scholarly journals Expression and function of bradykinin B1 and B2 receptors in normal and inflamed rat urinary bladder urothelium

2005 ◽  
Vol 562 (3) ◽  
pp. 859-871 ◽  
Author(s):  
Bikramjit Chopra ◽  
Stacey R. Barrick ◽  
Susan Meyers ◽  
Jonathan M. Beckel ◽  
Mark L. Zeidel ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Rat Urinary Bladder ◽  
Bladder Urothelium ◽  
B2 Receptors ◽  
And Function

scholarly journals Generalized Cellular Hypertrophy is Induced by a Dual-Acting PPAR Agonist in Rat Urinary Bladder Urothelium In Vivo

2005 ◽  
Vol 33 (5) ◽  
pp. 552-560 ◽  
Author(s):  
Martin B. Oleksiewicz ◽  
Inger Thorup ◽  
Henriette S. Nielsen ◽  
Hanne V. Andersen ◽  
Anne Charlotte Hegelund ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Rat Urinary Bladder ◽  
Ppar Agonist ◽  
Bladder Urothelium ◽  
Cellular Hypertrophy

scholarly journals Expression and function of CXCL12/CXCR4 in rat urinary bladder with cyclophosphamide-induced cystitis

2010 ◽  
Vol 298 (3) ◽  
pp. F589-F600 ◽  
Author(s):  
Lauren Arms ◽  
Beatrice M. Girard ◽  
Margaret A. Vizzard
Keyword(s):  
Urinary Bladder ◽  
Tissue Injury ◽  
Bladder Capacity ◽  
Rat Urinary Bladder ◽  
Cxcr4 Signaling ◽  
Qrt Pcr ◽  
Proinflammatory Mediators ◽  
Bladder Inflammation ◽  
And Function

Chemokines, otherwise known as chemotactic cytokines, are proinflammatory mediators of the immune response and have been implicated in altered sensory processing, hyperalgesia, and central sensitization following tissue injury or inflammation. To address the role of CXCL12/CXCR4 signaling in normal micturition and inflammation-induced bladder hyperreflexia, bladder inflammation in adult female Wistar rats (175–250 g) was induced by injecting cyclophosphamide (CYP) intraperitoneally at acute (150 mg/kg; 4 h), intermediate (150 mg/kg; 48 h), and chronic (75 mg/kg; every 3rd day for 10 days) time points. CXCL12, and its receptor, CXCR4, were examined in the whole urinary bladder of control and CYP-treated rats using enzyme-linked immunosorbent assays (ELISAs), quantitative PCR (qRT-PCR), and immunostaining techniques. ELISAs, qRT-PCR, and immunostaining experiments revealed a significant ( P ≤ 0.01) increase in CXCL12 and CXCR4 expression in the whole urinary bladder, and particularly in the urothelium, with CYP treatment. The functional role of CXCL12/CXCR4 signaling in micturition was evaluated using conscious cystometry with continuous instillation of saline and CXCR4 receptor antagonist (AMD-3100; 5 μM) administration in control and CYP (48 h)-treated rats. Receptor blockade of CXCR4 using AMD-3100 increased bladder capacity in control (no CYP) rats and reduced CYP-induced bladder hyperexcitability as demonstrated by significant ( P ≤ 0.01) increases in intercontraction interval, bladder capacity, and void volume. These results suggest a role for CXCL12/CXCR4 signaling in both normal micturition and with bladder hyperreflexia following bladder inflammation.

Distribution and Function of the Hydrogen Sulfide–Sensitive TRPA1 Ion Channel in Rat Urinary Bladder

2008 ◽  
Vol 53 (2) ◽  
pp. 391-400 ◽  
Author(s):  
Tomi Streng ◽  
Helena E. Axelsson ◽  
Petter Hedlund ◽  
David A. Andersson ◽  
Sven-Eric Jordt ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Urinary Bladder ◽  
Ion Channel ◽  
Rat Urinary Bladder ◽  
And Function

scholarly journals Erratum to: Expression and function of phosphodiesterases (PDEs) in the rat urinary bladder

BMC Urology ◽  
2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Xiaofei Zhu ◽  
Kui Zhai ◽  
Yue Mi ◽  
Guangju Ji
Keyword(s):  
Urinary Bladder ◽  
Rat Urinary Bladder ◽  
And Function

scholarly journals Expression and function of phosphodiesterases (PDEs) in the rat urinary bladder

BMC Urology ◽  
2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Xiaofei Zhu ◽  
Kui Zhai ◽  
Yue Mi ◽  
Guangju Ji
Keyword(s):  
Urinary Bladder ◽  
Rat Urinary Bladder ◽  
And Function

Expression and function of the cold channels in urinary bladder urothelium: TRPM8 and TRPA1

2005 ◽  
Vol 6 (3) ◽  
pp. S10 ◽  
Author(s):  
S. Barrick ◽  
B. Chopra ◽  
M. Caterina ◽  
M. Nealen ◽  
H. Lee ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Bladder Urothelium ◽  
And Function
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