scholarly journals Distinct ‘pattern of autofluorescence’ of acute ischemic stroke patients’ skin and fingernails: A novel diagnostic biomarker for acute ischemic stroke

2018 ◽  
Author(s):  
Danhong Wu ◽  
Mingchao Zhang ◽  
Yue Tao ◽  
Yujia Li ◽  
Shufan Zhang ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Risk Group ◽  
Stable Coronary Artery Disease ◽  
Recovery Phase ◽  
High Risk Group ◽  
Distinct Pattern ◽  
Diagnostic Biomarker ◽  
Stroke Patients ◽  
Artery Disease

AbstractEarly diagnosis of stroke is critical for therapeutic efficacy. Our study was designed to test our hypothesis that altered ‘Pattern of Autofluorescence (AF)’ may be a novel diagnostic biomarker for acute ischemic stroke (AIS). The major findings of our study include: First, the green AF intensity of the AIS Group in their fingernails and most regions of their skin examined is significantly higher than that of the Healthy group, the Low-Risk Group, the High-Risk Group, and the Groups of Ischemic Stroke Patients during Recovery Phase. Second, the AF increases of the AIS patients are asymmetrical: The AF intensity of their left hands is significantly different from that of their right hands. Third, ROC analyses show that both the sensitivity and the specificity of the AF-based diagnostic approach for AIS are greater than 0.86, when AF intensity is used as the sole factor for the analyses. Fourth, the number of the regions with increased AF intensity is highly positively correlated with the probability that the person examined is a AIS patient. Moreover, there are distinct differences among the ‘Pattern of AF’ of the patients of AIS, lung cancer as well as myocardial ischemia, stable coronary artery disease and Parkinson’s disease. Our study has further suggested that the AF increases in the skin and the fingernails of AIS patients may result from oxidative stress-induced alterations of keratins. Collectively, our study has indicated that the characteristic ‘Pattern of AF’ of AIS patients could become a novel diagnostic biomarker for the disease.

scholarly journals Selectively increased autofluorescence at fingernails and certain regions of skin: A potential novel diagnostic biomarker for Parkinson’s disease

2018 ◽  
Author(s):  
Danhong Wu ◽  
Yue Tao ◽  
Mingchao Zhang ◽  
Yujia Li ◽  
Liwei Shen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Clinical Symptoms ◽  
Risk Group ◽  
Distinct Pattern ◽  
Low Risk ◽  
Diagnostic Biomarker

AbstractDiagnosis of Parkinson’s disease (PD) mainly relies on the judgment of experienced neurologists on the clinical symptoms of patients. Quantitative and specific biomarker tests for PD is greatly needed. In this study we tested our hypothesis that increased autofluorescence (AF) of skin and fingernails may become a novel diagnostic biomarker for PD. Our study has indicated that PD patients have a distinct pattern of AF changes, compared with that of acute ischemic stroke (AIS) patients: First, the AF intensity of PD patients in the fingernails and a part of the examined regions of skin is significantly higher than that of the healthy and Low-Risk group, while the AF intensity of AIS patients is significantly higher than that of the healthy and Low-Risk group in most regions examined; second, there is AF asymmetry at the index fingernails and two regions of the skin of PD patients, while there is AF asymmetry at all examined regions of AIS patients; and third, both the AF intensity and AF asymmetry at Centremetacarpus of PD patients is significantly lower than those of AIS patients. The increased AF may result from the altered keratins’ AF induced by the oxidative stress in the plasma of PD patients. Collectively, our study has indicated that PD patients have a distinct pattern of AF changes compared with those of healthy and Low-Risk persons as well as AIS patients, which may become a novel diagnostic biomarker for PD.

scholarly journals Cardiac Magnetic Resonance Imaging in Patients with Acute Ischemic Stroke and Elevated Troponin: A TRoponin ELevation in Acute Ischemic Stroke (TRELAS) Sub-Study

2019 ◽  
Vol 9 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Karl Georg Haeusler ◽  
Christoph Jensen ◽  
Jan F. Scheitz ◽  
Thomas Krause ◽  
Christian Wollboldt ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Ischemic Stroke ◽  
Coronary Artery ◽  
Coronary Angiography ◽  
Acute Ischemic Stroke ◽  
Elevated Troponin ◽  
Resonance Imaging ◽  
Stroke Patients ◽  
Troponin Elevation ◽  
Artery Disease

Background: Elevated high-sensitive cardiac troponin (hs-cTn) can be found in more than 50% of the patients with acute ischemic stroke. The observational TRoponin ELevation in Acute ischemic Stroke (TRELAS) study revealed that about 25% of all stroke patients with elevated troponin had a coronary angiography-detected culprit lesion affording immediate intervention, and about 50% of all patients did not have any obstructive coronary artery disease. Given the risk of procedure-related complications, the identification of stroke patients in urgent need of invasive coronary angiography is desirable. Methods: TRELAS patients were prospectively enrolled into this sub-study. In addition to conventional coronary angiography, a cardiac magnetic resonance imaging (MRI) at 3T was performed during the in-hospital stay after acute ischemic stroke to compare the diagnostic value of both imaging modalities. Results:Nine stroke patients (median age 73 years [range 58–87]; four females; median NIH Stroke Severity score on admission 4 [range 0–6] with elevated hs-cTnT [median 74 ng/L, interquartile range 41–247] on admission) completed cardiac MRI and underwent coronary angiography. The absence of MRI-detected wall motion abnormalities and/or late gadolinium enhancement in 5 stroke patients corresponded with the exclusion of culprit lesions or significant coronary artery disease by coronary angiography. Four patients had abnormal MRI findings, whereof 2 showed evidence of myocardial infarction and in whom coronary angiography demonstrated a >70% stenosis of a coronary artery. Conclusions: The TRELAS sub-study indicates that noninvasive cardiac MRI may provide helpful information to identify stroke patients with or without acute coronary syndrome. Our findings might help to select stroke patients in urgent need of coronary angiography.

scholarly journals Relationship between arylesterase activity and pulse pressure index in patients with an acute ischemic stroke

2021 ◽  
Vol 38 (3) ◽  
pp. 246-250
Author(s):  
Pınar AYDIN OZTURK ◽  
UNAL OZTURK ◽  
Onder OZTURK
Keyword(s):  
Blood Pressure ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Pulse Pressure ◽  
Systolic Pressure ◽  
Control Group ◽  
Stroke Patients ◽  
Pressure Index ◽  
Artery Disease ◽  
The Relationship

Stroke is a multifactorial disease. Arylesterase (ARE) activities have been considered as an anti-atherosclerosis factor. Increased pulse pressure (PP) may lead to a high risk of coronary artery disease and neurovascular morbidity and mortality. Nevertheless, there are limitations for PP as an evaluation index. In order to overcome the defects of PP, there is a novel parameter, “pulse pressure/systolic pressure” named “pulse pressure index (PPI)” for evaluation of cardiovascular effect. We researched the relationship between ARE activities and pulse pressure index (PPI) in acute ischemic stroke patients. We evaluated and compared the ARE activity and PPI in 87 ischemic stroke patients and 48 control patients. ARE activity was measured with the ultraviolet (UV) spectrophotometric method by using “Rel Assay Diagnostic” kits. Pulse pressure was measured by subtraction of diastolic blood pressure from systolic blood pressure. PPI was calculated as “pulse pressure / systolic pressure”. Hypertension, age, diabetes mellitus, dyslipidemia importantly higher in ischemic stroke patients than the control group (p<0.05). PPI was significantly higher in ischemic stroke patients than the control group (0.486±0.075 and 0.417±0.051, p<0.05). ARE activity was significantly lower in ischemic stroke patients than in the control group (511.59 ± 68.51 and 584.16 ± 81.74 p=0.019). This study demonstrated that ARE activity is lower and PPI is higher in acute ischemic stroke patients than control subjects. Our results suggested that, ARE activity and PPI are important risk factors in acute ischemic stroke patients.

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