scholarly journals Activated Protein C in Cutaneous Wound Healing: From Bench to Bedside

2019 ◽  
Vol 20 (4) ◽  
pp. 903 ◽  
Author(s):  
Ruilong Zhao ◽  
Haiyan Lin ◽  
Lara Bereza-Malcolm ◽  
Elizabeth Clarke ◽  
Christopher Jackson ◽  
...  
Keyword(s):  
Wound Healing ◽  
Clinical Studies ◽  
Protein C ◽  
Activated Protein C ◽  
Epithelial Barrier ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Beneficial Effects ◽  
The Past ◽  
Complex Process

Independent of its well-known anticoagulation effects, activated protein C (APC) exhibits pleiotropic cytoprotective properties. These include anti-inflammatory actions, anti-apoptosis, and endothelial and epithelial barrier stabilisation. Such beneficial effects have made APC an attractive target of research in a plethora of physiological and pathophysiological processes. Of note, the past decade or so has seen the emergence of its roles in cutaneous wound healing—a complex process involving inflammation, proliferation and remodelling. This review will highlight APC’s functions and mechanisms, and detail its pre-clinical and clinical studies on cutaneous wound healing.

Activated protein C prevents inflammation yet stimulates angiogenesis to promote cutaneous wound healing

2005 ◽  
Vol 13 (3) ◽  
pp. 284-294 ◽  
Author(s):  
Christopher J. Jackson ◽  
Meilang Xue ◽  
Patrick Thompson ◽  
Ross A. Davey ◽  
Kaley Whitmont ◽  
...  
Keyword(s):  
Wound Healing ◽  
Protein C ◽  
Activated Protein C ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound

scholarly journals Protease Activated Receptor-2 Mediates Activated Protein C–Induced Cutaneous Wound Healing via Inhibition of p38

2011 ◽  
Vol 179 (5) ◽  
pp. 2233-2242 ◽  
Author(s):  
Sohel M. Julovi ◽  
Meilang Xue ◽  
Suat Dervish ◽  
Philip N. Sambrook ◽  
Lyn March ◽  
...  
Keyword(s):  
Wound Healing ◽  
Protein C ◽  
Activated Protein C ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Protease Activated Receptor 2

scholarly journals Systematic Review of the Application of Perinatal Derivatives in Animal Models on Cutaneous Wound Healing

2021 ◽  
Vol 9 ◽  
Author(s):  
Melanie Pichlsberger ◽  
Urška Dragin Jerman ◽  
Hristina Obradović ◽  
Larisa Tratnjek ◽  
Ana Sofia Macedo ◽  
...  
Keyword(s):  
Wound Healing ◽  
Animal Models ◽  
Cutaneous Wound Healing ◽  
Isolated Cells ◽  
Cutaneous Wound ◽  
Beneficial Effects ◽  
Preclinical Animal Models ◽  
Large Animals ◽  
The Impact

Knowledge of the beneficial effects of perinatal derivatives (PnD) in wound healing goes back to the early 1900s when the human fetal amniotic membrane served as a biological dressing to treat burns and skin ulcerations. Since the twenty-first century, isolated cells from perinatal tissues and their secretomes have gained increasing scientific interest, as they can be obtained non-invasively, have anti-inflammatory, anti-cancer, and anti-fibrotic characteristics, and are immunologically tolerated in vivo. Many studies that apply PnD in pre-clinical cutaneous wound healing models show large variations in the choice of the animal species (e.g., large animals, rodents), the choice of diabetic or non-diabetic animals, the type of injury (full-thickness wounds, burns, radiation-induced wounds, skin flaps), the source and type of PnD (placenta, umbilical cord, fetal membranes, cells, secretomes, tissue extracts), the method of administration (topical application, intradermal/subcutaneous injection, intravenous or intraperitoneal injection, subcutaneous implantation), and the type of delivery systems (e.g., hydrogels, synthetic or natural biomaterials as carriers for transplanted cells, extracts or secretomes). This review provides a comprehensive and integrative overview of the application of PnD in wound healing to assess its efficacy in preclinical animal models. We highlight the advantages and limitations of the most commonly used animal models and evaluate the impact of the type of PnD, the route of administration, and the dose of cells/secretome application in correlation with the wound healing outcome. This review is a collaborative effort from the COST SPRINT Action (CA17116), which broadly aims at approaching consensus for different aspects of PnD research, such as providing inputs for future standards for the preclinical application of PnD in wound healing.

scholarly journals The Role of Calcium in Wound Healing

2021 ◽  
Vol 22 (12) ◽  
pp. 6486
Author(s):  
Thayaalini Subramaniam ◽  
Mh Busra Fauzi ◽  
Yogeswaran Lokanathan ◽  
Jia Xian Law
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Healing Process ◽  
Wound Healing Process ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Cutaneous Wounds ◽  
Venous Ulcers ◽  
Complex Process ◽  
New Ideas

Skin injury is quite common, and the wound healing is a complex process involving many types of cells, the extracellular matrix, and soluble mediators. Cell differentiation, migration, and proliferation are essential in restoring the integrity of the injured tissue. Despite the advances in science and technology, we have yet to find the ideal dressing that can support the healing of cutaneous wounds effectively, particularly for difficult-to-heal chronic wounds such as diabetic foot ulcers, bed sores, and venous ulcers. Hence, there is a need to identify and incorporate new ideas and methods to design a more effective dressing that not only can expedite wound healing but also can reduce scarring. Calcium has been identified to influence the wound healing process. This review explores the functions and roles of calcium in skin regeneration and reconstruction during would healing. Furthermore, this review also investigates the possibility of incorporating calcium into scaffolds and examines how it modulates cutaneous wound healing. In summary, the preliminary findings are promising. However, some challenges remain to be addressed before calcium can be used for cutaneous wound healing in clinical settings.

scholarly journals Improvement of Cutaneous Wound Healing via Topical Application of Heat-Killed Lactococcus chungangensis CAU 1447 on Diabetic Mice

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2666
Author(s):  
YoHan Nam ◽  
Jong-Hwa Kim ◽  
Jihye Baek ◽  
Wonyong Kim
Keyword(s):  
Wound Healing ◽  
Wound Repair ◽  
Therapeutic Agents ◽  
Skin Wound ◽  
Skin Microbiome ◽  
Cutaneous Wound Healing ◽  
Diabetic Mice ◽  
Cutaneous Wound ◽  
Beneficial Effects ◽  
Systemic Network

Cutaneous wound healing comprises a complex systemic network. Probiotics, naturally extracted substances, medicine, and chemical compounds have been used for wound healing, but the application of postbiotics as therapeutic agents has yet to be explored. Our study shows potential beneficial effects of heat-killed Lactococcus chungangensis CAU 1447 on type 1 diabetic mice. The postbiotic strain significantly decreased the skin wound size. The activity of myeloperoxidase secreted from neutrophils also decreased. The molecular mechanism of wound healing was adjusted by important mediators, growth factors, chemokines, and cytokines. These elements regulated the anti-inflammatory activity and accelerated wound healing. To determine the role of the postbiotic in wound repair, we showed a similar taxonomic pattern as compared to the diabetic mice using skin microbiome analysis. These findings demonstrated that heat-killed Lactococcus chungangensis CAU 1447 had beneficial effects on wound healing and can be utilized as postbiotic therapeutic agents.

scholarly journals Selective Estrogen Receptor Modulators Accelerate Cutaneous Wound Healing in Ovariectomized Female Mice

Endocrinology ◽  
2007 ◽  
Vol 149 (2) ◽  
pp. 551-557 ◽  
Author(s):  
Matthew J. Hardman ◽  
Elaine Emmerson ◽  
Laura Campbell ◽  
Gillian S. Ashcroft
Keyword(s):  
Wound Healing ◽  
Estrogen Receptor ◽  
Selective Estrogen Receptor Modulators ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Beneficial Effects ◽  
Estrogen Receptor Modulators ◽  
Ovariectomized Mice ◽  
Receptor Modulators

A lack of systemic hormones in elderly postmenopausal women leads to delayed cutaneous wound healing. This effect can be reversed by systemic or topical estrogen replacement in both humans and rodent models. Over recent years selective estrogen receptor modulators have been developed in an attempt to achieve the beneficial effects of estrogen clinically, while minimizing the detrimental side effects. The effects of selective estrogen receptor modulators on the skin are poorly understood, and the effects on wound healing have not been assessed. In this study we treated 10-wk-old ovariectomized mice with estradiol, tamoxifen (TAM), raloxifene (RAL), or vehicle and examined the effect on healing of full-thickness incisional wounds. Both TAM and RAL substantially accelerate healing, associated with a dampened inflammatory response and altered inflammatory cytokine profile. In vitro TAM and RAL demonstrate antiinflammatory activity comparable to estrogen. These results have significant implications for the clinical modulation of wound healing.

Engineered growth factors and cutaneous wound healing: Success and possible questions in the past 10 years

2005 ◽  
Vol 13 (2) ◽  
pp. 122-130 ◽  
Author(s):  
Xiaobing Fu ◽  
Xiaokun Li ◽  
Biao Cheng ◽  
Wei Chen ◽  
Zhiyong Sheng
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
The Past

Study on the Effect of Cerium Oxide Nanocubes on Full-Thickness Cutaneous Wound Healing of Type 2 Diabetic Rats

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 643-P ◽  
Author(s):  
YANFEI HAN ◽  
LINDONG LI ◽  
YANJUN LIU ◽  
YOU WANG ◽  
CHUNHUA YAN ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cerium Oxide ◽  
Diabetic Rats ◽  
Cutaneous Wound Healing ◽  
Full Thickness ◽  
Cutaneous Wound ◽  
Type 2 Diabetic
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