scholarly journals Garlic-derived compound S-allylmercaptocysteine inhibits cell growth and induces apoptosis via the JNK and p38 pathways in human colorectal carcinoma cells

2014 ◽  
Vol 8 (6) ◽  
pp. 2591-2596 ◽  
Author(s):  
YAN ZHANG ◽  
HONG-YAN LI ◽  
ZHI-HUA ZHANG ◽  
HONG-LEI BIAN ◽  
GUI LIN
Keyword(s):  
Cell Growth ◽  
Colorectal Carcinoma ◽  
Carcinoma Cells ◽  
Human Colorectal Carcinoma

scholarly journals Syndecan-1 suppresses cell growth and migration via blocking JAK1/STAT3 and Ras/Raf/MEK/ERK pathways in human colorectal carcinoma cells

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Shaojun Wang ◽  
Xiaofei Zhang ◽  
Guimei Wang ◽  
Bin Cao ◽  
Hong Yang ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Cell Growth ◽  
Colorectal Carcinoma ◽  
Western Blot ◽  
B Cell Lymphoma ◽  
Carcinoma Cells ◽  
Janus Kinase ◽  
Cell Growth And Migration ◽  
Protein Levels ◽  
Human Colorectal Carcinoma

Abstract Background Syndecan-1 (SDC-1) is a crucial membrane proteoglycan, which is confirmed to participate in several tumor cell biological processes. However, the biological significance of SDC-1 in colorectal carcinoma is not yet clear. An objective of this study was to investigate the role of SDC-1 in colorectal carcinoma cells. Methods Expression of SDC-1 in colorectal carcinoma tissues was evaluated by Reverse transcription-quantitative real-time PCR (RT-qPCR) and western blot. After transfection with pcDNA3.1 or pc-SDC-1, the transfection efficiency was measured. Next, SW480, SW620 and LOVO cell viability, apoptosis, migration and adhesion were assessed to explore the effects of exogenous overexpressed SDC-1 on colorectal carcinoma. In addition, the influences of aberrant expressed SDC-1 in Janus kinase 1 (JAK1)/signal transducer and activator of transcription 3 (STAT3) and rat sarcoma virus (Ras)/rapidly accelerated fibrosarcoma (Raf)/mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) pathways were detected by western blot analysis. Results SDC-1 mRNA and protein levels were down-regulated in human colorectal carcinoma tissues. SDC-1 overexpression inhibited cell proliferation via suppressing CyclinD1 and c-Myc expression, meanwhile stimulated cell apoptosis via increasing the expression levels of B-cell lymphoma-2-associated x (Bax) and Cleaved-Caspase-3. Additionally, SDC-1 overexpression restrained cell migration via inhibiting the protein expression of matrix metallopeptidase 9 (MMP-9), and elicited cell adhesion through increasing intercellular cell adhesion molecule-1 (ICAM-1). Furthermore, SDC-1 overexpression suppressed JAK1/STAT3 and Ras/Raf/MEK/ERK-related protein levels. Conclusions In general, the evidence from this study suggested that SDC-1 suppressed cell growth, migration through blocking JAK1/STAT3 and Ras/Raf/MEK/ERK pathways in human colorectal carcinoma cells.

Interleukin-8 as a growth factor for human colorectal carcinoma cells in vitro

1997 ◽  
Vol 25 (2) ◽  
pp. 264S-264S ◽  
Author(s):  
ROBERT BREW ◽  
JOHN S. ERIKSON ◽  
DAVID C. WEST ◽  
BRIAN F. FLANAGAN ◽  
STEPHEN E. CHRISTMAS
Keyword(s):  
Growth Factor ◽  
Colorectal Carcinoma ◽  
Carcinoma Cells ◽  
Interleukin 8 ◽  
Human Colorectal Carcinoma

scholarly journals Induction of p53-Independent Apoptosis and G1 Cell Cycle Arrest by Fucoidan in HCT116 Human Colorectal Carcinoma Cells

Marine Drugs ◽  
2017 ◽  
Vol 15 (6) ◽  
pp. 154 ◽  
Author(s):  
Hye Park ◽  
Shin-Hyung Park ◽  
Jin-Woo Jeong ◽  
Dahye Yoon ◽  
Min Han ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colorectal Carcinoma ◽  
Cell Cycle Arrest ◽  
Carcinoma Cells ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest ◽  
Human Colorectal Carcinoma

scholarly journals Lentivirus-mediated LIGHT overexpression inhibits human colorectal carcinoma cell growth in vitro and in vivo

2013 ◽  
Vol 6 (4) ◽  
pp. 927-932 ◽  
Author(s):  
HAIBO WANG ◽  
ZHUANG YU ◽  
SHIHAI LIU ◽  
XIANGPING LIU ◽  
AIHUA SUI ◽  
...  
Keyword(s):  
Cell Growth ◽  
Colorectal Carcinoma ◽  
Carcinoma Cell ◽  
Human Colorectal Carcinoma Cell ◽  
Human Colorectal Carcinoma

Development of a fluvastatin-loaded self-nanoemulsifying system to maximize therapeutic efficacy in human colorectal carcinoma cells

2018 ◽  
Vol 46 ◽  
pp. 7-13 ◽  
Author(s):  
Hibah M. Aldawsari ◽  
Mahmoud A. Elfaky ◽  
Usama A. Fahmy ◽  
Bader M. Aljaeid ◽  
Ohood A. Alshareef ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Therapeutic Efficacy ◽  
Carcinoma Cells ◽  
Human Colorectal Carcinoma

scholarly journals Gene Modulation by the Cyclooxygenase Inhibitor, Sulindac Sulfide, in Human Colorectal Carcinoma Cells

2003 ◽  
Vol 278 (28) ◽  
pp. 25790-25801 ◽  
Author(s):  
Frank G. Bottone ◽  
Jeanelle M. Martinez ◽  
Jennifer B. Collins ◽  
Cynthia A. Afshari ◽  
Thomas E. Eling
Keyword(s):  
Colorectal Carcinoma ◽  
Carcinoma Cells ◽  
Cyclooxygenase Inhibitor ◽  
Gene Modulation ◽  
Sulindac Sulfide ◽  
Human Colorectal Carcinoma
Sign in / Sign up

Export Citation Format

Share Document