scholarly journals Dirofilaria immitis Could Be a Risk Factor for the Development of Allergic Diseases in Humans

Animals ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1847
Author(s):  
José Alberto Montoya-Alonso ◽  
Rodrigo Morchón ◽  
Jorge Isidoro Matos ◽  
Yaiza Falcón-Cordón ◽  
Noelia Costa-Rodriguez ◽  
...  
Keyword(s):  
Risk Factor ◽  
Canary Islands ◽  
Dirofilaria Immitis ◽  
Allergic Diseases ◽  
Specific Ige ◽  
Zoonotic Infection ◽  
Total Ige ◽  
High Prevalence ◽  
Heartworm Infection ◽  
The Relationship

The Canary Islands are hyperendemic for canine heartworm and the risk of zoonotic infection is high. Additionally, there is evidence of development of allergies due to nematode infections in animals and humans. Since the population of the Canary Islands presents high prevalence of allergic comorbidities, and previous studies have shown a possible relationship between allergies and seropositivity to heartworm, the aim was to evaluate whether exposure to heartworm may contribute to the development of allergies in the human population. First, an epidemiological study was conducted on 248 owners of dogs with/without heartworm infection in the Canary Islands. Secondly, a serological analysis of the presence of total IgE and specific IgE against heartworm was conducted in 66 samples of inhabitants of the Canary Islands. The survey showed that allergic owners had heartworm-positive dogs more frequently (p < 0.01). Of the analyzed human samples, 43.9% were seropositive to heartworm and Wolbachia. Total IgE concentrations were increased in 34.5% seropositive samples and 8.1% seronegative samples. Specific IgE against heartworm was only found in human seropositive samples (17.2%). Contact with heartworm may be a risk factor for the development of allergic diseases, although further studies to elucidate the relationship between heartworm and allergies should be carried out.

scholarly journals Clinical manifestations of atopy in children up to two years of age

2011 ◽  
Vol 68 (8) ◽  
pp. 690-695 ◽  
Author(s):  
Nevenka Ilic ◽  
Vesna Velickovic ◽  
Dragoljub Djokic ◽  
Nebojsa Rankovic ◽  
Gordana Kostic ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Clinical Manifestations ◽  
Allergic Diseases ◽  
Developed Countries ◽  
Specific Ige ◽  
Food Allergies ◽  
Atopic Diseases ◽  
Ige Antibodies ◽  
Total Ige

Background/Aim. Atopic diseases such as atopic dermatitis, allergic rhinitis and asthma have had increased prevalence during the past decade and nowadays occur in every third child in developed countries. The aim of the study was to determine frequency and type of atopic diseases at the age of two, as well as the importance the total IgE antibodies concentrations have in diagnosis and prognosis of the disease. Methods. The study involved 175 children up to two years of age. Allergy-like symptoms were found after surveying their parents and pediatric medical records. Using the fluorescence immunossay (FIA) method, total IgE antibodies concentrations and specific IgE antibodies (Phadiatop infant) were determined on an Immunocap 100 Dyagnostic System. Results. One or more allergy-like symptoms accounted for 57.7% of findings in children under the age of two, whilst in 19.4% the existence of IgE-related allergic diseases was found. Atopic diseases usually have clinical manifestations of atopic dermatitis (11.4%), IgE-bound wheezing/asthma (10.8%) and food allergies (7.4%), and to much lesser extent those of allergic rhinitis (3.4%) and urticaria (1.7%). The significantly higher total IgE antibodies concentrations were found in children with allergy-like symptoms (p < 0.0005) (cut-off 15.15 kU/L, sensitivity 76.5% specificity 71.6%). Conclusion. Almost 20% of two-year-old children have any of clinically manifested allergic diseases, with atopic dermatitis and IgE wheeze/asthma being predominant. The higher total IgE antibodies concentration is a good marker for sensitization in children with allergy-like symptoms.

scholarly journals Sensitisation patterns and allergy outcomes in pregnant women living in the urban area

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Hanna Danielewicz ◽  
Anna Dębińska ◽  
Grzegorz Myszczyszyn ◽  
Anna Myszkal ◽  
Lidia Hirnle ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Pregnant Women ◽  
Allergic Disease ◽  
De Novo ◽  
Allergic Diseases ◽  
Specific Ige ◽  
Food Allergens ◽  
Metabolic Complications ◽  
Total Ige ◽  
In Pregnancy

Abstract Background Worldwide, allergy affects more than one billion people, with particularly rising prevalence in industrialised areas. Specifically, young adults appear to be predominantly targeted for an allergy diagnosis. Allergic diseases in pregnancy are mainly pre-existing but could also occur de novo. The immunological changes while pregnant, with increased Th2 lymphocyte activity, can facilitate allergen sensitisation. Objective The aim of this study was to evaluate the pattern of specific IgE (sIgE) sensitisation to common inhalant and food allergens in pregnancy, and assess its relationship to self-reported allergic disease. Methods We assessed 200 pregnant women, aged 20–38 years (mean age = 29 years), participant of ELMA (Epigenetic Hallmark of Maternal Atopy and Diet) study, living in a metropolitan area, with no pregnancy associated metabolic complications, for total IgE and allergen specific IgE to 20 allergens. Results 48% of pregnant women were sensitised to at least one allergen, at a cut-off point of 0.35 kU/L and they were assigned as atopic. However 42% in atopic group were not reporting any allergic disease. The most common inhalant allergens were: pollen (24.5%) and animal dander (23.5%). The most common food allergens were: cow’s milk (5.5%) and apples (4.5%). 7.5% of women reported asthma, 21.5% allergic rhinitis, 11.5% atopic dermatitis and 18.5% food allergy. 8.5% of were taking medication for asthma or allergies. Atopic dermatitis had the highest tendency to become more severe during pregnancy. Total IgE values were significantly higher in atopic women. Conclusions Allergic sensitisation is a common phenomenon in pregnancy. Some sensitisations could be asymptomatic. Further studies should investigate if sensitisation in mothers confers risks for immune alterations in their children.

scholarly journals Lack of Consistent Association between Asthma, Allergic Diseases and Intestinal Helminth Infection in School-Aged Children in the Province of Bengo, Angola

2021 ◽  
Vol 18 (11) ◽  
pp. 6156
Author(s):  
Margarete Arrais ◽  
Ofélia Lulua ◽  
Francisca Quifica ◽  
José Rosado-Pinto ◽  
Jorge M. R. Gama ◽  
...  
Keyword(s):  
Helminth Infection ◽  
Allergic Diseases ◽  
Specific Ige ◽  
Epidemiological Studies ◽  
Cross Sectional Study ◽  
Intestinal Helminth ◽  
Cross Sectional ◽  
Positive Skin ◽  
Helminth Infections ◽  
The Relationship

Epidemiological studies have shown conflicting findings on the relationship between asthma, atopy, and intestinal helminth infections. There are no such studies from Angola; therefore, we aimed to evaluate the relationship between asthma, allergic diseases, atopy, and intestinal helminth infection in Angolan schoolchildren. We performed a cross-sectional study of schoolchildren between September and November 2017. Five schools (three urban, two rural) were randomly selected. Asthma, rhinoconjunctivitis, and eczema were defined by appropriate symptoms in the previous 12 months: atopy was defined by positive skin prick tests (SPT) or aeroallergen-specific IgE; intestinal helminths were detected by faecal sample microscopy. In total, 1023 children were evaluated (48.4% female; 57.6% aged 10–14 years; 60.5% urban). Asthma, rhinoconjunctivitis, or eczema were present in 9%, 6%, and 16% of the studies children, respectively. Only 8% of children had positive SPT, but 64% had positive sIgE. Additionally, 40% were infected with any intestinal helminth (A. lumbricoides 25.9%, T. trichiura 7.6%, and H. nana 6.3%). There were no consistent associations between intestinal helminth infections and asthma, allergic diseases, or atopy, except for A. lumbricoides, which was inversely associated with rhinoconjuctivitis and directly associated with aeroallergen-specific IgE. We concluded that, overall, intestinal helminth infections were not consistently associated with allergic symptoms or atopy. Future, preferably longitudinal, studies should collect more detailed information on helminth infections as part of clusters of environmental determinants of allergies.

scholarly journals THE PREVALENCE AND STRUCTURE OF ALLERGIC DISEASES IN ATHLETES OF THE HIGHEST ACHIEVEMENTS

2012 ◽  
Vol 9 (2) ◽  
pp. 3-8
Author(s):  
N V Shartanova
Keyword(s):  
Early Detection ◽  
Russian Federation ◽  
Athletic Performance ◽  
Drug Allergy ◽  
Allergic Diseases ◽  
Specific Ige ◽  
Pollen Allergens ◽  
High Prevalence ◽  
Skin Prick Tests ◽  
The Russian Federation

Background. To identify the prevalence of allergic diseases, characteristics of the spectrum of allergens in athletes of the highest achievements. Materials and Methods. 417 athletes of the highest achievements were examined (members of the Russian Federation national teams of different sports). To assess the allergic status of the athletes allergological, pharmacological, nutritional histories were collected. Also we used skin prick tests with various groups of allergens, identification of allergen-specific IgE in serum (indicated) to confirm allergy. Results. Among the athletes of highest achievements a high prevalence of AD (24,5%) was revealed. In 20,3% latent sensitization was determined. The sensitization to the domestic and epidermal allergens was predominant (90,2%). In the spectrum of pollen allergens in 62,5% of athletes sensitization to Compositae and Chenopodiaceae pollen was dominated. In structure of AD AR occurred in 50%, hay fever — in 20,5%, urticaria — in 13,7%, drug allergy — in 10,8%, asthma — in 7,8%. Conclusion. Early detection and adequate therapy of AD in athletes will significantly improve the health level and athletic performance.

Canine dirofilariosis caused by Dirofilaria immitis is a risk factor for the human population on the island of Gran Canaria, Canary Islands, Spain

2010 ◽  
Vol 107 (5) ◽  
pp. 1265-1269 ◽  
Author(s):  
Jose Alberto Montoya-Alonso ◽  
Isabel Mellado ◽  
Elena Carretón ◽  
Elena Dolores Cabrera-Pedrero ◽  
Rodrigo Morchón ◽  
...  
Keyword(s):  
Risk Factor ◽  
Canary Islands ◽  
Human Population ◽  
Dirofilaria Immitis ◽  
Gran Canaria

scholarly journals Depression as a risk factor for Alzheimer's disease: evidence and role of Nursing

2019 ◽  
Vol 18 (3) ◽  
pp. 612-642 ◽  
Author(s):  
Rebeca Montoiro Rodriguez ◽  
Alba Elena Martínez Santos ◽  
Raquel Rodríguez-González
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Field Methods ◽  
High Prevalence ◽  
Role Of Nursing ◽  
Diverse Data ◽  
The Relationship ◽  
Progressive Disorder

Introducción: La depresión y la demencia son dos patologías con una alta prevalencia a nivel mundial y multitud de rasgos en común. La demencia es un trastorno de carácter progresivo, siendo la Enfermedad de Alzheimer (EA) el tipo más común. Por su parte, la depresión representa la principal causa mundial de discapacidad. El objetivo de esta revisión es analizar la depresión como factor de riesgo para la EA resaltando, además, el papel de enfermería a nivel preventivo.Métodos: Se realizó una búsqueda bibliográfica sistemática en diversas fuentes de información. Es necesario destacar Pubmed como la principal base de datos a partir de la cual se obtuvieron la mayoría de artículos.Resultados y discusión: Existen principalmente tres hipótesis acerca de la relación depresión-demencia: depresión como factor de riesgo, depresión como pródromo, o depresión y demencia patologías independientes. Son múltiples los aspectos que deben valorarse en cada caso, agregándose así mayor complejidad a las investigaciones. A nivel neurobiológico también está probada la presencia de mecanismos patológicos comunes. Se destaca la prevención como punto clave en el abordaje de estos trastornos, donde enfermería desempeña un importante papel en la detección precoz y la educación para salud.Conclusiones: La depresión como factor de riesgo para la EA ha sido corroborada en numerosos estudios. Pese a ello, sigue sin existir acuerdo definitivo y, por lo tanto, resulta crucial continuar investigando y profundizando en el binomio depresión-demencia Introduction: Depression and dementia are two diseases with a high prevalence worldwide and many features in common. Dementia is a progressive disorder being Alzheimer's Disease the most frequent type. On the other hand, depression represents the first worldwide cause of disability. The objective of this review is to analyze depression as a risk factor in the development of Alzheimer's Disease and to highlight the role of nurses regarding prevention in this field. Methods: A bibliographic systematic search in diverse data bases was done. It is necessary to highlight PubMed as the main data base from which the majority of articles included were obtained.Results and discussion: There are mainly three hypotheses about the relationship between depression and dementia: depression as a risk factor, depression as a prodrome or depression and dementia as two independent pathologies. Moreover, there are a lot of aspects that must be taken into account in each case adding more complexity to the investigations. At the neurobiological level there is also evidence of common pathological mechanisms for both diseases. In addition, prevention has to be emphasized as a key point in the treatment of these disorders and nurses play a crucial role in early diagnosis and health education.Conclusions: Depression as a risk factor to Alzheimer's Disease has been demonstrated in many studies. However, there is not a conclusive agreement and, therefore, it is crucial to continue investigating the relation between depression and dementia.

scholarly journals IMPACT OF ENVIRONMENTAL POLLUTION ON THE PREVALENCE OF ALLERGIC DISEASES AMONG THE EMPLOYEES OF INDUSTRIAL SITES LOCATED AT FORMER URANIUM ORES MINES

2017 ◽  
Vol 14 (6) ◽  
pp. 26-35
Author(s):  
N I Ilina ◽  
L V Luss ◽  
A I Martynov ◽  
S V Tsarev ◽  
V I Astafurov ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Clinical Laboratory ◽  
Clinical Symptoms ◽  
Allergic Diseases ◽  
Inhibitory Mechanism ◽  
Total Ige ◽  
Industrial Sites ◽  
High Prevalence ◽  
Chemical Factors ◽  
Ige Synthesis

The article presents the study of prevalence of allergic diseases among the employees of industrial sites located at former uranium ores mines in Lermontov region. The aim of the research was to study the spectrum of etiologically significant allergens, prevalence and clinical features of allergic diseases among the employees of industrial sites located at former uranium ores mines in Lermontov region. Materials and Methods. Analysis of data of screening questioning, clinical laboratory, functional and allergological methods of examination was performed. Results. The high prevalence of allergic diseases among employees of hydrometallurgical plant (OJSC GMP) and electromechanical plant (LLC EMP): 27,1 and 24,7%, respectively was found. Two employees of OJSC GMP and one of LLC EMPin 2014 had latent sensitization to pollen, but in 2015 demonstrated severe clinical symptoms of allergic rhinitis (AR). Conclusion. Respiratory forms of Ig-Emediated allergy - AR, bronchial asthma (BA) prevailed in the structure of allergic diseases among the employees of industrial sites located at former uranium ores mines in Lermontov region. 19,6% of OJSC GMP and 16,4% of LLC EMP employees showed an increased level of total IgE in the blood serum. No correlation between the increased total IgE and the presence of allergic deseases was established. These results can be explained by the weakening of the T-suppressor inhibitory mechanism that promotes IgE synthesis in response to antigenic stimulation (allergens, chemical factors, etc.).

scholarly journals CMV seropositivity is a potential novel risk factor for severe COVID-19 in non-geriatric patients

2021 ◽  
Author(s):  
Simone Weber ◽  
Victoria Kehl ◽  
Johanna Erber ◽  
Karolin I. Wagner ◽  
Ana-Marija Jetzlsperger ◽  
...  
Keyword(s):  
Risk Factor ◽  
Geriatric Patients ◽  
Prediction Models ◽  
Severe Disease ◽  
Cross Reactivity ◽  
German Population ◽  
Mild Disease ◽  
High Prevalence ◽  
The Relationship ◽  
Cmv Status

Background: COVID-19 has so far affected more than 250 million individuals worldwide, causing more than 5 million deaths. Several risk factors for severe disease have been identified, most of which coincide with advanced age. In younger individuals, severe COVID-19 often occurs in the absence of obvious comorbidities. Guided by the finding of cytomegalovirus (CMV)-specific T cells with some cross-reactivity to SARS-CoV-2 in a COVID-19 intensive care unit (ICU) patient, we decided to investigate whether CMV seropositivity is associated with severe or critical COVID-19. Methods: National German COVID-19 bio-sample and data banks were used to retrospectively analyze the CMV serostatus of patients who experienced mild (n=101), moderate (n=130) or severe to critical (n=80) disease by CMV IgG serology. We then investigated the relationship between disease severity and CMV serostatus via statistical models. Results: Non-geriatric patients (< 70 years) with severe COVID-19 were found to have a very high prevalence of CMV-seropositivity, while CMV status distribution in individuals with mild disease was similar to the prevalence in the German population; interestingly, this was not detectable in older patients. Prediction models support the hypothesis that the CMV serostatus might be a strong biomarker in identifying younger individuals with a higher risk of developing severe COVID-19. Conclusions: We identified CMV-seropositivity as a potential novel risk factor for severe COVID-19 in non-geriatric individuals in the studied cohorts. More mechanistic analyses as well as confirmation of similar findings in cohorts representing the currently most relevant SARS-CoV-2 variants should be performed shortly.

scholarly journals Avidity Studies in Anisakis simplex-Associated Allergic Diseases

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Carmen Cuéllar ◽  
Ana Valls ◽  
Consolación de Frutos ◽  
Marta Rodero ◽  
Alvaro Daschner
Keyword(s):  
Fish Consumption ◽  
Eating Habits ◽  
Allergic Diseases ◽  
Specific Ige ◽  
Time Interval ◽  
Total Ige ◽  
Igg Avidity ◽  
Differential Behaviour ◽  
Specific Igg ◽  
Immunoglobulin Levels

Gastroallergic anisakiasis (GAA) and Anisakis-sensitization-associated chronic urticaria (CU+) differ with respect to specific IgE levels. We hypothesised different immunoglobulin avidities in both entities as well as their dependence on TI and fish consumption. 16 patients with GAA and 17 patients with CU+ were included, and immunoglobulin levels were analysed by CAP (Phadia). IgE and IgG avidity indexes (AvIgE and AvIgG, resp.) were also determined. IgG avidity was higher in GAA than in CU+ (P=0.035), whereas there was a tendency to lower IgE avidity in GAA (P=0.095). When analysing all patients, AvIgG was positively correlated with specific IgE, IgG, and IgG4 as well as total IgE (Rho between 0.66 and 0.71; P<0.002), but AvIgE was negatively correlated with specific IgE (Rho −0.57; P<0.001), specific IgG4 (Rho −0.38; P<0.05), and total IgE (Rho 0.66; P<0.001). In GAA, weekly fish consumption was positively associated with AvIgE (Rho 0.51; P=0.05). A multivariate regression showed that time interval was the main explaining factor for AvIgE in GAA. We could show a differential behaviour of immunoglobulin isotype avidities in both entities and their dependence on fish-eating habits as well as on the time elapsed to the last parasitic episode.

Sign in / Sign up

Export Citation Format

Share Document