scholarly journals Multicellular Agent-Based Models of Angiogenesis Evaluate Endothelial Cell Signaling and the Role of Pericytes in Vascular Network Patterning

2015 ◽  
Author(s):  
Joseph Walpole
Keyword(s):  
Endothelial Cell ◽  
Cell Signaling ◽  
Vascular Network ◽  
Agent Based Models ◽  
Agent Based

scholarly journals Dual role of endothelial cell signaling in cancer progression

2015 ◽  
Vol 26 ◽  
pp. iii29
Author(s):  
D.A. Ferraro ◽  
R. Goosen ◽  
F. Patella ◽  
S. Zanivan ◽  
M. Buess ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Signaling ◽  
Cancer Progression ◽  
Dual Role

scholarly journals The Meningococcal Minor Pilin PilX Is Responsible for Type IV Pilus Conformational Changes Associated with Signaling to Endothelial Cells

2012 ◽  
Vol 80 (9) ◽  
pp. 3297-3306 ◽  
Author(s):  
Terry Brissac ◽  
Guillain Mikaty ◽  
Guillaume Duménil ◽  
Mathieu Coureuil ◽  
Xavier Nassif
Keyword(s):  
Endothelial Cells ◽  
Endothelial Cell ◽  
Cell Signaling ◽  
Conformational Changes ◽  
Adrenergic Receptor ◽  
Type Iv Pili ◽  
Content Type ◽  
Type Iv ◽  
Β2 Adrenergic Receptor

ABSTRACTNeisseria meningitidiscrosses the blood-brain barrier (BBB) following the activation of the β2-adrenergic receptor by the type IV pili (TFP). Two components of the type IV pili recruit the β2-adrenergic receptor, the major pilin PilE and the minor pilin PilV. Here, we report that a strain deleted of PilX, one of the three minor pilins, is defective in endothelial cell signaling. The signaling role of PilX was abolished when pili were not retractable. Purified PilX was unable to recruit the β2-adrenergic receptor, thus suggesting that PilX was playing an indirect role in endothelial cell signaling. Considering the recent finding that type IV pili can transition into a new conformation (N. Biais, D. L. Higashi, J. Brujic, M. So, and M. P. Sheetz, Proc. Natl. Acad. Sci. U. S. A. 107:11358–11363, 2010), we hypothesized that PilX was responsible for a structural modification of the fiber and allowed hidden epitopes to be exposed. To confirm this hypothesis, we showed that a monoclonal antibody which recognizes a linear epitope of PilE bound fibers only when bacteria adhered to endothelial cells. On the other hand, this effect was not observed in PilX-deleted pili. A deletion of a region of PilX exposed on the surface of the fiber had phenotypical consequences identical to those of a PilX deletion. These data support a model in which surface-exposed motifs of PilX use forces generated by pilus retraction to promote conformational changes required for TFP-mediated signaling.

AI-Driven Agent-Based Models to Study the Role of Vaccine Acceptance in Controlling COVID-19 Spread in the US

2021 ◽  
Author(s):  
Parantapa Bhattacharya ◽  
Dustin Machi ◽  
Jiangzhuo Chen ◽  
Stefan Hoops ◽  
Bryan Lewis ◽  
...  
Keyword(s):  
Agent Based Models ◽  
Vaccine Acceptance ◽  
Agent Based ◽  
The Us

scholarly journals Leveraging social influence to address overweight and obesity using agent-based models: The role of adolescent social networks

2015 ◽  
Vol 125 ◽  
pp. 203-213 ◽  
Author(s):  
J. Zhang ◽  
L. Tong ◽  
P.J. Lamberson ◽  
R.A. Durazo-Arvizu ◽  
A. Luke ◽  
...  
Keyword(s):  
Social Networks ◽  
Social Influence ◽  
Overweight And Obesity ◽  
Agent Based Models ◽  
Agent Based

scholarly journals Cholesterol Trafficking: An Emerging Therapeutic Target for Angiogenesis and Cancer

Cells ◽  
2019 ◽  
Vol 8 (5) ◽  
pp. 389 ◽  
Author(s):  
Junfang Lyu ◽  
Eun Ju Yang ◽  
Joong Sup Shim
Keyword(s):  
Signal Transduction ◽  
Endothelial Cell ◽  
Cell Signaling ◽  
Steroid Hormones ◽  
Therapeutic Target ◽  
Structural Component ◽  
Clinical Development ◽  
Cholesterol Trafficking ◽  
Intracellular Signal

Cholesterol is an essential structural component of cellular membranes. In addition to the structural role, it also serves as a precursor to a variety of steroid hormones and has diverse functions in intracellular signal transduction. As one of its functions in cell signaling, recent evidence suggests that cholesterol plays a key role in regulating angiogenesis. This review discusses the role of cholesterol in angiogenesis, with a particular emphasis on cholesterol trafficking in endothelial cell signaling. Small molecule inhibitors of cholesterol trafficking and their preclinical and clinical development targeting angiogenesis and cancer are also discussed.

Role Of Sphingomyelin Synthesis In Pulmonary Endothelial Cell Signaling

2010 ◽  
Author(s):  
Satish Gowda ◽  
Clavin Yeang ◽  
Fatima Anjum ◽  
sunil wadgaonkar ◽  
Natalia Grinkina ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Signaling

scholarly journals Uncertainty Quantification, Model Calibration and Sensitivity

2021 ◽  
pp. 71-92
Author(s):  
Jakub Bijak ◽  
Jason Hilton
Keyword(s):  
Experimental Design ◽  
Uncertainty Quantification ◽  
Computational Models ◽  
Agent Based Models ◽  
Agent Based ◽  
Quantification Model ◽  
High Level ◽  
Comprehensive Framework ◽  
Shed Light

AbstractBetter understanding of the behaviour of agent-based models, aimed at embedding them in the broader, model-based line of scientific enquiry, requires a comprehensive framework for analysing their results. Seeing models as tools for experimenting in silico, this chapter discusses the basic tenets and techniques of uncertainty quantification and experimental design, both of which can help shed light on the workings of complex systems embedded in computational models. In particular, we look at: relationships between model inputs and outputs, various types of experimental design, methods of analysis of simulation results, assessment of model uncertainty and sensitivity, which helps identify the parts of the model that matter in the experiments, as well as statistical tools for calibrating models to the available data. We focus on the role of emulators, or meta-models – high-level statistical models approximating the behaviour of the agent-based models under study – and in particular, on Gaussian processes (GPs). The theoretical discussion is illustrated by applications to the Routes and Rumours model of migrant route formation introduced before.

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