scholarly journals Altered Differential Control of Sympathetic Outflow Following Sedentary Conditions: Role of Subregional Neuroplasticity in the RVLM

2016 ◽  
Vol 7 ◽  
Author(s):  
Madhan Subramanian ◽  
Patrick J. Mueller
Keyword(s):  
Sympathetic Outflow ◽  
Differential Control ◽  
Sedentary Conditions

scholarly journals Differential Control of Gonadotropin Secretion in the Human: Endocrine Role of Inhibin1

1998 ◽  
Vol 83 (6) ◽  
pp. 1835-1841 ◽  
Author(s):  
Frances J. Hayes ◽  
Janet E. Hall ◽  
Paul A. Boepple ◽  
William F. Crowley
Keyword(s):  
Gonadotropin Secretion ◽  
Differential Control

Regulated proteolysis of p62/SQSTM1 enables differential control of autophagy and nutrient sensing

2018 ◽  
Vol 11 (559) ◽  
pp. eaat6903 ◽  
Author(s):  
Julia Sanchez-Garrido ◽  
Vanessa Sancho-Shimizu ◽  
Avinash R. Shenoy
Keyword(s):  
Nutrient Sensing ◽  
Caspase 8 ◽  
Rimmed Vacuoles ◽  
Sequestosome 1 ◽  
Inflammatory Conditions ◽  
Mtorc1 Signaling ◽  
Differential Control ◽  
Antimicrobial Immunity ◽  
Lateral Sclerosis

The multidomain scaffold protein p62 (also called sequestosome-1) is involved in autophagy, antimicrobial immunity, and oncogenesis. Mutations in SQSTM1, which encodes p62, are linked to hereditary inflammatory conditions such as Paget’s disease of the bone, frontotemporal dementia (FTD), amyotrophic lateral sclerosis, and distal myopathy with rimmed vacuoles. Here, we report that p62 was proteolytically trimmed by the protease caspase-8 into a stable protein, which we called p62TRM. We found that p62TRM, but not full-length p62, was involved in nutrient sensing and homeostasis through the mechanistic target of rapamycin complex 1 (mTORC1). The kinase RIPK1 and caspase-8 controlled p62TRM production and thus promoted mTORC1 signaling. An FTD-linked p62 D329G polymorphism and a rare D329H variant could not be proteolyzed by caspase-8, and these noncleavable variants failed to activate mTORC1, thereby revealing the detrimental effect of these mutations. These findings on the role of p62TRM provide new insights into SQSTM1-linked diseases and mTORC1 signaling.

Role of Nitric Oxide in Central Sympathetic Outflow

2001 ◽  
Vol 226 (9) ◽  
pp. 814-824 ◽  
Author(s):  
Kaushik P. Patel ◽  
Yi-Fan Li ◽  
Yoshitaka Hirooka
Keyword(s):  
Nitric Oxide ◽  
Sympathetic Outflow ◽  
Central Sympathetic Outflow

scholarly journals Centrally mediated ejaculatory response via sympathetic outflow in rats: role of N-methyl-D-aspartic acid receptors in paraventricular nucleus

Andrology ◽  
2016 ◽  
Vol 5 (1) ◽  
pp. 153-159 ◽  
Author(s):  
J.-D. Xia ◽  
J. Chen ◽  
H.-J. Sun ◽  
L.-H. Zhou ◽  
G.-Q. Zhu ◽  
...  
Keyword(s):  
Aspartic Acid ◽  
Paraventricular Nucleus ◽  
Sympathetic Outflow
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