scholarly journals Experimental investigation of the lipin gravidoprotective action in the model of placental disfunction caused by oxidative stress

2014 ◽  
Vol 12 (2) ◽  
pp. 59-64
Author(s):  
Olesya Viktorovna Kudina
Keyword(s):  
Oxidative Stress ◽  
Experimental Investigation ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Morphological Changes ◽  
Placental Insufficiency ◽  
Pronounced Effect ◽  
Pregnant Rats ◽  
Reference Drug ◽  
Intrauterine Growth

In the model of placental insufficiency caused by tetrachlormethane during organogenesis in rats, a pronounced effect of the gravidoprotective drug lipin was found assessed in their ability to prevent intrauterine growth retardation of rats and to normalize the morphological changes in the liver, kidney and placenta of pregnant rats. The drug lipin exceeds the reference drug essentiale on the sum of these indicators.

scholarly journals Current trends in the treatment of chronic placental insufficiency

2020 ◽  
Vol 69 (1) ◽  
pp. 45-52
Author(s):  
Ekaterina V. Novitskaya ◽  
Vyacheslav M. Bolotskikh ◽  
Victoria O. Polyakova ◽  
Igor M. Kvetnoy
Keyword(s):  
Growth Retardation ◽  
Fetal Development ◽  
Intrauterine Growth Retardation ◽  
Experimental Studies ◽  
Placental Insufficiency ◽  
Melatonin Treatment ◽  
Successful Pregnancy ◽  
Intrauterine Growth ◽  
Current Trends

According to literature, intrauterine growth retardation complicates about 5% of pregnancies and is usually caused by chronic placental insufficiency. This article reviews literature data on modern views on the issue. Special attention is paid to the role of melatonin in chronic placental insufficiency and intrauterine growth. Examples of experimental studies demonstrate successful pregnancy course and functional fetal development in animals with melatonin treatment. The data obtained by other researchers on the effect of melatonin on pregnancy, in particular, on chronic placental insufficiency in women, are analyzed. Also in this review, we suggest that melatonin, which is a powerful antioxidant, can reduce morbidity and mortality associated with intrauterine growth retardation.

scholarly journals Dietary Supplemented Curcumin Improves Meat Quality and Antioxidant Status of Intrauterine Growth Retardation Growing Pigs via Nrf2 Signal Pathway

Animals ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 539 ◽  
Author(s):  
Ligen Zhang ◽  
Jiaqi Zhang ◽  
Enfa Yan ◽  
Jintian He ◽  
Xiang Zhong ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Meat Quality ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Redox Status ◽  
Signal Pathway ◽  
Growing Pigs ◽  
Heme Oxygenase 1 ◽  
Nrf2 Pathway ◽  
Intrauterine Growth

Intrauterine growth retardation (IUGR) exhibits programming consequences and may induce oxidative stress in growing animals and humans. This study was conducted to investigate the hypothesis that dietary curcumin may protect growing pigs from IUGR-induced oxidative stress via the Nrf2 pathway. Twelve normal birth weight (NBW) and 24 IUGR female piglets were selected and fed control diets supplemented 0 (NBW), 0 (IUGR) and 200 (IUGR + Cur) mg/kg curcumin from 26 to 115 days of age (n = 12). Growth performance, meat quality, redox status and its related Nrf2 pathway were determined. Results showed that IUGR pigs exhibited decreased body weight on 0 d, 26 d and 56 d (p < 0.01) but had no difference on 115 d among NBW, IUGR and IUGR + Cur groups (p > 0.05). Compared with NBW and IUGR groups, a significant decrease in drip loss (24 h and 48 h) was observed in the IUGR + Cur group (p < 0.01). IUGR pigs had higher concentrations of malondialdehyde (MDA) (p < 0.01) and protein carbonyl (PC) (p = 0.03) and lower activities of glutathione peroxidase (p = 0.02), catalase (p < 0.01) and peroxidase (p = 0.02) in leg muscles than NBW pigs. Dietary-added 200 mg/kg curcumin decreased concentrations of MDA and PC and improved the activities of catalase, superoxide dismutase (SOD) and peroxidase as compared to the IUGR group (p < 0.05). Additionally, dietary curcumin enhanced protein (NQO1) and mRNA expression of genes (Nrf2, NQO1, gamma-glutamyltransferase 1 (GGT1), heme oxygenase-1 (HO-1), glutathione S-transferase (GST) and catalase (CAT)) as compared to the IUGR group (p < 0.05). These results suggest that dietary curcumin could serve as a potential additive to enhance redox status and improve meat quality of IUGR growing pigs via the Nrf2 signal pathway.

scholarly journals Fetal Programming Is Deeply Related to Maternal Selenium Status and Oxidative Balance; Experimental Offspring Health Repercussions

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2085
Author(s):  
María Luisa Ojeda ◽  
Fátima Nogales ◽  
Inés Romero-Herrera ◽  
Olimpia Carreras
Keyword(s):  
Oxidative Stress ◽  
Growth Retardation ◽  
Fetal Programming ◽  
Intrauterine Growth Retardation ◽  
Antioxidant Properties ◽  
Experimental Studies ◽  
Abnormal Development ◽  
Endocrine Regulation ◽  
Intrauterine Growth ◽  
Oxidative Balance

Nutrients consumed by mothers during pregnancy and lactation can exert permanent effects upon infant developing tissues, which could represent an important risk factor for diseases during adulthood. One of the important nutrients that contributes to regulating the cell cycle and tissue development and functionality is the trace element selenium (Se). Maternal Se requirements increase during gestation and lactation. Se performs its biological action by forming part of 25 selenoproteins, most of which have antioxidant properties, such as glutathione peroxidases (GPxs) and selenoprotein P (SELENOP). These are also related to endocrine regulation, appetite, growth and energy homeostasis. In experimental studies, it has been found that low dietary maternal Se supply leads to an important oxidative disruption in dams and in their progeny. This oxidative stress deeply affects gestational parameters, and leads to intrauterine growth retardation and abnormal development of tissues, which is related to endocrine metabolic imbalance. Childhood pathologies related to oxidative stress during pregnancy and/or lactation, leading to metabolic programing disorders like fetal alcohol spectrum disorders (FASD), have been associated with a low maternal Se status and intrauterine growth retardation. In this context, Se supplementation therapy to alcoholic dams avoids growth retardation, hepatic oxidation and improves gestational and breastfeeding parameters in FASD pups. This review is focused on the important role that Se plays during intrauterine and breastfeeding development, in order to highlight it as a marker and/or a nutritional strategy to avoid diverse fetal programming disorders related to oxidative stress.

scholarly journals Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic study

2005 ◽  
Vol 16 (1) ◽  
pp. 62-66 ◽  
Author(s):  
Daniela Atili Brandini ◽  
Miguel Angel Sala ◽  
Ruberval Armando Lopes ◽  
Marisa Semprini ◽  
Mary Garcia Duarte Contrera
Keyword(s):  
Cigarette Smoke ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Pregnant Rats ◽  
Rat Fetus ◽  
Meckel's Cartilage ◽  
Intrauterine Growth ◽  
Meckel’S Cartilage ◽  
Female Wistar Rats ◽  
Experimental Group

The purpose of this study was to investigate the effects of cigarette smoke on the development of the embryo mandible (Meckel's) cartilage in rat fetuses. When inhaled by female Wistar rats between the 9th and the 12th day of pregnancy, cigarette smoke (5 cigarettes a day) caused intrauterine growth retardation, providing smaller fetuses and placentas. In fetuses from the experimental group, the histopathologic examination revealed a poorly developed Meckel's cartilage with smaller chondroblasts showing a scanty cytoplasm with spherical and paler central nuclei, as well as more abundant cartilage matrix. Morphometric analysis revealed that Meckel's cartilage lacunae were smaller in the fetuses from the experimental group, although not showing any remarkable alteration in shape. The results suggested that inhalation of cigarette smoke by pregnant rats during the organogenic period induced growth retardation and delayed cellular differentiation in rat fetal Meckel's cartilage.

scholarly journals Activity of the brain isoenzyme creatine kinase in newborns with intrauterine growth retardation

2003 ◽  
Vol 52 (4) ◽  
pp. 28-32
Author(s):  
D. S. Dodkhoev ◽  
I. I. Evsyukova ◽  
Z. N. Tumasova ◽  
А. V. Harutyunyan
Keyword(s):  
Creatine Kinase ◽  
Growth Retardation ◽  
Clinical Condition ◽  
Intrauterine Growth Retardation ◽  
Neonatal Period ◽  
Placental Insufficiency ◽  
Intrauterine Growth ◽  
Early Neonatal Period ◽  
The Brain

The CK-BB activity in neonates with intrauterine growth retardation (IUGR) was investi-gated and the results were compared to their clinical condition in early neonatal period. The re-sults of the study have shown that the CK-BB activity was increased in neonates with symmetric IUGR and in the presence of chronic placental insufficiency of infectious genesis.

Improvement of the hepatic lipid status in intrauterine growth retarded pigs by resveratrol is related to the inhibition of mitochondrial dysfunction, oxidative stress and inflammation

2021 ◽  
Author(s):  
Kang Cheng ◽  
Peilu Jia ◽  
Shuli Ji ◽  
Zhihua Song ◽  
Hao Zhang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Disease ◽  
Mitochondrial Dysfunction ◽  
Liver Damage ◽  
Growth Retardation ◽  
Fatty Liver Disease ◽  
Intrauterine Growth Retardation ◽  
Nonalcoholic Fatty Liver ◽  
Intrauterine Growth ◽  
Lipid Status

Mitochondrial dysfunction, oxidative stress and inflammation are crucial contributors to liver damage and nonalcoholic fatty liver disease (NAFLD) in adulthood in offspring affected by intrauterine growth retardation (IUGR).

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