scholarly journals Silk Fibroin-Sheathed Conducting Polymer Wires as Organic Connectors for Biosensors

Biosensors ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 103 ◽  
Author(s):  
Yanke Jiang ◽  
Meng Xu ◽  
Vamsi K Yadavalli
Keyword(s):  
Silk Fibroin ◽  
Environmental Sustainability ◽  
Protective Coatings ◽  
High Sensitivity ◽  
Flexible Polymers ◽  
Free Standing ◽  
Organic Systems ◽  
Spinning Process ◽  
Organic Electrode ◽  
Conductive Fibers

Conductive polymers, owing to their tunable mechanical and electrochemical properties, are viable candidates to replace metallic components for the development of biosensors and bioelectronics. However, conducting fibers/wires fabricated from these intrinsically conductive and mechanically flexible polymers are typically produced without protective coatings for physiological environments. Providing sheathed conductive fibers/wires can open numerous opportunities for fully organic biodevices. In this work, we report on a facile method to fabricate core-sheath poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) PEDOT:PSS-silk fibroin conductive wires. The conductive wires are formed through a wet-spinning process, and then coated with an optically transparent, photocrosslinkable silk fibroin sheath for insulation and protection in a facile and scalable process. The sheathed fibers were evaluated for their mechanical and electrical characteristics and overall stability. These wires can serve as flexible connectors to an organic electrode biosensor. The entire, fully organic, biodegradable, and free-standing flexible biosensor demonstrated a high sensitivity and rapid response for the detection of ascorbic acid as a model analyte. The entire system can be proteolytically biodegraded in a few weeks. Such organic systems can therefore provide promising solutions to address challenges in transient devices and environmental sustainability.

Exploiting Free-Standing p-CuO/n-TiO2 Nanochannels as a Flexible Gas Sensor with High Sensitivity for H2S at Room Temperature

ACS Sensors ◽  
2021 ◽  
Vol 6 (9) ◽  
pp. 3387-3397
Author(s):  
Haoxuan He ◽  
Chenxi Zhao ◽  
Jing Xu ◽  
Kuanzhi Qu ◽  
Zhen Jiang ◽  
...  
Keyword(s):  
Gas Sensor ◽  
Room Temperature ◽  
High Sensitivity ◽  
Free Standing

Effect of coagulation bath parameters on the morphology and absorption behavior of a skin–core filament based on biomedical polyurethane and native silk fibroin microparticles

2019 ◽  
Vol 90 (3-4) ◽  
pp. 460-468 ◽  
Author(s):  
Yan Zhuang ◽  
Han Wang ◽  
Linfeng Wang ◽  
Changjun Liu ◽  
Yuan Xu ◽  
...  
Keyword(s):  
Drug Release ◽  
Water Absorption ◽  
Silk Fibroin ◽  
Controlled Drug Release ◽  
Coagulation Bath ◽  
Wet Spinning ◽  
Electron Microscopy Analysis ◽  
Potential Applications ◽  
Spinning Process ◽  
Biomedical Polyurethane

This study investigates the effect of the constituents and temperature of a coagulation bath on the morphology and water absorption behavior of a skin–core filament, which has potential application in the field of controlled drug release, based on biomedical polyurethane (BPU) and native silk fibroin microparticles (NSFPs). BPU solution and BPU/NSFP blend solution were extruded from the cortex and core channel of a coaxial double injector into a coagulation bath with different constituents and at different temperatures to form filaments. Scanning electron microscopy analysis of the skin–core filament prepared by wet-spinning revealed that the addition of ethanol decreased the exchange speed between the solvent and non-solvent and led to the formation of micropores on the surface. Meanwhile, the interface between the cortex and core became pronounced and the water absorption capability of the filament decreased with increasing ethanol concentration in the coagulation bath. The high temperature of the coagulation bath also improved the exchange speed between the solvent and non-solvent; however, its effect on the morphology of the filament was weak. Thus, a skin–core filament with different morphologies and water absorption behaviors was fabricated by controlling the constituents and temperature of the coagulation bath during the wet-spinning process. This skin–core filament has potential applications in controlled drug release.

Nanoporous copper oxide ribbon assembly of free-standing nanoneedles as biosensors for glucose

The Analyst ◽  
2015 ◽  
Vol 140 (15) ◽  
pp. 5205-5215 ◽  
Author(s):  
Shaodong Sun ◽  
Yuexia Sun ◽  
Anran Chen ◽  
Xiaozhe Zhang ◽  
Zhimao Yang
Keyword(s):  
Detection Limit ◽  
High Sensitivity ◽  
Solution Phase ◽  
Glucose Detection ◽  
Two Dimensional ◽  
Free Standing ◽  
Amperometric Response ◽  
Nanoporous Copper ◽  
Green Solution ◽  
Promising Electrode Material

Two-dimensional (2D) hierarchical nanoporous CuO ribbons were successfully synthesized by a green solution-phase route. They serve as a promising electrode material for nonenzymatic glucose detection and show high sensitivity, a low detection limit, fast amperometric response and good selectivity.

scholarly journals Fabrication of Silk Nanofibres with Needle and Roller Electrospinning Methods

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Nongnut Sasithorn ◽  
Lenka Martinová
Keyword(s):  
Formic Acid ◽  
Production Rate ◽  
Calcium Chloride ◽  
Silk Fibroin ◽  
Applied Voltage ◽  
Rotating Cylinder ◽  
Spinning Process

In this study, silk nanofibres were prepared by electrospinning from silk fibroin in a mixture of formic acid and calcium chloride. A needle and a rotating cylinder were used as fibre generators in the spinning process. The influences of the spinning electrode and spinning parameters (silk concentration and applied voltage) on the spinning process, morphology of the obtained fibres, and the production rate of the spinning process were examined. The concentration of the spinning solution influenced the diameter of the silk electrospun fibres, with an increase in the concentration increasing the diameters of the fibres in both spinning systems. The diameters of the electrospun fibres produced by roller electrospinning were greater than those produced by needle electrospinning. Moreover, increasing the concentration of the silk solution and the applied voltage in the spinning process improved the production rate in roller electrospinning but had less influence on the production rate in needle electrospinning.

scholarly journals Microstructure Transitions and Dry-Wet Spinnability of Silk Fibroin Protein from Waste Silk Quilt

Polymers ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1622 ◽  
Author(s):  
Xin Zhang ◽  
Zhijuan Pan
Keyword(s):  
Silk Fibroin ◽  
Coagulation Bath ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
Leading Role ◽  
Regenerated Silk Fibroin ◽  
Spinning Process ◽  
Silk Fabrics ◽  
The Many ◽  
Conformation Transitions

With excellent biocompatibility and biodegradability, silk fibroin has been developed into many protein materials. For producing regenerated silk fibroin (RSF) fibers, the conformation transition of silk fibroin needs to be thoroughly studied during the spinning process. Since the many silk fabrics that are discarded comprise an increasing waste of resources and increase the pressure on the environment, in this paper, waste silk fiber was recycled in an attempt to prepare regenerated fibroin fiber by dry-wet spinning. Ethanol was the coagulation bath. The rheological properties of all the RSF solutions were investigated to acquire rheology curves and non-Newtonian indexes for spinnability analysis. Four stages of the spinning process were carried out to obtain RSF samples and study their conformation transitions, crystallization, and thermal properties by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction, and differential scanning calorimetry. Quantitative analysis of the FTIR results was performed to obtain specific data regarding the contents of the secondary structures. The results showed that higher concentration spinning solutions had better spinnability. As the spinning process progressed, random coils were gradually converted into β-sheets and crystallization increased. Among the different influencing factors, the ethanol coagulation bath played a leading role in the conformation transitions of silk fibroin.

Conductive regenerated silk fibroin composite fiber containing MWNTs

e-Polymers ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Negin Piri ◽  
Vahid Mottaghitalab ◽  
Shahram Arbab
Keyword(s):  
Silk Fibroin ◽  
General Scheme ◽  
Conductive Filler ◽  
Composite Fiber ◽  
Multiwalled Carbon ◽  
Sem Images ◽  
Chain Entanglement ◽  
Regenerated Silk Fibroin ◽  
Maximum Conductivity ◽  
Spinning Process

Abstract The electrically conductive regenerated silk fibroin (RSF) fiber containing multiwalled carbon nanotubes (MWNTs) was developed through wet spinning process. A general scheme used for extraction of RSF powder as biopolymer matrix for MWNTs conductive filler. The MWNTs inclusion demands for a sophisticated approach to prepare stable, exfoliated and well distributed filler in matrix solution. Dynamic Light Scattering (DLS) was utilized to show the ability of RSF in stabilizing of MWNTs throughout spinning solution. A non-Newtonian shear thinning behavior observed for RSF/MWNTs according to strong chain entanglement, whereas, the neat RSF solution shows a lower dependence on the shear rate. The scanning electron microscopy (SEM) images also confirmed the proper distribution of MWNTs as a continuous fibril media in the RSF matrix. The Fourier transform infrared spectroscopy (FTIR) demonstrated the role of MWNTs inclusion for increasing of the crystalinity compared to bare RSF fiber. The Raman spectra also confirmed the domination of RSF signatures by strong Raman bands of MWNTs most specifically in RBM region regarding to superior nanotube exfoliation. Moreover, the measurement of four-point probe electrical conductivity for different MWNTs content shows a maximum conductivity of 0.12 S/cm at percolation threshold. The higher thermal stability and greater crystalinity were also evidenced by DSC thermal analysis.

The mechanical Properties of CVD Diamond Films, and Diamond Coated Fibres and Wires

1995 ◽  
Vol 383 ◽  
Author(s):  
E D Nicholson ◽  
J E Field ◽  
P G Partridge ◽  
M N R Ashfold
Keyword(s):  
Mechanical Properties ◽  
Young’S Modulus ◽  
Microwave Plasma ◽  
Young's Modulus ◽  
Protective Coatings ◽  
Small Diameter ◽  
Cvd Diamond ◽  
Film Stress ◽  
Free Standing ◽  
Film Property

ABSTRACTTwo areas of thin film property measurement are addressed. The first is that of flat films, either on a substrate or free-standing. The film properties only are of interest. Therefore, when the film remains attached to a substrate during testing, an appropriate analysis is used to subtract the effect of the substrate. The films under test are prospective protective coatings and ‘window’ materials for infrared applications, namely CVD diamond (Hot filament Assisted, HFACVD and Microwave plasma assisted, MPACVD) and Germanium carbide (Ge:C). The mechanical properties under investigation are the Young's modulus and the internal film stress.In the second case the substrates are small diameter fibres and wires coated with CVD diamond. The mechanical properties measured were composite, containing contributions from both the substrate and the film. These coated fibres and wires, have possible applications as reinforcement phases in the production of composites. They are silicon carbide (SiC) and Tungsten (W) of diameters varying between 10 and 125μm. A technique has been developed to measure the Young's modulus of individual coated fibres.

scholarly journals Nanoparticles fabricated by the bubble electrospinning

2012 ◽  
Vol 16 (5) ◽  
pp. 1562-1563 ◽  
Author(s):  
Hao Dou ◽  
Ji-Huan He
Keyword(s):  
Aqueous Solution ◽  
Silk Fibroin ◽  
Low Concentration ◽  
Spinning Process

The bubble electrospinning is used to produce nanoparticles from several nano-meters to several hundred nanometers in diameter. Silk fibroin aqueous solution with low concentration is used in the experiment. The spinning process can be well controlled by temperature.

scholarly journals Combination of Porous Silk Fibroin Substrate and Gold Nanocracks as a Novel SERS Platform for a High-Sensitivity Biosensor

Biosensors ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 441
Author(s):  
Ji Hyeon Choi ◽  
Munsik Choi ◽  
Taeyoung Kang ◽  
Tien Son Ho ◽  
Seung Ho Choi ◽  
...  
Keyword(s):  
Detection Limit ◽  
Silk Fibroin ◽  
Local Field ◽  
Dynamic Range ◽  
Field Enhancement ◽  
Quantitative Measure ◽  
High Sensitivity ◽  
High Porosity ◽  
Local Field Enhancement

Novel concepts for developing a surface-enhanced Raman scattering (SERS) sensor based on biocompatible materials offer great potential in versatile applications, including wearable and in vivo monitoring of target analytes. Here, we report a highly sensitive SERS sensor consisting of a biocompatible silk fibroin substrate with a high porosity and gold nanocracks. Our silk-based SERS detection takes advantage of strong local field enhancement in the nanoscale crack regions induced by gold nanostructures evaporated on a porous silk substrate. The SERS performance of the proposed sensor is evaluated in terms of detection limit, sensitivity, and linearity. Compared to the performance of a counterpart SERS sensor with a thin gold film, SERS results using 4-ABT analytes present that a significant improvement in the detection limit and sensitivity by more than 4 times, and a good linearity and a wide dynamic range is achieved. More interestingly, overlap is integral, and a quantitative measure of the local field enhancement is highly consistent with the experimental SERS enhancement.

Evolution of elemental distribution in free-standing structures of Zr/ZrSi2 with MoSi2 and ZrSi2 protective coatings under annealing

2011 ◽  
Vol 75 (1) ◽  
pp. 76-79 ◽  
Author(s):  
M. N. Drozdov ◽  
Yu. N. Drozdov ◽  
E. B. Kluenkov ◽  
A. Ya. Lopatin ◽  
V. I. Luchin ◽  
...  
Keyword(s):  
Protective Coatings ◽  
Elemental Distribution ◽  
Free Standing
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