scholarly journals Binding of the Phage Display Derived Peptide CaIX-P1 on Human Colorectal Carcinoma Cells Correlates with the Expression of Carbonic Anhydrase IX

2012 ◽  
Vol 13 (12) ◽  
pp. 13030-13048 ◽  
Author(s):  
Vasileios Askoxylakis ◽  
Volker Ehemann ◽  
Shoaib Rana ◽  
Susanne Krämer ◽  
Nuh N. Rahbari ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Colorectal Carcinoma ◽  
Phage Display ◽  
Carcinoma Cells ◽  
Carbonic Anhydrase Ix ◽  
Human Colorectal Carcinoma

scholarly journals Granulocyte Colony Stimulating Factor Expression in Breast Cancer and Its Association with Carbonic Anhydrase IX and Immune Checkpoints

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1022
Author(s):  
Shawn C. Chafe ◽  
Nazia Riaz ◽  
Samantha Burugu ◽  
Dongxia Gao ◽  
Samuel C. Y. Leung ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Carbonic Anhydrase ◽  
Immune Checkpoint ◽  
Positive Association ◽  
Carcinoma Cells ◽  
Carbonic Anhydrase Ix ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Significant Positive Association ◽  
Stimulating Factor

Purpose: Granulocyte colony-stimulating factor (G-CSF) and hypoxia modulate the tumour immune microenvironment. In model systems, hypoxia-induced carbonic anhydrase IX (CAIX) has been associated with G-CSF and immune responses, including M2 polarization of macrophages. We investigated whether these associations exist in human breast cancer specimens, their relation to breast cancer subtypes, and clinical outcome. Methods: Using validated protocols and prespecified scoring methodology, G-CSF expression on carcinoma cells and CD163 expression on tumour-associated macrophages were assayed by immunohistochemistry and applied to a tissue microarray series of 2960 primary excision specimens linked to clinicopathologic, biomarker, and outcome data. Results: G-CSFhigh expression showed a significant positive association with ER negativity, HER2 positivity, presence of CD163+ M2 macrophages, and CAIX expression. In univariate analysis, G-CSFhigh phenotype was associated with improved survival in non-luminal cases, although the CAIX+ subset had a significantly adverse prognosis. A significant positive association was observed between immune checkpoint biomarkers on tumour-infiltrating lymphocytes and both G-CSF- and CAIX-expressing carcinoma cells. Immune checkpoint biomarkers correlated significantly with favourable prognosis in G-CSFhigh/non-luminal cases independent of standard clinicopathological features. Conclusions: The prognostic associations linking G-CSF to immune biomarkers and CAIX strongly support their immunomodulatory roles in the tumour microenvironment.

Interleukin-8 as a growth factor for human colorectal carcinoma cells in vitro

1997 ◽  
Vol 25 (2) ◽  
pp. 264S-264S ◽  
Author(s):  
ROBERT BREW ◽  
JOHN S. ERIKSON ◽  
DAVID C. WEST ◽  
BRIAN F. FLANAGAN ◽  
STEPHEN E. CHRISTMAS
Keyword(s):  
Growth Factor ◽  
Colorectal Carcinoma ◽  
Carcinoma Cells ◽  
Interleukin 8 ◽  
Human Colorectal Carcinoma

scholarly journals Induction of p53-Independent Apoptosis and G1 Cell Cycle Arrest by Fucoidan in HCT116 Human Colorectal Carcinoma Cells

Marine Drugs ◽  
2017 ◽  
Vol 15 (6) ◽  
pp. 154 ◽  
Author(s):  
Hye Park ◽  
Shin-Hyung Park ◽  
Jin-Woo Jeong ◽  
Dahye Yoon ◽  
Min Han ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colorectal Carcinoma ◽  
Cell Cycle Arrest ◽  
Carcinoma Cells ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest ◽  
Human Colorectal Carcinoma
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