Carbamoylphosphonates Control Tumor Cell Proliferation and Dissemination by Simultaneously Inhibiting Carbonic Anhydrase IX and Matrix Metalloproteinase-2. Toward Nontoxic Chemotherapy Targeting Tumor Microenvironment

2012 ◽  
Vol 55 (17) ◽  
pp. 7875-7882 ◽  
Author(s):  
Reuven Reich ◽  
Amnon Hoffman ◽  
Ainelly Veerendhar ◽  
Alfonso Maresca ◽  
Alessio Innocenti ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Tumor Microenvironment ◽  
Carbonic Anhydrase ◽  
Matrix Metalloproteinase ◽  
Tumor Cell ◽  
Carbonic Anhydrase Ix ◽  
Matrix Metalloproteinase 2 ◽  
Tumor Cell Proliferation ◽  
Control Tumor

scholarly journals Carbonic anhydrase IX enhances tumor cell proliferation and tumor progression in osteosarcoma

2018 ◽  
Vol Volume 11 ◽  
pp. 6879-6886 ◽  
Author(s):  
Kazuma Okuno ◽  
Takao Matsubara ◽  
Tomoki Nakamura ◽  
Takahiro Iino ◽  
Takuya Kakimoto ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Carbonic Anhydrase ◽  
Tumor Cell ◽  
Tumor Progression ◽  
Carbonic Anhydrase Ix ◽  
Tumor Cell Proliferation

scholarly journals Cyclodextrin-based host-guest complexes loaded with regorafenib for colorectal cancer treatment

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Hongzhen Bai ◽  
Jianwei Wang ◽  
Chi Uyen Phan ◽  
Qi Chen ◽  
Xiurong Hu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Tumor Microenvironment ◽  
Tumor Cell ◽  
Tumor Cell Proliferation ◽  
Therapeutic Targeting ◽  
Potential Strategy ◽  
Colorectal Cancer Treatment ◽  
Channel Type

AbstractThe malignancy of colorectal cancer (CRC) is connected with inflammation and tumor-associated macrophages (TAMs), but effective therapeutics for CRC are limited. To integrate therapeutic targeting with tumor microenvironment (TME) reprogramming, here we develop biocompatible, non-covalent channel-type nanoparticles (CNPs) that are fabricated through host-guest complexation and self-assemble of mannose-modified γ-cyclodextrin (M-γ-CD) with Regorafenib (RG), RG@M-γ-CD CNPs. In addition to its carrier role, M-γ-CD serves as a targeting device and participates in TME regulation. RG@M-γ-CD CNPs attenuate inflammation and inhibit TAM activation by targeting macrophages. They also improve RG’s anti-tumor effect by potentiating kinase suppression. In vivo application shows that the channel-type formulation optimizes the pharmacokinetics and bio-distribution of RG. In colitis-associated cancer and CT26 mouse models, RG@M-γ-CD is proven to be a targeted, safe and effective anti-tumor nanomedicine that suppresses tumor cell proliferation, lesions neovascularization, and remodels TME. These findings indicate RG@M-γ-CD CNPs as a potential strategy for CRC treatment.

scholarly journals Roles of CCL2-CCR2 Axis in the Tumor Microenvironment

2021 ◽  
Vol 22 (16) ◽  
pp. 8530
Author(s):  
Suguru Kadomoto ◽  
Kouji Izumi ◽  
Atsushi Mizokami
Keyword(s):  
Cell Proliferation ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Tumor Cell ◽  
Cancer Progression ◽  
Tumor Cell Proliferation ◽  
Chemokine Signaling ◽  
Chemotactic Factors ◽  
Immunosuppressive Cells ◽  
The Relationship

Chemokines are a small family of cytokines that were first discovered as chemotactic factors in leukocytes during inflammation, and reports on the relationship between chemokines and cancer progression have recently been increasing. The CCL2-CCR2 axis is one of the major chemokine signaling pathways, and has various functions in tumor progression, such as increasing tumor cell proliferation and invasiveness, and creating a tumor microenvironment through increased angiogenesis and recruitment of immunosuppressive cells. This review discusses the roles of the CCL2-CCR2 axis and the tumor microenvironment in cancer progression and their future roles in cancer therapy.

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