scholarly journals Prostaglandin E2 and F2alpha Modulate Urinary Bladder Urothelium, Lamina Propria and Detrusor Contractility via the FP Receptor

2020 ◽  
Vol 11 ◽  
Author(s):  
Zane Stromberga ◽  
Russ Chess-Williams ◽  
Christian Moro
Keyword(s):  
Urinary Bladder ◽  
Prostaglandin E2 ◽  
Lamina Propria ◽  
Bladder Urothelium ◽  
Detrusor Contractility ◽  
Fp Receptor

scholarly journals The five primary prostaglandins stimulate contractions and phasic activity of the urinary bladder urothelium, lamina propria and detrusor

2020 ◽  
Author(s):  
Zane Stromberga ◽  
Russ Chess-Williams ◽  
Christian Moro
Keyword(s):  
Urinary Bladder ◽  
Lamina Propria ◽  
Contractile Activity ◽  
Rank Order ◽  
Bladder Pain Syndrome ◽  
Lower Urinary Tract Dysfunction ◽  
Receptor System ◽  
Phasic Activity ◽  
Bladder Pain ◽  
Bladder Urothelium

Abstract Background: Inflammation is often associated with several bladder dysfunctions, including overactive bladder (OAB) and interstitial cystitis/bladder pain syndrome (IC/PBS). As such, inflammation of the bladder and the actions of inflammatory mediators may contribute to the development of the urinary symptoms. This study assessed the actions of PGE 2 , PGF 2 , PGD 2 , TXA 2 , and PGI 2 on the urinary bladder urothelium with lamina propria (U&LP), as well as the detrusor smooth muscle.Methods: Studies were carried out using isolated tissue baths, where strips porcine bladder U&LP or detrusor were exposed to varying concentrations of prostaglandin agonists (1 µM and 10 µM).Results: All assessed prostaglandin agonists contracted both the U&LP and detrusor smooth muscle, with the rank order of contractile response effectiveness as: PGE 2 > PGF 2α > TXA 2 > PGD 2 > PGI 2 . In U&LP, treatment with PGE 2 (10 µM) increased tonic contractions by 1.36 ± 0.09 g (n = 42, p < 0.001) and phasic contractions by 40.4 ± 9.6% (n = 42, p < 0.001). In response to PGF 2α (10 µM), U&LP tonic contractions increased by 0.79 ± 0.06 g (n = 14, p < 0.001) and phasic activity by 13.3% ± 5.3% (n = 15, p < 0.05). In detrusor preparations, PGE 2 (10 µM) increased tonic contractions by 1.32 ± 0.13 g (n = 38, p < 0.001) and PGF 2α (10 µM) by 0.97 ± 0.14 g (n = 12, p < 0.001). Only 34% (n = 48) of all detrusor preparations exhibited spontaneous activity prior to the addition of any agonist at a frequency of 2.03 ± 0.12 cpm. In preparations that did not exhibit initial phasic activity, all of the prostaglandin agonists were capable of commencing phasic activity.Conclusions: The urinary bladder U&LP and detrusor respond to a variety of prostaglandin agonists, with their activation resulting in direct contractions, as well as increases to spontaneous contractile activity. This study presents the prostaglandin receptor system as a potential therapeutic target for lower urinary tract dysfunction.

scholarly journals Rhythmic Calcium Events in the Lamina Propria Network of the Urinary Bladder of Rat Pups

2017 ◽  
Vol 11 ◽  
Author(s):  
Thomas J. Heppner ◽  
Grant W. Hennig ◽  
Mark T. Nelson ◽  
Margaret A. Vizzard
Keyword(s):  
Urinary Bladder ◽  
Lamina Propria ◽  
Rat Pups

scholarly journals Generalized Cellular Hypertrophy is Induced by a Dual-Acting PPAR Agonist in Rat Urinary Bladder Urothelium In Vivo

2005 ◽  
Vol 33 (5) ◽  
pp. 552-560 ◽  
Author(s):  
Martin B. Oleksiewicz ◽  
Inger Thorup ◽  
Henriette S. Nielsen ◽  
Hanne V. Andersen ◽  
Anne Charlotte Hegelund ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Rat Urinary Bladder ◽  
Ppar Agonist ◽  
Bladder Urothelium ◽  
Cellular Hypertrophy

scholarly journals Expression and function of bradykinin B1 and B2 receptors in normal and inflamed rat urinary bladder urothelium

2005 ◽  
Vol 562 (3) ◽  
pp. 859-871 ◽  
Author(s):  
Bikramjit Chopra ◽  
Stacey R. Barrick ◽  
Susan Meyers ◽  
Jonathan M. Beckel ◽  
Mark L. Zeidel ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Rat Urinary Bladder ◽  
Bladder Urothelium ◽  
B2 Receptors ◽  
And Function

M1821 Prostaglandin E2 Inhibits Migration of Colonic Lamina Propria Fibroblasts

2010 ◽  
Vol 138 (5) ◽  
pp. S-426
Author(s):  
Florian Rieder ◽  
Martina Georgieva ◽  
Anja Schirbel ◽  
Monika Artinger ◽  
Anita Zuegner ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Lamina Propria ◽  
Colonic Lamina Propria Fibroblasts
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