scholarly journals Genetic variant rs72613567 of HSD17B13 gene reduces alcohol‐related liver disease risk in Chinese Han population

2020 ◽  
Vol 40 (9) ◽  
pp. 2194-2202
Author(s):  
Haizhen Chen ◽  
Yanfang Zhang ◽  
Tongsheng Guo ◽  
Funing Yang ◽  
Yuanli Mao ◽  
...  
Keyword(s):  
Liver Disease ◽  
Genetic Variant ◽  
Disease Risk ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Related Liver Disease

scholarly journals Association Between a CCL17 Genetic Variant and Risk of Coronary Artery Disease in a Chinese Han Population

2018 ◽  
Vol 82 (1) ◽  
pp. 224-231 ◽  
Author(s):  
Yicong Ye ◽  
Xinglin Yang ◽  
Bo Long ◽  
Haiyu Pang ◽  
Yicheng Zhu ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Genetic Variant ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Artery Disease

scholarly journals Genetic variant of COL11A2 gene is functionally associated with developmental dysplasia of the hip in Chinese Han population

Aging ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 7694-7703
Author(s):  
Renjie Xu ◽  
Xin Jiang ◽  
Junlan Lu ◽  
Kexin Wang ◽  
Ye Sun ◽  
...  
Keyword(s):  
Genetic Variant ◽  
Developmental Dysplasia ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Dysplasia Of The Hip ◽  
Col11a2 Gene

scholarly journals Sirtuin3 rs28365927 functional variant confers to the high risk of non-alcoholic fatty liver disease in Chinese Han population

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Li-jie Chen ◽  
Jing Guo ◽  
Song-xia Zhang ◽  
Ying Xu ◽  
Qing Zhao ◽  
...  
Keyword(s):  
Liver Disease ◽  
High Risk ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Alcoholic Fatty Liver ◽  
Han Population ◽  
Functional Variant ◽  
Alcoholic Fatty Liver Disease

Abstract Background Non-alcoholic fatty liver disease (NAFLD) is a multifactorial condition associated with aging, insulin resistance, metabolic syndrome, genetic factors and more. Although genetic traits are among the most important risks factors for NAFLD, the understanding of their influence is still quite limited. The present study aimed at identifying novel single nucleotide polymorphisms (SNPs) that may confer a risk for NAFLD in the Han Chinese population. Methods Based on the “two-hit hypothesis”, candidate SNPs, including Sirtuin3 rs28365927, were genotyped by MassARRAY in B-type ultrasonography-proven NAFLD patients (n = 292) and healthy controls (n = 387). Results In a model analysis of individuals matched based on gender and age that compared 223 NAFLD and 223 non-NAFLD patients, the rs28365927 GA + AA genotype was a significant risk factor for the development of NAFLD in a dominant model. Rs28365927 was significantly associated with a higher NAFLD risk in both an additive model (A vs G) and genotypic model (GA vs GG). Among the NAFLD patients, serum levels of total bilirubin (TBIL), DBIL direct bilirubin (DBIL) and glutamic-pyruvic transaminase (ALT) in rs28365927 A allele carriers (GA + AA) were 11.1, 14.7 and 41.5% higher, respectively, than in non-carriers (GG). Furthermore, among the NAFLD patients, the carriers of Rs28365927 allele A were positively correlated with higher ALT levels. Conclusion Sirtuin3 rs28365927 functional variant confers to the high risk of non-alcoholic fatty liver disease in Chinese Han population. The rs28365927 A allele significantly increased the ALT levels of NAFLD patients.

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