scholarly journals Cholesterol Trafficking: An Emerging Therapeutic Target for Angiogenesis and Cancer

Cells ◽  
2019 ◽  
Vol 8 (5) ◽  
pp. 389 ◽  
Author(s):  
Junfang Lyu ◽  
Eun Ju Yang ◽  
Joong Sup Shim
Keyword(s):  
Signal Transduction ◽  
Endothelial Cell ◽  
Cell Signaling ◽  
Steroid Hormones ◽  
Therapeutic Target ◽  
Structural Component ◽  
Clinical Development ◽  
Cholesterol Trafficking ◽  
Intracellular Signal

Cholesterol is an essential structural component of cellular membranes. In addition to the structural role, it also serves as a precursor to a variety of steroid hormones and has diverse functions in intracellular signal transduction. As one of its functions in cell signaling, recent evidence suggests that cholesterol plays a key role in regulating angiogenesis. This review discusses the role of cholesterol in angiogenesis, with a particular emphasis on cholesterol trafficking in endothelial cell signaling. Small molecule inhibitors of cholesterol trafficking and their preclinical and clinical development targeting angiogenesis and cancer are also discussed.

scholarly journals Dual role of endothelial cell signaling in cancer progression

2015 ◽  
Vol 26 ◽  
pp. iii29
Author(s):  
D.A. Ferraro ◽  
R. Goosen ◽  
F. Patella ◽  
S. Zanivan ◽  
M. Buess ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Signaling ◽  
Cancer Progression ◽  
Dual Role

scholarly journals The role of interleukin-6 in intracellular signal transduction after chronic β-adrenergic stimulation in mouse myocardium

2019 ◽  
Vol 15 (6) ◽  
pp. 1565-1575 ◽  
Author(s):  
Magdalena Dziemidowicz ◽  
Tomasz Bonda ◽  
Siergiej Litvinovich ◽  
Andrzej Taranta ◽  
Maria Winnicka ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Interleukin 6 ◽  
Adrenergic Stimulation ◽  
Intracellular Signal Transduction ◽  
Intracellular Signal

Intracellular signal transduction: The role of endosomes

1996 ◽  
Vol 7 (1) ◽  
pp. 13-21 ◽  
Author(s):  
A.Paul Bevan ◽  
Paul G. Drake ◽  
John J.M. Bergeron ◽  
Barry I. Posner
Keyword(s):  
Signal Transduction ◽  
Intracellular Signal Transduction ◽  
Intracellular Signal

scholarly journals The Regulatory Role of Key Metabolites in the Control of Cell Signaling

Biomolecules ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 862 ◽  
Author(s):  
Riccardo Milanesi ◽  
Paola Coccetti ◽  
Farida Tripodi
Keyword(s):  
Signal Transduction ◽  
Cell Signaling ◽  
Cell Cycle Progression ◽  
Cell Metabolism ◽  
Signal Transduction Pathways ◽  
Protein Activity ◽  
Post Translational Modifications ◽  
Environmental Perturbations ◽  
Signal Transduction Protein

Robust biological systems are able to adapt to internal and environmental perturbations. This is ensured by a thick crosstalk between metabolism and signal transduction pathways, through which cell cycle progression, cell metabolism and growth are coordinated. Although several reports describe the control of cell signaling on metabolism (mainly through transcriptional regulation and post-translational modifications), much fewer information is available on the role of metabolism in the regulation of signal transduction. Protein-metabolite interactions (PMIs) result in the modification of the protein activity due to a conformational change associated with the binding of a small molecule. An increasing amount of evidences highlight the role of metabolites of the central metabolism in the control of the activity of key signaling proteins in different eukaryotic systems. Here we review the known PMIs between primary metabolites and proteins, through which metabolism affects signal transduction pathways controlled by the conserved kinases Snf1/AMPK, Ras/PKA and TORC1. Interestingly, PMIs influence also the mitochondrial retrograde response (RTG) and calcium signaling, clearly demonstrating that the range of this phenomenon is not limited to signaling pathways related to metabolism.

scholarly journals The Meningococcal Minor Pilin PilX Is Responsible for Type IV Pilus Conformational Changes Associated with Signaling to Endothelial Cells

2012 ◽  
Vol 80 (9) ◽  
pp. 3297-3306 ◽  
Author(s):  
Terry Brissac ◽  
Guillain Mikaty ◽  
Guillaume Duménil ◽  
Mathieu Coureuil ◽  
Xavier Nassif
Keyword(s):  
Endothelial Cells ◽  
Endothelial Cell ◽  
Cell Signaling ◽  
Conformational Changes ◽  
Adrenergic Receptor ◽  
Type Iv Pili ◽  
Content Type ◽  
Type Iv ◽  
Β2 Adrenergic Receptor

ABSTRACTNeisseria meningitidiscrosses the blood-brain barrier (BBB) following the activation of the β2-adrenergic receptor by the type IV pili (TFP). Two components of the type IV pili recruit the β2-adrenergic receptor, the major pilin PilE and the minor pilin PilV. Here, we report that a strain deleted of PilX, one of the three minor pilins, is defective in endothelial cell signaling. The signaling role of PilX was abolished when pili were not retractable. Purified PilX was unable to recruit the β2-adrenergic receptor, thus suggesting that PilX was playing an indirect role in endothelial cell signaling. Considering the recent finding that type IV pili can transition into a new conformation (N. Biais, D. L. Higashi, J. Brujic, M. So, and M. P. Sheetz, Proc. Natl. Acad. Sci. U. S. A. 107:11358–11363, 2010), we hypothesized that PilX was responsible for a structural modification of the fiber and allowed hidden epitopes to be exposed. To confirm this hypothesis, we showed that a monoclonal antibody which recognizes a linear epitope of PilE bound fibers only when bacteria adhered to endothelial cells. On the other hand, this effect was not observed in PilX-deleted pili. A deletion of a region of PilX exposed on the surface of the fiber had phenotypical consequences identical to those of a PilX deletion. These data support a model in which surface-exposed motifs of PilX use forces generated by pilus retraction to promote conformational changes required for TFP-mediated signaling.

scholarly journals Coronin 1B Regulates S1P-Induced Human Lung Endothelial Cell Chemotaxis: Role of PLD2, Protein Kinase C and Rac1 Signal Transduction

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e63007 ◽  
Author(s):  
Peter V. Usatyuk ◽  
Michael Burns ◽  
Vijay Mohan ◽  
Srikanth Pendyala ◽  
Donghong He ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Protein Kinase C ◽  
Endothelial Cell ◽  
Protein Kinase ◽  
Human Lung ◽  
Kinase C ◽  
Cell Chemotaxis
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