scholarly journals Antioxidant Properties and Reported Ethnomedicinal Use of the Genus Echium (Boraginaceae)

Antioxidants ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 722
Author(s):  
Ju Jin ◽  
Mark Boersch ◽  
Akshaya Nagarajan ◽  
Andrew K. Davey ◽  
Matthew Zunk
Keyword(s):  
Traditional Medicine ◽  
Antioxidant Properties ◽  
Future Research ◽  
Antiviral Effects ◽  
Pharmacological Studies ◽  
Phytochemical Components ◽  
Ethnomedicinal Uses ◽  
First Time

The genus Echium L. from the Boraginaceae family consists of 67 recognised species. The genus is widely distributed in the Mediterranean, having been documented in the traditional medicine of the area since 300 B.C. Current pharmacological studies have validated early ethnomedicinal properties showing that Echium spp. possesses antioxidant, analgesic, anxiolytic, anti-inflammatory, antibacterial, and antiviral effects. Nevertheless, only limited papers report specifically on the phytochemistry of this genus. Furthermore, the potential of utilising extracts from Echium species as natural antioxidant preparations has been significantly neglected. For the first time, this review comprehensively describes and discusses the presence of recorded Echium species with ethnomedicinal uses, their antioxidative properties in vitro and in vivo when available, and major phytochemical components recognised as potent antioxidants, as well as the possibilities and opportunities for future research.

scholarly journals The Genus Lagochilus (Lamiaceae): A Review of Its Diversity, Ethnobotany, Phytochemistry, and Pharmacology

Plants ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 132
Author(s):  
Nilufar Z. Mamadalieva ◽  
Davlat Kh. Akramov ◽  
Ludger A. Wessjohann ◽  
Hidayat Hussain ◽  
Chunlin Long ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Chemical Constituents ◽  
Iridoid Glycosides ◽  
Herbal Medicines ◽  
Future Research ◽  
South Central ◽  
Pharmacological Studies ◽  
Central South

The genus Lagochilus (Lamiaceae) is native to Central, South-Central, and Eastern Asia. It comprises 44 species, which have been commonly used as herbal medicines for the treatments of various ailments for thousands of years, especially in Asian countries. This review aims to summarize the chemical constituents and pharmacological activities of species from the genus Lagochilus to unveil opportunities for future research. In addition, we provide some information about their traditional uses, botany, and diversity. More than 150 secondary metabolites have been reported from Lagochilus, including diterpenes, flavonoids, phenolic compounds, triterpenoids, iridoid glycosides, lignans, steroids, alkaloids, polysaccharides, volatile, non-volatile and aromatic compounds, lipids, carbohydrates, minerals, vitamins, and other secondary metabolites. In vitro and in vivo pharmacological studies on the crude extracts, fractions, and isolated compounds from Lagochilus species showed hemostatic, antibacterial, anti-inflammatory, anti-allergic, cytotoxic, enzyme inhibitory, antispasmodic, hypotensive, sedative, psychoactive, and other activities.

scholarly journals Foeniculum vulgareMill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology

2014 ◽  
Vol 2014 ◽  
pp. 1-32 ◽  
Author(s):  
Shamkant B. Badgujar ◽  
Vainav V. Patel ◽  
Atmaram H. Bandivdekar
Keyword(s):  
Traditional Medicine ◽  
Scientific Evidence ◽  
New Drugs ◽  
Future Research ◽  
Foeniculum Vulgare ◽  
Wide Range ◽  
Research Findings ◽  
Valuable Compounds

Foeniculum vulgareMill commonly called fennel has been used in traditional medicine for a wide range of ailments related to digestive, endocrine, reproductive, and respiratory systems. Additionally, it is also used as a galactagogue agent for lactating mothers. The review aims to gather the fragmented information available in the literature regarding morphology, ethnomedicinal applications, phytochemistry, pharmacology, and toxicology ofFoeniculum vulgare. It also compiles available scientific evidence for the ethnobotanical claims and to identify gaps required to be filled by future research. Findings based on their traditional uses and scientific evaluation indicates thatFoeniculum vulgareremains to be the most widely used herbal plant. It has been used for more than forty types of disorders. Phytochemical studies have shown the presence of numerous valuable compounds, such as volatile compounds, flavonoids, phenolic compounds, fatty acids, and amino acids. Compiled data indicate their efficacy in severalin vitroandin vivopharmacological properties such as antimicrobial, antiviral, anti-inflammatory, antimutagenic, antinociceptive, antipyretic, antispasmodic, antithrombotic, apoptotic, cardiovascular, chemomodulatory, antitumor, hepatoprotective, hypoglycemic, hypolipidemic, and memory enhancing property.Foeniculum vulgarehas emerged as a good source of traditional medicine and it provides a noteworthy basis in pharmaceutical biology for the development/formulation of new drugs and future clinical uses.

scholarly journals Antiviral Activity of Resveratrol against Human and Animal Viruses

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Yusuf Abba ◽  
Hasliza Hassim ◽  
Hazilawati Hamzah ◽  
Mohamed Mustapha Noordin
Keyword(s):  
Gene Expression ◽  
Viral Infections ◽  
Antioxidant Properties ◽  
Acid Synthesis ◽  
Antioxidant Effect ◽  
Viral Diseases ◽  
Polyphenolic Compound ◽  
Antiviral Effects

Resveratrol is a potent polyphenolic compound that is being extensively studied in the amelioration of viral infections bothin vitroandin vivo. Its antioxidant effect is mainly elicited through inhibition of important gene pathways like the NF-κβpathway, while its antiviral effects are associated with inhibitions of viral replication, protein synthesis, gene expression, and nucleic acid synthesis. Although the beneficial roles of resveratrol in several viral diseases have been well documented, a few adverse effects have been reported as well. This review highlights the antiviral mechanisms of resveratrol in human and animal viral infections and how some of these effects are associated with the antioxidant properties of the compound.

Dichrostachys cinerea: Ethnomedicinal uses, phytochemistry and pharmacological activities - A review

2021 ◽  
Vol 11 ◽  
Author(s):  
Ofentse Mazimba ◽  
Tebogo E. Kwape ◽  
Goabaone Gaobotse
Keyword(s):  
Traditional Medicine ◽  
Animal Studies ◽  
Biological Activities ◽  
Root Extract ◽  
Dichrostachys Cinerea ◽  
Snake Bites ◽  
Wide Range ◽  
Ethnomedicinal Uses

: Indigenous and medicinal plants have proven crucial to the health of mankind for a very long time. Dichrostachys cinerea is a traditional herb used in the treatment of a variety of human diseases in African and Indian traditional medicine. This paper reviews the ethnomedicinal uses, phytochemical constituents, pharmacology and toxicity of D. cinerea, in order to provide scientific consensus for further research and exploitation of its therapeutic potential of this plant. Information was accessed by literature searches in different sources including Science direct, PubMed and Google Scholar. The findings of this review paper highlight D. Cinerea as an important component of African and Indian traditional medicine. D. cinerea is traditionally used in the treatment of rheumatism, diabetes, coughs, asthma, kidney disorders, gonorrhea, syphilis, malaria, tuberculosis, epilepsy, snake bites, pains, wounds, boils, burns, toothache, headache, and scabies. D. cinerea displays a diverse phytochemistry, with a wide range of isolated compounds that have well documented biological activities. D. cinerea has demonstrated both in vitro and in vivo biological activities. In vitro biological activities exhibited include enzyme inhibition, antibacterial, anti-fungal and anti-malarial activities. In vivo activities demonstrated by D. cinerea include anti-inflammatory, anti-diarrheal, anti-analgesic, hepatoprotective, anti-uro lithiatic, anti-lice, anti-dandruff and neuropharmacological activities. Animal studies have elucidated non-toxicity of D. cinerea for the ethanol root extract and methanol and water leaf extracts. It is vital that future studies on D. cinerea focus on the mechanisms of action behind these biological activities for both the crude extract and its individual chemical compounds. These studies could possibly lead to clinical trials to confirm biological activities found in animal studies. Further studies on multi-target network pharmacology, and molecular docking technology of D. cinerea sub fractions for enzyme inhibitions and neuropharmacological activities are of great importance and could accelerate the process of pharmaceutical development of this plant.

scholarly journals Phytochemical Profile and Antioxidant Properties of Bee-Collected Artichoke (Cynara scolymus) Pollen

Antioxidants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1091
Author(s):  
Aleksandar Ž. Kostić ◽  
Danijel D. Milinčić ◽  
Nebojša Nedić ◽  
Uroš M. Gašić ◽  
Bojana Špirović Trifunović ◽  
...  
Keyword(s):  
Antioxidant Properties ◽  
Reducing Power ◽  
Dry Weight ◽  
Cynara Scolymus ◽  
Nutritional Analysis ◽  
Extractable Fraction ◽  
First Time ◽  
Excellent Source

The current study intended to determine, for the first time, phenolic and fatty acid profile, antioxidant and certain nutritional properties of monofloral bee-collected artichoke (Cynara scolymus) pollen. Based on UHPLC-DAD MS-MS analysis the main phenolics in extractable fraction were different flavonol glycosides (in particular Isorhamnetin-3-O-glucoside, 49.2 mg/kg of dry weight) while ferulic acid was the predominant phenolic compound (39.4 mg/kg of dry weight) in the alkaline hydrolyzable fraction. Among fatty acids (FAs), results of GC-FID analysis revealed prevalence of unsaturated FAs with cis-5,8,11,14,17-eicosapentaenoic acid (EPA) and oleic acid as the main ones- 28.4% and 24.9%, respectively. Based on the FA composition, nutritional analysis proved that artichoke bee-collected pollen had balanced ω-6 and ω-3 FAs content. To determine the antioxidant properties of pollen, five different assays were applied. It was proved that bioactive compounds in artichoke pollen possessed significant ability to quench DPPH radical as well as ABTS radical cation. In addition, in vitro phosphomolybdenum assay confirmed that artichoke pollen is an excellent source of different antioxidants. Pollen extracts exhibited moderate ferric reducing power as well as low ferrous chelating ability. Some further antioxidant studies (preferably in vivo) should be performed to confirm the observed results.

scholarly journals A Study on the Quality and Identity of Brazilian Pampa Biome Honey: Evidences for Its Beneficial Effects against Oxidative Stress and Hyperglycemia

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
L. C. Cruz ◽  
J. E. S. Batista ◽  
A. P. P. Zemolin ◽  
M. E. M. Nunes ◽  
D. B. Lippert ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Antioxidant Properties ◽  
High Concentration ◽  
Beneficial Effects ◽  
Pampa Biome ◽  
First Time

We characterized, for the first time, the quality and identity of Brazilian Pampa biome honey and its antioxidant propertiesin vitro(FRAP, DDPH and ABTS). The potential protective effect of honey against oxidative stress induced by iron (Fe) and paraquat, (PQ) in aDrosophila melanogastermodel (in vivo) was also tested. The results indicated that all honey samples tested showed antioxidant activityin vitro. Flies treated with honey showed increased lifespan and were protected against oxidative stress induced by Fe and PQ. Despite the high concentration of sugars in honey (approximately 70–80%), our results demonstrate a hypoglycemic-like effect of honey inDrosophila. Thus, this study demonstrates the high quality of Brazilian Pampa biome honey as well as its significant antioxidant activityin vitroandin vivo, pointing to the potential use of this natural product as an alternative in the therapy of oxidative stress-associated diseases.

scholarly journals Lichen Depsidones with Biological Interest

Planta Medica ◽  
2021 ◽  
Author(s):  
Isabel Ureña-Vacas ◽  
Elena González-Burgos ◽  
Pradeep Kumar Divakar ◽  
M. Pilar Gómez-Serranillos
Keyword(s):  
Clinical Trials ◽  
Antioxidant Properties ◽  
Cytotoxic Agents ◽  
In Vivo Studies ◽  
Future Research ◽  
Candida Spp ◽  
In Vivo Models ◽  
Biological Interest

AbstractDepsidones are some of the most abundant secondary metabolites produced by lichens. These compounds have aroused great pharmacological interest due to their activities as antioxidants, antimicrobial, and cytotoxic agents. Hence, this paper aims to provide up-to-date knowledge including an overview of the potential biological interest of lichen depsidones. So far, the most studied depsidones are fumarprotocetraric acid, lobaric acid, norstictic acid, physodic acid, salazinic acid, and stictic acid. Their pharmacological activities have been mainly investigated in in vitro studies and, to a lesser extent, in in vivo studies. No clinical trials have been performed yet. Depsidones are promising cytotoxic agents that act against different cell lines of animal and human origin. Moreover, these compounds have shown antimicrobial activity against both Gram-positive and Gram-negative bacteria and fungi, mainly Candida spp. Furthermore, depsidones have antioxidant properties as revealed in oxidative stress in vitro and in vivo models. Future research should be focused on further investigating the mechanism of action of depsidones and in evaluating new potential actions as well as other depsidones that have not been studied yet from a pharmacological perspective. Likewise, more in vivo studies are prerequisite, and clinical trials for the most promising depsidones are encouraged.

Review of the Ethnopharmacology, Phytochemistry, and Pharmacology of the Genus Veronica

2019 ◽  
Vol 47 (06) ◽  
pp. 1193-1221
Author(s):  
Haibing Xue ◽  
Kai-Xian Chen ◽  
Liu-Qiang Zhang ◽  
Yi-Ming Li
Keyword(s):  
Clinical Practice ◽  
Traditional Medicine ◽  
Respiratory Diseases ◽  
Flowering Plant ◽  
Plant Family ◽  
Iridoid Glucosides ◽  
Pharmacological Studies ◽  
Hepatoprotective Effects

Veronica is the largest genus in the flowering plant family Plantaginaceae and comprises approximately 500 species. The genus was formerly placed in the Scrophulariaceae family, some species of which have been used in traditional medicine for the treatment of influenza, respiratory diseases, hemoptysis, laryngopharyngitis, cough, hernia, cancer, edema, and wounds. This review comprehensively summarizes the current information on the traditional uses, phytochemistry, and pharmacology of the genus Veronica on the basis of articles published from 1970 to 2018. More than 260 compounds have been isolated, and chemotaxonomic investigations of Veronica have revealed that iridoid glucosides — including aucubin, catalpol, and 6-[Formula: see text]-catalpol derivatives — are characteristic of this genus. Modern pharmacological studies and clinical practice have demonstrated that extracts or monomeric compounds from Veronica have several pharmacological actions, such as anti-inflammatory, anti-oxidative, anticancer, antibacterial, anti-angiogenic, antineurodegenerative, neuroprotective, and hepatoprotective effects both in vivo and in vitro.

scholarly journals Maerua edulis (Gilg & Gilg-Ben.) DeWolf: A review of its ethnomedicinal uses, phytochemistry and pharmacological properties

2020 ◽  
Vol 11 (4) ◽  
pp. 5089-5096
Author(s):  
Alfred Maroyi
Keyword(s):  
Traditional Medicine ◽  
Fungal Infections ◽  
Future Research ◽  
Pharmacological Properties ◽  
Ethnoveterinary Medicine ◽  
Scientific Publications ◽  
Sexually Transmitted ◽  
Phytochemical Compounds ◽  
Ethnomedicinal Uses

Maerua edulis (Gilg & Gilg-Ben.) DeWolf  is collected from the wild for its edible fruits and also used as traditional medicine. This study is aimed at evaluating the ethnomedicinal uses, phytochemistry and pharmacological properties of M. edulis. Results of the current study are based on data derived from several online databases such as Scopus, Google Scholar, PubMed and Science Direct, and pre-electronic sources such as scientific publications, books, dissertations, book chapters and journal articles. This study revealed that the bark, fruit, leaf, root and tuber infusion and decoction of M. edulis  are mainly used as a thirst quencher and ethnoveterinary medicine, and traditional medicine for eye infections, stomach ache, infertility in women, wounds, fungal infections, rheumatic swellings, cough and tuberculosis and sexually transmitted diseases. Phytochemical compounds identified from the species include agmatine, betaines, cardiac glycosides, fatty acids, flavonoids and quaternary ammonium compounds. Ethnopharmacological research revealed that M. edulis extracts and compounds isolated from the species have acaricidal, anthelmintic, antibacterial, antimycobacterial, antifungal, antiproliferative and insecticidal activities. Future research on M. edulis should focus on the possible biochemical mechanisms of both the crude extracts and identified phytochemical compounds including toxicological, in vivo and clinical studies to corroborate the traditional medicinal applications of the species.

Neuropharmacological Profile and Chemical Analysis of Moroccan Ormenis mixta L.

2018 ◽  
Vol 16 (S1) ◽  
pp. S55-S64
Author(s):  
G. Hajjaj ◽  
A. Bahlouli ◽  
M. Tajani ◽  
K. Alaoui ◽  
Y. Cherrah ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Body Weight ◽  
Traditional Medicine ◽  
Behavioral Tests ◽  
Phytochemical Screening ◽  
Activity Profile ◽  
Acute Toxicity Study ◽  
Pharmacological Studies

Ormenis mixta L. is traditionally used for central nervous system (CNS)-related diseases. Its anti-stress properties have received attention in Moroccan traditional medicine and aromatherapy. However, no pharmacological studies have yet been undertaken on this plant in Morocco. The present study provides a preliminary phytochemical screening and psychopharmacological profile of the essential oil and aqueous extract from Ormenis mixta L. by using behavioral tests in vivo, at graded doses. The result of this research shows that Ormenis mixta L. was safe up to 2 g/kg b.w. (body weight) in the acute toxicity study, possesses potential psychostimulant effect, and has antianxiety and antidepressant-like activity. This activity profile of Ormenis mixta L. was similar to the typical psychostimulant, caffeine. The exact mechanism of action underlying this stimulant-like effect should be clarified with further detailed studies. These results explained the extensive use of Ormenis mixta L. as a traditional medicine in Morocco.

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