scholarly journals Centrally mediated ejaculatory response via sympathetic outflow in rats: role of N-methyl-D-aspartic acid receptors in paraventricular nucleus

Andrology ◽  
2016 ◽  
Vol 5 (1) ◽  
pp. 153-159 ◽  
Author(s):  
J.-D. Xia ◽  
J. Chen ◽  
H.-J. Sun ◽  
L.-H. Zhou ◽  
G.-Q. Zhu ◽  
...  
Keyword(s):  
Aspartic Acid ◽  
Paraventricular Nucleus ◽  
Sympathetic Outflow

scholarly journals Regulation of sympathetic vasomotor activity by the hypothalamic paraventricular nucleus in normotensive and hypertensive states

2018 ◽  
Vol 315 (5) ◽  
pp. H1200-H1214 ◽  
Author(s):  
Roger A. Dampney ◽  
Lisete C. Michelini ◽  
De-Pei Li ◽  
Hui-Lin Pan
Keyword(s):  
Paraventricular Nucleus ◽  
Molecular Mechanisms ◽  
Spontaneously Hypertensive Rat ◽  
Hypothalamic Paraventricular Nucleus ◽  
Sympathetic Outflow ◽  
Spontaneously Hypertensive ◽  
Acute Hypotension ◽  
Vasomotor Activity ◽  
Spontaneously Hypertensive Rat Model

The hypothalamic paraventricular nucleus (PVN) is a unique and important brain region involved in the control of cardiovascular, neuroendocrine, and other physiological functions pertinent to homeostasis. The PVN is a major source of excitatory drive to the spinal sympathetic outflow via both direct and indirect projections. In this review, we discuss the role of the PVN in the regulation of sympathetic output in normal physiological conditions and in hypertension. In normal healthy animals, the PVN presympathetic neurons do not appear to have a major role in sustaining resting sympathetic vasomotor activity or in regulating sympathetic responses to short-term homeostatic challenges such as acute hypotension or hypoxia. Their role is, however, much more significant during longer-term challenges, such as sustained water deprivation, chronic intermittent hypoxia, and pregnancy. The PVN also appears to have a major role in generating the increased sympathetic vasomotor activity that is characteristic of multiple forms of hypertension. Recent studies in the spontaneously hypertensive rat model have shown that impaired inhibitory and enhanced excitatory synaptic inputs to PVN presympathetic neurons are the basis for the heightened sympathetic outflow in hypertension. We discuss the molecular mechanisms underlying the presynaptic and postsynaptic alterations in GABAergic and glutamatergic inputs to PVN presympathetic neurons in hypertension. In addition, we discuss the ability of exercise training to correct sympathetic hyperactivity by restoring blood-brain barrier integrity, reducing angiotensin II availability, and decreasing oxidative stress and inflammation in the PVN.

scholarly journals Studies on the role of actin's aspartic acid 3 and aspartic acid 11 using oligodeoxynucleotide-directed site-specific mutagenesis.

1988 ◽  
Vol 263 (36) ◽  
pp. 19662-19669
Author(s):  
T L Solomon ◽  
L R Solomon ◽  
L S Gay ◽  
P A Rubenstein
Keyword(s):  
Aspartic Acid ◽  
Site Specific

Role of the conserved histidine and aspartic acid residues in activity and stabilization of human gelatinase B: An example of matrix metalloproteinases

1995 ◽  
Vol 14 (7) ◽  
pp. 527-535 ◽  
Author(s):  
Tayebeh Pourmotabbed ◽  
Jacob A. Aelion ◽  
David Tyrrell ◽  
Karen A. Hasty ◽  
Chun Hui Bu ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Aspartic Acid ◽  
Gelatinase B

Salusin-β in paraventricular nucleus increases blood pressure and sympathetic outflow via vasopressin in hypertensive rats

2013 ◽  
Vol 98 (3) ◽  
pp. 344-351 ◽  
Author(s):  
Wei-Wei Chen ◽  
Hai-Jian Sun ◽  
Feng Zhang ◽  
Ye-bo Zhou ◽  
Xiao-Qing Xiong ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Paraventricular Nucleus ◽  
Sympathetic Outflow ◽  
Hypertensive Rats
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