scholarly journals The Formation and Therapeutic Update of Tumor-Associated Macrophages in Cervical Cancer

2019 ◽  
Vol 20 (13) ◽  
pp. 3310 ◽  
Author(s):  
Qun Wang ◽  
Alexander Steger ◽  
Sven Mahner ◽  
Udo Jeschke ◽  
Helene Heidegger
Keyword(s):  
Cervical Cancer ◽  
Cell Proliferation ◽  
Tumor Cell ◽  
Cancer Progression ◽  
Poor Prognosis ◽  
Experimental Studies ◽  
Clear Understanding ◽  
Tumor Cell Proliferation ◽  
Tumor Associated Macrophages ◽  
Therapy Development

Both clinicopathological and experimental studies have suggested that tumor-associated macrophages (TAMs) play a key role in cervical cancer progression and are associated with poor prognosis in the respects of tumor cell proliferation, invasion, angiogenesis, and immunosuppression. Therefore, having a clear understanding of TAMs is essential in treating this disease. In this review, we will discuss the origins and categories of macrophages, the molecules responsible for forming and reeducating TAMs in cervical cancer (CC), the biomarkers of macrophages and the therapy development targeting TAMs in CC research.

scholarly journals The Role of Chemokines in Cervical Cancers

Medicina ◽  
2021 ◽  
Vol 57 (11) ◽  
pp. 1141
Author(s):  
Fabian Garrido ◽  
Carl Mathis Wild ◽  
Johanna Mittelberger ◽  
Franziska Dobler ◽  
Mariella Schneider ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Progression ◽  
Immune Checkpoint ◽  
Cervical Dysplasia ◽  
Experimental Studies ◽  
Immune Checkpoints ◽  
Clear Understanding ◽  
Cervical Cancers ◽  
Therapy Development

Both clinical-pathological and experimental studies have shown that chemokines play a key role in activating the immune checkpoint modulator in cervical cancer progression and are associated with prognosis in tumor cell proliferation, invasion, angiogenesis, chemoresistance, and immunosuppression. Therefore, a clear understanding of chemokines and immune checkpoint modulators is essential for the treatment of this disease. This review discusses the origins and categories of chemokines and the mechanisms that are responsible for activating immune checkpoints in cervical dysplasia and cancer, chemokines as biomarkers, and therapy development that targets immune checkpoints in cervical cancer research.

Upregulation of CDK7 in gastric cancer cell promotes tumor cell proliferation and predicts poor prognosis

2016 ◽  
Vol 100 (3) ◽  
pp. 514-521 ◽  
Author(s):  
Qiuhong Wang ◽  
Manhua Li ◽  
Xunlei Zhang ◽  
Hua Huang ◽  
Jianfei Huang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Proliferation ◽  
Tumor Cell ◽  
Cancer Cell ◽  
Poor Prognosis ◽  
Gastric Cancer Cell ◽  
Tumor Cell Proliferation

Low Level Her2 Overexpression Is Associated with Rapid Tumor Cell Proliferation and Poor Prognosis in Prostate Cancer

2010 ◽  
Vol 16 (5) ◽  
pp. 1553-1560 ◽  
Author(s):  
Sarah Minner ◽  
Birte Jessen ◽  
Lars Stiedenroth ◽  
Eike Burandt ◽  
Jens Köllermann ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Tumor Cell ◽  
Poor Prognosis ◽  
Her2 Overexpression ◽  
Tumor Cell Proliferation ◽  
Low Level

scholarly journals CtBP2 overexpression promotes tumor cell proliferation and invasion in gastric cancer and is associated with poor prognosis

Oncotarget ◽  
2017 ◽  
Vol 8 (17) ◽  
pp. 28736-28749 ◽  
Author(s):  
Faxiang Dai ◽  
Yi Xuan ◽  
Jie-Jie Jin ◽  
Shengjia Yu ◽  
Zi-Wen Long ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Proliferation ◽  
Tumor Cell ◽  
Poor Prognosis ◽  
Tumor Cell Proliferation ◽  
Proliferation And Invasion

scholarly journals Roles of CCL2-CCR2 Axis in the Tumor Microenvironment

2021 ◽  
Vol 22 (16) ◽  
pp. 8530
Author(s):  
Suguru Kadomoto ◽  
Kouji Izumi ◽  
Atsushi Mizokami
Keyword(s):  
Cell Proliferation ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Tumor Cell ◽  
Cancer Progression ◽  
Tumor Cell Proliferation ◽  
Chemokine Signaling ◽  
Chemotactic Factors ◽  
Immunosuppressive Cells ◽  
The Relationship

Chemokines are a small family of cytokines that were first discovered as chemotactic factors in leukocytes during inflammation, and reports on the relationship between chemokines and cancer progression have recently been increasing. The CCL2-CCR2 axis is one of the major chemokine signaling pathways, and has various functions in tumor progression, such as increasing tumor cell proliferation and invasiveness, and creating a tumor microenvironment through increased angiogenesis and recruitment of immunosuppressive cells. This review discusses the roles of the CCL2-CCR2 axis and the tumor microenvironment in cancer progression and their future roles in cancer therapy.

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