scholarly journals Microfluidic Gradient Device for Studying the Mesothelial Cells' Migration and Effects of Carbon Nanotubes Chronic Exposure

2014 ◽  
Author(s):  
Hanyuan Zhang
Keyword(s):  
Carbon Nanotubes ◽  
Chronic Exposure ◽  
Mesothelial Cells ◽  
Gradient Device

scholarly journals Chronic Exposure to Carbon Nanotubes Induces Invasion of Human Mesothelial Cells through Matrix Metalloproteinase-2

ACS Nano ◽  
2013 ◽  
Vol 7 (9) ◽  
pp. 7711-7723 ◽  
Author(s):  
Warangkana Lohcharoenkal ◽  
Liying Wang ◽  
Todd A. Stueckle ◽  
Cerasela Zoica Dinu ◽  
Vincent Castranova ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Matrix Metalloproteinase ◽  
Chronic Exposure ◽  
Mesothelial Cells ◽  
Matrix Metalloproteinase 2

scholarly journals Mitochondrial Impairment Induced by Sub-Chronic Exposure to Multi-Walled Carbon Nanotubes

2019 ◽  
Vol 16 (5) ◽  
pp. 792 ◽  
Author(s):  
Giuseppa Visalli ◽  
Alessio Facciolà ◽  
Monica Currò ◽  
Pasqualina Laganà ◽  
Vincenza La Fauci ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Chronic Exposure ◽  
A549 Cells ◽  
Pyruvate Dehydrogenase Kinase ◽  
Biological Interactions ◽  
Cytochrome C Release ◽  
Toxic Dose ◽  
Mitochondrial Impairment ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

Human exposure to carbon nanotubes (CNTs) can cause health issues due to their chemical-physical features and biological interactions. These nanostructures cause oxidative stress, also due to endogenous reactive oxygen species (ROS) production, which increases following mitochondrial impairment. The aim of this in vitro study was to assess the health effects, due to mitochondrial dysfunction, caused by a sub-chronic exposure to a non-acutely toxic dose of multi walled CNTs (raw and functionalised). The A549 cells were exposed to multi-walled carbon nanotubes (MWCNTs) (2 µg mL−1) for 36 days. Periodically, cellular dehydrogenases, pyruvate dehydrogenase kinase 1 (PDK1), cytochrome c release, permeability transition pore (mPTP) opening, transmembrane potential (Δψ m), apoptotic cells, and intracellular ROS were measured. The results, compared to untreated cells and to positive control formed by cells treated with MWCNTs (20 µg mL−1), highlighted the efficiency of homeostasis to counteract ROS overproduction, but a restitutio ad integrum of mitochondrial functionality was not observed. Despite the tendency to restore, the mitochondrial impairment persisted. Overall, the results underlined the tissue damage that can arise following sub-chronic exposure to MWCNTs.

scholarly journals Carbon Nanotubes and Other Engineered Nanoparticles Induced Pathophysiology on Mesothelial Cells and Mesothelial Membranes

2018 ◽  
Vol 9 ◽  
Author(s):  
Sotirios I. Sinis ◽  
Chrissi Hatzoglou ◽  
Konstantinos I. Gourgoulianis ◽  
Sotirios G. Zarogiannis
Keyword(s):  
Carbon Nanotubes ◽  
Mesothelial Cells ◽  
Engineered Nanoparticles

Abstract 3752: Induction of lung cancer stem-like cells by chronic exposure to carbon nanotubes.

2013 ◽  
Author(s):  
Sudjit Luanpitpong ◽  
Liying Wang ◽  
Amruta Manke ◽  
Jamie Barr ◽  
Yon Rojanasakul
Keyword(s):  
Lung Cancer ◽  
Carbon Nanotubes ◽  
Chronic Exposure

scholarly journals Characterization of the proteome and lipidome profiles of human lung cells after low dose and chronic exposure to multiwalled carbon nanotubes

2018 ◽  
Vol 12 (2) ◽  
pp. 138-152 ◽  
Author(s):  
Santosh Phuyal ◽  
Mayes Kasem ◽  
Oskar Knittelfelder ◽  
Animesh Sharma ◽  
Davi de Miranda Fonseca ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Multiwalled Carbon Nanotubes ◽  
Chronic Exposure ◽  
Low Dose ◽  
Human Lung ◽  
Lung Cells ◽  
Multiwalled Carbon ◽  
Human Lung Cells

Genotoxicity of short single-wall and multi-wall carbon nanotubes in human bronchial epithelial and mesothelial cells in vitro

Toxicology ◽  
2013 ◽  
Vol 313 (1) ◽  
pp. 24-37 ◽  
Author(s):  
Hanna K. Lindberg ◽  
Ghita C.-M. Falck ◽  
Rajinder Singh ◽  
Satu Suhonen ◽  
Hilkka Järventaus ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Mesothelial Cells ◽  
Bronchial Epithelial ◽  
Multi Wall Carbon Nanotubes

scholarly journals Cytotoxicity of single wall carbon nanotubes to mesothelial cells and effects of alveolar surfactant

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Monisha Das ◽  
Tim Quinn ◽  
Louis Hagler ◽  
Betty Herndon ◽  
Elisabet Kostoryz
Keyword(s):  
Carbon Nanotubes ◽  
Mesothelial Cells ◽  
Single Wall Carbon Nanotubes ◽  
Single Wall Carbon ◽  
Alveolar Surfactant

Oxidative and molecular interactions of multi-wall carbon nanotubes (MWCNT) in normal and malignant human mesothelial cells

2008 ◽  
Vol 2 (3) ◽  
pp. 155-170 ◽  
Author(s):  
Maricica Pacurari ◽  
Xue J. Yin ◽  
Min Ding ◽  
Steve S. Leonard ◽  
Diana Schwegler-berry ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Molecular Interactions ◽  
Mesothelial Cells ◽  
Multi Wall Carbon Nanotubes

scholarly journals Mitochondrial Impairment Induced by Sub-Chronic Exposure to Multi-Walled Carbon Nanotubes

2019 ◽  
Author(s):  
Giuseppa Visalli ◽  
Alessio Facciolà ◽  
Monica Currò ◽  
Pasqualina Laganà ◽  
Vincenza La Fauci ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Chronic Exposure ◽  
A549 Cells ◽  
In Vitro Study ◽  
Pyruvate Dehydrogenase Kinase ◽  
Biological Interactions ◽  
Cytochrome C Release ◽  
Toxic Dose ◽  
Mitochondrial Impairment

Human exposure to carbon nanotubes (CNTs) can cause health issues due to their chemical–physical features and biological interactions. These nanostructures cause oxidative stress, also due to endogenous ROS production, which increases following mitochondrial impairment. The aim of this in vitro study was to assess the health effects, due to mitochondrial dysfunction, caused by a sub-chronic exposure to a non-acutely toxic dose of multi walled CNTs (raw and functionalised). The A549 cells were exposed to MWCNTs (2 µg mL-1) for 36 days. Periodically, cellular dehydrogenases, pyruvate dehydrogenase kinase 1 (PDK1), cytochrome c release, permeability transition pore (mPTP) opening, transmembrane potential (Δψ m), apoptotic cells, and intracellular ROS were measured. The results, compared to untreated cells and to positive control formed by cells treated with MWCNTs (20 µg mL-1), highlighted the efficiency of homeostasis to counteract ROS overproduction, but a restitutio ad integrum of mitochondrial functionality was not observed. Despite the tendency to restore, the mitochondrial impairment persisted. Overall, the results underlined the tissue damage that can arise following sub-chronic exposure to MWCNTs.

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