scholarly journals Alteration of Epigenetic Regulation by Long Noncoding RNAs in Cancer

2018 ◽  
Vol 19 (2) ◽  
pp. 570 ◽  
Author(s):  
Mariangela Morlando ◽  
Alessandro Fatica
Keyword(s):  
Epigenetic Regulation ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas

scholarly journals Epigenetic Regulation in Hepatocellular Carcinoma Requires Long Noncoding RNAs

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Laura Amicone ◽  
Franca Citarella ◽  
Carla Cicchini
Keyword(s):  
Hepatocellular Carcinoma ◽  
Epigenetic Regulation ◽  
Tumor Suppressors ◽  
Biological Significance ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Therapeutic Approaches ◽  
Adult Liver ◽  
Liver Malignancy ◽  
Epigenetic Modifiers

Recent evidence has proven the relevance of epigenetic changes in the development of hepatocellular carcinoma (HCC), the major adult liver malignancy. Moreover, HCC onset and progression correlate with the deregulation of several long noncoding RNAs (lncRNAs), exhibiting great biological significance. As discussed in this review, many of these transcripts are able to specifically act as tumor suppressors or oncogenes by means of their role as molecular platforms. Indeed, these lncRNAs are able to bind and recruit epigenetic modifiers on specific genomic loci, ultimately resulting in regulation of the gene expression relevant in cancer development. The evidence presented in this review highlights that lncRNAs-mediated epigenetic regulation should be taken into account for potential targeted therapeutic approaches.

Epigenetic Regulation by Long Noncoding RNAs

Science ◽  
2012 ◽  
Vol 338 (6113) ◽  
pp. 1435-1439 ◽  
Author(s):  
J. T. Lee
Keyword(s):  
Epigenetic Regulation ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas

scholarly journals Elucidating Epigenetic Regulation by Identifying Functional cis ‐Acting Long Noncoding RNAs and Their Targets in Osteoarthritic Articular Cartilage

2020 ◽  
Vol 72 (11) ◽  
pp. 1845-1854
Author(s):  
Marcella Hoolwerff ◽  
Paula I. Metselaar ◽  
Margo Tuerlings ◽  
H. Eka D. Suchiman ◽  
Nico Lakenberg ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Epigenetic Regulation ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Cis Acting

scholarly journals Epigenetic regulation by long noncoding RNAs in plants

2013 ◽  
Vol 21 (6-7) ◽  
pp. 685-693 ◽  
Author(s):  
Jae Bok Heo ◽  
Yong-Suk Lee ◽  
Sibum Sung
Keyword(s):  
Epigenetic Regulation ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas

Dysregulated Expression of Long Noncoding RNAs in Endometriosis

2019 ◽  
Vol 29 (2) ◽  
pp. 113-121 ◽  
Author(s):  
Xue-ying Zhang ◽  
Lian-wen Zheng ◽  
Chun-jin Li ◽  
Ying Xu ◽  
Xu Zhou ◽  
...  
Keyword(s):  
Noncoding Rnas ◽  
Long Noncoding Rnas
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