scholarly journals Genetic Variant in Interleukin-18 Is Associated with Idiopathic Recurrent Miscarriage in Chinese Han Population

2015 ◽  
Vol 16 (2) ◽  
pp. 4180-4189 ◽  
Author(s):  
Jun Yue ◽  
Yu Tong ◽  
Jing Zhou ◽  
Qingqing Liu ◽  
Jiyun Yang
Keyword(s):  
Genetic Variant ◽  
Recurrent Miscarriage ◽  
Chinese Han Population ◽  
Interleukin 18 ◽  
Chinese Han ◽  
Han Population ◽  
Idiopathic Recurrent Miscarriage

scholarly journals Association of interleukin-18 gene polymorphisms with Takayasu arteritis in a Chinese Han population

2020 ◽  
Vol 133 (19) ◽  
pp. 2315-2320
Author(s):  
Dan Wen ◽  
Xian-Liang Zhou ◽  
Xin Du ◽  
Jian-Zeng Dong ◽  
Chang-Sheng Ma
Keyword(s):  
Takayasu Arteritis ◽  
Gene Polymorphisms ◽  
Chinese Han Population ◽  
Interleukin 18 ◽  
Chinese Han ◽  
Han Population

scholarly journals Genetic variant rs72613567 of HSD17B13 gene reduces alcohol‐related liver disease risk in Chinese Han population

2020 ◽  
Vol 40 (9) ◽  
pp. 2194-2202
Author(s):  
Haizhen Chen ◽  
Yanfang Zhang ◽  
Tongsheng Guo ◽  
Funing Yang ◽  
Yuanli Mao ◽  
...  
Keyword(s):  
Liver Disease ◽  
Genetic Variant ◽  
Disease Risk ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Related Liver Disease

scholarly journals Association Between a CCL17 Genetic Variant and Risk of Coronary Artery Disease in a Chinese Han Population

2018 ◽  
Vol 82 (1) ◽  
pp. 224-231 ◽  
Author(s):  
Yicong Ye ◽  
Xinglin Yang ◽  
Bo Long ◽  
Haiyu Pang ◽  
Yicheng Zhu ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Genetic Variant ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Artery Disease

scholarly journals Genetic variant of COL11A2 gene is functionally associated with developmental dysplasia of the hip in Chinese Han population

Aging ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 7694-7703
Author(s):  
Renjie Xu ◽  
Xin Jiang ◽  
Junlan Lu ◽  
Kexin Wang ◽  
Ye Sun ◽  
...  
Keyword(s):  
Genetic Variant ◽  
Developmental Dysplasia ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Dysplasia Of The Hip ◽  
Col11a2 Gene

IL-28B Genetic Variant Is Associated with the Risk of Schizophrenia in the Chinese Han Population

2012 ◽  
Vol 31 (6) ◽  
pp. 988-992 ◽  
Author(s):  
Chunxia Chen ◽  
Bin Tan ◽  
Yi Zhou ◽  
Juan Zhou ◽  
Yong He ◽  
...  
Keyword(s):  
Genetic Variant ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

Influence of Interleukin-18 and Interleukin-17 Receptor A gene polymorphisms on the risk of thyroid cancer among Chinese Han population

2019 ◽  
Author(s):  
Yanhai Yin ◽  
Fen Li ◽  
Liangqian Tong ◽  
Chaoqun Wang ◽  
Kun Liang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Chinese Han Population ◽  
Interleukin 17 ◽  
Interleukin 18 ◽  
Chinese Han ◽  
Positive Interaction ◽  
Han Population ◽  
Increased Risk ◽  
Genetic Impact ◽  
Control Study

Abstract Background Thyroid cancer (TC) is a common endocrine pathology with an increasing incidence worldwide. It has been reported that high genetic impact is involved in the pathogenesis of TC, as well as cytokines, especially the interleukins play a crucial role in it. This study was designed to detect the association of IL-18 and IL-17RA polymorphisms with TC risk.Methods This case-control study conducted 365 TC patients and 503 healthy controls from Chinese Han population. Three selected SNPs (IL-18 rs360718, IL-18 rs1946519, and IL-17RA rs4819554) were genotyped to investigate the possible association of the polymorphisms with the risk of TC. Multifactor dimensionality reduction (MDR) was used to analyze the interactions of SNP-SNP.Results IL-17RA rs4819554 was associated with the decreased risk of TC under dominant model (OR = 0.76, 95% CI = 0.56-0.99, p = 0.04). IL-18 rs360718 significantly decreased the risk at age ≤ 44 years (C vs. A, OR = 0.63, 95% CI = 0.41-00.97, p = 0.033; CC vs. AA, OR = 0.12, 95% CI = 0.01-0.91, p = 0.040). On the contrast, among people older than 44 years, IL-18 rs1946519 (C vs. A, OR = 1.77, 95% CI = 1.03-3.06, p = 0.040) shown an increased risk with TC. MDR analysis revealed a positive interaction between the SNPs.Conclusion The present study firstly demonstrated that IL-18 rs360718, rs1946519 and IL-17RA rs4819554 polymorphisms might be related to thyroid cancer. The results were significantly worthy of further validation by larger studies.

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