scholarly journals Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the Stratum Corneum

Pharmaceutics ◽  
2015 ◽  
Vol 7 (4) ◽  
pp. 438-470 ◽  
Author(s):  
Ahlam Alkilani ◽  
Maelíosa T. McCrudden ◽  
Ryan Donnelly
Keyword(s):  
Drug Delivery ◽  
Stratum Corneum ◽  
Transdermal Drug Delivery ◽  
Barrier Properties

scholarly journals Enhancement strategies for transdermal drug delivery systems: current trends and applications

2021 ◽  
Author(s):  
Delly Ramadon ◽  
Maeliosa T. C. McCrudden ◽  
Aaron J. Courtenay ◽  
Ryan F. Donnelly
Keyword(s):  
Drug Delivery ◽  
Stratum Corneum ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Global Market ◽  
Therapeutic Drug ◽  
Current Trends ◽  
Transdermal Drug Delivery Systems

AbstractTransdermal drug delivery systems have become an intriguing research topic in pharmaceutical technology area and one of the most frequently developed pharmaceutical products in global market. The use of these systems can overcome associated drawbacks of other delivery routes, such as oral and parenteral. The authors will review current trends, and future applications of transdermal technologies, with specific focus on providing a comprehensive understanding of transdermal drug delivery systems and enhancement strategies. This article will initially discuss each transdermal enhancement method used in the development of first-generation transdermal products. These methods include drug/vehicle interactions, vesicles and particles, stratum corneum modification, energy-driven methods and stratum corneum bypassing techniques. Through suitable design and implementation of active stratum corneum bypassing methods, notably microneedle technology, transdermal delivery systems have been shown to deliver both low and high molecular weight drugs. Microneedle technology platforms have proven themselves to be more versatile than other transdermal systems with opportunities for intradermal delivery of drugs/biotherapeutics and therapeutic drug monitoring. These have shown that microneedles have been a prospective strategy for improving transdermal delivery systems. Graphical abstract

scholarly journals Progress in Microneedle-Mediated Protein Delivery

2020 ◽  
Vol 9 (2) ◽  
pp. 542 ◽  
Author(s):  
Rezvan Jamaledin ◽  
Concetta Di Natale ◽  
Valentina Onesto ◽  
Zahra Taraghdari ◽  
Ehsan Zare ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Stratum Corneum ◽  
Transdermal Drug Delivery ◽  
Protein Delivery ◽  
Scaling Up ◽  
Low Molecular Weight ◽  
Non Invasive ◽  
Promising Tool ◽  
Transdermal Patches

The growing demand for patient-compliance therapies in recent years has led to the development of transdermal drug delivery, which possesses several advantages compared with conventional methods. Delivering protein through the skin by transdermal patches is extremely difficult due to the presence of the stratum corneum which restricts the application to lipophilic drugs with relatively low molecular weight. To overcome these limitations, microneedle (MN) patches, consisting of micro/miniature-sized needles, are a promising tool to perforate the stratum corneum and to release drugs and proteins into the dermis following a non-invasive route. This review investigates the fabrication methods, protein delivery, and translational considerations for the industrial scaling-up of polymeric MNs for dermal protein delivery.

scholarly journals Derma rollers in therapy: the transition from cosmetics to transdermal drug delivery

2020 ◽  
Vol 22 (4) ◽  
Author(s):  
Leonna Dsouza ◽  
Vivek M. Ghate ◽  
Shaila A. Lewis
Keyword(s):  
Drug Delivery ◽  
Stratum Corneum ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Hair Follicles ◽  
Collagen Production ◽  
Site Of Action

AbstractDerma roller, a device rolled onto the skin to form micropores, is extensively used for cosmetic purposes. The pores thus created are utilized to either result in the induction of collagen production, leading to glowing and wrinkle-free skin or for permeating the applied formulations to the site of action within the skin. Recent studies have shown the benefits of using derma rollers for transdermal delivery of drugs. In the nascent stage, this approach paves a way to successfully breach the stratum corneum and aid in the movement of medications directed towards the dermis and the hair follicles. The review essentially summarizes the evidence of the use of derma rollers in cosmetic setup, their designing, and the preclinical and clinical reports of efficacy, safety, and concerns when translated for pharmaceutical purposes and transdermal drug delivery.

Microneedle-mediated transdermal nanodelivery systems: a review

2021 ◽  
Author(s):  
Shuyao Ruan ◽  
Yong-Tai Zhang ◽  
Nian-Ping Feng
Keyword(s):  
Drug Delivery ◽  
Stratum Corneum ◽  
Barrier Function ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Transdermal Drug Delivery Systems

The greatest limitation in the development of transdermal drug delivery systems is that only a few drugs can permeate the skin due to the barrier function of the stratum corneum....

scholarly journals Development of Topical/Transdermal Drug Delivery Based on Structure Analysis of Stratum Corneum

Hyomen Kagaku ◽  
2014 ◽  
Vol 35 (1) ◽  
pp. 34-39
Author(s):  
Yasuko OBATA ◽  
Noboru OHTA ◽  
Naoto YAGI ◽  
Yoshinori ONUKI ◽  
Kozo TAKAYAMA
Keyword(s):  
Drug Delivery ◽  
Stratum Corneum ◽  
Structure Analysis ◽  
Transdermal Drug Delivery

Photomechanical delivery of 100-nm microspheres through the stratum corneum: Implications for transdermal drug delivery

2002 ◽  
Vol 31 (3) ◽  
pp. 207-210 ◽  
Author(s):  
Shun Lee ◽  
Daniel J. McAuliffe ◽  
Nikiforos Kollias ◽  
Thomas J. Flotte ◽  
Apostolos G. Doukas
Keyword(s):  
Drug Delivery ◽  
Stratum Corneum ◽  
Transdermal Drug Delivery
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