scholarly journals Physiopathological Role of Neuroactive Steroids in the Peripheral Nervous System

2020 ◽  
Vol 21 (23) ◽  
pp. 9000
Author(s):  
Eva Falvo ◽  
Silvia Diviccaro ◽  
Roberto Cosimo Melcangi ◽  
Silvia Giatti
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Experimental Models ◽  
Neuroactive Steroids ◽  
Physiological Status ◽  
Sexually Dimorphic ◽  
Protective Effects ◽  
Traumatic Injuries ◽  
High Prevalence

Peripheral neuropathy (PN) refers to many conditions involving damage to the peripheral nervous system (PNS). Usually, PN causes weakness, numbness and pain and is the result of traumatic injuries, infections, metabolic problems, inherited causes, or exposure to chemicals. Despite the high prevalence of PN, available treatments are still unsatisfactory. Neuroactive steroids (i.e., steroid hormones synthesized by peripheral glands as well as steroids directly synthesized in the nervous system) represent important physiological regulators of PNS functionality. Data obtained so far and here discussed, indeed show that in several experimental models of PN the levels of neuroactive steroids are affected by the pathology and that treatment with these molecules is able to exert protective effects on several PN features, including neuropathic pain. Of note, the observations that neuroactive steroid levels are sexually dimorphic not only in physiological status but also in PN, associated with the finding that PN show sex dimorphic manifestations, may suggest the possibility of a sex specific therapy based on neuroactive steroids.

scholarly journals Neuroactive steroids, their metabolites, and neuroinflammation

2012 ◽  
Vol 49 (3) ◽  
pp. R125-R134 ◽  
Author(s):  
Silvia Giatti ◽  
Mariaserena Boraso ◽  
Roberto Cosimo Melcangi ◽  
Barbara Viviani
Keyword(s):  
Nervous System ◽  
Biomedical Research ◽  
Experimental Models ◽  
Neuroactive Steroids ◽  
Steroid Metabolism ◽  
Neuroactive Steroid ◽  
Neuroprotective Strategy ◽  
Testosterone Metabolites ◽  
Inflammatory Effect

Neuroinflammation represents a common feature of many neurodegenerative diseases implicated both in their onset and progression. Neuroactive steroids act as physiological regulators and protective agents in the nervous system. Therefore, the attention of biomedical research has been recently addressed in evaluating whether neuroactive steroids, such as progestagens, androgens, and estrogens may also affect neuroinflammatory pathways. Observations so far obtained suggest a general anti-inflammatory effect with a beneficial relapse on several neurodegenerative experimental models, thus confirming the potentiality of a neuroprotective strategy based on neuroactive steroids. In this scenario, neuroactive steroid metabolism and the sophisticated machinery involved in their signaling are becoming especially attractive. In particular, because metabolism of neuroactive steroids as well as expression of their receptors is affected during the course of neurodegenerative events, a crucial role of progesterone and testosterone metabolites in modulating neuroinflammation and neurodegeneration may be proposed. In the present review, we will address this issue, providing evidence supporting the hypothesis that the efficacy of neuroactive steroids could be improved through the use of their metabolites.

scholarly journals Role of Neuroactive Steroids in the Peripheral Nervous System

2011 ◽  
Vol 2 ◽  
Author(s):  
Roberto Cosimo Melcangi ◽  
Silvia Giatti ◽  
Marzia Pesaresi ◽  
Donato Calabrese ◽  
Nico Mitro ◽  
...  
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Neuroactive Steroids

scholarly journals Changes in peripheral nervous system at participants of accident consequences elimination in Chernobyl APP and population of the Tomsk northern industrial center

2004 ◽  
Vol 3 (4) ◽  
pp. 71-80
Author(s):  
Ya. V. Porovsky ◽  
V. I. Zhankova ◽  
A. I. Ryzhov ◽  
Ye. V. Kalyanov ◽  
F. F. Tetenev
Keyword(s):  
Nervous System ◽  
Immune System ◽  
Peripheral Nervous System ◽  
Radiochemical Plant ◽  
Chemical Complex ◽  
Tomsk Region ◽  
Industrial Center ◽  
Sensory Polyneuropathy ◽  
Siberian Chemical

A clinical, electroneuromyographic (ENMG) and pathomorphological investigation of 19 eliminators of accident consequences (EAC) in Chernobyl APP in 1986 and 27 Tomsk region inhabitants living in the accident area that has taken place at radiochemical plant of Siberian Chemical Complex in 1993 has been made with the aim of the influence study of low ionizing radiation levels on the peripheral nervous system. Symptoms of sensory polyneuropathy prevailed in both groups clinically. Mixed affection type has been found at EAC by ENGM method, affection of myelinic nerve fibre membrane has been found at people living in accident trace area. Morphofunctional changes in skin allow considering the role of immune system in mechanisms of neuroglial and neuronal damages, distant by time.

scholarly journals Nervous system injury in alcoholic disease

2019 ◽  
Vol 11 (2S) ◽  
pp. 83-88
Author(s):  
O. E. Zinovyeva ◽  
N. V. Vashchenko ◽  
O. E. Mozgovaya ◽  
T. A. Yanakaeva ◽  
A. Yu. Emelyanova
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Alcohol Intoxication ◽  
Clinical Manifestations ◽  
Symptomatic Treatment ◽  
Chronic Alcohol ◽  
Neurological Manifestations ◽  
Chronic Alcohol Intoxication ◽  
Alcoholic Disease

The paper considers various variants of nervous system injury in alcoholic disease. It discusses the epidemiology, pathogenesis, diagnosis, and clinical manifestations of central and peripheral nervous system lesions in the presence of acute and chronic alcohol intoxication. Attention is paid to the issues of etiotropic, pathogenetic, and symptomatic treatment for neurological manifestations of alcoholic disease and to the role of neurotropic B vitamins in the treatment of alcohol-induced deficiency and non-deficiency states.

The role of NGF in the peripheral nervous system

1995 ◽  
Vol 8 (1,2) ◽  
pp. 97-98
Author(s):  
Jack Diamond ◽  
Sandra Lourenssen ◽  
Yvonne Kril ◽  
Jim Fawcett ◽  
Andrew Gloster
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System

Nox, Nox, Are You There? The Role of NADPH Oxidases in the Peripheral Nervous System

2021 ◽  
Author(s):  
Stephanie A Eid ◽  
Masha G. Savelieff ◽  
Assaad Antoine Eid ◽  
Eva L Feldman
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Nadph Oxidases
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