scholarly journals Conventional Pig as Animal Model for Human Renal Drug Excretion Processes: Unravelling the Porcine Renal Function by Use of a Cocktail of Exogenous Markers

2020 ◽  
Vol 11 ◽  
Author(s):  
Laura Dhondt ◽  
Siska Croubels ◽  
Peter De Paepe ◽  
Steven C. Wallis ◽  
Saurabh Pandey ◽  
...  
Keyword(s):  
Animal Model ◽  
Renal Function ◽  
Drug Excretion

A small animal model utilizing salivary drug excretion for pharmacokinetic determinations

1980 ◽  
Vol 3 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Anthony J. Piraino ◽  
G.John Digregorio ◽  
Elleen K. Ruch
Keyword(s):  
Animal Model ◽  
Small Animal ◽  
Small Animal Model ◽  
Drug Excretion

EFFECTS OF SEPSIS ON RENAL FUNCTION AND MORPHOLOGY IN AN ANIMAL MODEL

1982 ◽  
Vol 10 (3) ◽  
pp. 219
Author(s):  
Adam L. Linton ◽  
Arsenio Avila ◽  
Paul Sharkey ◽  
Andrew Petrakas ◽  
Richard J. Finley ◽  
...  
Keyword(s):  
Animal Model ◽  
Renal Function

Impact of high doses of 6% hydroxyethyl starch 130/0.42 and 4% gelatin on renal function in a pediatric animal model

2015 ◽  
Vol 26 (3) ◽  
pp. 259-265 ◽  
Author(s):  
Lars Witt ◽  
Silke Glage ◽  
Ralf Lichtinghagen ◽  
Lars Pape ◽  
Dietmar Boethig ◽  
...  
Keyword(s):  
Animal Model ◽  
Renal Function ◽  
Hydroxyethyl Starch ◽  
High Doses

scholarly journals Issues Related to the Use of Canines in Toxicologic Pathology—Issues With Pharmacokinetics and Metabolism

2003 ◽  
Vol 31 (1_suppl) ◽  
pp. 17-24 ◽  
Author(s):  
Jay Tibbitts
Keyword(s):  
Animal Model ◽  
Renal Function ◽  
Protein Binding ◽  
Species Differences ◽  
Drug Disposition ◽  
Pharmaceutical Products ◽  
Dose Selection ◽  
Gastrointestinal Physiology ◽  
Veterinary Pharmaceutical

The dog is a commonly used animal model by virtue of its size, well-characterized physiology, and ease of handling. For these reasons and others, dogs are also useful in pharmacokinetic and metabolism studies during the development of both human and veterinary pharmaceutical products. In comparison with humans, or with other animals, dogs have some unique physiologic attributes that can affect the disposition of drugs. Species differences in gastrointestinal physiology, metabolism, renal function, and protein binding can affect the correlation of the pharmacokinetics and toxicology of dogs with those of other species. With the use of relevant examples, this article will provide an introduction to characteristics of dog physiology and their impact on pharmacokinetics, metabolism, drug disposition, toxicity, and dose selection.

Pharmacokinetic study of S-1, a novel oral fluorouracil antitumor agent in animal model and in patients with impaired renal function

2002 ◽  
Vol 50 (1) ◽  
pp. 25-32 ◽  
Author(s):  
Masataka Ikeda ◽  
Hiroshi Furukawa ◽  
Hiroshi Imamura ◽  
Jyunzo Shimizu ◽  
Hideyuki Ishida ◽  
...  
Keyword(s):  
Animal Model ◽  
Renal Function ◽  
Pharmacokinetic Study ◽  
Impaired Renal Function ◽  
Antitumor Agent

Renal Function in Pregnancy

1983 ◽  
Vol 65 (5) ◽  
pp. 449-455 ◽  
Author(s):  
J. C. Atherton ◽  
R. Green
Keyword(s):  
Animal Model ◽  
Renal Function ◽  
Experimental Animals ◽  
The Past ◽  
Water Handling ◽  
Methodological Problems ◽  
Glucose Excretion ◽  
In Pregnancy

Although our understanding of many renal mechanisms has been advancing rapidly over the past few years, there is still a dearth of information about changes that occur in renal function during pregnancy — surely one of the greatest physiological disturbances possible. It is difficult in many instances to find a description of the changes that occur quite apart from the underlying alterations in mechanisms that are responsible for them. Part of the difficulty has arisen because of the ethical and methodological problems that arise when women are used as ‘experimental animals’ until recently there has not been a suitably documented animal model, though whether this was because of technical difficulties or lack of interest on the part of investigators is not known. Recently, however, it has become apparent that many changes in renal function in the rat are similar to those occurring in women and some aspects of renal function in the rat have been investigated in detail. Since not all aspects of renal function can be covered in this review we shall concentrate on three of the more important areas, namely haemodynamics, sodium and water handling and glucose excretion, and discuss how these are changed during pregnancy; comments on the possible mechanisms involved in these changes are presented where appropriate.

scholarly journals Hypoxia-preconditioned MSCs Have Superior Effect in Ameliorating Renal Function on Acute Renal Failure Animal Model

2019 ◽  
Vol 7 (3) ◽  
pp. 305-310 ◽  
Author(s):  
Agung Putra ◽  
Dannis Pertiwi ◽  
Meidona Nurul Milla ◽  
Ulfah Dian Indrayani ◽  
Durotul Jannah ◽  
...  
Keyword(s):  
Renal Failure ◽  
Animal Model ◽  
Renal Function ◽  
Acute Renal Failure ◽  
Treatment Group ◽  
Creatinine Level ◽  
Histological Analysis ◽  
Control Group ◽  
Positive Effects

BACKGROUND: Acute renal failure (ARF) is a serious disease characterised by a rapid loss of renal functions due to nephrotoxic drug or ischemic insult. The clinical treatment approach such as dialysis techniques and continuous renal enhancement have grown rapidly during past decades. However, there is yet no significant effect in improving renal function. Hypoxia-preconditioned mesenchymal stem cells (HP-MSCs) have positive effects on the in vitro survival and stemness, in addition to angiogenic potential. AIM: In this study, we aimed to analyse the effect of HP-MSCs administration in improving renal function, characterised by blood urea nitrogen (BUN) and creatinine level. METHODS: A group of 15 male Wistar rats weighing 250 g to 300 g were used in this study (n = 5 for each group). Rats were randomly distributed into 3 groups: Vehicle control (Veh) as a control group, HP-MSCs and normoxia MSCs (N-MSCs) as the treatment group. Renal function was evaluated based on the BUN and creatinine levels using the colourimetric method on day 5 and 13. The histological analysis using HE staining was performed on day 13. RESULTS: The result showed there is a significant decrease in BUN and creatinine level (p < 0.05). The histological analysis of renal tissue also showed a significant decrease between Veh and treatment group (p < 0.05). CONCLUSION: Based on this study, we conclude that HP-MSCs have a superior beneficial effect than N-MSCs in improving renal function in an animal model of gentamicin-induced ARF.

scholarly journals Renoprotective Role of Tualang Honey Against High Cholesterol Diet Induced Acute Kidney Diseases in an Animal Model

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Zenab B. Hamad Mohamed ◽  
Hamad Abdulsalam Hamad Alfarisi ◽  
Nor Zamzila Abdullah ◽  
Naznin Muhammad ◽  
Roslina Abdul Rahim
Keyword(s):  
Animal Model ◽  
Renal Function ◽  
Histological Examination ◽  
Kidney Diseases ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Renoprotective Effect ◽  
Significant Difference ◽  
Tualang Honey

Introduction: Although there is a growing insight into the causes and mechanisms of kidney diseases, preventive and therapeutic measures are still few. The aim of this study was therefore to determine the renoprotective effect of tualang honey against high cholesterol diet induced acute kidney disease in an animal model. Materials and method: Ten female Sprague-Dawley rats were divided into two groups: high cholesterol diet (HCD) group, fed with 12% cholesterol diet with 0.3% cholic acid, and high cholesterol diet with tualang honey (HCD + TH) group, fed with HCD with oral daily dose of 1.4 g/kg/day of tualang honey by gavage. Biochemical analysis of lipid profile and renal function were performed at 48 hours, 7 days, and 6 weeks of the experiment. The animals were sacrificed at 6 weeks and the kidneys were harvested for histological examination. Results: There was no significant difference between the HCD and the HCD+TH groups in the level of TC. The mean serum LDL-c, TG and vLDL levels at completed 48 hours and 7 days for the HCD+TH group were lower as compared to the HCD group. The only significant difference in renal function test between HCD and HCD + TH groups reported were theserum creatinine at completed 48 hours. Histological examination of the kidney tissue of the HCD and HCD+TH groups at 6 weeks revealed segmental mesangial hypercellularity and mesangial matrix expansion of the glomeruli. Conclusion: Tualang honey supplementation has resulted in an improvement of the renal profile which is suggestive of its renoprotective effect. However, the histopathological examination of the kidneys revealed similar changesin both groups and this may be related to the dose of honey used in the study. Additionally, tualang honey showed improvement in LDL-c, triglyceride and vLDL levels indicating its lipid lowering activities.

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