scholarly journals The Role of Curcumin in the Modulation of Ageing

2019 ◽  
Vol 20 (5) ◽  
pp. 1239 ◽  
Author(s):  
Anna Bielak-Zmijewska ◽  
Wioleta Grabowska ◽  
Agata Ciolko ◽  
Agnieszka Bojko ◽  
Grażyna Mosieniak ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Natural Products ◽  
Cellular Senescence ◽  
Current Knowledge ◽  
Model Organisms ◽  
Age Related ◽  
Daily Diet

It is believed that postponing ageing is more effective and less expensive than the treatment of particular age-related diseases. Compounds which could delay symptoms of ageing, especially natural products present in a daily diet, are intensively studied. One of them is curcumin. It causes the elongation of the lifespan of model organisms, alleviates ageing symptoms and postpones the progression of age-related diseases in which cellular senescence is directly involved. It has been demonstrated that the elimination of senescent cells significantly improves the quality of life of mice. There is a continuous search for compounds, named senolytic drugs, that selectively eliminate senescent cells from organisms. In this paper, we endeavor to review the current knowledge about the anti-ageing role of curcumin and discuss its senolytic potential.

Resveratrol: A new potential therapeutic agent for melanoma?

2019 ◽  
Vol 26 ◽  
Author(s):  
Mohamad Hossein Pourhanifeh ◽  
Kazem Abbaszadeh-Goudarzi ◽  
Mohammad Goodarzi ◽  
Sara G.M. Piccirillo ◽  
Alimohammad Shafiee ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Therapeutic Agent ◽  
Current Knowledge ◽  
Treatment Resistance ◽  
Anti Cancer ◽  
Apoptosis Inducer ◽  
Life Threatening ◽  
First Time

: Melanoma is the most life-threatening and aggressive class of skin malignancies. The incidence of melanoma has steadily increased. Metastatic melanoma is greatly resistant to standard anti-melanomatreatments such as chemotherapy, and 5-year survival rate of cases with melanoma who have metastatic form of disease is less than 10%. The contributing role of apoptosis, angiogenesis and autophagy in the pathophysiology of melanoma has been previously demonstrated. Thus, it is extremely urgent to search for complementary therapeutic approachesthat couldenhance the quality of life of subjects and reduce treatment resistance and adverse effects. Resveratrol, known as a polyphenol component present in grapes and some plants, has anti-cancer properties due to its function as an apoptosis inducer in tumor cells, and anti-angiogenic agent to prevent metastasis. However, more clinical trials should be conducted to prove resveratrol efficacy. : Herein, for first time, we summarize current knowledge of anti-cancerous activities of resveratrol in melanoma.

Review on immunosenescence

2007 ◽  
Vol 17 (3) ◽  
pp. 161-169 ◽  
Author(s):  
Lia Ginaldi ◽  
Lucia Paola Mengoli ◽  
Massimo De Martinis
Keyword(s):  
Quality Of Life ◽  
Morbidity And Mortality ◽  
Old People ◽  
The Past ◽  
Human Lifespan ◽  
Age Related ◽  
Consequent Reduction ◽  
General Improvement

The improvements of socio-environmental conditions, medical care and quality of life have caused a general improvement in the health status of the population and a consequent reduction of morbidity and mortality, resulting in an overall increased life-expectancy. The role of immunosenescence was negligible in the past, when the human lifespan was 40–50 years, and its impact on morbidity and mortality has emerged in combination with the extension of lifespan. Immunosenescence results from multifactorial processes that act on all components of the immune system. The changes associated with immunosenescence are playing an increasingly important role in the emergence of a series of age-related pathologies, conditioning the present epidemiology of old people.

scholarly journals Age-Related Patterns in Cancer Pain and Its Psychosocial Impact: Investigating the Role of Variability in Physical and Mental Health Quality of Life

Pain Medicine ◽  
2017 ◽  
Vol 19 (4) ◽  
pp. 658-676 ◽  
Author(s):  
Lynn R Gauthier ◽  
Robert H Dworkin ◽  
David Warr ◽  
Rebecca Pillai Riddell ◽  
Alison K Macpherson ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Cancer Pain ◽  
Psychosocial Impact ◽  
Physical And Mental Health ◽  
Age Related ◽  
Health Quality ◽  
Health Quality Of Life

scholarly journals Terpenoids as Potential Geroprotectors

Antioxidants ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 529
Author(s):  
Ekaterina Proshkina ◽  
Sergey Plyusnin ◽  
Tatyana Babak ◽  
Ekaterina Lashmanova ◽  
Faniya Maganova ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Stress Resistance ◽  
Biological Effects ◽  
Plant Secondary Metabolites ◽  
Mechanisms Of Action ◽  
Model Organisms ◽  
Age Related ◽  
Evolutionarily Conserved ◽  
Low Toxicity

Terpenes and terpenoids are the largest groups of plant secondary metabolites. However, unlike polyphenols, they are rarely associated with geroprotective properties. Here we evaluated the conformity of the biological effects of terpenoids with the criteria of geroprotectors, including primary criteria (lifespan-extending effects in model organisms, improvement of aging biomarkers, low toxicity, minimal adverse effects, improvement of the quality of life) and secondary criteria (evolutionarily conserved mechanisms of action, reproducibility of the effects on different models, prevention of age-associated diseases, increasing of stress-resistance). The number of substances that demonstrate the greatest compliance with both primary and secondary criteria of geroprotectors were found among different classes of terpenoids. Thus, terpenoids are an underestimated source of potential geroprotectors that can effectively influence the mechanisms of aging and age-related diseases.

scholarly journals A Hypothesis on the Possible Potential of Plantago Major in the Treatment of Urticaria

2014 ◽  
Vol 3 (2) ◽  
pp. 123-126
Author(s):  
Mohammad Ali Yazdian ◽  
Mahmood Khodadoost ◽  
Mehdi Gheisari ◽  
Mohammad Kamalinejad ◽  
Amir Hooshang Ehsani
Keyword(s):  
Quality Of Life ◽  
Effective Properties ◽  
Current Knowledge ◽  
Hypersensitivity Reactions ◽  
Plantago Major ◽  
Herbal Therapy ◽  
Direct Role ◽  
Quality Of Life Index

Background:Urticaria is a skin disease characterized by pruritic edematous lesions also called wheals. Although these lesions are self-limited they may result in lowered quality of life index. By far, the most recognized mechanisms that trigger the progression of this condition are hypersensitivity reactions. As an herbal therapy, Plantago major has been named in several references of Persian traditional medicine with effective properties in ameliorating urticarial symptoms. In this study we aimed to investigate whether Plantago major has the potential to be used clinically in treatment of urticaria according to the current knowledge about the plant effects.Materials and Methods:A combination of “Plantago major” and other terms related to urticarial therapy such as “mast cell”, “anti-inflammatory”, “prostaglandin”, “histamine” and “IgE” that may have possible role in progression or suppression of urticaria was searched in Google Scholar and PubMed as the reference databases.Results:Eleven articles discussing either the direct role of Plantago major or any of its constituents in urticarial related bimolecular pathways were selected.Conclusion:Review of the selected articles indicated that Plantago major can effectively suppress many of hypersensitivity reactions which are also contributors in the pathophysiology of urticaria development. Further clinical trials are needed to prove the efficacy of this herbal treatment.

scholarly journals Quality of Life and Sexual Health in the Aging of PCa Survivors

2014 ◽  
Vol 2014 ◽  
pp. 1-16 ◽  
Author(s):  
Mauro Gacci ◽  
Elisabetta Baldi ◽  
Lara Tamburrino ◽  
Beatrice Detti ◽  
Lorenzo Livi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Sexual Health ◽  
Negative Impact ◽  
Current Knowledge ◽  
Urinary Continence ◽  
Low Grade ◽  
Sexual Hormones ◽  
Male Population

Prostate cancer (PCa) is the most common malignancy in elderly men. The progressive ageing of the world male population will further increase the need for tailored assessment and treatment of PCa patients. The determinant role of androgens and sexual hormones for PCa growth and progression has been established. However, several trials on androgens and PCa are recently focused on urinary continence, quality of life, and sexual function, suggesting a new point of view on the whole endocrinological aspect of PCa. During aging, metabolic syndrome, including diabetes, hypertension, dyslipidemia, and central obesity, can be associated with a chronic, low-grade inflammation of the prostate and with changes in the sex steroid pathways. These factors may affect both the carcinogenesis processes and treatment outcomes of PCa. Any treatment for PCa can have a long-lasting negative impact on quality of life and sexual health, which should be assessed by validated self-reported questionnaires. In particular, sexual health, urinary continence, and bowel function can be worsened after prostatectomy, radiotherapy, or hormone treatment, mostly in the elderly population. In the present review we summarized the current knowledge on the role of hormones, metabolic features, and primary treatments for PCa on the quality of life and sexual health of elderly Pca survivors.

scholarly journals Pharmacological Approaches and Natural Products for Prevention of Chemotherapy-Induced Peripheral Neuropathy - A Review

2017 ◽  
Vol 6 ◽  
pp. 47-53
Author(s):  
Marco Cascella ◽  
Maria Rosaria Muzio
Keyword(s):  
Quality Of Life ◽  
Adverse Effect ◽  
Natural Products ◽  
Peripheral Neuropathy ◽  
Effective Agent ◽  
Related Adverse Effect ◽  
Risk Patients

Chemotherapy-induced peripheral neuropathy (CIPN) is a one of the most common and severe cancer treatment-related adverse effect. It can often cause the stop of the treatment and affects the long-term quality of life of cancer survivors, too. Unfortunately, there are no effective agent or protocol to prevent with strong evidence of effectiveness this toxicity prevention of CIPN. Thus, CIPN prevention mainly consists of cumulative dose-reduction or lower dose-intensities, especially in higher risk patients. After a brief description of pathophysiology and features of CIPN, the purpose of this study is to analyse the role of standard pharmacological approaches and natural products for prevention of this serious side effect.

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