scholarly journals Quality of Life and Sexual Health in the Aging of PCa Survivors

2014 ◽  
Vol 2014 ◽  
pp. 1-16 ◽  
Author(s):  
Mauro Gacci ◽  
Elisabetta Baldi ◽  
Lara Tamburrino ◽  
Beatrice Detti ◽  
Lorenzo Livi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Sexual Health ◽  
Negative Impact ◽  
Current Knowledge ◽  
Urinary Continence ◽  
Low Grade ◽  
Sexual Hormones ◽  
Male Population

Prostate cancer (PCa) is the most common malignancy in elderly men. The progressive ageing of the world male population will further increase the need for tailored assessment and treatment of PCa patients. The determinant role of androgens and sexual hormones for PCa growth and progression has been established. However, several trials on androgens and PCa are recently focused on urinary continence, quality of life, and sexual function, suggesting a new point of view on the whole endocrinological aspect of PCa. During aging, metabolic syndrome, including diabetes, hypertension, dyslipidemia, and central obesity, can be associated with a chronic, low-grade inflammation of the prostate and with changes in the sex steroid pathways. These factors may affect both the carcinogenesis processes and treatment outcomes of PCa. Any treatment for PCa can have a long-lasting negative impact on quality of life and sexual health, which should be assessed by validated self-reported questionnaires. In particular, sexual health, urinary continence, and bowel function can be worsened after prostatectomy, radiotherapy, or hormone treatment, mostly in the elderly population. In the present review we summarized the current knowledge on the role of hormones, metabolic features, and primary treatments for PCa on the quality of life and sexual health of elderly Pca survivors.

Resveratrol: A new potential therapeutic agent for melanoma?

2019 ◽  
Vol 26 ◽  
Author(s):  
Mohamad Hossein Pourhanifeh ◽  
Kazem Abbaszadeh-Goudarzi ◽  
Mohammad Goodarzi ◽  
Sara G.M. Piccirillo ◽  
Alimohammad Shafiee ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Therapeutic Agent ◽  
Current Knowledge ◽  
Treatment Resistance ◽  
Anti Cancer ◽  
Apoptosis Inducer ◽  
Life Threatening ◽  
First Time

: Melanoma is the most life-threatening and aggressive class of skin malignancies. The incidence of melanoma has steadily increased. Metastatic melanoma is greatly resistant to standard anti-melanomatreatments such as chemotherapy, and 5-year survival rate of cases with melanoma who have metastatic form of disease is less than 10%. The contributing role of apoptosis, angiogenesis and autophagy in the pathophysiology of melanoma has been previously demonstrated. Thus, it is extremely urgent to search for complementary therapeutic approachesthat couldenhance the quality of life of subjects and reduce treatment resistance and adverse effects. Resveratrol, known as a polyphenol component present in grapes and some plants, has anti-cancer properties due to its function as an apoptosis inducer in tumor cells, and anti-angiogenic agent to prevent metastasis. However, more clinical trials should be conducted to prove resveratrol efficacy. : Herein, for first time, we summarize current knowledge of anti-cancerous activities of resveratrol in melanoma.

scholarly journals Sleep Disorders in Adults with Down Syndrome

2021 ◽  
Vol 10 (14) ◽  
pp. 3012
Author(s):  
Sandra Giménez ◽  
Miren Altuna ◽  
Esther Blessing ◽  
Ricardo M. Osorio ◽  
Juan Fortea
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Down Syndrome ◽  
Sleep Disorders ◽  
Negative Impact ◽  
Current Knowledge ◽  
Sleep Disruption ◽  
Physical And Mental Health ◽  
Future Directions

Sleep disorders, despite being very frequent in adults with Down syndrome (DS), are often overlooked due to a lack of awareness by families and physicians and the absence of specific clinical sleep guidelines. Untreated sleep disorders have a negative impact on physical and mental health, behavior, and cognitive performance. Growing evidence suggests that sleep disruption may also accelerate the progression to symptomatic Alzheimer’s disease (AD) in this population. It is therefore imperative to have a better understanding of the sleep disorders associated with DS in order to treat them, and in doing so, improve cognition and quality of life, and prevent related comorbidities. This paper reviews the current knowledge of the main sleep disorders in adults with DS, including evaluation and management. It highlights the existing gaps in knowledge and discusses future directions to achieve earlier diagnosis and better treatment of sleep disorders most frequently found in this population.

Coping with psychosomatic symptoms: The buffering role of psychological flexibility and impact on quality of life

2016 ◽  
Vol 24 (2) ◽  
pp. 175-187 ◽  
Author(s):  
Chrysanthi Leonidou ◽  
Georgia Panayiotou ◽  
Aspasia Bati ◽  
Maria Karekla
Keyword(s):  
Quality Of Life ◽  
Negative Impact ◽  
Community Sample ◽  
Psychological Flexibility ◽  
Avoidant Coping ◽  
Screening Criteria ◽  
Illness Anxiety ◽  
The Impact

Individual differences in avoidant coping were hypothesized to exacerbate quality of life impairment associated with somatization and illness anxiety symptoms; psychological flexibility was expected to moderate this impairment. Individuals from a random community sample ( N = 298; 182 females), who met screening criteria for somatization and illness anxiety, reported lower quality of life and psychological flexibility and greater avoidant coping compared to controls. Psychological flexibility significantly moderated the impact of somatization and illness anxiety on quality of life domains. Findings suggest that decreasing avoidant coping through therapy may be promising in mitigating the negative impact of these symptom categories.

scholarly journals RESULTS OF THE TERRITORIAL COMMUNITIES’ SURVEY ON THEIR IDENTIFICATION AND POSITIONING TO IMPROVE THE LIFE QUALITY OF POPULATION

2021 ◽  
pp. 47-58
Author(s):  
I.V. Zablodska ◽  
◽  
S.I. Hrechana ◽  
Keyword(s):  
Quality Of Life ◽  
Planning Process ◽  
Negative Impact ◽  
Life Quality ◽  
Living Environment ◽  
Reform Process ◽  
Administrative Services ◽  
The Future

The results of the territorial communities’ survey on their identification and positioning to improve the quality of life, which conducted among representatives of territorial communities of Luhansk and Donetsk regions located in the territories controlled by the Ukrainian government, were generalized. Its purpose was to determine the opinion of the respondents regarding the quality of life in the communi ties, their vision of the community uniqueness, as well as an idea of its image and positioning. Information collected on identifiers and signs of the communities’ attractiveness, the attitude of community residents to changes in the quality of life in the reform process, the desired directions for the future communities’ development, a vision of their positioning, the role of community branding and advertising. It was determined that the majority of the interviewed respondents positively assess the living environment of their communities, and not, however, associating changes for the better with decentralization. The subjective residents’ vision of their own community formed by the following main identifiers, such as the availability of administrative services, the condition of highways and sidewalks, infrastructure for recreation and leisure. The community attractiveness, according to the respondents, determined by the availability and level of administrative services, comfort of living and convenient transport location. The main obstacles for improving the quality of life, as well as the primary resources for its impro vement, are considered by the majority of respondents to be ineffective local authorities, as well as lack of initiative and activity of residents. More than 70% of respondents identified a negative impact on the development of the proximity of their community to the zone of armed conflict. The tendency of the respondents to focus more on problems than on the achievements of communities ascertained. In addition, trend of greater accentuation of respondents on the issues, as well as a certain indifference about the future of their community, in the process of determining the positioning of their own community and the vision of its image manifested most clearly in the number of uncertain options. It substantiates that the results obtained can be extrapolated to all communities in the region, and are the basis for optimizing the strategic planning process for the development of territorial communities, which will contribute to improving the life quality of population.

Social isolation in individuals aged 50+: what is the role of the internet? (Preprint)

2020 ◽  
Author(s):  
Patrícia Silva ◽  
Alice Delerue Matos ◽  
Roberto Martinez-Pecino
Keyword(s):  
Quality Of Life ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Social Isolation ◽  
Negative Impact ◽  
Health Determinants ◽  
The Internet ◽  
Internet Users

UNSTRUCTURED Social isolation has a negative impact on the quality of life of older people, which is why studies have focussed on identifying its sociodemographic, economic and health determinants. In view of the growing importance of the internet as a means of communication, it is important to examine the extent to which this technology also contributes to social isolation or, conversely, counters it. This study specifically aims to clarify this relationship for which other surveys present contradictory results. The current research uses a logistic regression analysis and a sample of 66,998 individuals aged 50+ from 17 European countries (Portugal, Greece, Italy, Spain, Denmark, Sweden, Austria, Belgium, France, Germany, Switzerland, Luxemburg, Poland, Czech Republic; Slovenia, Estonia, and Croatia) plus Israel, who were interviewed in SHARE (Survey of Health, Ageing and Retirement in Europe)- wave 6. The results show that countries differ in the level of social isolation and rate of internet use by individuals aged 50+. They also point to a lower social isolation of the internet users when compared to the non-users, in most of the countries analyzed, after controlling for a set of socio-demographic, economic and health characteristics of the individuals, described in the literature as determinants of social isolation. The results underline the importance of promoting e-inclusion in Europe as a way to deal with social isolation.

scholarly journals The Role of Curcumin in the Modulation of Ageing

2019 ◽  
Vol 20 (5) ◽  
pp. 1239 ◽  
Author(s):  
Anna Bielak-Zmijewska ◽  
Wioleta Grabowska ◽  
Agata Ciolko ◽  
Agnieszka Bojko ◽  
Grażyna Mosieniak ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Natural Products ◽  
Cellular Senescence ◽  
Current Knowledge ◽  
Model Organisms ◽  
Age Related ◽  
Daily Diet

It is believed that postponing ageing is more effective and less expensive than the treatment of particular age-related diseases. Compounds which could delay symptoms of ageing, especially natural products present in a daily diet, are intensively studied. One of them is curcumin. It causes the elongation of the lifespan of model organisms, alleviates ageing symptoms and postpones the progression of age-related diseases in which cellular senescence is directly involved. It has been demonstrated that the elimination of senescent cells significantly improves the quality of life of mice. There is a continuous search for compounds, named senolytic drugs, that selectively eliminate senescent cells from organisms. In this paper, we endeavor to review the current knowledge about the anti-ageing role of curcumin and discuss its senolytic potential.

scholarly journals Understanding the Role of Self-Judgment in the Association between Body Dissatisfaction and Quality of Life on Normal-Weight and Overweight Portuguese Women

2016 ◽  
Vol 19 ◽  
Author(s):  
Cláudia Ferreira ◽  
Patrícia Fortunato ◽  
Joana Marta-Simões ◽  
Inês A. Trindade
Keyword(s):  
Quality Of Life ◽  
Body Image ◽  
Body Dissatisfaction ◽  
Negative Impact ◽  
Body Image Dissatisfaction ◽  
Normal Weight ◽  
The Relationship ◽  
Psychological Quality Of Life

AbstractLiterature has demonstrated the negative impact of body image dissatisfaction on women’s quality of life. Nonetheless, it has been suggested that the relationship between body dissatisfaction and women’s well-being is not linear, and that the processes that mediate this association remain unclear. This study aims to clarify the mediator role of self-judgment in the association between negative body image and psychological quality of life, in two groups: normal-weight and overweight women. This cross-sectional study comprised 200 normal-weight and 92 overweight female college students, aged between 18 and 24 years old, that completed self-report instruments of body dissatisfaction, self-judgment, and quality of life. Results showed that women who presented harsher self-judgment about their perceived failures tended to present lower levels in all quality of life domains. Also, results from mediation analyses indicated the relationship between body dissatisfaction and psychological quality of life was significantly mediated by the mechanisms of self-judgment in the two BMI groups (95% CI [–2.41 to –0.04]; 95% CI [–6.35 to –.89]). This mediational model accounted for 28.3% and 40.7% of psychological quality of life in the normal-weight and overweight groups, respectively. These results suggest that a lower ability to deal with one’s failures or inadequacies (e.g., negative evaluation of body image) in a kind and accepting manner may significantly increase the negative impact of body dissatisfaction on one’s psychological quality of life. In this way, it seems that, the focus of interventions should go beyond body dissatisfaction and also target the development of adaptive attitudes (opposed to self-critical attitudes) to deal with negative body-related experiences.

scholarly journals A Hypothesis on the Possible Potential of Plantago Major in the Treatment of Urticaria

2014 ◽  
Vol 3 (2) ◽  
pp. 123-126
Author(s):  
Mohammad Ali Yazdian ◽  
Mahmood Khodadoost ◽  
Mehdi Gheisari ◽  
Mohammad Kamalinejad ◽  
Amir Hooshang Ehsani
Keyword(s):  
Quality Of Life ◽  
Effective Properties ◽  
Current Knowledge ◽  
Hypersensitivity Reactions ◽  
Plantago Major ◽  
Herbal Therapy ◽  
Direct Role ◽  
Quality Of Life Index

Background:Urticaria is a skin disease characterized by pruritic edematous lesions also called wheals. Although these lesions are self-limited they may result in lowered quality of life index. By far, the most recognized mechanisms that trigger the progression of this condition are hypersensitivity reactions. As an herbal therapy, Plantago major has been named in several references of Persian traditional medicine with effective properties in ameliorating urticarial symptoms. In this study we aimed to investigate whether Plantago major has the potential to be used clinically in treatment of urticaria according to the current knowledge about the plant effects.Materials and Methods:A combination of “Plantago major” and other terms related to urticarial therapy such as “mast cell”, “anti-inflammatory”, “prostaglandin”, “histamine” and “IgE” that may have possible role in progression or suppression of urticaria was searched in Google Scholar and PubMed as the reference databases.Results:Eleven articles discussing either the direct role of Plantago major or any of its constituents in urticarial related bimolecular pathways were selected.Conclusion:Review of the selected articles indicated that Plantago major can effectively suppress many of hypersensitivity reactions which are also contributors in the pathophysiology of urticaria development. Further clinical trials are needed to prove the efficacy of this herbal treatment.

465: Impact of Post-Prostatectomy Urethral Strictures on Urinary and Sexual Health Related Quality of Life

2006 ◽  
Vol 175 (4S) ◽  
pp. 150-151
Author(s):  
Jeffrey S. Montgomery ◽  
Bishoy A. Gayed ◽  
Brent K. Hollenbeck ◽  
Stephanie Daignault ◽  
Martin G. Sanda ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Sexual Health ◽  
Health Related Quality ◽  
Urethral Strictures ◽  
Related Quality ◽  
Health Related
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