scholarly journals Roles of CCL2-CCR2 Axis in the Tumor Microenvironment

2021 ◽  
Vol 22 (16) ◽  
pp. 8530
Author(s):  
Suguru Kadomoto ◽  
Kouji Izumi ◽  
Atsushi Mizokami
Keyword(s):  
Cell Proliferation ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Tumor Cell ◽  
Cancer Progression ◽  
Tumor Cell Proliferation ◽  
Chemokine Signaling ◽  
Chemotactic Factors ◽  
Immunosuppressive Cells ◽  
The Relationship

Chemokines are a small family of cytokines that were first discovered as chemotactic factors in leukocytes during inflammation, and reports on the relationship between chemokines and cancer progression have recently been increasing. The CCL2-CCR2 axis is one of the major chemokine signaling pathways, and has various functions in tumor progression, such as increasing tumor cell proliferation and invasiveness, and creating a tumor microenvironment through increased angiogenesis and recruitment of immunosuppressive cells. This review discusses the roles of the CCL2-CCR2 axis and the tumor microenvironment in cancer progression and their future roles in cancer therapy.

scholarly journals Cyclodextrin-based host-guest complexes loaded with regorafenib for colorectal cancer treatment

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Hongzhen Bai ◽  
Jianwei Wang ◽  
Chi Uyen Phan ◽  
Qi Chen ◽  
Xiurong Hu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Tumor Microenvironment ◽  
Tumor Cell ◽  
Tumor Cell Proliferation ◽  
Therapeutic Targeting ◽  
Potential Strategy ◽  
Colorectal Cancer Treatment ◽  
Channel Type

AbstractThe malignancy of colorectal cancer (CRC) is connected with inflammation and tumor-associated macrophages (TAMs), but effective therapeutics for CRC are limited. To integrate therapeutic targeting with tumor microenvironment (TME) reprogramming, here we develop biocompatible, non-covalent channel-type nanoparticles (CNPs) that are fabricated through host-guest complexation and self-assemble of mannose-modified γ-cyclodextrin (M-γ-CD) with Regorafenib (RG), RG@M-γ-CD CNPs. In addition to its carrier role, M-γ-CD serves as a targeting device and participates in TME regulation. RG@M-γ-CD CNPs attenuate inflammation and inhibit TAM activation by targeting macrophages. They also improve RG’s anti-tumor effect by potentiating kinase suppression. In vivo application shows that the channel-type formulation optimizes the pharmacokinetics and bio-distribution of RG. In colitis-associated cancer and CT26 mouse models, RG@M-γ-CD is proven to be a targeted, safe and effective anti-tumor nanomedicine that suppresses tumor cell proliferation, lesions neovascularization, and remodels TME. These findings indicate RG@M-γ-CD CNPs as a potential strategy for CRC treatment.

scholarly journals The Formation and Therapeutic Update of Tumor-Associated Macrophages in Cervical Cancer

2019 ◽  
Vol 20 (13) ◽  
pp. 3310 ◽  
Author(s):  
Qun Wang ◽  
Alexander Steger ◽  
Sven Mahner ◽  
Udo Jeschke ◽  
Helene Heidegger
Keyword(s):  
Cervical Cancer ◽  
Cell Proliferation ◽  
Tumor Cell ◽  
Cancer Progression ◽  
Poor Prognosis ◽  
Experimental Studies ◽  
Clear Understanding ◽  
Tumor Cell Proliferation ◽  
Tumor Associated Macrophages ◽  
Therapy Development

Both clinicopathological and experimental studies have suggested that tumor-associated macrophages (TAMs) play a key role in cervical cancer progression and are associated with poor prognosis in the respects of tumor cell proliferation, invasion, angiogenesis, and immunosuppression. Therefore, having a clear understanding of TAMs is essential in treating this disease. In this review, we will discuss the origins and categories of macrophages, the molecules responsible for forming and reeducating TAMs in cervical cancer (CC), the biomarkers of macrophages and the therapy development targeting TAMs in CC research.

Expression of β-Catenin in Hepatocellular Carcinoma

2001 ◽  
Vol 71 (3) ◽  
pp. 116-125
Author(s):  
Norina Basa ◽  
Daniela Lazar ◽  
Remus Cornea ◽  
Sorina Taban ◽  
Melania Ardelean ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
Tumor Cell ◽  
Mitotic Index ◽  
Histological Grade ◽  
Proliferation Index ◽  
Tumor Cell Proliferation ◽  
Ki 67 ◽  
B Virus ◽  
Development And Evolution

Alteration of β-catenin expression is involved in the development and evolution of hepatocellular carcinoma (HCC); β-catenin is able to influence tumor cell proliferation. We analyzed the immunohistochemical (IHC) expression of β-catenin on a group of 32 patients diagnosed with HCC using the anti-β-catenin monoclonal antibody (clone E247). We correlated the expression of β-catenin with the proliferation index of Ki-67 (PI Ki-67), the mitotic index (MI) and other clinical and pathological features. We observed an altered β-catenin expression in 58.38% of all HCC cases. This expression was insignificantly correlated with tumor size (]5 cm) (p = 0.683), histological grade G1-G2 (p = 0.307), vascular invasion (p = 0.299) and advanced pT stage (p = 0.453); we obtained a significantly higher MI in HCC with altered β-catenin expression (p = 0.018), as compared to HCC without overexpression (1.66 � 1.37) (p = 0.038) and a PI Ki-67 of 22.49 � 20.1 and 28.24 � 18.2, respectively in tumors with altered β-catenin expression with insignificant differences compared to HCC without overexpression (25.95 � 15.2) (p = 0.682 and p = 0.731, respectively). According to the results we obtained, aberrant β-catenin expression in HCC was correlated with a high mitotic index, therefore playing an important role in tumor progression by stimulating tumor cell proliferation; non-nuclear β-catenin overexpression can have a pathological significance in HCC, especially in cases of HCC associated with hepatitis B virus (HBV) infection.

Sign in / Sign up

Export Citation Format

Share Document