scholarly journals TFBN: A Cost Effective High Performance Hierarchical Interconnection Network

2020 ◽  
Vol 10 (22) ◽  
pp. 8252
Author(s):  
M. M. Hafizur Rahman ◽  
Mohammed Al-Naeem ◽  
Mohammed N. M. Ali ◽  
Abu Sufian
Keyword(s):  
Cost Effectiveness ◽  
High Performance ◽  
Mesh Networks ◽  
Interconnection Network ◽  
Cost Effective ◽  
Parallel Computer ◽  
Next Generation ◽  
Basic Module ◽  
Bisection Width ◽  
Butterfly Network

In order to fulfill the increasing demand for computation power to process a boundless data concurrently within a very short time or real-time in many areas such as IoT, AI, machine learning, smart grid, and big data analytics, we need exa-scale or zetta-scale computation in the near future. Thus, to have this level of computation, we need a massively parallel computer (MPC) system that shall consist of millions of nodes; and, for the interconnection of these massive numbers of nodes, conventional topologies are infeasible. Thus, a hierarchical interconnection network (HIN) is a rational way to connect huge nodes. Through this article, we are proposing a new HIN, which is a tori-connected flattened butterfly network (TFBN) for the next generation MPC system. Numerous basic modules are hierarchically interconnected as a toroidal connection, whereby the basic modules are flattened butterfly networks. We have studied the network architecture, static network performance, and static cost-effectiveness of the proposed TFBN in detail; and compared static network and cost-effectiveness performance of the TFBN to those of TTN, torus, TESH, and mesh networks. It is depicted that TFBN possesses low diameter and average distance, high arc connectivity, and temperate bisection width. It also has better cost-effectiveness and cost-performance trade-off factor compared to those of TTN, torus, TESH, and mesh networks. The only shortcoming is that the complexity of wiring of the TFBN is higher than that of those networks; this is because the basic module necessitates some extra short length link to form the flattened butterfly network. Therefore, TFBN is a high performance and cost-effective HIN, and it will be a good option for the next generation MPC system.

scholarly journals Application of an Queuing Model to WiMAX-Based Wireless Mesh Networks: Grid Topology Case Study

2012 ◽  
Vol 2012 ◽  
pp. 1-22
Author(s):  
Vahid Sattari Naeini ◽  
Naser Movahhedinia
Keyword(s):  
High Performance ◽  
Performance Metrics ◽  
Mesh Networks ◽  
Cost Effective ◽  
Mesh Network ◽  
Queuing Model ◽  
Basic Step ◽  
Broadband Internet ◽  
Mesh Structure ◽  
Wireless Mesh

Wireless mesh networking is an effective approach to reach high performance in the last mile of broadband Internet access. The mesh structure is the basic step toward providing cost-effective, dynamic, and high-bandwidth wireless connection. In this paper, WiMAX-like wireless mesh network is considered, emphasizing the grid arrangement which is the general topology described in the literature. To evaluate the performance of the conventional and proposed scheduling algorithms, each link is modeled using an M/D/1 queue and a virtual node concept is introduced to describe comparable performance metrics for the system. Performance measures of the system in addition to the simulation results are assessed in terms of the network length and the arrival rates.

scholarly journals Fluorouracil plasma monitoring: systematic review and economic evaluation of the My5-FU assay for guiding dose adjustment in patients receiving fluorouracil chemotherapy by continuous infusion

2015 ◽  
Vol 19 (91) ◽  
pp. 1-322 ◽  
Author(s):  
Karoline Freeman ◽  
Martin Connock ◽  
Ewen Cummins ◽  
Tara Gurung ◽  
Sian Taylor-Phillips ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Cost Effectiveness ◽  
Social Services ◽  
High Performance ◽  
Dose Adjustment ◽  
Progression Free Survival ◽  
Clinical Effectiveness ◽  
Cost Effective ◽  
Base Case ◽  
Practical Implementation

Background5-Fluorouracil (5-FU) is a chemotherapy used in colorectal, head and neck (H&N) and other cancers. Dose adjustment is based on body surface area (BSA) but wide variations occur. Pharmacokinetic (PK) dosing is suggested to bring plasma levels into the therapeutic range to promote fewer side effects and better patient outcomes. We investigated the clinical effectiveness and cost-effectiveness of the My5-FU assay for PK dose adjustment to 5-FU therapy.ObjectivesTo systematically review the evidence on the accuracy of the My5-FU assay compared with gold standard methods [high-performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS)]; the effectiveness of My5-FU PK dosing compared with BSA; the effectiveness of HPLC and/or LC-MS compared with BSA; the generalisability of published My5-FU and PK studies; costs of using My5-FU; to develop a cost-effectiveness model.Data sourcesWe searched MEDLINE, EMBASE, Science Citation Index and other databases between January and April 2014.MethodsTwo reviewers independently screened titles and abstracts with arbitration and consensus agreement. We undertook quality assessment. We reconstructed Kaplan–Meier plots for progression-free survival (PFS) and overall survival (OS) for comparison of BSA and PK dosing. We developed a Markov model to compare My5-FU with BSA dosing which modelled PFS, OS and adverse events, using a 2-week cycle over a 20 year time horizon with a 3.5% discount rate. Health impacts were evaluated from the patient perspective, while costs were evaluated from the NHS and Personal Social Services perspective.ResultsA total of 8341 records were identified through electronic searches and 35 and 54 studies were included in the clinical effectiveness and cost-effectiveness reviews respectively. There was a high apparent correlation between My5-FU, HPLC and LC-MS/mass spectrometer but upper and lower limits of agreement were –18% to 30%. Median OS were estimated as 19.6 [95% confidence interval (CI) 17.0 to 21.0] months for PK versus 14.6 (95% CI 14.1 to 15.3) months for BSA for 5-FU + folinic acid (FA); and 27.4 (95% CI 23.2 to 38.8) months for PK versus 20.6 (95% CI 18.4 to 22.9) months for BSA for FOLFOX6 in metastatic colorectal cancer (mCRC). PK versus BSA studies were generalisable to the relevant populations. We developed cost-effectiveness models for mCRC and H&N cancer. The base case assumed a cost per My5-FU assay of £61.03. For mCRC for 12 cycles of a oxaliplatin in combination with 5-fluorouracil and FA (FOLFOX) regimen, there was a quality-adjusted life-year (QALY) gain of 0.599 with an incremental cost-effectiveness ratio of £4148 per QALY. Probabilistic and scenario analyses gave similar results. The cost-effectiveness acceptability curve showed My5-FU to be 100% cost-effective at a threshold of £20,000 per QALY. For H&N cancer, again, given caveats about the poor evidence base, we also estimated that My5-FU is likely to be cost-effective at a threshold of £20,000 per QALY.LimitationsQuality and quantity of evidence were very weak for PK versus BSA dosing for all cancers with no randomised controlled trials (RCTs) using current regimens. For H&N cancer, two studies of regimens no longer in use were identified.ConclusionsUsing a linked evidence approach, My5-FU appears to be cost-effective at a willingness to pay of £20,000 per QALY for both mCRC and H&N cancer. Considerable uncertainties remain about evidence quality and practical implementation. RCTs are needed of PK versus BSA dosing in relevant cancers.FundingThe National Institute for Health Research Health Technology Assessment programme.

Architecture and Network-on-Chip Implementation of a New Hierarchical Interconnection Network

2014 ◽  
Vol 24 (02) ◽  
pp. 1540006 ◽  
Author(s):  
M. M. Hafizur Rahman ◽  
Rizal Mohd Nor ◽  
Tengku Mohd Bin Tengku Sembok ◽  
M. A. H. Akhand
Keyword(s):  
Mesh Networks ◽  
Fault Tolerant ◽  
Interconnection Network ◽  
Average Distance ◽  
Small Diameter ◽  
Network On Chip ◽  
Mesh Network ◽  
Minimal Distance ◽  
Bisection Width ◽  
On Chip

A Midimew-connected Mesh Network (MMN) is a minimal distance mesh with wrap-around links network of multiple basic modules (BMs), in which the BMs are 2D-mesh networks that are hierarchically interconnected for higher-level networks. In this paper, we present the architecture of the MMN, addressing of node, routing of message, and evaluate the static network performance of MMN, TESH, mesh and torus networks. In addition, we propose the network-on-chip (NoC) implementation of MMN. With innovative combination of diagonal and hierarchical structure, the MMN possesses several attractive features, including constant degree, small diameter, low cost, small average distance, moderate bisection width and high fault tolerant performance than that of other conventional and hierarchical interconnection networks. The simple architecture of MMN is also highly suitable for NoC implementation. To implement all the links of level-3 MMN, only four layers are needed which is feasible with current and future VLSI technologies.

scholarly journals A New Cost Effective and Reliable Interconnection Topology for Parallel Computing Systems

2019 ◽  
Vol 8 (6) ◽  
pp. 1186-1195
Keyword(s):  
Data Transmission ◽  
Fault Tolerant ◽  
Interconnection Network ◽  
Average Distance ◽  
Low Cost ◽  
Cost Effective ◽  
Routing Algorithms ◽  
Computing Systems ◽  
Bisection Width ◽  
High Connectivity

Topology of the of interconnection network is one of the most important considerations in the design of parallel systems as it is the backbone network over which the different components of the computer communicate with each other. The properties of the topology such as connectivity, reliability, cost, fault tolerance, diameter and bisection width determine the flawless-less data transmission between the source and the sink nodes. In this paper, we propose a new hybrid interconnection network topology called TOR-CUBE (TC) which is a product of two classical popular interconnection topologies namely hypercube and torus. Further, we show the construction and characteristics of the proposed interconnection topology. We also presented some basic important properties and formulated two routing algorithms for TC. Our results show that the proposed interconnection topology has high connectivity, lesser diameter, low cost, fault tolerant, scalable and low average distance. The different reliability measures of TC are computed and found to be better as compared with its counterpart topologies and the parent topologies.

Mineral/microfibrillated cellulose composite materials: High performance products, applications, and product forms

TAPPI Journal ◽  
2018 ◽  
Vol 17 (09) ◽  
pp. 507-515 ◽  
Author(s):  
David Skuse ◽  
Mark Windebank ◽  
Tafadzwa Motsi ◽  
Guillaume Tellier
Keyword(s):  
Composite Materials ◽  
High Performance ◽  
Aqueous Suspension ◽  
Production Capacity ◽  
Cost Savings ◽  
Cost Effective ◽  
New Materials ◽  
Wet Strength ◽  
Product Forms ◽  
Cellulose Composite

When pulp and minerals are co-processed in aqueous suspension, the mineral acts as a grinding aid, facilitating the cost-effective production of fibrils. Furthermore, this processing allows the utilization of robust industrial milling equipment. There are 40000 dry metric tons of mineral/microfbrillated (MFC) cellulose composite production capacity in operation across three continents. These mineral/MFC products have been cleared by the FDA for use as a dry and wet strength agent in coated and uncoated food contact paper and paperboard applications. We have previously reported that use of these mineral/MFC composite materials in fiber-based applications allows generally improved wet and dry mechanical properties with concomitant opportunities for cost savings, property improvements, or grade developments and that the materials can be prepared using a range of fibers and minerals. Here, we: (1) report the development of new products that offer improved performance, (2) compare the performance of these new materials with that of a range of other nanocellulosic material types, (3) illustrate the performance of these new materials in reinforcement (paper and board) and viscosification applications, and (4) discuss product form requirements for different applications.

Within trial cost-effectiveness of a structured lifestyle intervention in adults with overweight/obesity and type 2 diabetes: Results from the Action for Health in Diabetes (Look AHEAD) Study

2020 ◽  
Author(s):  
Ping Zhang ◽  
Karen M. Atkinson ◽  
George Bray ◽  
Haiying Chen ◽  
Jeanne M. Clark ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cost Effectiveness ◽  
Lifestyle Intervention ◽  
Health Utility Index ◽  
Health Benefit ◽  
Cost Effective ◽  
Health Utility ◽  
Health Care Expenditures ◽  
Quality Adjusted Life Year

<b>OBJECTIVE </b>To assess the cost-effectiveness (CE) of an intensive lifestyle intervention (ILI) compared to standard diabetes support and education (DSE) in adults with overweight/obesity and type 2 diabetes, as implemented in the Action for Health in Diabetes study. <p><b>RESEARCH DESIGN AND METHODS</b> Data were from 4,827 participants during the first 9 years of the study from 2001 to 2012. Information on Health Utility Index-2 and -3, SF-6D, and Feeling Thermometer [FT]), cost of delivering the interventions, and health expenditures were collected during the study. CE was measured by incremental cost-effectiveness ratios (ICERs) in costs per quality-adjusted life year (QALY). Future costs and QALYs were discounted at 3% annually. Costs were in 2012 US dollars. </p> <p><b>RESULTS </b><a>Over the </a>9 years studied, the mean cumulative intervention costs and mean cumulative health care expenditures were $11,275 and $64,453 per person for ILI and $887 and $68,174 for DSE. Thus, ILI cost $6,666 more per person than DSE. Additional QALYs gained by ILI were not statistically significant measured by the HUIs and were 0.17 and 0.16, respectively, measured by SF-6D and FT. The ICERs ranged from no health benefit with a higher cost based on HUIs, to $96,458/QALY and $43,169/QALY, respectively, based on SF-6D and FT. </p> <p><b>Conclusions </b>Whether<b> </b>ILI was cost-effective over the 9-year period is unclear because different health utility measures led to different conclusions. </p>

Parallel Computing for Tire Simulations

2011 ◽  
Vol 39 (3) ◽  
pp. 193-209 ◽  
Author(s):  
H. Surendranath ◽  
M. Dunbar
Keyword(s):  
High Performance ◽  
Effective Means ◽  
Cost Effective ◽  
Turnaround Time ◽  
Careful Consideration ◽  
Rolling Contact ◽  
Element Analysis ◽  
Parallel Solvers ◽  
Design Changes ◽  
Highly Nonlinear

Abstract Over the last few decades, finite element analysis has become an integral part of the overall tire design process. Engineers need to perform a number of different simulations to evaluate new designs and study the effect of proposed design changes. However, tires pose formidable simulation challenges due to the presence of highly nonlinear rubber compounds, embedded reinforcements, complex tread geometries, rolling contact, and large deformations. Accurate simulation requires careful consideration of these factors, resulting in the extensive turnaround time, often times prolonging the design cycle. Therefore, it is extremely critical to explore means to reduce the turnaround time while producing reliable results. Compute clusters have recently become a cost effective means to perform high performance computing (HPC). Distributed memory parallel solvers designed to take advantage of compute clusters have become increasingly popular. In this paper, we examine the use of HPC for various tire simulations and demonstrate how it can significantly reduce simulation turnaround time. Abaqus/Standard is used for routine tire simulations like footprint and steady state rolling. Abaqus/Explicit is used for transient rolling and hydroplaning simulations. The run times and scaling data corresponding to models of various sizes and complexity are presented.

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