scholarly journals Sulfamate inhibitor S4 influences carbonic anhydrase IX ectodomain shedding in colorectal carcinoma cells

2015 ◽  
Vol 31 (5) ◽  
pp. 779-786 ◽  
Author(s):  
Helga Helseth Hektoen ◽  
Anne Hansen Ree ◽  
Kathrine Røe Redalen ◽  
Kjersti Flatmark
Keyword(s):  
Carbonic Anhydrase ◽  
Colorectal Carcinoma ◽  
Carcinoma Cells ◽  
Carbonic Anhydrase Ix ◽  
Ectodomain Shedding

scholarly journals Binding of the Phage Display Derived Peptide CaIX-P1 on Human Colorectal Carcinoma Cells Correlates with the Expression of Carbonic Anhydrase IX

2012 ◽  
Vol 13 (12) ◽  
pp. 13030-13048 ◽  
Author(s):  
Vasileios Askoxylakis ◽  
Volker Ehemann ◽  
Shoaib Rana ◽  
Susanne Krämer ◽  
Nuh N. Rahbari ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Colorectal Carcinoma ◽  
Phage Display ◽  
Carcinoma Cells ◽  
Carbonic Anhydrase Ix ◽  
Human Colorectal Carcinoma

scholarly journals Granulocyte Colony Stimulating Factor Expression in Breast Cancer and Its Association with Carbonic Anhydrase IX and Immune Checkpoints

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1022
Author(s):  
Shawn C. Chafe ◽  
Nazia Riaz ◽  
Samantha Burugu ◽  
Dongxia Gao ◽  
Samuel C. Y. Leung ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Carbonic Anhydrase ◽  
Immune Checkpoint ◽  
Positive Association ◽  
Carcinoma Cells ◽  
Carbonic Anhydrase Ix ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Significant Positive Association ◽  
Stimulating Factor

Purpose: Granulocyte colony-stimulating factor (G-CSF) and hypoxia modulate the tumour immune microenvironment. In model systems, hypoxia-induced carbonic anhydrase IX (CAIX) has been associated with G-CSF and immune responses, including M2 polarization of macrophages. We investigated whether these associations exist in human breast cancer specimens, their relation to breast cancer subtypes, and clinical outcome. Methods: Using validated protocols and prespecified scoring methodology, G-CSF expression on carcinoma cells and CD163 expression on tumour-associated macrophages were assayed by immunohistochemistry and applied to a tissue microarray series of 2960 primary excision specimens linked to clinicopathologic, biomarker, and outcome data. Results: G-CSFhigh expression showed a significant positive association with ER negativity, HER2 positivity, presence of CD163+ M2 macrophages, and CAIX expression. In univariate analysis, G-CSFhigh phenotype was associated with improved survival in non-luminal cases, although the CAIX+ subset had a significantly adverse prognosis. A significant positive association was observed between immune checkpoint biomarkers on tumour-infiltrating lymphocytes and both G-CSF- and CAIX-expressing carcinoma cells. Immune checkpoint biomarkers correlated significantly with favourable prognosis in G-CSFhigh/non-luminal cases independent of standard clinicopathological features. Conclusions: The prognostic associations linking G-CSF to immune biomarkers and CAIX strongly support their immunomodulatory roles in the tumour microenvironment.

scholarly journals Apoptosis-induced ectodomain shedding of hypoxia-regulated carbonic anhydrase IX from tumor cells: a double-edged response to chemotherapy

BMC Cancer ◽  
2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Ivana Vidlickova ◽  
Franck Dequiedt ◽  
Lenka Jelenska ◽  
Olga Sedlakova ◽  
Michal Pastorek ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Tumor Cells ◽  
Carbonic Anhydrase Ix ◽  
Ectodomain Shedding ◽  
Response To Chemotherapy

scholarly journals Carbonic anhydrase IX is associated with early pulmonary spreading of primary colorectal carcinoma and tobacco smoking

2013 ◽  
Vol 46 (1) ◽  
pp. 92-99 ◽  
Author(s):  
Thomas Schweiger ◽  
Dagmar Kollmann ◽  
Christoph Nikolowsky ◽  
Denise Traxler ◽  
Emmanuella Guenova ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Colorectal Carcinoma ◽  
Tobacco Smoking ◽  
Carbonic Anhydrase Ix

scholarly journals Ectodomain shedding of the hypoxia-induced carbonic anhydrase IX is a metalloprotease-dependent process regulated by TACE/ADAM17

2005 ◽  
Vol 93 (11) ◽  
pp. 1267-1276 ◽  
Author(s):  
M Zatovicova ◽  
O Sedlakova ◽  
E Svastova ◽  
A Ohradanova ◽  
F Ciampor ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Carbonic Anhydrase Ix ◽  
Ectodomain Shedding ◽  
Dependent Process

scholarly journals Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells

Cell Cycle ◽  
2013 ◽  
Vol 12 (11) ◽  
pp. 1791-1801 ◽  
Author(s):  
Tania Fiaschi ◽  
Elisa Giannoni ◽  
Letizia Taddei ◽  
Paolo Cirri ◽  
Alberto Marini ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Prostate Carcinoma ◽  
Epithelial Mesenchymal Transition ◽  
Carcinoma Cells ◽  
Carbonic Anhydrase Ix ◽  
Cancer Associated Fibroblasts ◽  
Mesenchymal Transition
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