scholarly journals Elucidating Epigenetic Regulation by Identifying Functional cis ‐Acting Long Noncoding RNAs and Their Targets in Osteoarthritic Articular Cartilage

2020 ◽  
Vol 72 (11) ◽  
pp. 1845-1854
Author(s):  
Marcella Hoolwerff ◽  
Paula I. Metselaar ◽  
Margo Tuerlings ◽  
H. Eka D. Suchiman ◽  
Nico Lakenberg ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Epigenetic Regulation ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Cis Acting

scholarly journals Epigenetic Regulation in Hepatocellular Carcinoma Requires Long Noncoding RNAs

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Laura Amicone ◽  
Franca Citarella ◽  
Carla Cicchini
Keyword(s):  
Hepatocellular Carcinoma ◽  
Epigenetic Regulation ◽  
Tumor Suppressors ◽  
Biological Significance ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Therapeutic Approaches ◽  
Adult Liver ◽  
Liver Malignancy ◽  
Epigenetic Modifiers

Recent evidence has proven the relevance of epigenetic changes in the development of hepatocellular carcinoma (HCC), the major adult liver malignancy. Moreover, HCC onset and progression correlate with the deregulation of several long noncoding RNAs (lncRNAs), exhibiting great biological significance. As discussed in this review, many of these transcripts are able to specifically act as tumor suppressors or oncogenes by means of their role as molecular platforms. Indeed, these lncRNAs are able to bind and recruit epigenetic modifiers on specific genomic loci, ultimately resulting in regulation of the gene expression relevant in cancer development. The evidence presented in this review highlights that lncRNAs-mediated epigenetic regulation should be taken into account for potential targeted therapeutic approaches.

Epigenetic Regulation by Long Noncoding RNAs

Science ◽  
2012 ◽  
Vol 338 (6113) ◽  
pp. 1435-1439 ◽  
Author(s):  
J. T. Lee
Keyword(s):  
Epigenetic Regulation ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas

scholarly journals Genome-Wide Identification of Barley Long Noncoding RNAs and Analysis of Their Regulatory Interactions during Shoot and Grain Development

2021 ◽  
Vol 22 (10) ◽  
pp. 5087
Author(s):  
Sebastian Gasparis ◽  
Mateusz Przyborowski ◽  
Anna Nadolska-Orczyk
Keyword(s):  
Target Genes ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Shoot Apices ◽  
Protein Coding ◽  
Cis Acting ◽  
Rna Molecules ◽  
Functional Studies ◽  
Potential Target ◽  
Genome Wide

Long noncoding RNAs (lncRNAs) are a class of RNA molecules with gene regulatory functions in plant development and the stress response. Although the number of lncRNAs identified in plants is rapidly increasing, very little is known about their role in barley development. In this study, we performed global identification of barley lncRNAs based on 53 RNAseq libraries derived from nine different barley tissues and organs. In total, 17,250 lncRNAs derived from 10,883 loci were identified, including 8954 novel lncRNAs. Differential expression of lncRNAs was observed in the developing shoot apices and grains, the two organs that have a direct influence on the final yield. The regulatory interaction of differentially expressed lncRNAs with the potential target genes was evaluated. We identified 176 cis-acting lncRNAs in shoot apices and 424 in grains, while the number of trans-acting lncRNAs in these organs was 1736 and 540, respectively. The potential target protein-coding genes were identified, and their biological function was annotated using MapMan ontology. This is the first insight into the roles of lncRNAs in barley development on the genome-wide scale, and our results provide a solid background for future functional studies.

scholarly journals Epigenetic regulation by long noncoding RNAs in plants

2013 ◽  
Vol 21 (6-7) ◽  
pp. 685-693 ◽  
Author(s):  
Jae Bok Heo ◽  
Yong-Suk Lee ◽  
Sibum Sung
Keyword(s):  
Epigenetic Regulation ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas

Dysregulated Expression of Long Noncoding RNAs in Endometriosis

2019 ◽  
Vol 29 (2) ◽  
pp. 113-121 ◽  
Author(s):  
Xue-ying Zhang ◽  
Lian-wen Zheng ◽  
Chun-jin Li ◽  
Ying Xu ◽  
Xu Zhou ◽  
...  
Keyword(s):  
Noncoding Rnas ◽  
Long Noncoding Rnas
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