CYTOKINES MODULATE ENDOTHELIAL CELL INTRACELLULAR SIGNAL TRANSDUCTION REQUIRED FOR VCAM-1-DEPENDENT LYMPHOCYTE TRANSENDOTHELIAL MIGRATION

Cytokine ◽  
2001 ◽  
Vol 15 (4) ◽  
pp. 196-211 ◽  
Author(s):  
Kim-Sue R.S. Tudor ◽  
Krista L. Hess ◽  
Joan M. Cook-Mills
Keyword(s):  
Signal Transduction ◽  
Endothelial Cell ◽  
Transendothelial Migration ◽  
Intracellular Signal Transduction ◽  
Intracellular Signal

scholarly journals The p53 Protein Family in the Response of Tumor Cells to Ionizing Radiation: Problem Development

Acta Naturae ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 65-76
Author(s):  
Oleg A. Kuchur ◽  
Daria O. Kuzmina ◽  
Marina S. Dukhinova ◽  
Alexandr A. Shtil
Keyword(s):  
Signal Transduction ◽  
Ionizing Radiation ◽  
Radiation Exposure ◽  
Tumor Cells ◽  
P53 Protein ◽  
Intracellular Signal Transduction ◽  
Radiation Problem ◽  
The Family ◽  
Intracellular Signal ◽  
Survival Mechanisms

Survival mechanisms are activated in tumor cells in response to therapeutic ionizing radiation. This reduces a treatments effectiveness. The p53, p63, and p73 proteins belonging to the family of proteins that regulate the numerous pathways of intracellular signal transduction play a key role in the development of radioresistance. This review analyzes the p53-dependent and p53-independent mechanisms involved in overcoming the resistance of tumor cells to radiation exposure.

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