scholarly journals DNA Damage in Human Pleural Mesothelial Cells Induced by Exposure to Carbon Nanotubes

2012 ◽  
Vol 67 (1) ◽  
pp. 76-83 ◽  
Author(s):  
Yuki OGASAWARA ◽  
Noriaki UMEZU ◽  
Kazuyuki ISHII
1994 ◽  
Vol 15 (6) ◽  
pp. 1251-1255 ◽  
Author(s):  
Hang Ying Dong ◽  
Annie Buard ◽  
Annie Renier ◽  
Francoise Lévy ◽  
Laure Saint-Etienne ◽  
...  

Author(s):  
Torry A. Tucker ◽  
LaTerrica Williams ◽  
Kathy Koenig ◽  
Hema Kothari ◽  
Andrey Komissarov ◽  
...  

2015 ◽  
Vol 34 (4) ◽  
pp. 325-335 ◽  
Author(s):  
Masanao Yokohira ◽  
Nozomi Hashimoto ◽  
Toshitaka Nakagawa ◽  
Yuko Nakano ◽  
Keiko Yamakawa ◽  
...  

The present study was conducted to examine the chronic effects of potassium octatitanate fibers (trade name TISMO; chemical formula K2O·6TiO2) on the mouse lung and thoracic cavity. This method of infusion was employed to examine the direct effects of the fibers to the pleura. In the present study, 52- and 65-week experiments were employed to examine the long-term chronic effects after infusion of fiber-shaped TISMO into the thoracic cavities of A/J mice. Following this infusion, TISMO fibers were observed in the alveoli, indicating penetration through the visceral pleura. The additional histopathological detection of TISMO fibers in the liver, spleen, kidneys, ovary, heart, bone marrow, and brain of TISMO-infused mice indicated migration of the fibers out from the thoracic cavity. Atypical mesothelial cells with severe pleural proliferation were observed, but malignant mesotheliomas were not detected. This study demonstrated that intrathoracic infusion of TISMO fiber did not cause malignant mesothelioma but did cause severe chronic inflammation and proliferation of pleural mesothelial cells.


PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0142773 ◽  
Author(s):  
Claire J. Heath ◽  
Maria del Mar Cendra ◽  
Alastair Watson ◽  
Jean-Philippe Auger ◽  
Anish Pandey ◽  
...  

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