scholarly journals Protease Activated Receptor-2 Mediates Activated Protein C–Induced Cutaneous Wound Healing via Inhibition of p38

2011 ◽  
Vol 179 (5) ◽  
pp. 2233-2242 ◽  
Author(s):  
Sohel M. Julovi ◽  
Meilang Xue ◽  
Suat Dervish ◽  
Philip N. Sambrook ◽  
Lyn March ◽  
...  
Keyword(s):  
Wound Healing ◽  
Protein C ◽  
Activated Protein C ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Protease Activated Receptor 2

scholarly journals Activated Protein C in Cutaneous Wound Healing: From Bench to Bedside

2019 ◽  
Vol 20 (4) ◽  
pp. 903 ◽  
Author(s):  
Ruilong Zhao ◽  
Haiyan Lin ◽  
Lara Bereza-Malcolm ◽  
Elizabeth Clarke ◽  
Christopher Jackson ◽  
...  
Keyword(s):  
Wound Healing ◽  
Clinical Studies ◽  
Protein C ◽  
Activated Protein C ◽  
Epithelial Barrier ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Beneficial Effects ◽  
The Past ◽  
Complex Process

Independent of its well-known anticoagulation effects, activated protein C (APC) exhibits pleiotropic cytoprotective properties. These include anti-inflammatory actions, anti-apoptosis, and endothelial and epithelial barrier stabilisation. Such beneficial effects have made APC an attractive target of research in a plethora of physiological and pathophysiological processes. Of note, the past decade or so has seen the emergence of its roles in cutaneous wound healing—a complex process involving inflammation, proliferation and remodelling. This review will highlight APC’s functions and mechanisms, and detail its pre-clinical and clinical studies on cutaneous wound healing.

Activated protein C prevents inflammation yet stimulates angiogenesis to promote cutaneous wound healing

2005 ◽  
Vol 13 (3) ◽  
pp. 284-294 ◽  
Author(s):  
Christopher J. Jackson ◽  
Meilang Xue ◽  
Patrick Thompson ◽  
Ross A. Davey ◽  
Kaley Whitmont ◽  
...  
Keyword(s):  
Wound Healing ◽  
Protein C ◽  
Activated Protein C ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound

Study on the Effect of Cerium Oxide Nanocubes on Full-Thickness Cutaneous Wound Healing of Type 2 Diabetic Rats

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 643-P ◽  
Author(s):  
YANFEI HAN ◽  
LINDONG LI ◽  
YANJUN LIU ◽  
YOU WANG ◽  
CHUNHUA YAN ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cerium Oxide ◽  
Diabetic Rats ◽  
Cutaneous Wound Healing ◽  
Full Thickness ◽  
Cutaneous Wound ◽  
Type 2 Diabetic

scholarly journals Optical coherence tomography angiography monitors human cutaneous wound healing over time

2018 ◽  
Vol 8 (2) ◽  
pp. 135-150 ◽  
Author(s):  
Anthony J. Deegan ◽  
Wendy Wang ◽  
Shaojie Men ◽  
Yuandong Li ◽  
Shaozhen Song ◽  
...  
Keyword(s):  
Wound Healing ◽  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Optical Coherence ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Over Time

Sulfated glycosaminoglycans in decellularized placenta matrix as critical regulators for cutaneous wound healing

2021 ◽  
Vol 122 ◽  
pp. 199-210
Author(s):  
Chen Wang ◽  
Guoyun Li ◽  
Kaige Cui ◽  
Zihan Chai ◽  
Ziyu Huang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound

In vitro and in vivo Effect of Platelet-Rich Plasma-Based Autologous Topical Serum on Cutaneous Wound Healing

2021 ◽  
pp. 1-13
Author(s):  
Eduardo Anitua ◽  
Victoria Muñoz ◽  
Libe Aspe ◽  
Roberto Tierno ◽  
Adrian García-Salvador ◽  
...  
Keyword(s):  
Wound Healing ◽  
Tissue Damage ◽  
Collagen Synthesis ◽  
Dermal Fibroblast ◽  
Platelet Rich Plasma ◽  
Cell Activity ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Fibroblast Migration ◽  
Edge Contraction

<b><i>Introduction:</i></b> Skin injury and wound healing is an inevitable event during lifetime. However, several complications may hamper the regeneration of the cutaneous tissue and lead to a chronic profile that prolongs patient recovery. Platelet-rich plasma is rising as an effective and safe alternative to the management of wounds. However, this technology presents some limitations such as the need for repeated blood extractions and health-care interventions. <b><i>Objective:</i></b> The aim of this study was to assess the use of an endogenous and storable topical serum (ES) derived from plasma rich in growth factors promoting wound healing, and to obtain preliminary data regarding its clinical and experimental effect over ulcerated skin models and patient care. <b><i>Methods:</i></b> Human dermal fibroblast and 3D organotypic ulcerated skin models were used to assess ES over the main mechanisms of wound healing including cell migration, edge contraction, collagen synthesis, tissue damage, extracellular matrix remodeling, cell death, metabolic activity, and histomorphometry analysis. Additionally, 4 patients suffering from skin wounds were treated and clinically assessed. <b><i>Results:</i></b> ES promoted dermal fibroblast migration, wound edge contraction, and collagen synthesis. When topically applied, ES increased collagen and elastin deposition and reduced tissue damage. The interstitial edema, structural integrity, and cell activity were also maintained, and apoptotic levels were reduced. Patients suffering from hard-to-heal wounds of different etiologies were treated with ES, and the ulcers healed completely within few weeks with no reported adverse events. <b><i>Conclusion:</i></b> This preliminary study suggests that ES might promote cutaneous wound healing and may be useful for accelerating the re-epithelization of skin ulcers.

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