scholarly journals Carbon Nanotubes and Other Engineered Nanoparticles Induced Pathophysiology on Mesothelial Cells and Mesothelial Membranes

2018 ◽  
Vol 9 ◽  
Author(s):  
Sotirios I. Sinis ◽  
Chrissi Hatzoglou ◽  
Konstantinos I. Gourgoulianis ◽  
Sotirios G. Zarogiannis
Keyword(s):  
Carbon Nanotubes ◽  
Mesothelial Cells ◽  
Engineered Nanoparticles

Genotoxicity of short single-wall and multi-wall carbon nanotubes in human bronchial epithelial and mesothelial cells in vitro

Toxicology ◽  
2013 ◽  
Vol 313 (1) ◽  
pp. 24-37 ◽  
Author(s):  
Hanna K. Lindberg ◽  
Ghita C.-M. Falck ◽  
Rajinder Singh ◽  
Satu Suhonen ◽  
Hilkka Järventaus ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Mesothelial Cells ◽  
Bronchial Epithelial ◽  
Multi Wall Carbon Nanotubes

scholarly journals Assessing the colloidal properties of engineered nanoparticles in water: case studies from fullerene C60 nanoparticles and carbon nanotubes

2010 ◽  
Vol 7 (1) ◽  
pp. 10 ◽  
Author(s):  
Kai Loon Chen ◽  
Billy A. Smith ◽  
William P. Ball ◽  
D. Howard Fairbrother
Keyword(s):  
Carbon Nanotubes ◽  
Physicochemical Properties ◽  
Case Studies ◽  
Fullerene C60 ◽  
Engineered Nanoparticles ◽  
Aquatic Systems ◽  
Colloidal Properties ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes ◽  
Carbon Based

Environmental context. The fate and bioavailability of engineered nanoparticles in natural aquatic systems are strongly influenced by their ability to remain dispersed in water. Consequently, understanding the colloidal properties of engineered nanoparticles through rigorous characterisation of physicochemical properties and measurements of particle stability will allow for a more accurate prediction of their environmental, health, and safety effects in aquatic systems. This review highlights some important techniques suitable for the assessment of the colloidal properties of engineered nanoparticles and discusses some recent findings obtained by using these techniques on two popular carbon-based nanoparticles, fullerene C60 and multi-walled carbon nanotubes. Abstract. The colloidal properties of engineered nanoparticles directly affect their use in a wide variety of applications and also control their environmental fate and mobility. The colloidal stability of engineered nanoparticles depends on their physicochemical properties within the given aqueous medium and is ultimately reflected in the particles’ aggregation and deposition behaviour. This review presents some of the key experimental methods that are currently used to probe colloidal properties and quantify engineered nanoparticle stability in water. Case studies from fullerene C60 nanoparticles and multi-walled carbon nanotubes illustrate how the characterisation and measurement methods are used to understand and predict nanoparticle fate in aquatic systems. Consideration of the comparisons between these two classes of carbon-based nanoparticles provides useful insights into some major current knowledge gaps while also revealing clues about needed future developments. Key issues to be resolved relate to the nature of near-range surface forces and the origins of surface charge, particularly for the reportedly unmodified or ‘pure’ carbon-based nanoparticles.

scholarly journals Cytotoxicity of single wall carbon nanotubes to mesothelial cells and effects of alveolar surfactant

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Monisha Das ◽  
Tim Quinn ◽  
Louis Hagler ◽  
Betty Herndon ◽  
Elisabet Kostoryz
Keyword(s):  
Carbon Nanotubes ◽  
Mesothelial Cells ◽  
Single Wall Carbon Nanotubes ◽  
Single Wall Carbon ◽  
Alveolar Surfactant

Oxidative and molecular interactions of multi-wall carbon nanotubes (MWCNT) in normal and malignant human mesothelial cells

2008 ◽  
Vol 2 (3) ◽  
pp. 155-170 ◽  
Author(s):  
Maricica Pacurari ◽  
Xue J. Yin ◽  
Min Ding ◽  
Steve S. Leonard ◽  
Diana Schwegler-berry ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Molecular Interactions ◽  
Mesothelial Cells ◽  
Multi Wall Carbon Nanotubes

scholarly journals Chronic Exposure to Carbon Nanotubes Induces Invasion of Human Mesothelial Cells through Matrix Metalloproteinase-2

ACS Nano ◽  
2013 ◽  
Vol 7 (9) ◽  
pp. 7711-7723 ◽  
Author(s):  
Warangkana Lohcharoenkal ◽  
Liying Wang ◽  
Todd A. Stueckle ◽  
Cerasela Zoica Dinu ◽  
Vincent Castranova ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Matrix Metalloproteinase ◽  
Chronic Exposure ◽  
Mesothelial Cells ◽  
Matrix Metalloproteinase 2

scholarly journals Endocytosis of Multiwalled Carbon Nanotubes in Bronchial Epithelial and Mesothelial Cells

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Kayo Maruyama ◽  
Hisao Haniu ◽  
Naoto Saito ◽  
Yoshikazu Matsuda ◽  
Tamotsu Tsukahara ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Epithelial Cells ◽  
Safety Assessment ◽  
Mesothelial Cells ◽  
Bronchial Epithelial Cells ◽  
Multiwalled Carbon ◽  
Bronchial Epithelial ◽  
Cell Functions ◽  
Species Production ◽  
Multiwalled Cnts

Bronchial epithelial cells and mesothelial cells are crucial targets for the safety assessment of inhalation of carbon nanotubes (CNTs), which resemble asbestos particles in shape. Intrinsic properties of multiwalled CNTs (MWCNTs) are known to cause potentially hazardous effects on intracellular and extracellular pathways. These interactions alter cellular signaling and affect major cell functions, resulting in cell death, lysosome injury, reactive oxygen species production, apoptosis, and cytokine release. Furthermore, CNTs are emerging as a novel class of autophagy inducers. Thus, in this study, we focused on the mechanisms of MWCNT uptake into the human bronchial epithelial cells (HBECs) and human mesothelial cells (HMCs). We verified that MWCNTs are actively internalized into HBECs and HMCs and were accumulated in the lysosomes of the cells after 24-hour treatment. Next, we determined which endocytosis pathways (clathrin-mediated, caveolae-mediated, and macropinocytosis) were associated with MWCNT internalization by using corresponding endocytosis inhibitors, in two nonphagocytic cell lines derived from bronchial epithelial cells and mesothelioma cells. Clathrin-mediated endocytosis inhibitors significantly suppressed MWCNT uptake, whereas caveolae-mediated endocytosis and macropinocytosis were also found to be involved in MWCNT uptake. Thus, MWCNTs were positively taken up by nonphagocytic cells, and their cytotoxicity was closely related to these three endocytosis pathways.

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