Mallory bodies and their role in the patho- and morphogenesis of alcoholic disease

The authors consider alcohol disease (AD) as an independent disease, the pathogenesis of which passes 3 stages: episodic alcohol intoxication, drunkenness and alcoholism. In the last 2 stages, severe changes in organs and tissues develop. In this case, Mallory bodies appear in the liver, which is considered to be a marker of chronic alcohol intoxication (CAI). They are observed in most patients with alcoholism and very rarely in those suffering from alcoholism. The authors believe that the alcoholic hyaline Mallory bodies, appearing in the liver and other organs in CAI, is an autoantigen to which the body responds with an autoimmune inflammatory response that is not curable. Therefore, drunkenness, in which there are no Mallory bodies, is curable when alcohol is consumed within the basal metabolism of the liver and treated by therapists, and the treatment of alcoholism is futile. Therefore, the problem of CAI can be solved only with the active treatment of the stage of drunkenness by therapists with the participation of psychiatrists.

Neurological complications of alcoholic disease and ways of their correction

The problem of alcohol abuse and its social and medical consequences has remained relevant for many years. Damage to the nervous system is one of the most common manifestations of alcoholic disease. The effect of ethanol and its metabolites results in damage to all parts of the nervous system and skeletal muscles. The paper provides a brief overview of Russian and foreign literature on the neurological manifestations of chronic alcohol intoxication. It considers modern ideas about the pathogenesis of alcoholic neuropathy (APN). It also discusses differences in the clinical presentation, course, and developmental mechanisms of the main (chronic toxic and acute/subacute) forms of APN associated with thiamine deficiency. The paper notes difficulties in diagnosing peripheral nerve damage, especially in the early stages of the disease and describes modern methods for objectifying damage to thin nerve fibers in chronic APN. It presents approaches to treating alcohol-induced damage to the peripheral nervous system, by taking into account the leading mechanisms of pathogenesis. Special attention is paid to B-complex vitamins and alpha-lipoic acid preparations frequently used in this disease, to the mechanisms of their therapeutic action, and to the evaluation of their efficacy in APN.

Nervous system injury in alcoholic disease

The paper considers various variants of nervous system injury in alcoholic disease. It discusses the epidemiology, pathogenesis, diagnosis, and clinical manifestations of central and peripheral nervous system lesions in the presence of acute and chronic alcohol intoxication. Attention is paid to the issues of etiotropic, pathogenetic, and symptomatic treatment for neurological manifestations of alcoholic disease and to the role of neurotropic B vitamins in the treatment of alcohol-induced deficiency and non-deficiency states.

Structural and Functional Fundamentals of Alcoholic Disease

Aim. To suggest a new perspective on chronic alcohol intoxication by means of investigating the associated severe multiple organ pathology, which frequently becomes the cause of lethal outcome in patients suffering from drunkenness and alcoholism.Key points. The empirical basis of the study consisted in the analysis of autopsy results obtained from 1,115 corpses of persons having abused alcohol during their lifetime. In addition, 800 experiments on rats were carried out. As a result, a concept of alcoholic disease (AD) is proposed. AD is defined as a condition, in which chronic ethanol intoxication leads to the development of morphological changes in organs and systems: from minimal injuries of the microcirculatory pathway to a multiple organ pathology showing signs of alcoholism. AD pathogenesis is demonstrated to undergo 3 major stages, from (1) episodic alcohol intoxication, through (2) drunkenness and to (3) alcoholism. It is noted that, while the morphological changes are considered to be reversible during the first two stages, they become irreversible at the stage of alcoholism.Conclusion. It is concluded that the forms of the disease that involve the described morphological changes in organs and systems should be primarily treated by physicians, not by psychiatrists and narcology practitioners who are only capable of dealing with the psychological aspect of the problem.

OBJECTIFICATION OF LABORATORY DIAGNOSTICS OF ACUTE AND CHRONIC ALCOHOL INTOXICATION WITH USING MODERN BIOCHEMICAL MARKERS

The consideration is given to problems of alcoholic disease-pathology, which has recently become so widespread in many countries, and is ranked number three in the causes of death and disability after cardiovascular and oncological diseases. The article highlights the main issues of pathogenesis and diagnostics of the most common affection of internal organs resulted from alcoholic etiology. Special attention is paid to laboratory methods for diagnosing the acute and chronic alcohol intoxication.