scholarly journals Accelerated Aging and Age-Related Diseases (CVD and Neurological) due to Air Pollution and Traffic Noise Exposure

2021 ◽  
Vol 22 (5) ◽  
pp. 2419
Author(s):  
Omar Hahad ◽  
Katie Frenis ◽  
Marin Kuntic ◽  
Andreas Daiber ◽  
Thomas Münzel
Keyword(s):  
Air Pollution ◽  
Aging Process ◽  
Healthy Aging ◽  
Noise Exposure ◽  
Traffic Noise ◽  
Environmental Pollutants ◽  
World Health ◽  
Past Century ◽  
Average Life Expectancy ◽  
Age Related

The World Health Organization estimates that only approximately 25% of diversity in longevity is explained by genetic factors, while the other 75% is largely determined by interactions with the physical and social environments. Indeed, aging is a multifactorial process that is influenced by a range of environmental, sociodemographic, and biopsychosocial factors, all of which might act in concert to determine the process of aging. The global average life expectancy increased fundamentally over the past century, toward an aging population, correlating with the development and onset of age-related diseases, mainly from cardiovascular and neurological nature. Therefore, the identification of determinants of healthy and unhealthy aging is a major goal to lower the burden and socioeconomic costs of age-related diseases. The role of environmental factors (such as air pollution and noise exposure) as crucial determinants of the aging process are being increasingly recognized. Here, we critically review recent findings concerning the pathomechanisms underlying the aging process and their correlates in cardiovascular and neurological disease, centered on oxidative stress and inflammation, as well as the influence of prominent environmental pollutants, namely air pollution and traffic noise exposure, which is suggested to accelerate the aging process. Insight into these types of relationships and appropriate preventive strategies are urgently needed to promote healthy aging.

Aging of the Retina: Molecular and Metabolic Turbulences and Potential Interventions

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Laura Campello ◽  
Nivedita Singh ◽  
Jayshree Advani ◽  
Anupam K. Mondal ◽  
Ximena Corso-Diaz ◽  
...  
Keyword(s):  
Healthy Aging ◽  
Cell Types ◽  
Lifestyle Changes ◽  
Annual Review ◽  
Past Century ◽  
Publication Date ◽  
Vision Science ◽  
Human Lifespan ◽  
Cellular Events ◽  
Age Related

Multifaceted and divergent manifestations across tissues and cell types have curtailed advances in deciphering the cellular events that accompany advanced age and contribute to morbidities and mortalities. Increase in human lifespan during the past century has heightened awareness of the need to prevent age-associated frailty of neuronal and sensory systems to allow a healthy and productive life. In this review, we discuss molecular and physiological attributes of aging of the retina, with a goal of understanding age-related impairment of visual function. We highlight the epigenome–metabolism nexus and proteostasis as key contributors to retinal aging and discuss lifestyle changes as potential modulators of retinal function. Finally, we deliberate promising intervention strategies for promoting healthy aging of the retina for improved vision. Expected final online publication date for the Annual Review of Vision Science, Volume 7 is September 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Long-term air pollution and road traffic noise exposure and COPD: the Danish Nurse Cohort

2021 ◽  
pp. 2004594
Author(s):  
Shuo Liu ◽  
Youn-Hee Lim ◽  
Marie Pedersen ◽  
Jeanette T. Jørgensen ◽  
Heresh Amini ◽  
...  
Keyword(s):  
Air Pollution ◽  
Noise Exposure ◽  
Cox Regression ◽  
Road Traffic ◽  
Traffic Noise ◽  
Potential Interaction ◽  
Chronic Obstructive ◽  
Road Traffic Noise ◽  
Obstructive Pulmonary Disease

BackgroundWhile air pollution has been linked to the development of chronic obstructive pulmonary disease (COPD), evidence on the role of environmental noise is just emerging. We examined the associations of long-term exposure to air pollution and road traffic noise with COPD incidence.MethodsWe defined COPD incidence for 24 538 female nurses from the Danish Nurse Cohort (age>44 years) as the first hospital contact between baseline (1993 or 1999) and 2015. We estimated residential annual mean concentrations of particulate matter with diameter<2.5 µm (PM2.5) since 1990 and nitrogen dioxide (NO2) since 1970 by the Danish DEHM/UBM/AirGIS modeling system, and road traffic noise (Lden) since 1970 by the Nord2000 model. Time-varying Cox regression models were applied to assess the associations of air pollution and road traffic noise with COPD incidence.Results977 nurses developed COPD during 18.6 years’ mean follow-up. We observed associations with COPD for all three exposures with hazard ratios (HRs) and 95% confidence intervals (CIs) of 1.19 (1.01, 1.41) per 6.26 µg·m−3 for PM2.5, 1.13 (1.05, 1.20) per 8.19 µg·m−3 for NO2, and 1.15 (1.06, 1.25) per 10 dB for Lden. Associations with NO2 and Lden attenuated slightly after mutual adjustment, but were robust to adjustment for PM2.5. Associations with PM2.5 were attenuated to null after adjustment for either NO2 or Lden. No potential interaction effect was observed between air pollutants and noise.ConclusionsLong-term exposure to air pollution, especially traffic-related NO2, and road traffic noise were independently associated with COPD.

scholarly journals Ambient air pollution, traffic noise and adult asthma prevalence: a BioSHaRE approach

2016 ◽  
Vol 49 (1) ◽  
pp. 1502127 ◽  
Author(s):  
Yutong Cai ◽  
Wilma L. Zijlema ◽  
Dany Doiron ◽  
Marta Blangiardo ◽  
Paul R. Burton ◽  
...  
Keyword(s):  
Air Pollution ◽  
Noise Exposure ◽  
Traffic Noise ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Asthma Prevalence ◽  
Pool Data ◽  
Cross Sectional ◽  
Adult Asthma ◽  
Logistic Regression Models

We investigated the effects of both ambient air pollution and traffic noise on adult asthma prevalence, using harmonised data from three European cohort studies established in 2006–2013 (HUNT3, Lifelines and UK Biobank).Residential exposures to ambient air pollution (particulate matter with aerodynamic diameter ≤10 µm (PM10) and nitrogen dioxide (NO2)) were estimated by a pan-European Land Use Regression model for 2007. Traffic noise for 2009 was modelled at home addresses by adapting a standardised noise assessment framework (CNOSSOS-EU). A cross-sectional analysis of 646 731 participants aged ≥20 years was undertaken using DataSHIELD to pool data for individual-level analysis via a “compute to the data” approach. Multivariate logistic regression models were fitted to assess the effects of each exposure on lifetime and current asthma prevalence.PM10 or NO2 higher by 10 µg·m−3 was associated with 12.8% (95% CI 9.5–16.3%) and 1.9% (95% CI 1.1–2.8%) higher lifetime asthma prevalence, respectively, independent of confounders. Effects were larger in those aged ≥50 years, ever-smokers and less educated. Noise exposure was not significantly associated with asthma prevalence.This study suggests that long-term ambient PM10 exposure is associated with asthma prevalence in western European adults. Traffic noise is not associated with asthma prevalence, but its potential to impact on asthma exacerbations needs further investigation.

scholarly journals Traffic noise exposure depresses plasma corticosterone and delays offspring growth in breeding zebra finches

2019 ◽  
Vol 7 (1) ◽  
Author(s):  
Sue Anne Zollinger ◽  
Adriana Dorado-Correa ◽  
Wolfgang Goymann ◽  
Wolfgang Forstmeier ◽  
Ulrich Knief ◽  
...  
Keyword(s):  
Reproductive Success ◽  
Health Effects ◽  
Noise Exposure ◽  
Traffic Noise ◽  
Plasma Corticosterone ◽  
World Health ◽  
Anthropogenic Noise ◽  
Zebra Finches ◽  
Offspring Growth ◽  
The Impact

Abstract The impact of human activity on the acoustic environment is overwhelming, with anthropogenic noise reaching even remote areas of the planet. The World Health Organization has identified noise pollution as one of the leading environmental health risks in humans, and it has been linked to a myriad of short- and long-term health effects in exposed individuals. However, less is known about the health effects of anthropogenic noise exposure on animals. We investigated long- and short-term effects of traffic noise on zebra finches breeding in small communal aviaries, using a repeated measures design. Birds bred in both noise and no-noise conditions, and we measured baseline plasma glucocorticoid levels before, during and after breeding. In addition, we assayed immune function, measured reproductive success and offspring growth and compared rates of extra-pair paternity of breeding adults. Breeding birds had significantly lower baseline plasma corticosterone levels when exposed to traffic noise than when they were not exposed to noise playback. In addition, the nestlings reared during noise exposure were lighter than nestlings of the same parents when breeding in control conditions. Our results suggest that traffic noise poses a more severe hurdle to birds at more vulnerable stages of their life history, such as during reproductive events and ontogeny. While chronic exposure to traffic noise in our birds did not, by itself, prove to be a sufficient stressor to cause acute effects on health or reproductive success in exposed individuals, it did result in disruptions to normal glucocorticoid profiles and delayed offspring growth. However, animals living in urban habitats are exposed to a multitude of anthropogenic disturbances, and it is likely that even species that appear to be thriving in noisy environments may suffer cumulative effects of these multiple disturbances that may together impact their fitness in urban environments.

scholarly journals Environmental Noise-Induced Effects on Stress Hormones, Oxidative Stress, and Vascular Dysfunction: Key Factors in the Relationship between Cerebrocardiovascular and Psychological Disorders

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Omar Hahad ◽  
Jürgen H. Prochaska ◽  
Andreas Daiber ◽  
Thomas Münzel
Keyword(s):  
Oxidative Stress ◽  
Mental Stress ◽  
Noise Exposure ◽  
Vascular Dysfunction ◽  
Traffic Noise ◽  
Psychological Disorders ◽  
World Health ◽  
Stress Hormone ◽  
Hormone Levels ◽  
The Relationship

The role of noise as an environmental pollutant and its adverse effects on health are being increasingly recognized. Beyond its direct effects on the auditory system (e.g., hearing loss and tinnitus induced by exposure to high levels of noise), chronic low-level noise exposure causes mental stress associated with known cardiovascular complications. According to recent estimates of the World Health Organization, exposure to traffic noise is responsible for a loss of more than 1.5 million healthy life years per year in Western Europe alone, a major part being related to annoyance, cognitive impairment, and sleep disturbance. Underlying mechanisms of noise-induced mental stress are centered on increased stress hormone levels, blood pressure, and heart rate, which in turn favor the development of cerebrocardiovascular disease such as stroke, arterial hypertension, ischemic heart disease, and myocardial infarction. Furthermore, traffic noise exposure is also associated with mental health symptoms and psychological disorders such as depression and anxiety, which further increase maladaptive coping mechanisms (e.g., alcohol and tobacco use). From a molecular point of view, experimental studies suggest that traffic noise exposure can increase stress hormone levels, thereby triggering inflammatory and oxidative stress pathways by activation of the nicotinamide adenine dinucleotide phosphate oxidase, uncoupling of endothelial/neuronal nitric oxide synthase inducing endothelial and neuronal dysfunction. This review elucidates the mechanisms underlying the relationship between noise exposure and cerebrocardiovascular and psychological disorders, focusing on mental stress signaling pathways including activation of the autonomous nervous system and endocrine signaling and its association with inflammation, oxidative stress, and vascular dysfunction.

scholarly journals Long-term exposure to road traffic noise and stroke incidence: a Danish Nurse Cohort study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Tom Cole-Hunter ◽  
Christian Dehlendorff ◽  
Heresh Amini ◽  
Amar Mehta ◽  
Youn-Hee Lim ◽  
...  
Keyword(s):  
Air Pollution ◽  
Air Pollutants ◽  
Cox Regression ◽  
Road Traffic ◽  
Traffic Noise ◽  
World Health ◽  
Road Traffic Noise ◽  
Stroke Incidence ◽  
Increased Risk

Abstract Background Road traffic noise has been linked to increased risk of ischemic heart disease, yet evidence on stroke shows mixed results. We examine the association between long-term exposure to road traffic noise and incidence of stroke, overall and by subtype (ischemic or hemorrhagic), after adjustment for air pollution. Methods Twenty-five thousand six hundred and sixty female nurses from the Danish Nurse Cohort recruited in 1993 or 1999 were followed for stroke-related first-ever hospital contact until December 31st, 2014. Full residential address histories since 1970 were obtained and annual means of road traffic noise (Lden [dB]) and air pollutants (particulate matter with diameter < 2.5 μm and < 10 μm [PM2.5 and PM10], nitrogen dioxide [NO2], nitrogen oxides [NOx]) were determined using validated models. Time-varying Cox regression models were used to estimate hazard ratios (HR) (95% confidence intervals [CI]) for the associations of one-, three-, and 23-year running means of Lden preceding stroke (all, ischemic or hemorrhagic), adjusting for stroke risk factors and air pollutants. The World Health Organization and the Danish government’s maximum exposure recommendations of 53 and 58 dB, respectively, were explored as potential Lden thresholds. Results Of 25,660 nurses, 1237 developed their first stroke (1089 ischemic, 148 hemorrhagic) during 16 years mean follow-up. For associations between a 1-year mean of Lden and overall stroke incidence, the estimated HR (95% CI) in the fully adjusted model was 1.06 (0.98–1.14) per 10 dB, which attenuated to 1.01 (0.93–1.09) and 1.00 (0.91–1.09) in models further adjusted for PM2.5 or NO2, respectively. Associations for other exposure periods or separately for ischemic or hemorrhagic stroke were similar. There was no evidence of a threshold association between Lden and stroke. Conclusions Long-term exposure to road traffic noise was suggestively positively associated with the risk of overall stroke, although not after adjusting for air pollution.

Individual DNA Methylation Profile is Correlated with Age and can be Targeted to Modulate Healthy Aging and Longevity

2019 ◽  
Vol 25 (39) ◽  
pp. 4139-4149 ◽  
Author(s):  
Francesco Guarasci ◽  
Patrizia D'Aquila ◽  
Alberto Montesanto ◽  
Andrea Corsonello ◽  
Dina Bellizzi ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Mitochondrial Dna ◽  
Aging Process ◽  
Healthy Aging ◽  
Nuclear Dna ◽  
Epigenetic Modification ◽  
Biological Aging ◽  
Biomarkers Of Aging ◽  
Age Related

: Patterns of DNA methylation, the best characterized epigenetic modification, are modulated by aging. In humans, different studies at both site-specific and genome-wide levels have reported that modifications of DNA methylation are associated with the chronological aging process but also with the quality of aging (or biological aging), providing new perspectives for establishing powerful biomarkers of aging. : In this article, the role of DNA methylation in aging and longevity has been reviewed by analysing literature data about DNA methylation variations occurring during the lifetime in response to environmental factors and genetic background, and their association with the aging process and, in particular, with the quality of aging. Special attention has been devoted to the relationship between nuclear DNA methylation patterns, mitochondrial DNA epigenetic modifications, and longevity. Mitochondrial DNA has recently been reported to modulate global DNA methylation levels of the nuclear genome during the lifetime, and, in spite of the previous belief, it has been found to be the target of methylation modifications. : Analysis of DNA methylation profiles across lifetime shows that a remodeling of the methylome occurs with age and/or with age-related decline. Thus, it can be an excellent biomarker of aging and of the individual decline and frailty status. The knowledge about the mechanisms underlying these modifications is crucial since it might allow the opportunity for targeted treatment to modulate the rate of aging and longevity.

scholarly journals Burden of Sleep Disturbance Due to Traffic Noise in Bulgaria

Folia Medica ◽  
2016 ◽  
Vol 57 (3-4) ◽  
pp. 264-269 ◽  
Author(s):  
Angel M. Dzhambov ◽  
Donka D. Dimitrova ◽  
Vanina K. Mihaylova-Alakidi
Keyword(s):  
Sleep Disturbance ◽  
Economic Burden ◽  
Noise Exposure ◽  
Political Action ◽  
Road Traffic ◽  
Traffic Noise ◽  
Population Based ◽  
Environmental Research ◽  
World Health ◽  
Life Years

Abstract BACKGROUND: Sleep disturbance is a risk factor for somatic, psycho-social and spiritual dysfunction. It is also arguably the most deleterious effect of traffic noise pollution. Quantification of its burden is an anchor element of environmental policy making but no data are currently available for Bulgaria where the preponderance of dangerous nighttime noise exposure is highest in Europe. AIM: The aim of this study was to quantify the socio-economic burden of severe sleep disturbance due to traffic noise (road, aircraft and railway) in Bulgaria. MATERIAL AND METHODS: The official World Health Organization methodology used in Europe was applied in order to estimate this annual loss expressed as disability-adjusted life-years (DALYs) and their corresponding monetary value (assuming € 12 000 per DALY). RESULTS: Results showed that severe sleep disturbance due to all traffic sources was associated conservatively with 15 468 DALYs (8 839 - 22 097) and € 185 615 861 (€ 106 066 206 - € 265 165 516) lost in 2012, with road traffic being the single most important noise source. CONCLUSION: In conclusion, severe sleep disturbance due to traffic noise bears a heavy environmental and socio-economic burden in Bulgaria which prompts vigorous political action and greater involvement in environmental research. In order to increase the accuracy of future burden of disease analyses other studies would need to establish exposure-response functions based on population-based socio-acoustic surveys in the country.

scholarly journals A Comprehensive Study on Environmental Pollution and Pregnancy Outcomes

2021 ◽  
pp. 41-47
Author(s):  
Abhishek Adkine ◽  
Kalyani Mahajan
Keyword(s):  
Air Pollution ◽  
Birth Outcomes ◽  
Pregnancy Outcomes ◽  
Noise Exposure ◽  
Deterministic Model ◽  
Traffic Noise ◽  
Noise Pollution ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
The Government

Vehicular traffic contributes significantly to the pollution of air and neighborhood noise. Since there is increasing affirmation that ambient air pollution hurts reproductive health, which is less known regarding the relationship between traffic noise and pregnancy outcomes. Many researchers have investigated all the possible adverse effects of ambient air pollution on birth outcomes during the last decade or so. We examined these studies, which were discovered by thoroughly searching the major scientific databases. Overall, research suggests that air pollution and noise pollution significantly impact birth outcomes, while the quality of the deposition varies. Researchers utilized connected administrative health data sources to discover pregnancy outcomes with detailed covariate data (gender, contemporary lifestyle, total no of pregnancies, birth month and year, and so on), earnings and education, and mother housing history. Using the deterministic model (CadnaA) and air pollutants exposure, they assessed noise exposure during pregnancy by assessing temporally adjusted land-use regression. Noise exposure is related to reduced birth weight. We also looked into various processes to prevent air pollution and noise. As a result of the policy change and technical innovation, the government, authorities, and industry have been at the forefront of combating pollution. Pollution levels in and around people's homes and workplaces are typically beyond their control. However, few things may be done to mitigate the impacts of contaminated air.

scholarly journals Healthy Diet for Healthy Aging

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4310
Author(s):  
Suey S. Y. Yeung ◽  
Michelle Kwan ◽  
Jean Woo
Keyword(s):  
Dietary Patterns ◽  
Healthy Aging ◽  
Good Health ◽  
Epidemiological Studies ◽  
Healthy Diet ◽  
Sensory Function ◽  
World Health ◽  
Age Related ◽  
Modifiable Factors ◽  
Intrinsic Capacity

Extending healthspan is a major public health challenge. Diet is one of the modifiable factors for preventing age-related diseases and preserving overall good health status during aging. Optimizing individuals’ intrinsic capacity, including domains in cognition, psychological, sensory function, vitality, and locomotion, has been proposed as a model of healthy aging by the World Health Organization. To better understand the relationships between a healthy diet and healthy aging, this review summarizes the recent epidemiologic and clinical data for dietary patterns that have been shown to play a role in (domains of) healthy aging. Regardless of priori or posteriori dietary patterns, it appears that dietary patterns centered on plant-based foods have a beneficial role in (domains of) healthy aging. Our review identified a knowledge gap in dietary patterns and multidimensional concepts of healthy aging. More epidemiological studies should consider intrinsic capacity as an outcome measure to further our understanding of a healthy diet and multidimensional concepts of healthy aging. When a sufficient number of epidemiological studies is available, evidence can be synthesized and clinical trials can be designed to evaluate a healthy diet as a strategy for healthy aging to further our progress in translating evidence to practice and promoting healthy aging.

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