Molina ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Dietary Protein ◽  
Protein Intake ◽  
Dietary Protein Intake

scholarly journals Association between dietary protein intake and type 2 diabetes varies by dietary pattern

2018 ◽  
Vol 10 (1) ◽  
Author(s):  
Qiuyi Ke ◽  
Chaogang Chen ◽  
Fengyi He ◽  
Yongxin Ye ◽  
Xinxiu Bai ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dietary Protein ◽  
Dietary Pattern ◽  
Protein Intake ◽  
Dietary Protein Intake

scholarly journals Dietary Protein Intake and Lean Muscle Mass in Survivors of Childhood Acute Lymphoblastic Leukemia: Report From the St. Jude Lifetime Cohort Study

2016 ◽  
Vol 96 (7) ◽  
pp. 1029-1038 ◽  
Author(s):  
Alexandra M. Boland ◽  
Todd M. Gibson ◽  
Lu Lu ◽  
Sue C. Kaste ◽  
James P. DeLany ◽  
...  
Keyword(s):  
Resistance Training ◽  
Muscle Mass ◽  
Dietary Protein ◽  
Protein Intake ◽  
Lymphoblastic Leukemia ◽  
Cross Sectional Study ◽  
Dietary Protein Intake ◽  
Cross Sectional ◽  
Childhood All ◽  
Lean Muscle Mass

Abstract Background Survivors of childhood acute lymphoblastic leukemia (ALL) are at risk for low lean muscle mass and muscle weakness, which may contribute to inactivity and early development of chronic diseases typically seen in older adults. Although increasing protein intake, in combination with resistance training, improves lean muscle mass in other populations, it is not known whether muscular tissue among survivors of ALL, whose impairments are treatment-related, will respond similarly. Objective The aim of this study was to evaluate associations among dietary protein intake, resistance training, and lean muscle mass in survivors of ALL and age-, sex-, and race-matched controls. Design This was a cross-sectional study. Methods Lean muscle mass was determined with dual-energy x-ray absorptiometry, dietary information with 24-hour recalls, and participation in resistance training with a questionnaire. Participants were 365 survivors of ALL (52% male; 87% white; median age=28.5 years, range=23.6–31.7) and 365 controls with no previous cancer. Results Compared with controls, survivors of ALL had lower lean muscle mass (55.0 versus 57.2 kg, respectively) and lower percentage of lean muscle mass (68.6% versus 71.4%, respectively) than controls. Similar proportions of survivors (71.1%) and controls (69.7%) met recommended dietary protein intake (0.8 g/kg/d). Survivors (45.4%) were less likely to report resistance training than controls (53.8%). In adjusted models, 1-g higher protein intake per kilogram of body mass per day was associated with a 7.9% increase and resistance training ≥1×wk, with a 2.8% increase in lean muscle mass. Limitations The cross-sectional study design limits temporal evaluation of the association between protein intake and lean muscle mass. Conclusions The findings suggest that survivors of childhood ALL with low lean muscle mass may benefit from optimizing dietary protein intake in combination with resistance training. Research is needed to determine whether resistance training with protein supplementation improves lean muscle mass in survivors of childhood ALL.

scholarly journals Dietary Protein Intake and Risk of Type 2 Diabetes in US Men and Women

2016 ◽  
Vol 183 (8) ◽  
pp. 715-728 ◽  
Author(s):  
Vasanti S. Malik ◽  
Yanping Li ◽  
Deirdre K. Tobias ◽  
An Pan ◽  
Frank B. Hu
Keyword(s):  
Type 2 Diabetes ◽  
Dietary Protein ◽  
Protein Intake ◽  
Dietary Protein Intake ◽  
Men And Women

Dietary protein intake and risk of type 2 diabetes: a dose–response meta-analysis of prospective studies

2018 ◽  
Vol 58 (4) ◽  
pp. 1351-1367 ◽  
Author(s):  
Long-Gang Zhao ◽  
Qing-Li Zhang ◽  
Xiao-Li Liu ◽  
Hua Wu ◽  
Jia-Li Zheng ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dose Response ◽  
Prospective Studies ◽  
Dietary Protein ◽  
Protein Intake ◽  
Meta Analysis ◽  
Dietary Protein Intake
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