scholarly journals Dietary Supplemented Curcumin Improves Meat Quality and Antioxidant Status of Intrauterine Growth Retardation Growing Pigs via Nrf2 Signal Pathway

Animals ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 539 ◽  
Author(s):  
Ligen Zhang ◽  
Jiaqi Zhang ◽  
Enfa Yan ◽  
Jintian He ◽  
Xiang Zhong ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Meat Quality ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Redox Status ◽  
Signal Pathway ◽  
Growing Pigs ◽  
Heme Oxygenase 1 ◽  
Nrf2 Pathway ◽  
Intrauterine Growth

Intrauterine growth retardation (IUGR) exhibits programming consequences and may induce oxidative stress in growing animals and humans. This study was conducted to investigate the hypothesis that dietary curcumin may protect growing pigs from IUGR-induced oxidative stress via the Nrf2 pathway. Twelve normal birth weight (NBW) and 24 IUGR female piglets were selected and fed control diets supplemented 0 (NBW), 0 (IUGR) and 200 (IUGR + Cur) mg/kg curcumin from 26 to 115 days of age (n = 12). Growth performance, meat quality, redox status and its related Nrf2 pathway were determined. Results showed that IUGR pigs exhibited decreased body weight on 0 d, 26 d and 56 d (p < 0.01) but had no difference on 115 d among NBW, IUGR and IUGR + Cur groups (p > 0.05). Compared with NBW and IUGR groups, a significant decrease in drip loss (24 h and 48 h) was observed in the IUGR + Cur group (p < 0.01). IUGR pigs had higher concentrations of malondialdehyde (MDA) (p < 0.01) and protein carbonyl (PC) (p = 0.03) and lower activities of glutathione peroxidase (p = 0.02), catalase (p < 0.01) and peroxidase (p = 0.02) in leg muscles than NBW pigs. Dietary-added 200 mg/kg curcumin decreased concentrations of MDA and PC and improved the activities of catalase, superoxide dismutase (SOD) and peroxidase as compared to the IUGR group (p < 0.05). Additionally, dietary curcumin enhanced protein (NQO1) and mRNA expression of genes (Nrf2, NQO1, gamma-glutamyltransferase 1 (GGT1), heme oxygenase-1 (HO-1), glutathione S-transferase (GST) and catalase (CAT)) as compared to the IUGR group (p < 0.05). These results suggest that dietary curcumin could serve as a potential additive to enhance redox status and improve meat quality of IUGR growing pigs via the Nrf2 signal pathway.

scholarly journals Resveratrol Improves Hepatic Redox Status and Lipid Balance of Neonates with Intrauterine Growth Retardation in a Piglet Model

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Kang Cheng ◽  
Shuli Ji ◽  
Peilu Jia ◽  
Hao Zhang ◽  
Ting Wang ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Growth Retardation ◽  
Lipid Accumulation ◽  
Intrauterine Growth Retardation ◽  
Redox Status ◽  
Heme Oxygenase 1 ◽  
Hepatic Lipid ◽  
Intrauterine Growth ◽  
Hepatic Lipid Accumulation ◽  
Lipid Balance

Abnormal lipid metabolism, oxidative stress (OS), and inflammation play a pivotal role in the increased susceptibility to neonatal fatty liver diseases associated with intrauterine growth retardation (IUGR). This study was firstly conducted to investigate whether resveratrol could alleviate IUGR-induced hepatic lipid accumulation, alteration of redox and immune status in a sucking piglet model and explore the possible mechanisms at transcriptional levels. A total of 36 pairs of 7 d old male normal birth weight (NBW) and IUGR piglets were orally fed with either 80 mg resveratrol/kg body weight/d or 0.5% carboxymethylcellulose sodium for a period of 14 days, respectively. Compared with the NBW piglets, the IUGR piglets displayed compromised growth performance and liver weight, reduced plasma free fatty acid (FFA) level, increased hepatic OS, abnormal hepatic lipid accumulation and weakened hepatic immune function, and hepatic aberrant transcriptional expression of some genes such as heme oxygenase 1, superoxide dismutase 1, sterol regulatory element-binding protein 1c, stearoyl-CoA desaturase 1, liver fatty acid-binding proteins 1, toll-like receptor 4, and tumor necrosis factor alpha (TNF-α). Oral administration of resveratrol to piglets decreased the levels of FFA and total triglycerides (TG) in the plasma and hepatic TNF-α concentration, and increased glutathione reductase activity and reduced glutathione level in the liver. Resveratrol restored the increased alanine aminotransferase activity in the plasma of IUGR piglets. Treatment with resveratrol ameliorated the increased hepatic malondialdehyde, protein carbonyl, TG, and FFA concentrations induced by IUGR. Resveratrol treatment alleviated the reduced lipoprotein lipase activity and its mRNA expression as well as TNF-α gene expression in the liver of IUGR piglets. Hepatic glutathione peroxidase 1 and monocyte chemotactic protein 1 genes expression of piglets was upregulated by oral resveratrol administration. In conclusion, resveratrol administration plays a beneficial role in hepatic redox status and lipid balance of the IUGR piglets.

scholarly journals Dietary Curcumin Supplementation Increases Antioxidant Capacity, Upregulates Nrf2 and Hmox1 Levels in the Liver of Piglet Model with Intrauterine Growth Retardation

Nutrients ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2978 ◽  
Author(s):  
Yu Niu ◽  
Jintian He ◽  
Hussain Ahmad ◽  
Mingming Shen ◽  
Yongwei Zhao ◽  
...  
Keyword(s):  
Antioxidant Enzymes ◽  
Antioxidant Capacity ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Body Weight Gain ◽  
Heme Oxygenase 1 ◽  
Weaned Piglets ◽  
Intrauterine Growth ◽  
Normal Birth ◽  
Neonatal Piglets

Curcumin has improved effects on antioxidant capacity via multiple mechanisms. Intrauterine growth retardation (IUGR) has had adverse influences on human health. IUGR is always associated with elevated oxidative stress and deficiencies in antioxidant defense. Therefore, we chose IUGR piglets as a model to investigate the effects of IUGR on antioxidant capacity of newborn and weaned piglets and determine how these alterations were regulated after supplementation with curcumin in weaned IUGR piglets. In experiment 1, eight normal-birth-weight (NBW) and eight IUGR newborn piglets were selected to determine the effect of IUGR on the antioxidant capacity of neonatal piglets. In experiment 2, thirty-two weaned piglets from four experimental groups: NBW, NC (curcumin supplementation), IUGR, IC (curcumin supplementation) were selected. The results showed that both IUGR newborn and weaned piglets exhibited oxidative damage and lower antioxidant enzymes activities in the liver compared with the NBW piglets. Dietary curcumin supplementation increased body-weight gain, feed intake, activities of antioxidant enzymes, and the expressions of nuclear factor, erythroid 2-like 2 (Nrf2) and heme oxygenase-1 (Hmox1) proteins in the liver of weaned piglets with IUGR. In conclusion, IUGR decreased the antioxidant capacity of newborn and weaned piglets. Curcumin could efficiently improve the growth, increase hepatic antioxidant capacity, and upregulate Nrf2 and Hmox1 levels in the liver of IUGR weaned piglets.

scholarly journals Effects of Choline on Meat Quality and Intramuscular Fat in Intrauterine Growth Retardation Pigs

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0129109 ◽  
Author(s):  
Bo Li ◽  
Wei Li ◽  
Hussain Ahmad ◽  
Lili Zhang ◽  
Chao Wang ◽  
...  
Keyword(s):  
Meat Quality ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Intramuscular Fat ◽  
Intrauterine Growth

scholarly journals Fetal Programming Is Deeply Related to Maternal Selenium Status and Oxidative Balance; Experimental Offspring Health Repercussions

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2085
Author(s):  
María Luisa Ojeda ◽  
Fátima Nogales ◽  
Inés Romero-Herrera ◽  
Olimpia Carreras
Keyword(s):  
Oxidative Stress ◽  
Growth Retardation ◽  
Fetal Programming ◽  
Intrauterine Growth Retardation ◽  
Antioxidant Properties ◽  
Experimental Studies ◽  
Abnormal Development ◽  
Endocrine Regulation ◽  
Intrauterine Growth ◽  
Oxidative Balance

Nutrients consumed by mothers during pregnancy and lactation can exert permanent effects upon infant developing tissues, which could represent an important risk factor for diseases during adulthood. One of the important nutrients that contributes to regulating the cell cycle and tissue development and functionality is the trace element selenium (Se). Maternal Se requirements increase during gestation and lactation. Se performs its biological action by forming part of 25 selenoproteins, most of which have antioxidant properties, such as glutathione peroxidases (GPxs) and selenoprotein P (SELENOP). These are also related to endocrine regulation, appetite, growth and energy homeostasis. In experimental studies, it has been found that low dietary maternal Se supply leads to an important oxidative disruption in dams and in their progeny. This oxidative stress deeply affects gestational parameters, and leads to intrauterine growth retardation and abnormal development of tissues, which is related to endocrine metabolic imbalance. Childhood pathologies related to oxidative stress during pregnancy and/or lactation, leading to metabolic programing disorders like fetal alcohol spectrum disorders (FASD), have been associated with a low maternal Se status and intrauterine growth retardation. In this context, Se supplementation therapy to alcoholic dams avoids growth retardation, hepatic oxidation and improves gestational and breastfeeding parameters in FASD pups. This review is focused on the important role that Se plays during intrauterine and breastfeeding development, in order to highlight it as a marker and/or a nutritional strategy to avoid diverse fetal programming disorders related to oxidative stress.

scholarly journals Experimental investigation of the lipin gravidoprotective action in the model of placental disfunction caused by oxidative stress

2014 ◽  
Vol 12 (2) ◽  
pp. 59-64
Author(s):  
Olesya Viktorovna Kudina
Keyword(s):  
Oxidative Stress ◽  
Experimental Investigation ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Morphological Changes ◽  
Placental Insufficiency ◽  
Pronounced Effect ◽  
Pregnant Rats ◽  
Reference Drug ◽  
Intrauterine Growth

In the model of placental insufficiency caused by tetrachlormethane during organogenesis in rats, a pronounced effect of the gravidoprotective drug lipin was found assessed in their ability to prevent intrauterine growth retardation of rats and to normalize the morphological changes in the liver, kidney and placenta of pregnant rats. The drug lipin exceeds the reference drug essentiale on the sum of these indicators.

Improvement of the hepatic lipid status in intrauterine growth retarded pigs by resveratrol is related to the inhibition of mitochondrial dysfunction, oxidative stress and inflammation

2021 ◽  
Author(s):  
Kang Cheng ◽  
Peilu Jia ◽  
Shuli Ji ◽  
Zhihua Song ◽  
Hao Zhang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Disease ◽  
Mitochondrial Dysfunction ◽  
Liver Damage ◽  
Growth Retardation ◽  
Fatty Liver Disease ◽  
Intrauterine Growth Retardation ◽  
Nonalcoholic Fatty Liver ◽  
Intrauterine Growth ◽  
Lipid Status

Mitochondrial dysfunction, oxidative stress and inflammation are crucial contributors to liver damage and nonalcoholic fatty liver disease (NAFLD) in adulthood in offspring affected by intrauterine growth retardation (IUGR).

scholarly journals Effects of Early Resveratrol Intervention on Skeletal Muscle Mitochondrial Function and Redox Status in Neonatal Piglets with or without Intrauterine Growth Retardation

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Kang Cheng ◽  
Ting Wang ◽  
Simian Li ◽  
Zhihua Song ◽  
Hao Zhang ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mitochondrial Function ◽  
Growth Retardation ◽  
Nicotinamide Adenine Dinucleotide ◽  
Intrauterine Growth Retardation ◽  
Redox Status ◽  
Nicotinamide Adenine ◽  
Reduced Form ◽  
Mitochondrial Morphology ◽  
Intrauterine Growth

Skeletal muscle mitochondrial malfunction of offspring induced by intrauterine growth retardation (IUGR) may be a contributor to growth restriction and metabolic disorder at various periods of life. This study explored the effects of IUGR and resveratrol (RSV) on mitochondrial function and redox status in the longissimus dorsi muscle (LM) of piglets during the sucking period. A total of 36 pairs of IUGR and normal birth weight male piglets were orally fed with either 80 mg RSV/kg body weight/d or 0.5% carboxymethylcellulose sodium during days 7-21 after birth. The results showed that RSV treatment improved anomalous mitochondrial morphology, increased adenosine triphosphate and glycogen contents, and enhanced nicotinamide adenine dinucleotide/reduced form of nicotinamide-adenine dinucleotide ratio in the LM of IUGR piglets. Moreover, the IUGR-induced increased malondialdehyde and protein carbonyl concentrations, abnormal mtDNA number, and suppressed genes expression of mitochondrial biogenesis such as nuclear respiratory factor 1, estrogen-related receptor alpha, and polymerase gamma in the LM were restored to some extent by RSV treatment. Additionally, RSV increased mitochondrial complex V activity in the LM of piglets. Collectively, RSV administration alleviated the LM mitochondrial dysfunction and oxidative damage of IUGR piglets.

Oxidative stress in intrauterine growth retardation

2016 ◽  
Vol 03 (03) ◽  
pp. 137-142
Author(s):  
Ana Pineda-Caplliure ◽  
Pilar Codoñer-Franch
Keyword(s):  
Oxidative Stress ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Intrauterine Growth
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