scholarly journals Efficacy of Intra-Operative Topical Wound Anaesthesia to Mitigate Piglet Castration Pain—A Large, Multi-Centred Field Trial

Animals ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 2763
Author(s):  
Meredith Sheil ◽  
Giulia Maria De Benedictis ◽  
Annalisa Scollo ◽  
Suzanne Metcalfe ◽  
Giles Innocent ◽  
...  
Keyword(s):  
Field Trial ◽  
Animal Ethics ◽  
Skin Incision ◽  
Commercial Production ◽  
Vocal Response ◽  
Neonatal Piglets ◽  
Vocal Responses ◽  
Post Operative Pain ◽  
On Farm ◽  
Production Conditions

Piglet castration results in acute pain and stress to the animal. There is a critical need for effective on-farm methods of pain mitigation. Local anaesthesia using Tri-Solfen® (Animal Ethics Pty Ltd., Melbourne, Australia), a topical local anaesthetic and antiseptic formulation instilled to the wound during surgery, is a newly evolving on-farm method to mitigate castration pain. To investigate the efficacy of Tri-Solfen®, instilled to the wound during the procedure, to alleviate subsequent castration-related pain in neonatal piglets, we performed a large, negatively controlled, randomised field trial in two commercial pig farms in Europe. Piglets (173) were enrolled and randomised to undergo castration with or without Tri-Solfen®, instilled to the wound immediately following skin incision. A 30 s wait period was then observed prior to completing castration. Efficacy was investigated by measuring pain-induced motor and vocal responses during the subsequent procedure and post-operative pain-related behaviour in treated versus untreated piglets. There was a significant reduction in nociceptive motor and vocal response during castration and in the post-operative pain-related behaviour response in Tri-Solfen®-treated compared to untreated piglets, in the first 30 min following castration. Although not addressing pain of skin incision, Tri-Solfen® is effective to mitigate subsequent acute castration-related pain in piglets under commercial production conditions.

Powder Metallurgy Aluminum Alloys: Structure and Porosity

2019 ◽  
Author(s):  
Will Judge ◽  
Georges Kipouros
Keyword(s):  
Powder Metallurgy ◽  
Aluminum Alloys ◽  
Material Properties ◽  
Cost Effective ◽  
High Reactivity ◽  
Commercial Production ◽  
Processing Conditions ◽  
Near Net Shape ◽  
And Performance ◽  
Production Conditions

The production of aluminum alloys through powder metallurgy (PM) processes allows for the manufacture of net- or near-net-shape components in a cost-effective and sustainable manner. The high reactivity of aluminum metal, however, complicates PM processing, and special attention must be given to certain steps during production, particularly sintering. PM processing conditions strongly affect the structure and porosity of aluminum PM alloys, which ultimately determine their material properties and performance. In this article, the fundamental aspects of the commercial production of aluminum PM alloys are presented, along with the effects of production conditions on the structure and porosity of aluminum PM alloys. The properties and performance of aluminum PM alloys are then analyzed and interpreted with respect to their structure and porosity.

scholarly journals Evaluation of physical euthanasia for neonatal piglets on-farm

2020 ◽  
Vol 98 (7) ◽  
Author(s):  
Filipe Antonio Dalla Costa ◽  
Troy J Gibson ◽  
Steffan Edward Octávio Oliveira ◽  
Neville George Gregory ◽  
Arlei Coldebella ◽  
...  
Keyword(s):  
Nasal Bone ◽  
Occipital Lobe ◽  
Total Power ◽  
Weight Class ◽  
Blunt Force ◽  
Concrete Floor ◽  
Neonatal Piglets ◽  
Blunt Force Trauma ◽  
Beta Power ◽  
On Farm

Abstract Twenty-seven neonate piglets (range from 0.35 to 1.17 kg) were evaluated for the effectiveness of blunt force trauma as a method of on-farm cull. Brainstem function, brain injury, and hemorrhage scores (increasing from 0 to 3) were assessed after striking the head against a concrete floor. Electroencephalograms (EEG) from a subset of 15 piglets were recorded before and after blunt force trauma for electrophysiological assessments. Blunt force trauma was performed by a single experienced farmer in a commercial farm by holding the piglet by its both hind legs and striking the head against the concrete floor. All piglets remained recumbent and did not show brainstem reflexes. Only one piglet did not presented tonic/clonic physical activity. The mean time to the onset of persistent isoelectric EEG was 64.3 ± 7.3 s (range 18 to 115). Total power, theta, alpha, and beta power decreased to approximately 45%, 30%, 20%, and 15% from pretreatment power, respectively, by 15-s post-impact. There were no periods of normal-like EEG after the culling. Bruises in the neck and shoulder were found in 67% and 70% of piglets, respectively. All piglets presented skull fractures with 20% having the nasal bone(s) fractured. Brain damage was found in all piglets, mainly in the frontal lobe(s). The occipital lobe(s) presented the greatest frequency of severe damage. The analysis of the radiographs also found a high frequency of fractures in this region. Hemorrhage was most frequent in the frontal, parietal, occipital lobes, and midbrain. When performed correctly with the appropriate weight class, blunt force trauma can be used as an effective method for the on-farm killing of nursing piglets resulting in death. However, this method should not be promoted over more reliable and repeatable cull methods such as captive bolt gun. As with blunt force trauma, there is a significant potential for animal welfare harm associated with inappropriate practice, lack of accuracy, issues with repeatability, and operator fatigue.

Maternal Accommodation in Infant-Directed Speech during Mother's and Twin-Infants' Vocal Interactions

2003 ◽  
Vol 92 (2) ◽  
pp. 481-487 ◽  
Author(s):  
Katsuko Niwano ◽  
Kuniaki Sugai
Keyword(s):  
Fundamental Frequency ◽  
Acoustic Analysis ◽  
The Other ◽  
Vocal Response ◽  
Vocal Responses ◽  
Fraternal Twin ◽  
Maternal Speech ◽  
Vocal Interactions ◽  
Vocal Fundamental Frequency ◽  
At Home

In this study a mother's instinctive accommodations of vocal fundamental frequency (f0) of infant-directed speech to two different infants was explored. Maternal speech directed to individual 3-mo.-old fraternal twin-infants was subjected to acoustic analysis. Natural samples of infant-directed speech were recorded at home. There were differences in the rate of infants' vocal responses. The mother changed her f0 and patterns of intonation contour when she spoke to each infant. When she spoke to the infant whose vocal response was less frequent than the other infant, she used a higher mean f0 and a rising intonation contour more than when she spoke to the other infant. The result suggested that the mother's speech characteristic is not inflexible and that the mother may use a higher f0 and rising contour as a strategy to elicit an infant's less frequent vocal response.

scholarly journals Suffixation influences receivers' behaviour in non-human primates

2015 ◽  
Vol 282 (1807) ◽  
pp. 20150265 ◽  
Author(s):  
Camille Coye ◽  
Karim Ouattara ◽  
Klaus Zuberbühler ◽  
Alban Lemasson
Keyword(s):  
Vocal Response ◽  
Adaptive Responses ◽  
Primate Communication ◽  
Mixed Species ◽  
Vocal Production ◽  
Vocal Responses ◽  
Cercopithecus Diana ◽  
Cercopithecus Campbelli ◽  
Species Groups ◽  
Mixed Species Groups

Compared to humans, non-human primates have very little control over their vocal production. Nonetheless, some primates produce various call combinations, which may partially offset their lack of acoustic flexibility. A relevant example is male Campbell's monkeys ( Cercopithecus campbelli ), which give one call type (‘Krak’) to leopards, while the suffixed version of the same call stem (‘Krak-oo’) is given to unspecific danger. To test whether recipients attend to this suffixation pattern, we carried out a playback experiment in which we broadcast naturally and artificially modified suffixed and unsuffixed ‘Krak’ calls of male Campbell's monkeys to 42 wild groups of Diana monkeys ( Cercopithecus diana diana ). The two species form mixed-species groups and respond to each other's vocalizations. We analysed the vocal response of male and female Diana monkeys and overall found significantly stronger vocal responses to unsuffixed (leopard) than suffixed (unspecific danger) calls. Although the acoustic structure of the ‘Krak’ stem of the calls has some additional effects, subject responses were mainly determined by the presence or the absence of the suffix. This study indicates that suffixation is an evolved function in primate communication in contexts where adaptive responses are particularly important.

scholarly journals Scalpel versus diathermy skin incision: a randomised clinical trial

2019 ◽  
Vol 7 (1) ◽  
pp. 258
Author(s):  
Monali Patole Mukherjee ◽  
Mandar Madhukar Patole
Keyword(s):  
Randomised Clinical Trial ◽  
Skin Incision ◽  
Tissue Destruction ◽  
Incised Wound ◽  
Medical College ◽  
Post Operative Pain ◽  
Insignificant Difference ◽  
Scalpel Blade ◽  
Main Thing ◽  
The One

Background: Scalpel skin incision produces a clean, incised wound with minimal tissue destruction. Cutting diathermy also produces an incised wound that heals as well as the one that is created by cold scalpel but with an added advantage of achieving quick hemostasis and saving operative time. The main thing of the present study is to verify and compare the usefulness of diathermy skin incision vs. scalpel skin incision in general surgical patients.Methods: The study was conducted in Medical College and Hospital, in 60 patients randomly selected for diathermy and scalpel incision, between 14-65 years age group, between January 2011-June 2012. Post operative pain, seroma, hematoma, discharge were observed and results were analyzed and compared for the two groups using Mann-Whitney U Test.Results: Diathermy group, with incision related time of 6.20±0.97 sec/cm, was significantly quicker (p=0.003) than scalpel incision, with incision time of 6.76±0.84 sec/cm. Postoperative pain scores, recorded daily over five days, showed insignificant difference between the two groups.Conclusions: We demonstrate that the diathermy provides efficient cutting of skin, with no superior wound-healing profile, comparable to that of the traditional scalpel blade.

scholarly journals Optimal Methods of Documenting Analgesic Efficacy in Neonatal Piglets Undergoing Castration

2020 ◽  
Author(s):  
Meredith Sheil ◽  
Adam Polkinghorne
Keyword(s):  
Analgesic Efficacy ◽  
Vocal Response ◽  
Sensory Threshold ◽  
Optimal Methods ◽  
Neonatal Piglets ◽  
Threshold Response ◽  
Literature Base ◽  
High Degree ◽  
Response Testing ◽  
Proof Of Efficacy

Analgesic products for piglet castration are critically needed. This requires extensive animal experimentation such as to meet regulatory-required proof of efficacy. At present, there are no validated methods of assessing pain in neonatal piglets. This poses challenges for investigators to optimize trial design and to meet ethical obligations to minimize the number of animals needed. Pain in neonatal piglets may be subtle, transient and / or variably expressed and, in the absence of validated methods, investigators must rely on using a range of biochemical, physiological and behavioural variables, many of which appear to have very low (or unknown) sensitivity or specificity for documenting pain, or pain-relieving effects. A previous systematic review of this subject was hampered by the high degree of variability in the literature base both in terms of methods used to assess pain and pain mitigation, as well as in outcomes reported. In this setting we provide a narrative review, to assist in determining the optimal methods currently available to detect piglet pain during castration and methods to mitigate castration-induced pain. In overview, the optimal outcome variables identified are nociceptive motor and vocal response scores during castration, and quantitative sensory-threshold response testing and pain-associated behaviour scores following castration.

scholarly journals Optimal Methods of Documenting Analgesic Efficacy in Neonatal Piglets Undergoing Castration

Animals ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1450 ◽  
Author(s):  
Meredith Sheil ◽  
Adam Polkinghorne
Keyword(s):  
Analgesic Efficacy ◽  
Vocal Response ◽  
Sensory Threshold ◽  
Optimal Methods ◽  
Neonatal Piglets ◽  
Threshold Response ◽  
Literature Base ◽  
High Degree ◽  
Response Testing ◽  
Proof Of Efficacy

Analgesic products for piglet castration are critically needed. This requires extensive animal experimentation such as to meet regulatory-required proof of efficacy. At present, there are no validated methods of assessing pain in neonatal piglets. This poses challenges for investigators to optimize trial design and to meet ethical obligations to minimize the number of animals needed. Pain in neonatal piglets may be subtle, transient, and/or variably expressed and, in the absence of validated methods, investigators must rely on using a range of biochemical, physiological and behavioural variables, many of which appear to have very low (or unknown) sensitivity or specificity for documenting pain, or pain-relieving effects. A previous systematic review of this subject was hampered by the high degree of variability in the literature base both in terms of methods used to assess pain and pain mitigation, as well as in outcomes reported. In this setting we provide a narrative review to assist in determining the optimal methods currently available to detect piglet pain during castration and methods to mitigate castration-induced pain. In overview, the optimal outcome variables identified are nociceptive motor and vocal response scores during castration and quantitative sensory-threshold response testing and pain-associated behaviour scores following castration.

scholarly journals Bupivacaine scalp nerve block: hemodynamic response during craniotomy, intraoperative and post-operative analgesia

2010 ◽  
Vol 4 (2) ◽  
pp. 243-251 ◽  
Author(s):  
Lawan Tuchinda ◽  
Wanna Somboonviboon ◽  
Kaew Supbornsug ◽  
Sukhumakorn Worathongchai ◽  
Supodjanee Limutaitip
Keyword(s):  
Hemodynamic Response ◽  
Skin Incision ◽  
Morphine Consumption ◽  
Arterial Blood ◽  
Post Operative Pain ◽  
Morphine Administration ◽  
Group A ◽  
Scalp Block ◽  
Noxious Stimuli ◽  
Group B

Abstract Background: Noxious stimuli during craniotomy may induce hypertension and tachycardia, giving rise to morbidity in patients with intracranial hypertension. Craniotomy is followed by moderate level of postoperative pain. Objective: Evaluate the effectiveness of scalp block on hemodynamic response to noxious stimuli, intraoperative fentanyl requirement and post-operative analgesia. Methods: Sixty patients undergoing elective craniotomy were randomly assigned to receive a scalp block with either 0.5% bupivacaine or 0.25% bupivacaine and 1:200,000 adrenaline (group A and B) or normal saline with 1:200,000 adrenaline (group C). Fentanyl 0.5 mcg/kg was administered for hemodynamic control. Intraoperative mean arterial blood pressure (MAP), heart rate (HR), fentanyl doses, and post-operative pain scores were recorded. Post-operative analgesia was provided by patient-controlled analgesia (PCA) morphine for 24 hours. Results: MAP was greater in group C than group A during pinning and incision (p <0.05), and was greater in group C than group B during pinning, incision and craniotomy (p <0.05). HR differences were not statistically significant between all groups (p >0.05). Intraoperative fentanyl requirement was significantly greater in group C compared with group A and B (p < 0.05). Pain score, time to the first morphine administration and total morphine consumption were not significantly different between all groups. Conclusion: Pre-incision scalp blocks using either 0.25% or 0.5% bupivacaine with 1:200,000 adrenaline were effective to prevent rising of MAP, but not HR in response to cranial pinning and skin incision, causing less intraoperative fentanyl requirement. However, they did not reduce post-craniotomy pain and morphine consumption.

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