scholarly journals Continuous and Noninvasive Estimation of Right Ventricle Systolic Blood Pressure Using Heart Sound Signal by Deep Bidirectional LSTM Network

2020 ◽  
Vol 10 (16) ◽  
pp. 5466
Author(s):  
Miao Wang ◽  
Hong Tang ◽  
Tengfei Feng ◽  
Binbin Guo

Objective: Timely monitoring right ventricular systolic blood pressure (RVSBP) is helpful in the early detection of pulmonary hypertension (PH). However, it is not easy to monitor RVSBP directly. The objective of this paper is to develop a deep learning technique for RVSBP noninvasive estimation using heart sound (HS) signals supported by (electrocardiography) ECG signals without complex features extraction. Methods: Five beagle dog subjects were used. The medicine U-44069 was injected into the subjects to induce a wide range of RVSBP variation. The blood pressure in right ventricle, ECG of lead I and HS signals were recorded simultaneously. Thirty-two records were collected. The relations between RVSBP and cyclic HS signals were modeled by the Bidirectional Long Short-Term Memory (Bi-LSTM) network. Results: The mean absolute error (MAE) ± standard deviation (SD) inside record was 1.85 ± 1.82 mmHg. It was 4.37 ± 2.49 mmHg across record but within subject. The corrective factors were added after training the Bi-LSTM network across subjects. Finally, the MAE ± SD from 12.46 ± 6.56 mmHg dropped to 6.37 ± 4.90 mmHg across subjects. Significance: Our work was the first to apply the Bi-LSTM network to build relations between the HS signal and RVSBP. This work suggested a noninvasive and continuous RVSBP estimation using the HS signal supported by the ECG signal by deep learning architecture without the need of healthcare professionals.

Sensors ◽  
2020 ◽  
Vol 20 (6) ◽  
pp. 1761 ◽  
Author(s):  
Xiangyu Zhou ◽  
Zhengjiang Liu ◽  
Fengwu Wang ◽  
Yajuan Xie ◽  
Xuexi Zhang

Forecasting vessel flows is important to the development of intelligent transportation systems in the maritime field, as real-time and accurate traffic information has favorable potential in helping a maritime authority to alleviate congestion, mitigate emission of GHG (greenhouse gases) and enhance public safety, as well as assisting individual vessel users to plan better routes and reduce additional costs due to delays. In this paper, we propose three deep learning-based solutions to forecast the inflow and outflow of vessels within a given region, including a convolutional neural network (CNN), a long short-term memory (LSTM) network, and the integration of a bidirectional LSTM network with a CNN (BDLSTM-CNN). To apply those solutions, we first divide the given maritime region into M × N grids, then we forecast the inflow and outflow for all the grids. Experimental results based on the real AIS (Automatic Identification System) data of marine vessels in Singapore demonstrate that the three deep learning-based solutions significantly outperform the conventional method in terms of mean absolute error and root mean square error, with the performance of the BDLSTM-CNN-based hybrid solution being the best.


2021 ◽  
Vol 53 (2) ◽  
Author(s):  
Sen Yang ◽  
Yaping Zhang ◽  
Siu-Yeung Cho ◽  
Ricardo Correia ◽  
Stephen P. Morgan

AbstractConventional blood pressure (BP) measurement methods have different drawbacks such as being invasive, cuff-based or requiring manual operations. There is significant interest in the development of non-invasive, cuff-less and continual BP measurement based on physiological measurement. However, in these methods, extracting features from signals is challenging in the presence of noise or signal distortion. When using machine learning, errors in feature extraction result in errors in BP estimation, therefore, this study explores the use of raw signals as a direct input to a deep learning model. To enable comparison with the traditional machine learning models which use features from the photoplethysmogram and electrocardiogram, a hybrid deep learning model that utilises both raw signals and physical characteristics (age, height, weight and gender) is developed. This hybrid model performs best in terms of both diastolic BP (DBP) and systolic BP (SBP) with the mean absolute error being 3.23 ± 4.75 mmHg and 4.43 ± 6.09 mmHg respectively. DBP and SBP meet the Grade A and Grade B performance requirements of the British Hypertension Society respectively.


2021 ◽  
Vol 2 (2) ◽  
Author(s):  
Kate Highnam ◽  
Domenic Puzio ◽  
Song Luo ◽  
Nicholas R. Jennings

AbstractBotnets and malware continue to avoid detection by static rule engines when using domain generation algorithms (DGAs) for callouts to unique, dynamically generated web addresses. Common DGA detection techniques fail to reliably detect DGA variants that combine random dictionary words to create domain names that closely mirror legitimate domains. To combat this, we created a novel hybrid neural network, Bilbo the “bagging” model, that analyses domains and scores the likelihood they are generated by such algorithms and therefore are potentially malicious. Bilbo is the first parallel usage of a convolutional neural network (CNN) and a long short-term memory (LSTM) network for DGA detection. Our unique architecture is found to be the most consistent in performance in terms of AUC, $$F_1$$ F 1 score, and accuracy when generalising across different dictionary DGA classification tasks compared to current state-of-the-art deep learning architectures. We validate using reverse-engineered dictionary DGA domains and detail our real-time implementation strategy for scoring real-world network logs within a large enterprise. In 4 h of actual network traffic, the model discovered at least five potential command-and-control networks that commercial vendor tools did not flag.


2021 ◽  
Author(s):  
Chonghua Xue ◽  
Cody Karjadi ◽  
Ioannis Ch. Paschalidis ◽  
Rhoda Au ◽  
Vijaya B. Kolachalama

AbstractBackgroundIdentification of reliable, affordable and easy-to-use strategies for detection of dementia are sorely needed. Digital technologies, such as individual voice recordings, offer an attractive modality to assess cognition but methods that could automatically analyze such data without any pre-processing are not readily available.MethodsWe used a subset of 1264 digital voice recordings of neuropsychological examinations administered to participants from the Framingham Heart Study (FHS), a community-based longitudinal observational study. The recordings were 73 minutes in duration, on average, and contained at least two speakers (participant and clinician). Of the total voice recordings, 483 were of participants with normal cognition (NC), 451 recordings were of participants with mild cognitive impairment (MCI), and 330 were of participants with dementia. We developed two deep learning models (a two-level long short-term memory (LSTM) network and a convolutional neural network (CNN)), which used the raw audio recordings to classify if the recording included a participant with only NC or only dementia, and also to differentiate between recordings corresponding to non-demented (NC+MCI) and demented participants.FindingsBased on 5-fold cross-validation, the LSTM model achieved a mean (±std) area under the sensitivity-specificity curve (AUC) of 0.744±0.038, mean accuracy of 0.680±0.032, mean sensitivity of 0.719±0.112, and mean specificity of 0.652±0.089 in predicting cases with dementia from those with normal cognition. The CNN model achieved a mean AUC of 0.805±0.027, mean accuracy of 0.740±0.033, mean sensitivity of 0.735±0.094, and mean specificity of 0.750±0.083 in predicting cases with only dementia from those with only NC. For the task related to classification of demented participants from non-demented ones, the LSTM model achieved a mean AUC of 0.659±0.043, mean accuracy of 0.701±0.057, mean sensitivity of 0.245±0.161 and mean specificity of 0.856±0.105. The CNN model achieved a mean AUC of 0.730±0.039, mean accuracy of 0.735±0.046, mean sensitivity of 0.443±0.113, and mean specificity of 0.840±0.076 in predicting cases with dementia from those who were not demented.InterpretationThis proof-of-concept study demonstrates the potential that raw audio recordings of neuropsychological testing performed on individuals recruited within a community cohort setting can provide a level of screening for dementia.


2021 ◽  
Author(s):  
Sophie Jacqueline Andree Betka ◽  
David Watson ◽  
Sarah N Garfinkel ◽  
Gaby Pfeifer ◽  
Henrique Sequeira ◽  
...  

Objective: Emotional states are expressed in body and mind through subjective experience of physiological changes. In previous work, subliminal priming of anger prior to lexical decisions increased systolic blood pressure (SBP). This increase predicted the slowing of response times (RT), suggesting that baroreflex-related autonomic changes and their interoceptive (feedback) representations, influence cognition. Alexithymia is a subclinical affective dysfunction characterized by difficulty in identifying emotions. Atypical autonomic and interoceptive profiles are observed in alexithymia. Therefore, we sought to identify mechanisms through which SBP fluctuations during emotional processing might influence decision-making, including whether alexithymia contributes to this relationship. Methods Thirty-two male participants performed an affect priming paradigm and completed the Toronto Alexithymia Scale. Emotional faces were briefly presented (20ms) prior a short-term memory task. RT, accuracy and SBP were recorded on a trial-by-trial basis. Generalized mixed-effects linear models were used to evaluate the impact of emotion, physiological changes, alexithymia score, and their interactions, on performances. Results A main effect of emotion was observed on accuracy. Participants were more accurate on trials with anger primes, compared to neutral priming. Greater accuracy was related to increased SBP. An interaction between SBP and emotion was observed on RT: Increased SBP was associated with RT prolongation in the anger priming condition, yet this relationship was absent under the sadness priming. Alexithymia did not significantly moderate the above relationships. Conclusions Our data suggest that peripheral autonomic responses during affective challenges guide cognitive processes. We discuss our findings in the theoretical framework proposed by Lacey and Lacey (1970).


2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Ludi Wang ◽  
Wei Zhou ◽  
Ying Xing ◽  
Xiaoguang Zhou

The prevention, evaluation, and treatment of hypertension have attracted increasing attention in recent years. As photoplethysmography (PPG) technology has been widely applied to wearable sensors, the noninvasive estimation of blood pressure (BP) using the PPG method has received considerable interest. In this paper, a method for estimating systolic and diastolic BP based only on a PPG signal is developed. The multitaper method (MTM) is used for feature extraction, and an artificial neural network (ANN) is used for estimation. Compared with previous approaches, the proposed method obtains better accuracy; the mean absolute error is 4.02 ± 2.79 mmHg for systolic BP and 2.27 ± 1.82 mmHg for diastolic BP.


Sensors ◽  
2019 ◽  
Vol 19 (9) ◽  
pp. 2137 ◽  
Author(s):  
Soojeong Lee ◽  
Gangseong Lee ◽  
Gwanggil Jeon

Oscillometric blood pressure (BP) monitors currently estimate a single point but do not identify variations in response to physiological characteristics. In this paper, to analyze BP’s normality based on oscillometric measurements, we use statistical approaches including kurtosis, skewness, Kolmogorov-Smirnov, and correlation tests. Then, to mitigate uncertainties, we use a deep learning method to determine the confidence limits (CLs) of BP measurements based on their normality. The proposed deep learning regression model decreases the standard deviation of error (SDE) of the mean error and the mean absolute error and reduces the uncertainties of the CLs and SDEs of the proposed technique. We validate the normality of the distribution of the BP estimation which fits the standard normal distribution very well. We use a rank test in the deep learning technique to demonstrate the independence of the artificial systolic BP and diastolic BP estimations. We perform statistical tests to verify the normality of the BP measurements for individual subjects. The proposed methodology provides accurate BP estimations and reduces the uncertainties associated with the CLs and SDEs using the deep learning algorithm.


Symmetry ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1942
Author(s):  
Pyae Pyae Phyo ◽  
Yung-Cheol Byun

The energy manufacturers are required to produce an accurate amount of energy by meeting the energy requirements at the end-user side. Consequently, energy prediction becomes an essential role in the electric industrial zone. In this paper, we propose the hybrid ensemble deep learning model, which combines multilayer perceptron (MLP), convolutional neural network (CNN), long short-term memory (LSTM), and hybrid CNN-LSTM to improve the forecasting performance. These DL architectures are more popular and better than other machine learning (ML) models for time series electrical load prediction. Therefore, hourly-based energy data are collected from Jeju Island, South Korea, and applied for forecasting. We considered external features associated with meteorological conditions affecting energy. Two-year training and one-year testing data are preprocessed and arranged to reform the times series, which are then trained in each DL model. The forecasting results of the proposed ensemble model are evaluated by using mean square error (MSE), mean absolute error (MAE), and mean absolute percentage error (MAPE). Error metrics are compared with DL stand-alone models such as MLP, CNN, LSTM, and CNN-LSTM. Our ensemble model provides better performance than other forecasting models, providing minimum MAPE at 0.75%, and was proven to be inherently symmetric for forecasting time-series energy and demand data, which is of utmost concern to the power system sector.


2021 ◽  
Vol 15 ◽  
Author(s):  
Alexander Malafeev ◽  
Anneke Hertig-Godeschalk ◽  
David R. Schreier ◽  
Jelena Skorucak ◽  
Johannes Mathis ◽  
...  

Brief fragments of sleep shorter than 15 s are defined as microsleep episodes (MSEs), often subjectively perceived as sleepiness. Their main characteristic is a slowing in frequency in the electroencephalogram (EEG), similar to stage N1 sleep according to standard criteria. The maintenance of wakefulness test (MWT) is often used in a clinical setting to assess vigilance. Scoring of the MWT in most sleep-wake centers is limited to classical definition of sleep (30 s epochs), and MSEs are mostly not considered in the absence of established scoring criteria defining MSEs but also because of the laborious work. We aimed for automatic detection of MSEs with machine learning, i.e., with deep learning based on raw EEG and EOG data as input. We analyzed MWT data of 76 patients. Experts visually scored wakefulness, and according to recently developed scoring criteria MSEs, microsleep episode candidates (MSEc), and episodes of drowsiness (ED). We implemented segmentation algorithms based on convolutional neural networks (CNNs) and a combination of a CNN with a long-short term memory (LSTM) network. A LSTM network is a type of a recurrent neural network which has a memory for past events and takes them into account. Data of 53 patients were used for training of the classifiers, 12 for validation and 11 for testing. Our algorithms showed a good performance close to human experts. The detection was very good for wakefulness and MSEs and poor for MSEc and ED, similar to the low inter-expert reliability for these borderline segments. We performed a visualization of the internal representation of the data by the artificial neuronal network performing best using t-distributed stochastic neighbor embedding (t-SNE). Visualization revealed that MSEs and wakefulness were mostly separable, though not entirely, and MSEc and ED largely intersected with the two main classes. We provide a proof of principle that it is feasible to reliably detect MSEs with deep neuronal networks based on raw EEG and EOG data with a performance close to that of human experts. The code of the algorithms (https://github.com/alexander-malafeev/microsleep-detection) and data (https://zenodo.org/record/3251716) are available.


Entropy ◽  
2020 ◽  
Vol 22 (5) ◽  
pp. 517 ◽  
Author(s):  
Ali M. Hasan ◽  
Mohammed M. AL-Jawad ◽  
Hamid A. Jalab ◽  
Hadil Shaiba ◽  
Rabha W. Ibrahim ◽  
...  

Many health systems over the world have collapsed due to limited capacity and a dramatic increase of suspected COVID-19 cases. What has emerged is the need for finding an efficient, quick and accurate method to mitigate the overloading of radiologists’ efforts to diagnose the suspected cases. This study presents the combination of deep learning of extracted features with the Q-deformed entropy handcrafted features for discriminating between COVID-19 coronavirus, pneumonia and healthy computed tomography (CT) lung scans. In this study, pre-processing is used to reduce the effect of intensity variations between CT slices. Then histogram thresholding is used to isolate the background of the CT lung scan. Each CT lung scan undergoes a feature extraction which involves deep learning and a Q-deformed entropy algorithm. The obtained features are classified using a long short-term memory (LSTM) neural network classifier. Subsequently, combining all extracted features significantly improves the performance of the LSTM network to precisely discriminate between COVID-19, pneumonia and healthy cases. The maximum achieved accuracy for classifying the collected dataset comprising 321 patients is 99.68%.


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