scholarly journals Apolipoprotein A1-Unique Peptide as a Diagnostic Biomarker for Acute Ischemic Stroke

2016 ◽  
Vol 17 (4) ◽  
pp. 458 ◽  
Author(s):  
Xu Zhao ◽  
Yue Yu ◽  
Wenlong Xu ◽  
Lei Dong ◽  
Yuan Wang ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Apolipoprotein A1 ◽  
Diagnostic Biomarker ◽  
Unique Peptide

scholarly journals Brain Natriuretic Peptide is a Predictor of Cardiac Thrombus in Critically Ill Acute Ischemic Stroke Patients

2020 ◽  
Vol 8 (B) ◽  
pp. 119-124
Author(s):  
Hossam A. Mowafy ◽  
Hossam El Sherif ◽  
Khaled A. Wahab ◽  
Nora I. Abbas ◽  
Gihan El Hilaly ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Brain Natriuretic Peptide ◽  
Acute Ischemic Stroke ◽  
Natriuretic Peptide ◽  
Significant Positive Correlation ◽  
Inverse Correlation ◽  
International Normalized Ratio ◽  
Diagnostic Biomarker ◽  
Positive Correlation ◽  
Cardiac Thrombus

CONTEXT: Plasma brain natriuretic peptide (BNP) levels are elevated in patients with acute ischemic stroke, particularly when accompanied by atrial fibrillation (AF). Plasma BNP might be a useful marker of vulnerability to thromboembolism in non-valvular AF patients. AIM: The aim of the present study was to assess whether the BNP level can serve as a biomarker of the left atrial (LA) thrombus in AF patients with acute ischemic stroke. SETTINGS AND DESIGN: This was a multicenter prospective cohort study. PATIENTS AND METHODS: Thirty AF patients with acute ischemic stroke were included in the study. Their transesophageal echocardiography (TEE) and BNP were assessed. RESULTS: There was a positive significant relation between serum BNP levels and LA thrombus detection by TEE. BNP with a cutoff value >498 pg/l can be used as a diagnostic biomarker for the presence of the LA thrombus. A significant positive correlation existed between serum BNP and LA diameter. Furthermore, a statistically significant positive correlation between serum BNP and AF rate and duration was found in all patients. In addition, a statistically significant inverse correlation was detected between serum BNP and direct bilirubin, international normalized ratio, and albumin. A statistically significant positive correlation existed between serum BNP and prothrombin concentration. CONCLUSION: BNP can be a good diagnostic biomarker for the detection of the LA thrombus in chronic AF patients with acute ischemic stroke.

scholarly journals Serum Sphingosine 1-Phosphate (S1P): A Novel Diagnostic Biomarker in Early Acute Ischemic Stroke

2020 ◽  
Vol 11 ◽  
Author(s):  
Jia Liu ◽  
Kazuo Sugimoto ◽  
Yuanbo Cao ◽  
Masahiro Mori ◽  
Li Guo ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Diagnostic Biomarker ◽  
Sphingosine 1 Phosphate

scholarly journals Lipopolysaccharide (LPS) induces increased epidermal green autofluorescence of mouse

2018 ◽  
Author(s):  
Yujia Li ◽  
Mingchao Zhang ◽  
Yue Tao ◽  
Weihai Ying
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Linear Relationship ◽  
Systemic Inflammation ◽  
Rapid Detection ◽  
Diagnostic Biomarker ◽  
Characteristic Structure ◽  
Non Invasive ◽  
Stratum Spinosum ◽  
Keratin 1

AbstractOur recent studies have suggested that characteristic ‘Pattern of Autofluorescence (AF)’ of each disease could be a novel biomarker for non-invasive diagnosis of multiple major diseases such as acute ischemic stroke. It is necessary to determine if increased epidermal green AF may be produced by major pathological factors such as inflammation. In our current study, we used C57BL/6Slac mice exposed to LPS to test our hypothesis that inflammation may induce increased epidermal green AF: LPS rapidly induced significant increases in the epidermal green AF of the mice’s ears at 1 hr after LPS injection. LPS also dose-dependently increased the epidermal green AF. The AF intensity had a linear relationship with the LPS dosages at both 3 and 7 days after the LPS administration. The AF images exhibited the characteristic structure of the keratinocytes in Stratum Spinosum, suggesting that the origin of the increased AF was keratin 1 and/or keratin 10. Collectively, our current study has provided the first evidence indicating that inflammation can rapidly and dose-dependently induce increased epidermal green AF, suggesting that the green AF may be the first biomarker for non-invasive and rapid detection of systemic inflammation. Since inflammation is a key pathological factor of numerous diseases, our finding has highlighted the value of the epidermal AF as a novel diagnostic biomarker for numerous diseases.

scholarly journals Selectively increased autofluorescence at fingernails and certain regions of skin: A potential novel diagnostic biomarker for Parkinson’s disease

2018 ◽  
Author(s):  
Danhong Wu ◽  
Yue Tao ◽  
Mingchao Zhang ◽  
Yujia Li ◽  
Liwei Shen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Clinical Symptoms ◽  
Risk Group ◽  
Distinct Pattern ◽  
Low Risk ◽  
Diagnostic Biomarker

AbstractDiagnosis of Parkinson’s disease (PD) mainly relies on the judgment of experienced neurologists on the clinical symptoms of patients. Quantitative and specific biomarker tests for PD is greatly needed. In this study we tested our hypothesis that increased autofluorescence (AF) of skin and fingernails may become a novel diagnostic biomarker for PD. Our study has indicated that PD patients have a distinct pattern of AF changes, compared with that of acute ischemic stroke (AIS) patients: First, the AF intensity of PD patients in the fingernails and a part of the examined regions of skin is significantly higher than that of the healthy and Low-Risk group, while the AF intensity of AIS patients is significantly higher than that of the healthy and Low-Risk group in most regions examined; second, there is AF asymmetry at the index fingernails and two regions of the skin of PD patients, while there is AF asymmetry at all examined regions of AIS patients; and third, both the AF intensity and AF asymmetry at Centremetacarpus of PD patients is significantly lower than those of AIS patients. The increased AF may result from the altered keratins’ AF induced by the oxidative stress in the plasma of PD patients. Collectively, our study has indicated that PD patients have a distinct pattern of AF changes compared with those of healthy and Low-Risk persons as well as AIS patients, which may become a novel diagnostic biomarker for PD.

scholarly journals Distinct ‘pattern of autofluorescence’ of acute ischemic stroke patients’ skin and fingernails: A novel diagnostic biomarker for acute ischemic stroke

2018 ◽  
Author(s):  
Danhong Wu ◽  
Mingchao Zhang ◽  
Yue Tao ◽  
Yujia Li ◽  
Shufan Zhang ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Risk Group ◽  
Stable Coronary Artery Disease ◽  
Recovery Phase ◽  
High Risk Group ◽  
Distinct Pattern ◽  
Diagnostic Biomarker ◽  
Stroke Patients ◽  
Artery Disease

AbstractEarly diagnosis of stroke is critical for therapeutic efficacy. Our study was designed to test our hypothesis that altered ‘Pattern of Autofluorescence (AF)’ may be a novel diagnostic biomarker for acute ischemic stroke (AIS). The major findings of our study include: First, the green AF intensity of the AIS Group in their fingernails and most regions of their skin examined is significantly higher than that of the Healthy group, the Low-Risk Group, the High-Risk Group, and the Groups of Ischemic Stroke Patients during Recovery Phase. Second, the AF increases of the AIS patients are asymmetrical: The AF intensity of their left hands is significantly different from that of their right hands. Third, ROC analyses show that both the sensitivity and the specificity of the AF-based diagnostic approach for AIS are greater than 0.86, when AF intensity is used as the sole factor for the analyses. Fourth, the number of the regions with increased AF intensity is highly positively correlated with the probability that the person examined is a AIS patient. Moreover, there are distinct differences among the ‘Pattern of AF’ of the patients of AIS, lung cancer as well as myocardial ischemia, stable coronary artery disease and Parkinson’s disease. Our study has further suggested that the AF increases in the skin and the fingernails of AIS patients may result from oxidative stress-induced alterations of keratins. Collectively, our study has indicated that the characteristic ‘Pattern of AF’ of AIS patients could become a novel diagnostic biomarker for the disease.

scholarly journals Serum Level of Transferrin Unique Peptide Is Decreased in Patients With Acute Ischemic Stroke

2021 ◽  
Vol 12 ◽  
Author(s):  
Xizheng Hu ◽  
Yinghui Li ◽  
Peng Cheng ◽  
Anhua Wu ◽  
Guangyu Li
Keyword(s):  
Ischemic Stroke ◽  
Brain Tumor ◽  
Acute Ischemic Stroke ◽  
Glial Cell ◽  
Cell Damage ◽  
Interquartile Range ◽  
Serum Biomarker ◽  
Unique Peptide ◽  
Stroke Mimics ◽  
Stroke Group

Objectives: Free irons are transported into brain tissues by transferrin and play an important role in neuronal/glial cell damage. Lower serum levels of transferrin have been found in patients with ischemic stroke, compared with healthy subjects. In present study, we investigated whether transferrin unique peptide (TF-UP) could be employed as a serum biomarker for brain tissue damage in acute ischemic stroke.Methods: The venous blood samples of 94 ischemic stroke patients and 35 brain tumor-stroke mimics (BT-SM) patients were collected within the first 72 h (Median time 23.25, Interquartile range 60.75) of acute onset in the emergency room. Total TF-UP and total albumin unique peptide (Alb-UP) were identified with liquid chromatography/mass spectrometry (LC–MS/MS) and quantified by multiple reaction monitoring (MRM) method using labeled reference peptide (LRP) for further analysis.Results: Median ratio of total TF-UP/LRP was 0.85 (Interquartile range, 0.21) in the brain tumor-stroke mimics (BT-SM) group, and 0.45 (0.14) in the ischemic stroke group; median Alb-UP/LRP ratio was 0.66 (0.16) in the BT-SM group, and 0.55 (0.20) in the ischemic stroke group. The overall trend from low to high levels was statistically significant for TF-UP/LRP (P < 0.0001), but not for Alb-UP/LRP (P = 0.1667). According to the receiver operating characteristic (ROC) curve, the area under the curve (AUC) was 0.9565 and the optimal cutoff value of serum TF-UP was 0.6317, which yielded a sensitivity of 91.49% and a specificity of 88.57%. The odds ratio (95% confidence intervals) of serum TF-UP/LRP was 83.31 (23.43, 296.22, P < 0.0001).Conclusions: Serum TF-UP/LRP level is decreased in patients with acute ischemic stroke in comparison with brain tumor, and it may serve as a serum biomarker for the neuronal/glial cell damage in cerebral infarction.

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