scholarly journals Assessment of the effects of aerobic fitness on cerebrovascular function in young adults using multiple inversion time arterial spin labelling MRI

2019 ◽  
Author(s):  
Catherine Foster ◽  
Jessica J Steventon ◽  
Daniel Helme ◽  
Valentina Tomassini ◽  
Richard G. Wise
Keyword(s):  
Young Adults ◽  
Aerobic Fitness ◽  
Arterial Spin Labelling ◽  
Cerebrovascular Reactivity ◽  
Inverse Association ◽  
Cross Sectional ◽  
Whole Brain ◽  
Inversion Time ◽  
Cerebrovascular Function ◽  
Spin Labelling

AbstractThe cross-sectional study investigated the effects of aerobic fitness on cerebrovascular function in the healthy brain. We quantified grey matter (GM) cerebral blood flow (CBF) and cerebrovascular reactivity (CVR), in a sample of young adults within a normal fitness range. Based on existing TCD and fMRI evidence, we predicted a positive relationship between fitness and resting GM CBF, and CVR. Exploratory hypotheses that higher peak would be associated with higher GM volume and cognitive performance were also investigated.20 adults underwent a peak test and a battery of cognitive tests. All subjects underwent an MRI scan where multiple inversion time (MTI) pulsed arterial spin labelling (PASL) was used to quantify resting CBF and CVR to 5% CO2.ROI analysis showed a non-significant negative correlation between whole-brain GM CBF and peak; r=-0.4, p=0.08, corrected p (p’) =0.16 and a significant positive correlation between peak and voxelwise whole-brain GM CVR; r=0.62, p=0.003, p’ =0.006. Voxelwise analysis revealed a significant inverse association between peak and resting CBF in the left and right thalamus, brainstem, right lateral occipital cortex, left intracalcarine cortex and cerebellum. The results of this study suggest that aerobic fitness is associated with lower CBF and greater CVR in young adults.

scholarly journals In vivo Assessment of Human Brainstem Cerebrovascular Function: A Multi-Inversion Time Pulsed Arterial Spin Labelling Study

2014 ◽  
Vol 34 (6) ◽  
pp. 956-963 ◽  
Author(s):  
Esther AH Warnert ◽  
Ashley D Harris ◽  
Kevin Murphy ◽  
Neeraj Saxena ◽  
Neeta Tailor ◽  
...  
Keyword(s):  
Repeated Measures ◽  
Vascular Reactivity ◽  
Kinetic Curve ◽  
Tissue Perfusion ◽  
Compartment Model ◽  
Arterial Spin Labelling ◽  
Inversion Time ◽  
Cerebrovascular Function ◽  
Spin Labelling

The brainstem (BS) is involved in critical physiologic processes, including control of cardiovascular and respiratory functions. This study implements a multi-inversion time pulsed arterial spin labelling (MTI PASL) imaging sequence that addresses the challenges of BS imaging and aims to measure normal and elevated BS perfusion in healthy volunteers. An initial experiment was performed to obtain the kinetic curve of the label in the BS and consequently to estimate the label arrival times and tissue perfusion in seven participants. A second experiment estimated the BS cerebral vascular reactivity (CVR) to hypercapnia in 10 participants. Images were acquired with a gradient-echo sequence with two spiral interleaves and short echo time (TE = 2.7 ms). Data were analyzed with a two-compartment model, including a tissue and arterial component. In both experiments, perfusion in the BS was significantly lower than in cortical gray matter (repeated measures analysis of variance (RM-ANOVA), P<0.05), which is as expected since the BS consists of gray and white matter, the latter typically showing lower perfusion. The BS CVR found here is comparable to previous reports obtained with positron emission tomography (PET) imaging. Multi-inversion time pulsed ASL in combination with a two-compartment signal model can be used to assess BS perfusion and CVR.

scholarly journals Cerebral perfusion changes in presymptomatic genetic frontotemporal dementia: a GENFI study

Brain ◽  
2019 ◽  
Vol 142 (4) ◽  
pp. 1108-1120 ◽  
Author(s):  
Henri J M M Mutsaerts ◽  
Saira S Mirza ◽  
Jan Petr ◽  
David L Thomas ◽  
David M Cash ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Frontotemporal Dementia ◽  
Symptom Onset ◽  
Arterial Spin Labelling ◽  
Anterior Cingulate ◽  
Middle Temporal Gyrus ◽  
Inverse Association ◽  
Mutation Carriers ◽  
Spin Labelling

Abstract Genetic forms of frontotemporal dementia are most commonly due to mutations in three genes, C9orf72, GRN or MAPT, with presymptomatic carriers from families representing those at risk. While cerebral blood flow shows differences between frontotemporal dementia and other forms of dementia, there is limited evidence of its utility in presymptomatic stages of frontotemporal dementia. This study aimed to delineate the cerebral blood flow signature of presymptomatic, genetic frontotemporal dementia using a voxel-based approach. In the multicentre GENetic Frontotemporal dementia Initiative (GENFI) study, we investigated cross-sectional differences in arterial spin labelling MRI-based cerebral blood flow between presymptomatic C9orf72, GRN or MAPT mutation carriers (n = 107) and non-carriers (n = 113), using general linear mixed-effects models and voxel-based analyses. Cerebral blood flow within regions of interest derived from this model was then explored to identify differences between individual gene carrier groups and to estimate a timeframe for the expression of these differences. The voxel-based analysis revealed a significant inverse association between cerebral blood flow and the expected age of symptom onset in carriers, but not non-carriers. Regions included the bilateral insulae/orbitofrontal cortices, anterior cingulate/paracingulate gyri, and inferior parietal cortices, as well as the left middle temporal gyrus. For all bilateral regions, associations were greater on the right side. After correction for partial volume effects in a region of interest analysis, the results were found to be largely driven by the C9orf72 genetic subgroup. These cerebral blood flow differences first appeared approximately 12.5 years before the expected symptom onset determined on an individual basis. Cerebral blood flow was lower in presymptomatic mutation carriers closer to and beyond their expected age of symptom onset in key frontotemporal dementia signature regions. These results suggest that arterial spin labelling MRI may be a promising non-invasive imaging biomarker for the presymptomatic stages of genetic frontotemporal dementia.

scholarly journals Reference Values for Aerobic Fitness in Children, Adolescents, and Young Adults Who Have Cerebral Palsy and Are Ambulatory

2010 ◽  
Vol 90 (8) ◽  
pp. 1148-1156 ◽  
Author(s):  
Olaf Verschuren ◽  
Manon Bloemen ◽  
Cas Kruitwagen ◽  
Tim Takken
Keyword(s):  
Young Adults ◽  
Cerebral Palsy ◽  
Young People ◽  
Reference Values ◽  
Aerobic Fitness ◽  
Adolescents And Young Adults ◽  
Cross Sectional ◽  
Level I ◽  
Shuttle Run ◽  
Gmfcs Level

BackgroundVery few objective data exist regarding aerobic performance in young people with cerebral palsy (CP). The characterization of aerobic fitness could provide baseline and outcome measures for the rehabilitation of young people with CP.ObjectiveThe objective of this study was to provide reference values for aerobic fitness in a group of children, adolescents, and young adults who had CP and who were classified at Gross Motor Function Classification System (GMFCS) level I or II. Data were collected with 10-m shuttle run tests.DesignThis investigation was a cross-sectional observational study conducted between August 2008 and June 2009.MethodsReference values were established using data from a total of 306 children, adolescents, and young adults who had CP, who were 6 to 20 years old, and who were recruited from 26 rehabilitation centers in the Netherlands, Switzerland, Australia, Canada, and the United States. A total of 211 participants were classified at GMFCS level I (mean age=12.2 years, SD=3.0), and 95 were classified at GMFCS level II (mean age=12.4 years, SD=3.2); 181 were male, and 125 were female. Aerobic fitness was reflected by the level achieved on the 10-m shuttle run tests.ResultsOn the basis of a total of 306 assessments from the 10-m shuttle run tests, 4 reference curves were created.LimitationsThe limitation of this study is the cross-sectional nature of the design.ConclusionsThis study provided height-related reference values for aerobic fitness in children, adolescents, and young adults who had CP, who were 6 to 20 years old, and who were classified at GMFCS level I or II. Generalized additive models for location, scale, and shape were used to construct centile curves. These curves are clinically relevant and provide a user-friendly method for the prediction of aerobic fitness in young people with CP.

Association between aerobic fitness and cerebrovascular function with neurocognitive functions in healthy, young adults

2018 ◽  
Vol 236 (5) ◽  
pp. 1421-1430 ◽  
Author(s):  
Jungyun Hwang ◽  
Kiyoung Kim ◽  
R. Matthew Brothers ◽  
Darla M. Castelli ◽  
F. Gonzalez-Lima
Keyword(s):  
Young Adults ◽  
Aerobic Fitness ◽  
Neurocognitive Functions ◽  
Cerebrovascular Function

Influence of Habitual Aerobic and Resistance Exercise on Cerebrovascular Reactivity in Healthy Young Adults

2021 ◽  
Author(s):  
Adam T. Corkery ◽  
Anna J. Howery ◽  
Kathleen B. Miller ◽  
Jill N. Barnes
Keyword(s):  
Young Adults ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Vascular Function ◽  
Cerebrovascular Reactivity ◽  
Future Research ◽  
Limited Information ◽  
Men 2 ◽  
Cerebrovascular Function ◽  
Habitual Exercise

Diminished cerebrovascular function is associated with reduced cognitive ability. Habitual exercise may maintain or improve cerebrovascular function; however, limited information exists regarding the optimal exercise prescription for cerebrovascular health. While aerobic exercise is associated with improved systemic vascular function, the influence of resistance exercise on vascular health is unclear. Therefore, the purpose of this study was to examine the influence of habitual exercise training on cerebrovascular function in healthy young adults. We evaluated 13 untrained (age = 27 ± 5 yr; 11 men, 2 women), 13 aerobic trained (age = 28 ± 5 yr; 10 men, 3 women), and 13 resistance trained (age = 24 ± 4 yr; 11 men, 2 women) adults. Middle cerebral artery velocity (MCAv), mean arterial pressure (MAP), and end-tidal carbon dioxide (ETCO2) were continuously measured at rest, and in response to hypercapnia. At rest, there were no differences between groups for MCAv; however, resistance trained adults had greater cerebrovascular conductance compared with aerobic trained adults (0.79 ± 0.26 cm/s/mmHg vs. 0.56 ± 0.17 cm/s/mmHg; p < 0.05). In response to hypercapnia, cerebrovascular reactivity and MAP reactivity were not different between groups. There was no association between aerobic fitness or measures of exercise volume and any variable of cerebrovascular function in the combined or individual groups. Our results suggest that the mode of exercise training does not impact cerebrovascular reactivity in healthy young adults; however, it may influence resting cerebral hemodynamics. Future research could examine the influence of habitual exercise training on cerebrovascular function with aging.

Compromised Resting Cerebral Metabolism After Sport-Related Concussion: A Calibrated MRI Study

Neurology ◽  
2020 ◽  
Vol 95 (20 Supplement 1) ◽  
pp. S15.1-S15
Author(s):  
Allen Anthony Champagne ◽  
Nicole Coverdale ◽  
Juan Fernandez Ruis ◽  
Clarisse Mark ◽  
Douglas J. Cook
Keyword(s):  
Cerebral Metabolism ◽  
Head Injuries ◽  
Blood Oxygenation ◽  
Arterial Spin Labelling ◽  
Cerebrovascular Reactivity ◽  
Biophysical Model ◽  
Metabolic Demand ◽  
Post Injury ◽  
End Tidal ◽  
Spin Labelling

ObjectiveUse calibrated MRI to model baseline cerebrovascular physiology parameters and investigate whether changes in resting cerebral blood flow (CBF0) following sport-related concussion (SRC) are concordant with changes in resting and dynamic cerebral physiologic markers, within two weeks of the injury.BackgroundAltered CBF0 in the acute phase post-concussion may contribute to neurobehavioral deficiencies, often reported weeks after the injury. However, in addition to changes in CBF0, little is known about other physiologic mechanisms that may be disturbed within the cerebrovasculature. The aim of this study was to assess whether changes in baseline perfusion following SRC were co-localized with changes in cerebral metabolic demand.Design/MethodsForty-two subjects (15 SRC patients 8.0 ± 4.6 days post-injury and 27 age-matched healthy control athletes) were studied cross-sectionally. CBF0, cerebrovascular reactivity (CVR), resting oxygen extraction (OEF0) and cerebral metabolic rate of oxygen consumption (CMRO2|0) were measured using a combination of hypercapnic and hyperoxic breathing protocols, and the biophysical model developed in calibrated MRI. Blood Oxygenation Level Dependent and Arterial Spin Labelling data were acquired simultaneously using a dual-echo arterial spin labelling sequence.ResultsSRC patients showed significant decreases in CBF0 spread across the grey-matter (p < 0.05, corrected), and these differences were also confounded by the effects of baseline end-tidal CO2 (p < 0.0001). Lower perfusion was co-localized with reductions in regional CMRO2|0 (p = 0.006) post-SRC, despite finding no group-differences in OEF0 (p = 0.800). Higher CVR within voxels showing differences in CBF0 was also observed in the SRC group (p = 0.001), compared to controls.ConclusionsReductions in metabolic demand despite no significant changes in OEF0 suggests that hypoperfusion post-SRC may reflect compromised metabolic function after the injury. These results provide novel insight about the possible pathophysiologic mechanisms underlying concussion that may affect the clinical recovery of athletes after sport-related head injuries.

scholarly journals Quantitative Physical Fitness Measures Inversely Associated With Myopia Severity in Military Males: The CHIEF Study

2019 ◽  
Vol 13 (5) ◽  
pp. 155798831988376 ◽  
Author(s):  
Shao-Chi Lu ◽  
Fang-Yu Liu ◽  
Chia-Jung Hsieh ◽  
Fang-Ying Su ◽  
Tien Yin Wong ◽  
...  
Keyword(s):  
Physical Fitness ◽  
Aerobic Fitness ◽  
High Myopia ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Inverse Association ◽  
Cross Sectional ◽  
A Value ◽  
Run Test ◽  
The Military

Myopia has been linked to body weight and sedentary status, but the association with quantitatively measured physical fitness in adults has not been examined. Cross-sectional analyses were performed to investigate the association between physical fitness and myopia in 3,669 military men (aged 29.4 years) in Taiwan. The severity of myopia obtained from the left eye was classified as mild (−0.5 to −3.0 diopters; n = 544), moderate −3.1 to −6.0 diopters; n = 563), and high (<−6.0 diopters; n =150); others were defined as nonmyopia ( n = 2,412). Aerobic fitness was evaluated by time for a 3000-meter run test, and muscular endurance was evaluated by numbers of 2-min sit-ups and 2-min push-ups. A value of p < .0125 was considered significant. A multiple linear regression analysis was used to determine the relationship. Individuals who were less physically fit had higher risk of myopia. The associations were dose-dependently significant with mild, moderate, and high myopia for 3000-meter running time (β = 9.64; 95% confidence intervals [3.22, 16.05], β = 12.41; 95% CI [6.05, 18.76], and β = 20.87; 95% CI [9.22, 32.51], respectively) after controlling for the potential covariates. There tended to be an inverse association with moderate and high myopia for numbers of 2-min push-ups (β = −1.38; 95% CI [−2.43, −0.34] and β = −2.10; 95% CI [− 3.97, −0.22], respectively) and 2-min sit-ups (β = −0.83; 95% CI [−1.54, −0.12] and β = −1.29; 95% CI [−2.56, −0.02], respectively), respectively. This study suggested that physical fitness, particularly aerobic fitness of the military males who received regular training, is inversely associated with myopia severity, independent of service specialty, body mass index, and educational level.

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