scholarly journals Epigenetic Regulation in Hepatocellular Carcinoma Requires Long Noncoding RNAs

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Laura Amicone ◽  
Franca Citarella ◽  
Carla Cicchini
Keyword(s):  
Hepatocellular Carcinoma ◽  
Epigenetic Regulation ◽  
Tumor Suppressors ◽  
Biological Significance ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Therapeutic Approaches ◽  
Adult Liver ◽  
Liver Malignancy ◽  
Epigenetic Modifiers

Recent evidence has proven the relevance of epigenetic changes in the development of hepatocellular carcinoma (HCC), the major adult liver malignancy. Moreover, HCC onset and progression correlate with the deregulation of several long noncoding RNAs (lncRNAs), exhibiting great biological significance. As discussed in this review, many of these transcripts are able to specifically act as tumor suppressors or oncogenes by means of their role as molecular platforms. Indeed, these lncRNAs are able to bind and recruit epigenetic modifiers on specific genomic loci, ultimately resulting in regulation of the gene expression relevant in cancer development. The evidence presented in this review highlights that lncRNAs-mediated epigenetic regulation should be taken into account for potential targeted therapeutic approaches.

scholarly journals Functional Roles and Therapeutic Applications of Exosomes in Hepatocellular Carcinoma

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Laura Santangelo ◽  
Cecilia Battistelli ◽  
Claudia Montaldo ◽  
Franca Citarella ◽  
Raffaele Strippoli ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Noncoding Rnas ◽  
Circulating Dna ◽  
Therapeutic Approaches ◽  
Adult Liver ◽  
Liver Malignancy ◽  
Rna Molecules ◽  
Functional Roles ◽  
Tumor Growth And Metastasis

Exosomes are important in intercellular communication. They assure the horizontal transfer of specific functional contents (i.e., proteins, lipids, RNA molecules, and circulating DNA) from donor to recipient cells. Notably, tumor-derived exosomes (TDEs) appear to be an important vehicle of specific signals in cancer, impacting on tumor growth and metastasis. Recent researches point to the characterization of exosomes in Hepatocellular Carcinoma (HCC), the major adult liver malignancy. In this review, we summarize current findings on HCC exosomes, focusing on the identification of noncoding RNAs as exosome-enriched functional regulators and new potential biomarkers. The great potential of exosomes in future HCC diagnostic and therapeutic approaches is underlined.

Long Noncoding RNAs and Human Liver Disease

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Johanna K. DiStefano ◽  
Glenn S. Gerhard
Keyword(s):  
Liver Disease ◽  
Biological Significance ◽  
Noncoding Rnas ◽  
Classification Systems ◽  
Long Noncoding Rnas ◽  
Annual Review ◽  
Publication Date ◽  
Cholestatic Liver Disease ◽  
Diverse Range ◽  
Number Of Publications

Long noncoding RNAs (lncRNAs) are pervasively transcribed in the genome, exhibit a diverse range of biological functions, and exert effects through a variety of mechanisms. The sheer number of lncRNAs in the human genome has raised important questions about their potential biological significance and roles in human health and disease. Technological and computational advances have enabled functional annotation of a large number of lncRNAs. Though the number of publications related to lncRNAs has escalated in recent years, relatively few have focused on those involved in hepatic physiology and pathology. We provide an overview of evolving lncRNA classification systems and characteristics and highlight important advances in our understanding of the contribution of lncRNAs to liver disease, with a focus on nonalcoholic steatohepatitis, hepatocellular carcinoma, and cholestatic liver disease. Expected final online publication date for the Annual Review of Pathology: Mechanisms of Disease, Volume 17 is January 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Four long noncoding RNAs as potential prognostic biomarkers for hepatocellular carcinoma

2018 ◽  
Vol 234 (6) ◽  
pp. 8709-8716 ◽  
Author(s):  
Jianchu Wang ◽  
Jian Pu ◽  
Tianwei Yao ◽  
Xiaojie Lu ◽  
Yibin Deng
Keyword(s):  
Hepatocellular Carcinoma ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Prognostic Biomarkers

scholarly journals The emerging role of microRNAs and long noncoding RNAs in drug resistance of hepatocellular carcinoma

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Ling Wei ◽  
Xingwu Wang ◽  
Liyan Lv ◽  
Jibing Liu ◽  
Huaixin Xing ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Resistance ◽  
Human Cancer ◽  
Noncoding Rnas ◽  
Circular Rna ◽  
Long Noncoding Rnas ◽  
Protein Coding ◽  
Multiple Tumor ◽  
Nucleolar Rnas

Abstract Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide and the second most lethal human cancer. A portion of patients with advanced HCC can significantly benefit from treatments with sorafenib, adriamycin, 5-fluorouracil and platinum drugs. However, most HCC patients eventually develop drug resistance, resulting in a poor prognosis. The mechanisms involved in HCC drug resistance are complex and inconclusive. Human transcripts without protein-coding potential are known as noncoding RNAs (ncRNAs), including microRNAs (miRNAs), small nucleolar RNAs (snoRNAs), long noncoding RNAs (lncRNAs) and circular RNA (circRNA). Accumulated evidences demonstrate that several deregulated miRNAs and lncRNAs are important regulators in the development of HCC drug resistance which elucidates their potential clinical implications. In this review, we summarized the detailed mechanisms by which miRNAs and lncRNAs affect HCC drug resistance. Multiple tumor-specific miRNAs and lncRNAs may serve as novel therapeutic targets and prognostic biomarkers for HCC.

scholarly journals Current Research Progress on Long Noncoding RNAs Associated with Hepatocellular Carcinoma

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Haihong Shi ◽  
Yuxin Xu ◽  
Xin Yi ◽  
Dandan Fang ◽  
Xia Hou
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
Liver Cancer ◽  
Biological Activities ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Research Progress ◽  
Invasion And Metastasis ◽  
Complex Processes ◽  
And Function

Hepatocellular carcinoma (HCC) is the second leading cause of mortality among cancers. It has been found that long noncoding RNAs (lncRNAs) are involved in many human cancers, including liver cancer. It has been identified that carcinogenic and tumor-suppressing lncRNAs are associated with complex processes in liver cancer. These lncRNAs may participate in a variety of pathological and biological activities, such as cell proliferation, apoptosis, invasion, and metastasis. Here, we review the regulation and function of lncRNA in liver cancer and evaluate the potential of lncRNA as a new goal for liver cancer.

Sign in / Sign up

Export Citation Format

Share Document